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Items: 32


Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex.

Jia N, Xie W, de la Cruz MJ, Eng ET, Patel DJ.

Cell Res. 2020 Feb;30(2):182-184. doi: 10.1038/s41422-019-0272-2. Epub 2020 Jan 10. No abstract available.


Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.

Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schön A, Todd JP, Wang S, Wei H, Wu W; NISC Comparative Sequencing Program, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR.

Cell. 2019 Jul 25;178(3):567-584.e19. doi: 10.1016/j.cell.2019.06.030.


Reducing cryoEM file storage using lossy image formats.

Eng ET, Kopylov M, Negro CJ, Dallaykan S, Rice WJ, Jordan KD, Kelley K, Carragher B, Potter CS.

J Struct Biol. 2019 Jul 1;207(1):49-55. doi: 10.1016/j.jsb.2019.04.013. Epub 2019 May 21.


Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A.

Elife. 2019 Jan 16;8. pii: e43229. doi: 10.7554/eLife.43229.


Mechanisms of opening and closing of the bacterial replicative helicase.

Chase J, Catalano A, Noble AJ, Eng ET, Olinares PD, Molloy K, Pakotiprapha D, Samuels M, Chait B, des Georges A, Jeruzalmi D.

Elife. 2018 Dec 24;7. pii: e41140. doi: 10.7554/eLife.41140.


Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Jia N, Mo CY, Wang C, Eng ET, Marraffini LA, Patel DJ.

Mol Cell. 2019 Jan 17;73(2):264-277.e5. doi: 10.1016/j.molcel.2018.11.007. Epub 2018 Nov 29.


High resolution single particle cryo-electron microscopy using beam-image shift.

Cheng A, Eng ET, Alink L, Rice WJ, Jordan KD, Kim LY, Potter CS, Carragher B.

J Struct Biol. 2018 Nov;204(2):270-275. doi: 10.1016/j.jsb.2018.07.015. Epub 2018 Jul 25.


Routine determination of ice thickness for cryo-EM grids.

Rice WJ, Cheng A, Noble AJ, Eng ET, Kim LY, Carragher B, Potter CS.

J Struct Biol. 2018 Oct;204(1):38-44. doi: 10.1016/j.jsb.2018.06.007. Epub 2018 Jul 4.


Benchmarking cryo-EM Single Particle Analysis Workflow.

Kim LY, Rice WJ, Eng ET, Kopylov M, Cheng A, Raczkowski AM, Jordan KD, Bobe D, Potter CS, Carragher B.

Front Mol Biosci. 2018 Jun 4;5:50. doi: 10.3389/fmolb.2018.00050. eCollection 2018.


Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.

Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD.

Nat Med. 2018 Jun;24(6):857-867. doi: 10.1038/s41591-018-0042-6. Epub 2018 Jun 4.


Routine single particle CryoEM sample and grid characterization by tomography.

Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B.

Elife. 2018 May 29;7. pii: e34257. doi: 10.7554/eLife.34257.


Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).

Lin W, Das K, Degen D, Mazumder A, Duchi D, Wang D, Ebright YW, Ebright RY, Sineva E, Gigliotti M, Srivastava A, Mandal S, Jiang Y, Liu Y, Yin R, Zhang Z, Eng ET, Thomas D, Donadio S, Zhang H, Zhang C, Kapanidis AN, Ebright RH.

Mol Cell. 2018 Apr 5;70(1):60-71.e15. doi: 10.1016/j.molcel.2018.02.026. Epub 2018 Mar 29.


Spotiton: New features and applications.

Dandey VP, Wei H, Zhang Z, Tan YZ, Acharya P, Eng ET, Rice WJ, Kahn PA, Potter CS, Carragher B.

J Struct Biol. 2018 May;202(2):161-169. doi: 10.1016/j.jsb.2018.01.002.


Big data in cryoEM: automated collection, processing and accessibility of EM data.

Baldwin PR, Tan YZ, Eng ET, Rice WJ, Noble AJ, Negro CJ, Cianfrocco MA, Potter CS, Carragher B.

Curr Opin Microbiol. 2018 Jun;43:1-8. doi: 10.1016/j.mib.2017.10.005. Epub 2017 Oct 31. Review.


Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.

Guo TW, Bartesaghi A, Yang H, Falconieri V, Rao P, Merk A, Eng ET, Raczkowski AM, Fox T, Earl LA, Patel DJ, Subramaniam S.

Cell. 2017 Oct 5;171(2):414-426.e12. doi: 10.1016/j.cell.2017.09.006.


Best practices for managing large CryoEM facilities.

Alewijnse B, Ashton AW, Chambers MG, Chen S, Cheng A, Ebrahim M, Eng ET, Hagen WJH, Koster AJ, López CS, Lukoyanova N, Ortega J, Renault L, Reyntjens S, Rice WJ, Scapin G, Schrijver R, Siebert A, Stagg SM, Grum-Tokars V, Wright ER, Wu S, Yu Z, Zhou ZH, Carragher B, Potter CS.

J Struct Biol. 2017 Sep;199(3):225-236. doi: 10.1016/j.jsb.2017.07.011. Epub 2017 Aug 4.


Visualization of HIV T Cell Virological Synapses and Virus-Containing Compartments by Three-Dimensional Correlative Light and Electron Microscopy.

Wang L, Eng ET, Law K, Gordon RE, Rice WJ, Chen BK.

J Virol. 2017 Jan 3;91(2). pii: e01605-16. doi: 10.1128/JVI.01605-16. Print 2017 Jan 15.


β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.

Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA.

J Biol Chem. 2016 Feb 26;291(9):4537-46. doi: 10.1074/jbc.M115.705624. Epub 2015 Dec 2.


Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs.

Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG.

Arch Biochem Biophys. 2014 Mar 15;546:33-40. doi: 10.1016/ Epub 2014 Feb 3.


Organization of the human mitochondrial transcription initiation complex.

Yakubovskaya E, Guja KE, Eng ET, Choi WS, Mejia E, Beglov D, Lukin M, Kozakov D, Garcia-Diaz M.

Nucleic Acids Res. 2014 Apr;42(6):4100-12. doi: 10.1093/nar/gkt1360. Epub 2014 Jan 9.


Sequence and structure relationships within von Willebrand factor.

Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA.

Blood. 2012 Jul 12;120(2):449-58. doi: 10.1182/blood-2012-01-405134. Epub 2012 Apr 6.


A pH-regulated dimeric bouquet in the structure of von Willebrand factor.

Zhou YF, Eng ET, Nishida N, Lu C, Walz T, Springer TA.

EMBO J. 2011 Aug 19;30(19):4098-111. doi: 10.1038/emboj.2011.297.


Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy.

Eng ET, Smagghe BJ, Walz T, Springer TA.

J Biol Chem. 2011 Oct 7;286(40):35218-26. doi: 10.1074/jbc.M111.275107. Epub 2011 Aug 9.


Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB.

Hung KW, Chang YW, Eng ET, Chen JH, Chen YC, Sun YJ, Hsiao CD, Dong G, Spasov KA, Unger VM, Huang TH.

J Struct Biol. 2010 Jun;170(3):501-12. doi: 10.1016/j.jsb.2010.01.017. Epub 2010 Feb 1.


Characterization of a novel prokaryotic GDP dissociation inhibitor domain from the G protein coupled membrane protein FeoB.

Eng ET, Jalilian AR, Spasov KA, Unger VM.

J Mol Biol. 2008 Jan 25;375(4):1086-97. Epub 2007 Nov 19.


Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds.

Eng ET, Ye J, Williams D, Phung S, Moore RE, Young MK, Gruntmanis U, Braunstein G, Chen S.

Cancer Res. 2003 Dec 1;63(23):8516-22.


Structure-function studies of aromatase and its inhibitors: a progress report.

Chen S, Zhang F, Sherman MA, Kijima I, Cho M, Yuan YC, Toma Y, Osawa Y, Zhou D, Eng ET.

J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):231-7. Review.


Anti-aromatase chemicals in red wine.

Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S.

Ann N Y Acad Sci. 2002 Jun;963:239-46.


Prevention and treatment of breast cancer by suppressing aromatase activity and expression.

Chen S, Zhou D, Okubo T, Kao YC, Eng ET, Grube B, Kwon A, Yang C, Yu B.

Ann N Y Acad Sci. 2002 Jun;963:229-38.


White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.

Grube BJ, Eng ET, Kao YC, Kwon A, Chen S.

J Nutr. 2001 Dec;131(12):3288-93.


Suppression of aromatase (estrogen synthetase) by red wine phytochemicals.

Eng ET, Williams D, Mandava U, Kirma N, Tekmal RR, Chen S.

Breast Cancer Res Treat. 2001 May;67(2):133-46.


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