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Items: 23

1.

Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity.

Arensman MD, Yang XS, Leahy DM, Toral-Barza L, Mileski M, Rosfjord EC, Wang F, Deng S, Myers JS, Abraham RT, Eng CH.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9533-9542. doi: 10.1073/pnas.1814932116. Epub 2019 Apr 24.

2.

Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging.

Arensman MD, Eng CH.

Mol Cell. 2018 Aug 16;71(4):485-486. doi: 10.1016/j.molcel.2018.08.002.

3.

ClusterCAD: a computational platform for type I modular polyketide synthase design.

Eng CH, Backman TWH, Bailey CB, Magnan C, García Martín H, Katz L, Baldi P, Keasling JD.

Nucleic Acids Res. 2018 Jan 4;46(D1):D509-D515. doi: 10.1093/nar/gkx893.

4.

Revisiting autophagy addiction of tumor cells.

Nyfeler B, Eng CH.

Autophagy. 2016 Jul 2;12(7):1206-7. doi: 10.1080/15548627.2016.1170265. Epub 2016 Apr 20. Review.

5.

Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.

Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD.

Biochemistry. 2016 Mar 29;55(12):1677-80. doi: 10.1021/acs.biochem.6b00129. Epub 2016 Mar 15.

PMID:
26976746
6.

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.

Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham RT, Murphy LO, Nyfeler B.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):182-7. doi: 10.1073/pnas.1515617113. Epub 2015 Dec 17.

7.

Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity.

Onyango JO, Chung MS, Eng CH, Klees LM, Langenbacher R, Yao L, An M.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3658-3663. doi: 10.1002/anie.201409770. Epub 2015 Feb 4.

8.

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.

Shanware NP, Bray K, Eng CH, Wang F, Follettie M, Myers J, Fantin VR, Abraham RT.

Nat Commun. 2014 Sep 25;5:4900. doi: 10.1038/ncomms5900.

9.

Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin.

Yuzawa S, Eng CH, Katz L, Keasling JD.

J Antibiot (Tokyo). 2014 Feb;67(2):199-201. doi: 10.1038/ja.2013.110. Epub 2013 Oct 30. No abstract available.

PMID:
24169801
10.

Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.

Yuzawa S, Eng CH, Katz L, Keasling JD.

Biochemistry. 2013 Jun 4;52(22):3791-3. doi: 10.1021/bi400520t. Epub 2013 May 23.

PMID:
23692164
11.

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming.

Eng CH, Abraham RT.

Oncogene. 2011 Nov 24;30(47):4687-96. doi: 10.1038/onc.2011.220. Epub 2011 Jun 13. Review.

PMID:
21666712
12.

Glutaminolysis yields a metabolic by-product that stimulates autophagy.

Eng CH, Abraham RT.

Autophagy. 2010 Oct;6(7):968-70. doi: 10.4161/auto.6.7.13082. Epub 2010 Oct 20.

13.

A metabolic (re-)balancing act.

Abraham RT, Eng CH.

Mol Cell. 2010 May 28;38(4):481-2. doi: 10.1016/j.molcel.2010.05.008.

14.

Ammonia derived from glutaminolysis is a diffusible regulator of autophagy.

Eng CH, Yu K, Lucas J, White E, Abraham RT.

Sci Signal. 2010 Apr 27;3(119):ra31. doi: 10.1126/scisignal.2000911.

15.

Mammalian target of rapamycin as a therapeutic target in oncology.

Abraham RT, Eng CH.

Expert Opin Ther Targets. 2008 Feb;12(2):209-22. doi: 10.1517/14728222.12.2.209 . Review.

PMID:
18208369
16.
17.

Regulation of microtubules by Rho GTPases in migrating cells.

Gundersen GG, Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Gomes ER.

Novartis Found Symp. 2005;269:106-16; discussion 116-26, 223-30.

PMID:
16358406
18.

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.

Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG.

Nat Cell Biol. 2004 Sep;6(9):820-30. Epub 2004 Aug 15.

PMID:
15311282
19.

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling.

Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG.

Science. 2004 Feb 6;303(5659):836-9.

20.
21.

Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus.

Samsonov AV, Chatterjee PK, Razinkov VI, Eng CH, Kielian M, Cohen FS.

J Virol. 2002 Dec;76(24):12691-702.

22.

Testis-specific HMG-domain protein alters the responses of cells to cisplatin.

Zamble DB, Mikata Y, Eng CH, Sandman KE, Lippard SJ.

J Inorg Biochem. 2002 Aug 30;91(3):451-62.

PMID:
12175937
23.

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