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Items: 1 to 50 of 62

1.

Actin stabilizing compounds show specific biological effects due to their binding mode.

Wang S, Crevenna AH, Ugur I, Marion A, Antes I, Kazmaier U, Hoyer M, Lamb DC, Gegenfurtner F, Kliesmete Z, Ziegenhain C, Enard W, Vollmar A, Zahler S.

Sci Rep. 2019 Jul 5;9(1):9731. doi: 10.1038/s41598-019-46282-w.

2.

Chivosazole A Modulates Protein-Protein Interactions of Actin.

Wang S, Gegenfurtner FA, Crevenna AH, Ziegenhain C, Kliesmete Z, Enard W, Müller R, Vollmar AM, Schneider S, Zahler S.

J Nat Prod. 2019 Jul 26;82(7):1961-1970. doi: 10.1021/acs.jnatprod.9b00335. Epub 2019 Jul 1.

PMID:
31260301
3.

Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity.

Gunz P, Tilot AK, Wittfeld K, Teumer A, Shapland CY, van Erp TGM, Dannemann M, Vernot B, Neubauer S, Guadalupe T, Fernández G, Brunner HG, Enard W, Fallon J, Hosten N, Völker U, Profico A, Di Vincenzo F, Manzi G, Kelso J, St Pourcain B, Hublin JJ, Franke B, Pääbo S, Macciardi F, Grabe HJ, Fisher SE.

Curr Biol. 2019 Mar 4;29(5):895. doi: 10.1016/j.cub.2019.02.008. No abstract available.

4.

Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels.

Schreiweis C, Irinopoulou T, Vieth B, Laddada L, Oury F, Burguière E, Enard W, Groszer M.

Cortex. 2019 Sep;118:212-222. doi: 10.1016/j.cortex.2019.01.008. Epub 2019 Jan 30.

PMID:
30808549
5.

Studying Cancer Heterogeneity by Single-Cell RNA Sequencing.

Bagnoli JW, Wange LE, Janjic A, Enard W.

Methods Mol Biol. 2019;1956:305-319. doi: 10.1007/978-1-4939-9151-8_14.

PMID:
30779041
6.

Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity.

Gunz P, Tilot AK, Wittfeld K, Teumer A, Shapland CY, van Erp TGM, Dannemann M, Vernot B, Neubauer S, Guadalupe T, Fernández G, Brunner HG, Enard W, Fallon J, Hosten N, Völker U, Profico A, Di Vincenzo F, Manzi G, Kelso J, St Pourcain B, Hublin JJ, Franke B, Pääbo S, Macciardi F, Grabe HJ, Fisher SE.

Curr Biol. 2019 Jan 7;29(1):120-127.e5. doi: 10.1016/j.cub.2018.10.065. Epub 2018 Dec 13. Erratum in: Curr Biol. 2019 Mar 4;29(5):895.

7.

Altered social behavior in mice carrying a cortical Foxp2 deletion.

Medvedeva VP, Rieger MA, Vieth B, Mombereau C, Ziegenhain C, Ghosh T, Cressant A, Enard W, Granon S, Dougherty JD, Groszer M.

Hum Mol Genet. 2019 Mar 1;28(5):701-717. doi: 10.1093/hmg/ddy372.

PMID:
30357341
8.

Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone.

Gegenfurtner FA, Zisis T, Al Danaf N, Schrimpf W, Kliesmete Z, Ziegenhain C, Enard W, Kazmaier U, Lamb DC, Vollmar AM, Zahler S.

Cell Mol Life Sci. 2018 Dec;75(24):4539-4555. doi: 10.1007/s00018-018-2919-4. Epub 2018 Sep 11.

PMID:
30206640
9.

Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata).

Nakai R, Ohnuki M, Kuroki K, Ito H, Hirai H, Kitajima R, Fujimoto T, Nakagawa M, Enard W, Imamura M.

Sci Rep. 2018 Aug 15;8(1):12187. doi: 10.1038/s41598-018-30734-w.

10.

Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq.

Bagnoli JW, Ziegenhain C, Janjic A, Wange LE, Vieth B, Parekh S, Geuder J, Hellmann I, Enard W.

Nat Commun. 2018 Jul 26;9(1):2937. doi: 10.1038/s41467-018-05347-6.

11.

zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs.

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I.

Gigascience. 2018 Jun 1;7(6). doi: 10.1093/gigascience/giy059.

12.

Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing.

Gegenfurtner FA, Jahn B, Wagner H, Ziegenhain C, Enard W, Geistlinger L, Rädler JO, Vollmar AM, Zahler S.

J Cell Sci. 2018 May 29;131(10). pii: jcs212886. doi: 10.1242/jcs.212886.

13.

Quantitative single-cell transcriptomics.

Ziegenhain C, Vieth B, Parekh S, Hellmann I, Enard W.

Brief Funct Genomics. 2018 Jul 1;17(4):220-232. doi: 10.1093/bfgp/ely009. Review.

14.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Cadiñanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R.

Nature. 2018 Feb 1;554(7690):62-68. doi: 10.1038/nature25459. Epub 2018 Jan 24.

15.

The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants.

Elife. 2017 Dec 5;6. pii: e27041. doi: 10.7554/eLife.27041.

16.

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency.

Krendl C, Shaposhnikov D, Rishko V, Ori C, Ziegenhain C, Sass S, Simon L, Müller NS, Straub T, Brooks KE, Chavez SL, Enard W, Theis FJ, Drukker M.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9579-E9588. doi: 10.1073/pnas.1708341114. Epub 2017 Oct 25.

17.

powsimR: power analysis for bulk and single cell RNA-seq experiments.

Vieth B, Ziegenhain C, Parekh S, Enard W, Hellmann I.

Bioinformatics. 2017 Nov 1;33(21):3486-3488. doi: 10.1093/bioinformatics/btx435.

PMID:
29036287
18.

Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes.

Witzel M, Petersheim D, Fan Y, Bahrami E, Racek T, Rohlfs M, Puchałka J, Mertes C, Gagneur J, Ziegenhain C, Enard W, Stray-Pedersen A, Arkwright PD, Abboud MR, Pazhakh V, Lieschke GJ, Krawitz PM, Dahlhoff M, Schneider MR, Wolf E, Horny HP, Schmidt H, Schäffer AA, Klein C.

Nat Genet. 2017 May;49(5):742-752. doi: 10.1038/ng.3833. Epub 2017 Apr 3.

19.

Comparative Analysis of Single-Cell RNA Sequencing Methods.

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.

Mol Cell. 2017 Feb 16;65(4):631-643.e4. doi: 10.1016/j.molcel.2017.01.023.

20.

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes.

Nissen JD, Lykke K, Bryk J, Stridh MH, Zaganas I, Skytt DM, Schousboe A, Bak LK, Enard W, Pääbo S, Waagepetersen HS.

Glia. 2017 Mar;65(3):474-488. doi: 10.1002/glia.23105. Epub 2016 Dec 29.

PMID:
28032919
21.

Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.

Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA.

J Exp Med. 2017 Jan;214(1):165-181. doi: 10.1084/jem.20151414. Epub 2016 Dec 20.

22.

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia.

Ebinger S, Özdemir EZ, Ziegenhain C, Tiedt S, Castro Alves C, Grunert M, Dworzak M, Lutz C, Turati VA, Enver T, Horny HP, Sotlar K, Parekh S, Spiekermann K, Hiddemann W, Schepers A, Polzer B, Kirsch S, Hoffmann M, Knapp B, Hasenauer J, Pfeifer H, Panzer-Grümayer R, Enard W, Gires O, Jeremias I.

Cancer Cell. 2016 Dec 12;30(6):849-862. doi: 10.1016/j.ccell.2016.11.002. Epub 2016 Dec 1.

23.

Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c.

Chen YC, Kuo HY, Bornschein U, Takahashi H, Chen SY, Lu KM, Yang HY, Chen GM, Lin JR, Lee YH, Chou YC, Cheng SJ, Chien CT, Enard W, Hevers W, Pääbo S, Graybiel AM, Liu FC.

Nat Neurosci. 2016 Nov;19(11):1513-1522. doi: 10.1038/nn.4380. Epub 2016 Sep 5.

24.

The Molecular Basis of Human Brain Evolution.

Enard W.

Curr Biol. 2016 Oct 24;26(20):R1109-R1117. doi: 10.1016/j.cub.2016.09.030. Review.

25.

The impact of amplification on differential expression analyses by RNA-seq.

Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I.

Sci Rep. 2016 May 9;6:25533. doi: 10.1038/srep25533.

26.

Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development.

Li Q, Guo S, Jiang X, Bryk J, Naumann R, Enard W, Tomita M, Sugimoto M, Khaitovich P, Pääbo S.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5358-63. doi: 10.1073/pnas.1519261113. Epub 2016 Apr 26.

27.

A humanized version of Foxp2 does not affect ultrasonic vocalization in adult mice.

Hammerschmidt K, Schreiweis C, Minge C, Pääbo S, Fischer J, Enard W.

Genes Brain Behav. 2015 Nov;14(8):583-90. doi: 10.1111/gbb.12237. Epub 2015 Aug 25.

28.

Human evolution: enhancing the brain.

Enard W.

Curr Biol. 2015 May 18;25(10):R421-3. doi: 10.1016/j.cub.2015.03.031.

29.

Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance.

Schreiweis C, Bornschein U, Burguière E, Kerimoglu C, Schreiter S, Dannemann M, Goyal S, Rea E, French CA, Puliyadi R, Groszer M, Fisher SE, Mundry R, Winter C, Hevers W, Pääbo S, Enard W, Graybiel AM.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14253-8. doi: 10.1073/pnas.1414542111. Epub 2014 Sep 15.

30.

Mouse models of human evolution.

Enard W.

Curr Opin Genet Dev. 2014 Dec;29:75-80. doi: 10.1016/j.gde.2014.08.008. Epub 2014 Sep 16. Review.

PMID:
25218860
31.

Comparative genomics of brain size evolution.

Enard W.

Front Hum Neurosci. 2014 May 21;8:345. doi: 10.3389/fnhum.2014.00345. eCollection 2014.

32.

Primate iPS cells as tools for evolutionary analyses.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Göhring G, Glage S, Schambach A, Curnow EC, Pääbo S, Martin U, Enard W.

Stem Cell Res. 2014 May;12(3):622-9. doi: 10.1016/j.scr.2014.02.001. Epub 2014 Feb 8.

33.

A recent evolutionary change affects a regulatory element in the human FOXP2 gene.

Maricic T, Günther V, Georgiev O, Gehre S, Curlin M, Schreiweis C, Naumann R, Burbano HA, Meyer M, Lalueza-Fox C, de la Rasilla M, Rosas A, Gajovic S, Kelso J, Enard W, Schaffner W, Pääbo S.

Mol Biol Evol. 2013 Apr;30(4):844-52. doi: 10.1093/molbev/mss271. Epub 2012 Nov 28.

PMID:
23197593
34.

Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons.

Clovis YM, Enard W, Marinaro F, Huttner WB, De Pietri Tonelli D.

Development. 2012 Sep;139(18):3332-42. doi: 10.1242/dev.078063. Epub 2012 Aug 8.

35.

Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.

Fietz SA, Lachmann R, Brandl H, Kircher M, Samusik N, Schröder R, Lakshmanaperumal N, Henry I, Vogt J, Riehn A, Distler W, Nitsch R, Enard W, Pääbo S, Huttner WB.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11836-41. doi: 10.1073/pnas.1209647109. Epub 2012 Jul 2.

36.

Functional primate genomics--leveraging the medical potential.

Enard W.

J Mol Med (Berl). 2012 May;90(5):471-80. doi: 10.1007/s00109-012-0901-4. Epub 2012 May 4. Review.

PMID:
22555407
37.

FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution.

Enard W.

Curr Opin Neurobiol. 2011 Jun;21(3):415-24. doi: 10.1016/j.conb.2011.04.008. Epub 2011 May 16. Review.

PMID:
21592779
38.

Humanized Foxp2 specifically affects cortico-basal ganglia circuits.

Reimers-Kipping S, Hevers W, Pääbo S, Enard W.

Neuroscience. 2011 Feb 23;175:75-84. doi: 10.1016/j.neuroscience.2010.11.042. Epub 2010 Nov 25.

PMID:
21111790
39.

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.

Pulvers JN, Bryk J, Fish JL, Wilsch-Bräuninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, Nitsch R, Tóth A, Enard W, Pääbo S, Huttner WB.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7.

40.

Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates.

Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T.

PLoS One. 2010 Jun 15;5(6):e11133. doi: 10.1371/journal.pone.0011133.

41.

Linkage disequilibrium extends across putative selected sites in FOXP2.

Ptak SE, Enard W, Wiebe V, Hellmann I, Krause J, Lachmann M, Pääbo S.

Mol Biol Evol. 2009 Oct;26(10):2181-4. doi: 10.1093/molbev/msp143. Epub 2009 Jul 16.

PMID:
19608635
42.

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S.

Cell. 2009 May 29;137(5):961-71. doi: 10.1016/j.cell.2009.03.041.

43.

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

Groszer M, Keays DA, Deacon RM, de Bono JP, Prasad-Mulcare S, Gaub S, Baum MG, French CA, Nicod J, Coventry JA, Enard W, Fray M, Brown SD, Nolan PM, Pääbo S, Channon KM, Costa RM, Eilers J, Ehret G, Rawlins JN, Fisher SE.

Curr Biol. 2008 Mar 11;18(5):354-62. doi: 10.1016/j.cub.2008.01.060.

44.

The derived FOXP2 variant of modern humans was shared with Neandertals.

Krause J, Lalueza-Fox C, Orlando L, Enard W, Green RE, Burbano HA, Hublin JJ, Hänni C, Fortea J, de la Rasilla M, Bertranpetit J, Rosas A, Pääbo S.

Curr Biol. 2007 Nov 6;17(21):1908-12. Epub 2007 Oct 18.

45.

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.

Timpson N, Heron J, Smith GD, Enard W.

Science. 2007 Aug 24;317(5841):1036; author reply 1036.

46.

LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.

Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP.

Mol Psychiatry. 2007 Dec;12(12):1129-39, 1057. Epub 2007 Jul 31.

47.

FUNC: a package for detecting significant associations between gene sets and ontological annotations.

Prüfer K, Muetzel B, Do HH, Weiss G, Khaitovich P, Rahm E, Pääbo S, Lachmann M, Enard W.

BMC Bioinformatics. 2007 Feb 6;8:41.

48.

Evolution of primate gene expression.

Khaitovich P, Enard W, Lachmann M, Pääbo S.

Nat Rev Genet. 2006 Sep;7(9):693-702. Review.

PMID:
16921347
49.

Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.

Fish JL, Kosodo Y, Enard W, Pääbo S, Huttner WB.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10438-10443. doi: 10.1073/pnas.0604066103. Epub 2006 Jun 23.

50.

Positive selection on gene expression in the human brain.

Khaitovich P, Tang K, Franz H, Kelso J, Hellmann I, Enard W, Lachmann M, Pääbo S.

Curr Biol. 2006 May 23;16(10):R356-8. Epub 2006 Apr 20. No abstract available.

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