Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27

1.

Deriving a No Expected Sensitization Induction Level for Fragrance Ingredients Without Animal Testing: An Integrated Approach Applied to Specific Case Studies.

Natsch A, Emter R, Haupt T, Ellis G.

Toxicol Sci. 2018 Sep 1;165(1):170-185. doi: 10.1093/toxsci/kfy135.

PMID:
29860528
2.

Effect of Fluorination on Skin Sensitization Potential and Fragrant Properties of Cinnamyl Compounds.

Charpentier J, Emter R, Koch H, Lelièvre D, Pannecoucke X, Couve-Bonnaire S, Natsch A, Bombrun A.

Chem Biodivers. 2018 Apr;15(4):e1800013. doi: 10.1002/cbdv.201800013. Epub 2018 Apr 19.

PMID:
29476591
3.

Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued.

Natsch A, Emter R.

Chem Res Toxicol. 2017 Jan 17;30(1):315-331. doi: 10.1021/acs.chemrestox.6b00365. Epub 2016 Nov 30. Review.

PMID:
28092944
4.
5.

Response to the Letter to the Editor Regarding Our Article (Natsch et al., 2015).

Natsch A, Emter R, Badertscher R, Brunner G, Granier T, Kern S, Ellis G.

Chem Res Toxicol. 2015 Nov 16;28(11):2082-4. doi: 10.1021/acs.chemrestox.5b00423. Epub 2015 Oct 23. No abstract available.

PMID:
26496065
6.

Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line.

Emter R, Natsch A.

Toxicol Appl Pharmacol. 2015 Nov 1;288(3):281-8. doi: 10.1016/j.taap.2015.07.027. Epub 2015 Aug 2.

PMID:
26244607
7.

Reporter cell lines for skin sensitization testing.

Natsch A, Emter R.

Arch Toxicol. 2015 Oct;89(10):1645-68. doi: 10.1007/s00204-015-1555-0. Epub 2015 Jul 21. Review.

PMID:
26194644
8.

Oxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic tests.

Natsch A, Emter R, Badertscher RP, Brunner G, Granier T, Kern S, Ellis G.

Chem Res Toxicol. 2015 Jun 15;28(6):1205-8. doi: 10.1021/acs.chemrestox.5b00039. Epub 2015 May 26.

PMID:
25942677
9.

A fast Resazurin-based live viability assay is equivalent to the MTT-test in the KeratinoSens assay.

Emter R, Natsch A.

Toxicol In Vitro. 2015 Jun;29(4):688-93. doi: 10.1016/j.tiv.2015.02.003. Epub 2015 Feb 14.

PMID:
25687527
10.

Assessing skin sensitization hazard in mice and men using non-animal test methods.

Urbisch D, Mehling A, Guth K, Ramirez T, Honarvar N, Kolle S, Landsiedel R, Jaworska J, Kern PS, Gerberick F, Natsch A, Emter R, Ashikaga T, Miyazawa M, Sakaguchi H.

Regul Toxicol Pharmacol. 2015 Mar;71(2):337-51. doi: 10.1016/j.yrtph.2014.12.008. Epub 2014 Dec 23.

11.

Predicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic peptide binding: global versus domain-based assessment.

Natsch A, Emter R, Gfeller H, Haupt T, Ellis G.

Toxicol Sci. 2015 Feb;143(2):319-32. doi: 10.1093/toxsci/kfu229. Epub 2014 Oct 22.

PMID:
25338925
12.

Epoxyalcohols: bioactivation and conjugation required for skin sensitization.

Delaine T, Ponting DJ, Niklasson IB, Emter R, Hagvall L, Norrby PO, Natsch A, Luthman K, Karlberg AT.

Chem Res Toxicol. 2014 Oct 20;27(10):1860-70. doi: 10.1021/tx500297d. Epub 2014 Sep 22.

PMID:
25195701
13.

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals.

van der Veen JW, Rorije E, Emter R, Natsch A, van Loveren H, Ezendam J.

Regul Toxicol Pharmacol. 2014 Aug;69(3):371-9. doi: 10.1016/j.yrtph.2014.04.018. Epub 2014 May 9.

PMID:
24813372
14.

Gene expression changes induced by skin sensitizers in the KeratinoSensâ„¢ cell line: Discriminating Nrf2-dependent and Nrf2-independent events.

Emter R, van der Veen JW, Adamson G, Ezendam J, van Loveren H, Natsch A.

Toxicol In Vitro. 2013 Dec;27(8):2225-32. doi: 10.1016/j.tiv.2013.09.009. Epub 2013 Sep 20.

PMID:
24055896
15.

A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation.

Natsch A, Ryan CA, Foertsch L, Emter R, Jaworska J, Gerberick F, Kern P.

J Appl Toxicol. 2013 Nov;33(11):1337-52. doi: 10.1002/jat.2868. Epub 2013 Apr 9.

PMID:
23576290
16.

Structure--activity relationship between the in vivo skin sensitizing potency of analogues of phenyl glycidyl ether and the induction of Nrf2-dependent luciferase activity in the KeratinoSens in vitro assay.

Delaine T, Niklasson IB, Emter R, Luthman K, Karlberg AT, Natsch A.

Chem Res Toxicol. 2011 Aug 15;24(8):1312-8. doi: 10.1021/tx200196s. Epub 2011 Jul 22.

PMID:
21751775
17.

Evaluating the sensitization potential of surfactants: integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach.

Ball N, Cagen S, Carrillo JC, Certa H, Eigler D, Emter R, Faulhammer F, Garcia C, Graham C, Haux C, Kolle SN, Kreiling R, Natsch A, Mehling A.

Regul Toxicol Pharmacol. 2011 Aug;60(3):389-400. doi: 10.1016/j.yrtph.2011.05.007. Epub 2011 May 27.

PMID:
21645576
18.

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro.

Emter R, Ellis G, Natsch A.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):281-90. doi: 10.1016/j.taap.2010.03.009. Epub 2010 Mar 20.

PMID:
20307559
19.

Use of in vitro testing to identify an unexpected skin sensitizing impurity in a commercial product: a case study.

Natsch A, Gfeller H, Emter R, Ellis G.

Toxicol In Vitro. 2010 Mar;24(2):411-6. doi: 10.1016/j.tiv.2009.10.015. Epub 2009 Oct 31.

PMID:
19883749
20.
23.

PGC-1alpha regulates the isoform mRNA ratio of the alternatively spliced thyroid hormone receptor alpha transcript.

Thijssen-Timmer DC, Schiphorst MP, Kwakkel J, Emter R, Kralli A, Wiersinga WM, Bakker O.

J Mol Endocrinol. 2006 Oct;37(2):251-7.

PMID:
17032743
24.

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation.

Teyssier C, Ma H, Emter R, Kralli A, Stallcup MR.

Genes Dev. 2005 Jun 15;19(12):1466-73.

25.

The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis.

Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, Oakeley EJ, Kralli A.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6472-7. Epub 2004 Apr 15.

26.

ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms.

Emter R, Heese-Peck A, Kralli A.

FEBS Lett. 2002 Jun 19;521(1-3):57-61.

Supplemental Content

Support Center