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A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling.

Suzuki SW, Chuang YS, Li M, Seaman MNJ, Emr SD.

J Cell Biol. 2019 Sep 2;218(9):2876-2886. doi: 10.1083/jcb.201901019. Epub 2019 Jul 23.


Genetic and Biochemical Analyses of Yeast ESCRT.

Banjade S, Tang S, Emr SD.

Methods Mol Biol. 2019;1998:105-116. doi: 10.1007/978-1-4939-9492-2_8.


Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly.

Banjade S, Tang S, Shah YH, Emr SD.

Elife. 2019 Jun 27;8. pii: e46207. doi: 10.7554/eLife.46207.


Methods for studying the regulation of membrane traffic by ubiquitin and the ESCRT pathway.

Guiney EL, Zhu L, Sardana R, Emr SD, Baile MG.

Methods Enzymol. 2019;619:269-291. doi: 10.1016/bs.mie.2018.12.041. Epub 2019 Feb 4.


Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane.

Sardana R, Zhu L, Emr SD.

J Cell Biol. 2019 Jan 7;218(1):234-250. doi: 10.1083/jcb.201806094. Epub 2018 Oct 25.


Retrograde trafficking from the vacuole/lysosome membrane.

Suzuki SW, Emr SD.

Autophagy. 2018;14(9):1654-1655. doi: 10.1080/15548627.2018.1496719. Epub 2018 Aug 17.


Membrane protein recycling from the vacuole/lysosome membrane.

Suzuki SW, Emr SD.

J Cell Biol. 2018 May 7;217(5):1623-1632. doi: 10.1083/jcb.201709162. Epub 2018 Mar 6.


ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins.

Zhu L, Jorgensen JR, Li M, Chuang YS, Emr SD.

Elife. 2017 Jun 29;6. pii: e26403. doi: 10.7554/eLife.26403.


Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs.

Ho HC, MacGurn JA, Emr SD.

Mol Biol Cell. 2017 May 1;28(9):1271-1283. doi: 10.1091/mbc.E17-01-0008. Epub 2017 Mar 15.


Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex.

Guiney EL, Klecker T, Emr SD.

Mol Biol Cell. 2016 Dec 15;27(25):4043-4054. Epub 2016 Oct 19.


ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis.

Tang S, Buchkovich NJ, Henne WM, Banjade S, Kim YJ, Emr SD.

Elife. 2016 Apr 13;5. pii: e15507. doi: 10.7554/eLife.15507.


Phosphoinositide kinase signaling controls ER-PM cross-talk.

Omnus DJ, Manford AG, Bader JM, Emr SD, Stefan CJ.

Mol Biol Cell. 2016 Apr 1;27(7):1170-80. doi: 10.1091/mbc.E16-01-0002. Epub 2016 Feb 10.


Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments.

Tang S, Henne WM, Borbat PP, Buchkovich NJ, Freed JH, Mao Y, Fromme JC, Emr SD.

Elife. 2015 Dec 15;4. pii: e12548. doi: 10.7554/eLife.12548.


Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins.

Li M, Koshi T, Emr SD.

J Cell Biol. 2015 Nov 9;211(3):639-52. doi: 10.1083/jcb.201505062. Epub 2015 Nov 2.


Mdm1/Snx13 is a novel ER-endolysosomal interorganelle tethering protein.

Henne WM, Zhu L, Balogi Z, Stefan C, Pleiss JA, Emr SD.

J Cell Biol. 2015 Aug 17;210(4):541-51. doi: 10.1083/jcb.201503088.


Molecular mechanisms of inter-organelle ER-PM contact sites.

Henne WM, Liou J, Emr SD.

Curr Opin Cell Biol. 2015 Aug;35:123-30. doi: 10.1016/ Epub 2015 May 27. Review.


Ubiquitin-dependent lysosomal membrane protein sorting and degradation.

Li M, Rong Y, Chuang YS, Peng D, Emr SD.

Mol Cell. 2015 Feb 5;57(3):467-78. doi: 10.1016/j.molcel.2014.12.012. Epub 2015 Jan 22.


A Nobel Prize for membrane traffic: vesicles find their journey's end.

Mellman I, Emr SD.

J Cell Biol. 2013 Nov 25;203(4):559-61. doi: 10.1083/jcb.201310134. Epub 2013 Nov 8.


Essential N-terminal insertion motif anchors the ESCRT-III filament during MVB vesicle formation.

Buchkovich NJ, Henne WM, Tang S, Emr SD.

Dev Cell. 2013 Oct 28;27(2):201-214. doi: 10.1016/j.devcel.2013.09.009. Epub 2013 Oct 17.


Molecular mechanisms of the membrane sculpting ESCRT pathway.

Henne WM, Stenmark H, Emr SD.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a016766. doi: 10.1101/cshperspect.a016766. Review.


ER-PM connections: sites of information transfer and inter-organelle communication.

Stefan CJ, Manford AG, Emr SD.

Curr Opin Cell Biol. 2013 Aug;25(4):434-42. doi: 10.1016/ Epub 2013 Mar 20. Review.


ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.

Manford AG, Stefan CJ, Yuan HL, Macgurn JA, Emr SD.

Dev Cell. 2012 Dec 11;23(6):1129-40. doi: 10.1016/j.devcel.2012.11.004.


The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices.

Henne WM, Buchkovich NJ, Zhao Y, Emr SD.

Cell. 2012 Oct 12;151(2):356-71. doi: 10.1016/j.cell.2012.08.039.


The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis.

Ling Y, Stefan CJ, Macgurn JA, Audhya A, Emr SD.

EMBO J. 2012 Jun 29;31(13):2882-94. doi: 10.1038/emboj.2012.127. Epub 2012 May 4.


Ubiquitin and membrane protein turnover: from cradle to grave.

MacGurn JA, Hsu PC, Emr SD.

Annu Rev Biochem. 2012;81:231-59. doi: 10.1146/annurev-biochem-060210-093619. Epub 2012 Mar 8. Review.


Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation.

MacDonald C, Buchkovich NJ, Stringer DK, Emr SD, Piper RC.

EMBO Rep. 2012 Apr;13(4):331-8. doi: 10.1038/embor.2012.18.


Eisosome proteins assemble into a membrane scaffold.

Karotki L, Huiskonen JT, Stefan CJ, Ziółkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC.

J Cell Biol. 2011 Nov 28;195(5):889-902. doi: 10.1083/jcb.201104040.


TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor.

MacGurn JA, Hsu PC, Smolka MB, Emr SD.

Cell. 2011 Nov 23;147(5):1104-17. doi: 10.1016/j.cell.2011.09.054.


Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.

Shi Y, Stefan CJ, Rue SM, Teis D, Emr SD.

Mol Biol Cell. 2011 Nov;22(21):4093-107. doi: 10.1091/mbc.E11-05-0440. Epub 2011 Aug 31.


Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis.

McMurray MA, Stefan CJ, Wemmer M, Odorizzi G, Emr SD, Thorner J.

Biol Chem. 2011 Aug;392(8-9):699-712. doi: 10.1515/BC.2011.091.


The ESCRT pathway.

Henne WM, Buchkovich NJ, Emr SD.

Dev Cell. 2011 Jul 19;21(1):77-91. doi: 10.1016/j.devcel.2011.05.015. Review.


Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.

Han BK, Emr SD.

Genes Dev. 2011 May 1;25(9):984-95. doi: 10.1101/gad.1998611.


Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites.

Stefan CJ, Manford AG, Baird D, Yamada-Hanff J, Mao Y, Emr SD.

Cell. 2011 Feb 4;144(3):389-401. doi: 10.1016/j.cell.2010.12.034.


Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.

Garrenton LS, Stefan CJ, McMurray MA, Emr SD, Thorner J.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11805-10. doi: 10.1073/pnas.1005817107. Epub 2010 Jun 14.


Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function.

Manford A, Xia T, Saxena AK, Stefan C, Hu F, Emr SD, Mao Y.

EMBO J. 2010 May 5;29(9):1489-98. doi: 10.1038/emboj.2010.57. Epub 2010 Apr 13. Erratum in: EMBO J. 2010 Jul 21;29(14):2472.


ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.

Teis D, Saksena S, Judson BL, Emr SD.

EMBO J. 2010 Mar 3;29(5):871-83. doi: 10.1038/emboj.2009.408. Epub 2010 Feb 4.


SnapShot: the ESCRT machinery.

Teis D, Saksena S, Emr SD.

Cell. 2009 Apr 3;137(1):182-182.e1. doi: 10.1016/j.cell.2009.03.027. No abstract available.


ESCRTs and human disease.

Saksena S, Emr SD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):167-72. doi: 10.1042/BST0370167. Review.


Functional reconstitution of ESCRT-III assembly and disassembly.

Saksena S, Wahlman J, Teis D, Johnson AE, Emr SD.

Cell. 2009 Jan 9;136(1):97-109. doi: 10.1016/j.cell.2008.11.013.


Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.

Baird D, Stefan C, Audhya A, Weys S, Emr SD.

J Cell Biol. 2008 Dec 15;183(6):1061-74. doi: 10.1083/jcb.200804003.


Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.

Lin CH, MacGurn JA, Chu T, Stefan CJ, Emr SD.

Cell. 2008 Nov 14;135(4):714-25. doi: 10.1016/j.cell.2008.09.025. Epub 2008 Oct 30.


Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation.

Teis D, Saksena S, Emr SD.

Dev Cell. 2008 Oct;15(4):578-89. doi: 10.1016/j.devcel.2008.08.013.


Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24.

Ghazi-Tabatabai S, Saksena S, Short JM, Pobbati AV, Veprintsev DB, Crowther RA, Emr SD, Egelman EH, Williams RL.

Structure. 2008 Sep 10;16(9):1345-56. doi: 10.1016/j.str.2008.06.010.


Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.

Botelho RJ, Efe JA, Teis D, Emr SD.

Mol Biol Cell. 2008 Oct;19(10):4273-86. doi: 10.1091/mbc.E08-04-0405. Epub 2008 Jul 23.


Isolation of subcellular fractions from the yeast Saccharomyces cerevisiae.

Rieder SE, Emr SD.

Curr Protoc Cell Biol. 2001 May;Chapter 3:Unit 3.8. doi: 10.1002/0471143030.cb0308s08.


Overview of subcellular fractionation procedures for the yeast Saccharomyces cerevisiae.

Rieder SE, Emr SD.

Curr Protoc Cell Biol. 2001 May;Chapter 3:Unit 3.7. doi: 10.1002/0471143030.cb0307s07.


Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting.

Rue SM, Mattei S, Saksena S, Emr SD.

Mol Biol Cell. 2008 Feb;19(2):475-84. Epub 2007 Nov 21.


ESCRTing proteins in the endocytic pathway.

Saksena S, Sun J, Chu T, Emr SD.

Trends Biochem Sci. 2007 Dec;32(12):561-73. Epub 2007 Nov 7. Review.


Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

Obita T, Saksena S, Ghazi-Tabatabai S, Gill DJ, Perisic O, Emr SD, Williams RL.

Nature. 2007 Oct 11;449(7163):735-9.


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