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Items: 49


High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital.

Tiago I, Alarico S, Maranha A, Coelho C, Gonçalves Pereira S, Empadinhas N.

Microbiol Resour Announc. 2019 May 23;8(21). pii: e00496-19. doi: 10.1128/MRA.00496-19.


Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.

Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB.

MBio. 2019 May 14;10(3). pii: e00239-19. doi: 10.1128/mBio.00239-19.


Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment.

Pereira SG, Alarico S, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Maranha A, Empadinhas N.

BMC Microbiol. 2019 Mar 19;19(1):62. doi: 10.1186/s12866-019-1428-4.


Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides.

Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S, Pereira PJB, Empadinhas N.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):835-844. doi: 10.1073/pnas.1813450116. Epub 2019 Jan 3.


The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease.

Cardoso SM, Empadinhas N.

Front Physiol. 2018 May 9;9:471. doi: 10.3389/fphys.2018.00471. eCollection 2018. Review.


Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.

Pereira SG, Moura J, Carvalho E, Empadinhas N.

Front Microbiol. 2017 Sep 21;8:1791. doi: 10.3389/fmicb.2017.01791. eCollection 2017. Review.


Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase.

Cereija TB, Alarico S, Empadinhas N, Pereira PJB.

Acta Crystallogr F Struct Biol Commun. 2017 Sep 1;73(Pt 9):536-540. doi: 10.1107/S2053230X17012419. Epub 2017 Sep 1.


Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria.

Geadas Farias P, Gama F, Reis D, Alarico S, Empadinhas N, Martins JC, de Almeida AF, Morais PV.

Antonie Van Leeuwenhoek. 2017 Jul;110(7):863-876. doi: 10.1007/s10482-017-0857-z. Epub 2017 Mar 23.


Glucosylglycerate metabolism, bioversatility and mycobacterial survival.

Nunes-Costa D, Maranha A, Costa M, Alarico S, Empadinhas N.

Glycobiology. 2017 Mar 4;27(3):213-227. doi: 10.1093/glycob/cww132. Review.


Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism.

Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL.

Sci Rep. 2015 Nov 30;5:17144. doi: 10.1038/srep17144.


The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil.

Nunes-Costa D, Alarico S, Dalcolmo MP, Correia-Neves M, Empadinhas N.

Tuberculosis (Edinb). 2016 Jan;96:107-19. doi: 10.1016/ Epub 2015 Oct 24. Review.


Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides.

Maranha A, Moynihan PJ, Miranda V, Correia Lourenço E, Nunes-Costa D, Fraga JS, José Barbosa Pereira P, Macedo-Ribeiro S, Ventura MR, Clarke AJ, Empadinhas N.

Sci Rep. 2015 Sep 1;5:13610. doi: 10.1038/srep13610.


Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway.

Fraga J, Maranha A, Mendes V, Pereira PJ, Empadinhas N, Macedo-Ribeiro S.

Sci Rep. 2015 Jan 26;5:8026. doi: 10.1038/srep08026.


Autophagy in the fight against tuberculosis.

Bento CF, Empadinhas N, Mendes V.

DNA Cell Biol. 2015 Apr;34(4):228-42. doi: 10.1089/dna.2014.2745. Epub 2015 Jan 21. Review.


Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.

Alarico S, Costa M, Sousa MS, Maranha A, Lourenço EC, Faria TQ, Ventura MR, Empadinhas N.

Sci Rep. 2014 Oct 24;4:6766. doi: 10.1038/srep06766.


The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies.

Nobre A, Alarico S, Maranha A, Mendes V, Empadinhas N.

Microbiology. 2014 Aug;160(Pt 8):1547-70. doi: 10.1099/mic.0.075895-0. Epub 2014 May 23. Review.


A new bacterial hydrolase specific for the compatible solutes α-D-mannopyranosyl-(1→2)-D-glycerate and α-D-glucopyranosyl-(1→2)-D-glycerate.

Alarico S, Empadinhas N, da Costa MS.

Enzyme Microb Technol. 2013 Feb 5;52(2):77-83. doi: 10.1016/j.enzmictec.2012.10.008. Epub 2012 Nov 16.


Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins.

Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJ, Empadinhas N.

J Bacteriol. 2012 Dec;194(24):7010-1. doi: 10.1128/JB.01880-12.


The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate.

Nobre A, Empadinhas N, Nobre MF, Lourenço EC, Maycock C, Ventura MR, Mingote A, da Costa MS.

Planta. 2013 Mar;237(3):891-901. doi: 10.1007/s00425-012-1808-6. Epub 2012 Nov 20.


Biosynthesis of mycobacterial methylglucose lipopolysaccharides.

Mendes V, Maranha A, Alarico S, Empadinhas N.

Nat Prod Rep. 2012 Aug;29(8):834-44. doi: 10.1039/c2np20014g. Epub 2012 Jun 8.


Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.

Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N.

Sci Rep. 2011;1:177. doi: 10.1038/srep00177. Epub 2011 Nov 30.


Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea.

Empadinhas N, da Costa MS.

Environ Microbiol. 2011 Aug;13(8):2056-77. doi: 10.1111/j.1462-2920.2010.02390.x. Epub 2010 Dec 22. Review.


Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity.

Empadinhas N, Pereira PJ, Albuquerque L, Costa J, Sá-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS.

Mol Microbiol. 2011 Jan;79(1):76-93. doi: 10.1111/j.1365-2958.2010.07432.x. Epub 2010 Nov 2.


Biochemical characterization of the maltokinase from Mycobacterium bovis BCG.

Mendes V, Maranha A, Lamosa P, da Costa MS, Empadinhas N.

BMC Biochem. 2010 May 27;11:21. doi: 10.1186/1471-2091-11-21.


Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis.

Fernandes C, Mendes V, Costa J, Empadinhas N, Jorge C, Lamosa P, Santos H, da Costa MS.

J Bacteriol. 2010 Mar;192(6):1624-33. doi: 10.1128/JB.01424-09. Epub 2010 Jan 8.


Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis.

Pereira PJ, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S.

PLoS One. 2008;3(11):e3748. doi: 10.1371/journal.pone.0003748. Epub 2008 Nov 18.


Osmoadaptation mechanisms in prokaryotes: distribution of compatible solutes.

Empadinhas N, da Costa MS.

Int Microbiol. 2008 Sep;11(3):151-61. Review.


A unique combination of genetic systems for the synthesis of trehalose in Rubrobacter xylanophilus: properties of a rare actinobacterial TreT.

Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS.

J Bacteriol. 2008 Dec;190(24):7939-46. doi: 10.1128/JB.01055-08. Epub 2008 Oct 3.


Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus.

Sá-Moura B, Albuquerque L, Empadinhas N, da Costa MS, Pereira PJ, Macedo-Ribeiro S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt 8):760-3. doi: 10.1107/S1744309108021490. Epub 2008 Jul 31.


To be or not to be a compatible solute: bioversatility of mannosylglycerate and glucosylglycerate.

Empadinhas N, da Costa MS.

Syst Appl Microbiol. 2008 Aug;31(3):159-68. doi: 10.1016/j.syapm.2008.05.002. Epub 2008 Jul 2. Review.


Molecular and physiological role of the trehalose-hydrolyzing alpha-glucosidase from Thermus thermophilus HB27.

Alarico S, da Costa MS, Empadinhas N.

J Bacteriol. 2008 Apr;190(7):2298-305. doi: 10.1128/JB.01794-07. Epub 2008 Jan 25.


Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase.

Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS.

FEMS Microbiol Lett. 2008 Mar;280(2):195-202. doi: 10.1111/j.1574-6968.2007.01064.x. Epub 2008 Jan 24.


Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1.

Alarico S, Empadinhas N, Mingote A, Simões C, Santos MS, da Costa MS.

Extremophiles. 2007 Nov;11(6):833-40. Epub 2007 Aug 29.


Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H.

J Bacteriol. 2007 Aug;189(15):5405-12. Epub 2007 May 25.


Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile.

Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, Costa MS.

Extremophiles. 2007 Sep;11(5):667-73. Epub 2007 May 18.


Single-step pathway for synthesis of glucosylglycerate in Persephonella marina.

Fernandes C, Empadinhas N, da Costa MS.

J Bacteriol. 2007 Jun;189(11):4014-9. Epub 2007 Mar 16.


Diversity and biosynthesis of compatible solutes in hyper/thermophiles.

Empadinhas N, da Costa MS.

Int Microbiol. 2006 Sep;9(3):199-206. Review.


Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.

Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS.

J Bacteriol. 2006 Feb;188(3):1022-30.


Distribution of genes for synthesis of trehalose and Mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance.

Alarico S, Empadinhas N, Simões C, Silva Z, Henne A, Mingote A, Santos H, da Costa MS.

Appl Environ Microbiol. 2005 May;71(5):2460-6.


Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species.

Pires AL, Albuquerque L, Tiago I, Nobre MF, Empadinhas N, Veríssimo A, da Costa MS.

FEMS Microbiol Lett. 2005 Apr 1;245(1):39-45.


A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase.

Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MA, Santos H, da Costa MS.

J Bacteriol. 2004 Jul;186(13):4075-84.


Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus.

Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H.

J Biol Chem. 2004 Mar 12;279(11):9892-8. Epub 2003 Dec 29.


Gamma-proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. infect protozoa and require activated charcoal for growth in laboratory media.

Santos P, Pinhal I, Rainey FA, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A, Da Costa MS.

Appl Environ Microbiol. 2003 Nov;69(11):6533-40.


The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerate.

Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS.

Appl Environ Microbiol. 2003 Jun;69(6):3272-9.


Rubritepida flocculans gen. nov., sp. nov., a new slightly thermophilic member of the alpha-1 subclass of the Proteobacteria.

Alarico S, Rainey FA, Empadinhas N, Schumann P, Nobre MF, da Costa MS.

Syst Appl Microbiol. 2002 Aug;25(2):198-206.


Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum.

Albuquerque L, Santos J, Travassos P, Nobre MF, Rainey FA, Wait R, Empadinhas N, Silva MT, da Costa MS.

Appl Environ Microbiol. 2002 Sep;68(9):4266-73.


Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.

Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.

J Biol Chem. 2001 Nov 23;276(47):43580-8. Epub 2001 Sep 18.


Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.

Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H.

J Biol Chem. 1999 Dec 10;274(50):35407-14.

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