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Tumour Heterogeneity and Resistance to Therapy in Prostate Cancer: A Fundamental Limitation of Prostate-specific Membrane Antigen Theranostics or a Key Strength?

Hofman MS, Emmett L.

Eur Urol. 2019 Jul 24. pii: S0302-2838(19)30584-6. doi: 10.1016/j.eururo.2019.07.030. [Epub ahead of print] No abstract available.


Diagnostic accuracy of 68 Ga-prostate-specific membrane antigen (PSMA) positron-emission tomography (PET) and multiparametric (mp)MRI to detect intermediate-grade intra-prostatic prostate cancer using whole-mount pathology: impact of the addition of 68 Ga-PSMA PET to mpMRI.

Scheltema MJ, Chang JI, Stricker PD, van Leeuwen PJ, Nguyen QA, Ho B, Delprado W, Lee J, Thompson JE, Cusick T, Spriensma AS, Siriwardana AR, Yuen C, Kooner R, Hruby G, O'Neill G, Emmett L.

BJU Int. 2019 Jul 9. doi: 10.1111/bju.14794. [Epub ahead of print]


Radiotherapy for node-positive prostate cancer: 2019 Recommendations of the Australian and New Zealand Radiation Oncology Genito-Urinary group.

Lieng H, Kneebone A, Hayden AJ, Christie DRH, Davis BJ, Eade TN, Emmett L, Holt T, Hruby G, Pryor D, Sidhom M, Skala M, Yaxley J, Shakespeare TP.

Radiother Oncol. 2019 Jun 6;140:68-75. doi: 10.1016/j.radonc.2019.05.016. [Epub ahead of print]


Neoadjuvant dabrafenib combined with trametinib for resectable, stage IIIB-C, BRAFV600 mutation-positive melanoma (NeoCombi): a single-arm, open-label, single-centre, phase 2 trial.

Long GV, Saw RPM, Lo S, Nieweg OE, Shannon KF, Gonzalez M, Guminski A, Lee JH, Lee H, Ferguson PM, Rawson RV, Wilmott JS, Thompson JF, Kefford RF, Ch'ng S, Stretch JR, Emmett L, Kapoor R, Rizos H, Spillane AJ, Scolyer RA, Menzies AM.

Lancet Oncol. 2019 Jul;20(7):961-971. doi: 10.1016/S1470-2045(19)30331-6. Epub 2019 Jun 3.


Asymptomatic Prostate Cancer Brain Metastases on 68Ga-PSMA PET/CT.

Yin C, Ho B, Chan L, Emmett L.

Clin Nucl Med. 2019 Jun;44(6):e382-e384. doi: 10.1097/RLU.0000000000002548.


Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial.

Fendler WP, Calais J, Eiber M, Flavell RR, Mishoe A, Feng FY, Nguyen HG, Reiter RE, Rettig MB, Okamoto S, Emmett L, Zacho HD, Ilhan H, Wetter A, Rischpler C, Schoder H, Burger IA, Gartmann J, Smith R, Small EJ, Slavik R, Carroll PR, Herrmann K, Czernin J, Hope TA.

JAMA Oncol. 2019 Jun 1;5(6):856-863. doi: 10.1001/jamaoncol.2019.0096.


The contribution of multiparametric pelvic & whole body MR to interpretation of 18F-fluoromethylcholine or 68Ga-HBED-CC PSMA-11 PET/CT in patients with biochemical failure following radical prostatectomy.

Metser U, Chua SS, Ho B, Punwani S, Johnston E, Pouliot F, Tau N, Hawsawy A, Anconina R, Bauman G, Hicks RJ, Weickhardt A, Davis ID, Pond G, Scott A, Tunariu N, Sidhu H, Emmett LM.

J Nucl Med. 2019 Mar 22. pii: jnumed.118.225185. doi: 10.2967/jnumed.118.225185. [Epub ahead of print]


68Ga-HBEDD PSMA-11 PET/CT staging prior to radical prostatectomy in prostate cancer patients: Diagnostic and predictive value for the biochemical response to surgery.

Nandurkar R, van Leeuwen P, Stricker P, Woo H, Kooner R, Yuen C, O'Neill G, Ende D, Cusick T, Ho B, Hickey A, Emmett L.

Br J Radiol. 2019 Mar;92(1095):20180667. doi: 10.1259/bjr.20180667. Epub 2019 Jan 23.


Rapid Modulation of PSMA Expression by Androgen Deprivation: Serial 68Ga-PSMA-11 PET in Men with Hormone-Sensitive and Castrate-Resistant Prostate Cancer Commencing Androgen Blockade.

Emmett L, Yin C, Crumbaker M, Hruby G, Kneebone A, Epstein R, Nguyen Q, Hickey A, Ihsheish N, O'Neill G, Horvath L, Chalasani V, Stricker P, Joshua AM.

J Nucl Med. 2019 Jul;60(7):950-954. doi: 10.2967/jnumed.118.223099. Epub 2018 Dec 14.


Prospective, Multisite, International Comparison of 18F-Fluoromethylcholine PET/CT, Multiparametric MRI, and 68Ga-HBED-CC PSMA-11 PET/CT in Men with High-Risk Features and Biochemical Failure After Radical Prostatectomy: Clinical Performance and Patient Outcomes.

Emmett L, Metser U, Bauman G, Hicks RJ, Weickhardt A, Davis ID, Punwani S, Pond G, Chua S, Ho B, Johnston E, Pouliot F, Scott AM.

J Nucl Med. 2019 Jun;60(6):794-800. doi: 10.2967/jnumed.118.220103. Epub 2018 Nov 15.


Results of a Prospective Phase 2 Pilot Trial of 177Lu-PSMA-617 Therapy for Metastatic Castration-Resistant Prostate Cancer Including Imaging Predictors of Treatment Response and Patterns of Progression.

Emmett L, Crumbaker M, Ho B, Willowson K, Eu P, Ratnayake L, Epstein R, Blanksby A, Horvath L, Guminski A, Mahon K, Gedye C, Yin C, Stricker P, Joshua AM.

Clin Genitourin Cancer. 2019 Feb;17(1):15-22. doi: 10.1016/j.clgc.2018.09.014. Epub 2018 Sep 27.


Risk factors for late HIV diagnosis in the East of England: evidence from national surveillance data and policy implications.

Bath RE, Emmett L, Verlander NQ, Reacher M.

Int J STD AIDS. 2019 Jan;30(1):37-44. doi: 10.1177/0956462418793327. Epub 2018 Aug 31.


FDG-PET response and outcome from anti-PD-1 therapy in metastatic melanoma.

Tan AC, Emmett L, Lo S, Liu V, Kapoor R, Carlino MS, Guminski AD, Long GV, Menzies AM.

Ann Oncol. 2018 Oct 1;29(10):2115-2120. doi: 10.1093/annonc/mdy330.


Gallium-68-prostate-specific membrane antigen (68 Ga-PSMA) positron emission tomography (PET)/computed tomography (CT) predicts complete biochemical response from radical prostatectomy and lymph node dissection in intermediate- and high-risk prostate cancer.

van Leeuwen PJ, Donswijk M, Nandurkar R, Stricker P, Ho B, Heijmink S, Wit EMK, Tillier C, van Muilenkom E, Nguyen Q, van der Poel HG, Emmett L.

BJU Int. 2019 Jul;124(1):62-68. doi: 10.1111/bju.14506. Epub 2019 Apr 7.


Radiotherapy for recurrent prostate cancer: 2018 Recommendations of the Australian and New Zealand Radiation Oncology Genito-Urinary group.

Lieng H, Hayden AJ, Christie DRH, Davis BJ, Eade TN, Emmett L, Holt T, Hruby G, Pryor D, Shakespeare TP, Sidhom M, Skala M, Wiltshire K, Yaxley J, Kneebone A.

Radiother Oncol. 2018 Nov;129(2):377-386. doi: 10.1016/j.radonc.2018.06.027. Epub 2018 Jul 20. Review.


Imaging Prostate Cancer With Prostate-Specific Membrane Antigen PET/CT and PET/MRI: Current and Future Applications.

Hope TA, Afshar-Oromieh A, Eiber M, Emmett L, Fendler WP, Lawhn-Heath C, Rowe SP.

AJR Am J Roentgenol. 2018 Aug;211(2):286-294. doi: 10.2214/AJR.18.19957. Epub 2018 Jun 27. Review.


Improved management of acute kidney injury in primary care using e-alerts and an educational outreach programme.

Tollitt J, Flanagan E, McCorkindale S, Glynn-Atkins S, Emmett L, Darby D, Ritchie J, Bennett B, Sinha S, Poulikakos D.

Fam Pract. 2018 Dec 12;35(6):684-689. doi: 10.1093/fampra/cmy030.


68 Ga-PSMA-PET/CT staging prior to definitive radiation treatment for prostate cancer.

Hruby G, Eade T, Emmett L, Ho B, Hsiao E, Schembri G, Guo L, Kwong C, Hunter J, Byrne K, Kneebone A.

Asia Pac J Clin Oncol. 2018 Aug;14(4):343-346. doi: 10.1111/ajco.12872. Epub 2018 Apr 16.


Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency.

Deenick EK, Morey A, Danta M, Emmett L, Fay K, Gracie G, Ma CS, Macintosh R, Smith SABC, Sasson SC, Sewell WA, Cowley M, Tangye SG, Kelleher AD; CIRCA, Phan TG.

J Clin Immunol. 2018 Feb;38(2):159-162. doi: 10.1007/s10875-018-0477-z. Epub 2018 Jan 19. No abstract available.


Delineating sites of failure following post-prostatectomy radiation treatment using 68Ga-PSMA-PET.

Byrne K, Eade T, Kneebone A, Guo L, Hsiao E, Schembri G, Kwong C, Hunter J, Emmett L, Hruby G.

Radiother Oncol. 2018 Feb;126(2):244-248. doi: 10.1016/j.radonc.2017.10.022. Epub 2017 Nov 10.


Acute kidney injury in primary care: where are we now and where are we going?

Tollitt J, Emmett L, McCorkindale S, Flanagan E, O'Donoghue D, Sinha S, Poulikakos D.

Br J Gen Pract. 2017 Sep;67(662):394-395. doi: 10.3399/bjgp17X692225. No abstract available.


Treatment Outcomes from 68Ga-PSMA PET/CT-Informed Salvage Radiation Treatment in Men with Rising PSA After Radical Prostatectomy: Prognostic Value of a Negative PSMA PET.

Emmett L, van Leeuwen PJ, Nandurkar R, Scheltema MJ, Cusick T, Hruby G, Kneebone A, Eade T, Fogarty G, Jagavkar R, Nguyen Q, Ho B, Joshua AM, Stricker P.

J Nucl Med. 2017 Dec;58(12):1972-1976. doi: 10.2967/jnumed.117.196683. Epub 2017 Jul 26.


The Impact of 68Ga-PSMA PET/CT on Management Intent in Prostate Cancer: Results of an Australian Prospective Multicenter Study.

Roach PJ, Francis R, Emmett L, Hsiao E, Kneebone A, Hruby G, Eade T, Nguyen QA, Thompson BD, Cusick T, McCarthy M, Tang C, Ho B, Stricker PD, Scott AM.

J Nucl Med. 2018 Jan;59(1):82-88. doi: 10.2967/jnumed.117.197160. Epub 2017 Jun 23.


Melanoma patient imaging in the era of effective systemic therapies.

Stodell M, Thompson JF, Emmett L, Uren RF, Kapoor R, Saw RPM.

Eur J Surg Oncol. 2017 Aug;43(8):1517-1527. doi: 10.1016/j.ejso.2017.05.014. Epub 2017 May 25. Review.


Frusemide aids diagnostic interpretation of 68 Ga-PSMA positron emission tomography/CT in men with prostate cancer.

Fennessy N, Lee J, Shin J, Ho B, Ali SA, Paschkewitz R, Emmett L.

J Med Imaging Radiat Oncol. 2017 Dec;61(6):739-744. doi: 10.1111/1754-9485.12625. Epub 2017 Jun 17.


Initial multicentre experience of 68 gallium-PSMA PET/CT guided robot-assisted salvage lymphadenectomy: acceptable safety profile but oncological benefit appears limited.

Siriwardana A, Thompson J, van Leeuwen PJ, Doig S, Kalsbeek A, Emmett L, Delprado W, Wong D, Samaratunga H, Haynes AM, Coughlin G, Stricker P.

BJU Int. 2017 Nov;120(5):673-681. doi: 10.1111/bju.13919. Epub 2017 Jun 20.


Development of standardized image interpretation for 68Ga-PSMA PET/CT to detect prostate cancer recurrent lesions.

Fanti S, Minozzi S, Morigi JJ, Giesel F, Ceci F, Uprimny C, Hofman MS, Eiber M, Schwarzenbock S, Castellucci P, Bellisario C, Chauvie S, Bergesio F, Emmett L, Haberkorn U, Virgolini I, Schwaiger M, Hicks RJ, Krause BJ, Chiti A.

Eur J Nucl Med Mol Imaging. 2017 Sep;44(10):1622-1635. doi: 10.1007/s00259-017-3725-1. Epub 2017 May 23.


Futility of imaging to stage melanoma patients with a positive sentinel lymph node.

Holtkamp LHJ, Read RL, Emmett L, Thompson JF, Nieweg OE.

Melanoma Res. 2017 Oct;27(5):457-462. doi: 10.1097/CMR.0000000000000362.


Lutetium-177-labelled anti-prostate-specific membrane antigen antibody and ligands for the treatment of metastatic castrate-resistant prostate cancer: a systematic review and meta-analysis.

Calopedos RJS, Chalasani V, Asher R, Emmett L, Woo HH.

Prostate Cancer Prostatic Dis. 2017 Sep;20(3):352-360. doi: 10.1038/pcan.2017.23. Epub 2017 Apr 25. Review.


68Ga-PSMA-11 PET/CT Interobserver Agreement for Prostate Cancer Assessments: An International Multicenter Prospective Study.

Fendler WP, Calais J, Allen-Auerbach M, Bluemel C, Eberhardt N, Emmett L, Gupta P, Hartenbach M, Hope TA, Okamoto S, Pfob CH, Pöppel TD, Rischpler C, Schwarzenböck S, Stebner V, Unterrainer M, Zacho HD, Maurer T, Gratzke C, Crispin A, Czernin J, Herrmann K, Eiber M.

J Nucl Med. 2017 Oct;58(10):1617-1623. doi: 10.2967/jnumed.117.190827. Epub 2017 Apr 13.


The Evidence of Acute Kidney Injury in the Community and for Primary Care Interventions.

Emmett L, Tollitt J, McCorkindale S, Sinha S, Poulikakos D.

Nephron. 2017;136(3):202-210. doi: 10.1159/000460266. Epub 2017 Mar 25. Review.


Lutetium 177 PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy.

Emmett L, Willowson K, Violet J, Shin J, Blanksby A, Lee J.

J Med Radiat Sci. 2017 Mar;64(1):52-60. doi: 10.1002/jmrs.227. Review.


Delineating biochemical failure with 68Ga-PSMA-PET following definitive external beam radiation treatment for prostate cancer.

Hruby G, Eade T, Kneebone A, Emmett L, Guo L, Ho B, Hsiao E, Schembri G, Hunter J, Kwong C.

Radiother Oncol. 2017 Jan;122(1):99-102. doi: 10.1016/j.radonc.2016.11.023. Epub 2016 Dec 28.


SPECT-CT/VQ versus CTPA for diagnosing pulmonary embolus and other lung pathology: Pre-existing lung disease should not be a contraindication.

Bhatia KD, Ambati C, Dhaliwal R, Paschkewitz R, Hsu E, Ho B, Young A, Emmett L.

J Med Imaging Radiat Oncol. 2016 Aug;60(4):492-7. doi: 10.1111/1754-9485.12471. Epub 2016 May 11.


Navigating an outbreak: geospatial methods for STI outbreak investigations.

Smith CM, Emmett L.

Sex Transm Infect. 2016 Aug;92(5):327-8. doi: 10.1136/sextrans-2015-052377. No abstract available.


Schwannoma Showing Avid Uptake on 68Ga-PSMA-HBED-CC PET/CT.

Kanthan GL, Izard MA, Emmett L, Hsiao E, Schembri GP.

Clin Nucl Med. 2016 Sep;41(9):703-4. doi: 10.1097/RLU.0000000000001281.


Prospective evaluation of 68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer.

van Leeuwen PJ, Emmett L, Ho B, Delprado W, Ting F, Nguyen Q, Stricker PD.

BJU Int. 2017 Feb;119(2):209-215. doi: 10.1111/bju.13540. Epub 2016 Jun 18.


Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans.

Lee P, Bova R, Schofield L, Bryant W, Dieckmann W, Slattery A, Govendir MA, Emmett L, Greenfield JR.

Cell Metab. 2016 Apr 12;23(4):602-9. doi: 10.1016/j.cmet.2016.02.007. Epub 2016 Mar 10.


(68) Ga-PSMA has a high detection rate of prostate cancer recurrence outside the prostatic fossa in patients being considered for salvage radiation treatment.

van Leeuwen PJ, Stricker P, Hruby G, Kneebone A, Ting F, Thompson B, Nguyen Q, Ho B, Emmett L.

BJU Int. 2016 May;117(5):732-9. doi: 10.1111/bju.13397. Epub 2016 Jan 24.


Impact of Patient Preparation on the Diagnostic Performance of 18F-FDG PET in Cardiac Sarcoidosis: A Systematic Review and Meta-analysis.

Tang R, Wang JT, Wang L, Le K, Huang Y, Hickey AJ, Emmett L.

Clin Nucl Med. 2016 Jul;41(7):e327-39. doi: 10.1097/RLU.0000000000001063. Review.


Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy.

Morigi JJ, Stricker PD, van Leeuwen PJ, Tang R, Ho B, Nguyen Q, Hruby G, Fogarty G, Jagavkar R, Kneebone A, Hickey A, Fanti S, Tarlinton L, Emmett L.

J Nucl Med. 2015 Aug;56(8):1185-90. doi: 10.2967/jnumed.115.160382. Epub 2015 Jun 25.


Granulomatous sarcoid aortitis: a serious complication of a well-known multisystem disease.

Wang LW, Omari A, Emmett L, Jansz PC, Huilgol R, Rainer S, Subbiah RN.

Lancet. 2015 May 16;385(9981):2014. doi: 10.1016/S0140-6736(15)60649-3. No abstract available.


Outbreak of mumps in a school setting, United Kingdom, 2013.

Aasheim ET, Inns T, Trindall A, Emmett L, Brown KE, Williams CJ, Reacher M.

Hum Vaccin Immunother. 2014;10(8):2446-9. doi: 10.4161/hv.29484.


Recent outbreaks of infectious syphilis, United Kingdom, January 2012 to April 2014.

Simms I, Wallace L, Thomas DR, Emmett L, Shankar AG, Vinson M, Padfield S, Andrady U, Whiteside C, Williams CJ, Midgley C, Johnman C, McLellan A, Currie A, Logan J, Leslie G, Licence K, Hughes G.

Euro Surveill. 2014 Jun 19;19(24). pii: 20833. Erratum in: Euro Surveill. 2014;19(24):pii/20833.


Sentinel lymph node mapping for defining site and extent of elective radiotherapy management of regional nodes in Merkel cell carcinoma: a pilot case series.

Naehrig D, Uren RF, Emmett L, Ioannou K, Hong A, Wratten C, Thompson JF, Hruby G.

J Med Imaging Radiat Oncol. 2014;58(3):353-9. doi: 10.1111/1754-9485.12180. Epub 2014 Apr 29.


Complete Radiologic Response of Bulky Cerebral Metastases From Newly Diagnosed HER2-Positive Breast Cancer to Upfront Trastuzumab-Based Chemotherapy.

Brungs D, Sze V, Emmett L, Epstein RJ.

World J Oncol. 2013 Apr;4(2):122-125. doi: 10.4021/wjon639w. Epub 2013 May 6.


Geminin is required for epithelial to mesenchymal transition at gastrulation.

Emmett LS, O'Shea KS.

Stem Cells Dev. 2012 Sep 1;21(13):2395-409. doi: 10.1089/scd.2011.0483. Epub 2012 Apr 16.


Investigation of a cluster of syphilis among heterosexuals in an English town.

Moussa R, Sundkvist T, Emmett L.

Int J STD AIDS. 2011 Sep;22(9):521-2. doi: 10.1258/ijsa.2011.011010.


Will chlamydia screening reach young people in deprived areas in England? Baseline analysis of the English National Chlamydia Screening Programme delivery in 2008.

Sheringham J, Simms I, Riha J, Talebi A, Emmett L, Macintosh M, Raine R.

Sex Transm Dis. 2011 Aug;38(8):677-84. doi: 10.1097/OLQ.0b013e31821597ca. Erratum in: Sex Transm Dis. 2012 Mar;39(3):240.


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