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Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma.

Sekhar V, Pollicino T, Diaz G, Engle RE, Alayli F, Melis M, Kabat J, Tice A, Pomerenke A, Altan-Bonnet N, Zamboni F, Lusso P, Emerson SU, Farci P.

PLoS Pathog. 2018 Mar 14;14(3):e1006916. doi: 10.1371/journal.ppat.1006916. eCollection 2018 Mar.


Consensus proposals for classification of the family Hepeviridae.

Smith DB, Simmonds P; members of the International Committee on the Taxonomy of Viruses Hepeviridae Study Group, Jameel S, Emerson SU, Harrison TJ, Meng XJ, Okamoto H, Van der Poel WH, Purdy MA.

J Gen Virol. 2015 May;96(Pt 5):1191-2. doi: 10.1099/vir.0.000115. No abstract available.


Complete genome sequence of a rat hepatitis e virus strain isolated in the United States.

Debing Y, Emerson SU, Purcell RH, Neyts J, Dallmeier K.

Genome Announc. 2014 Nov 6;2(6). pii: e01096-14. doi: 10.1128/genomeA.01096-14.


Consensus proposals for classification of the family Hepeviridae.

Smith DB, Simmonds P; International Committee on Taxonomy of Viruses Hepeviridae Study Group, Jameel S, Emerson SU, Harrison TJ, Meng XJ, Okamoto H, Van der Poel WH, Purdy MA.

J Gen Virol. 2014 Oct;95(Pt 10):2223-32. doi: 10.1099/vir.0.068429-0. Epub 2014 Jul 2. Erratum in: J Gen Virol. 2015 May;96(Pt 5):1191-2.


Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors.

Engle RE, Bukh J, Alter HJ, Emerson SU, Trenbeath JL, Nguyen HT, Brockington A, Mitra T, Purcell RH.

Transfusion. 2014 Nov;54(11):2833-41. doi: 10.1111/trf.12682. Epub 2014 May 5.


Hepatitis E virus genotype 1 infection of swine kidney cells in vitro is inhibited at multiple levels.

Nguyen HT, Shukla P, Torian U, Faulk K, Emerson SU.

J Virol. 2014 Jan;88(2):868-77. doi: 10.1128/JVI.02205-13. Epub 2013 Nov 6.


Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon.

Debing Y, Emerson SU, Wang Y, Pan Q, Balzarini J, Dallmeier K, Neyts J.

Antimicrob Agents Chemother. 2014;58(1):267-73. doi: 10.1128/AAC.01795-13. Epub 2013 Oct 21.


An essential RNA element resides in a central region of hepatitis E virus ORF2.

Emerson SU, Nguyen HT, Torian U, Mather K, Firth AE.

J Gen Virol. 2013 Jul;94(Pt 7):1468-76. doi: 10.1099/vir.0.051870-0. Epub 2013 Mar 20.


Chronic hepatitis E with neurologic manifestations and rapid progression of liver fibrosis in a liver transplant recipient.

Maddukuri VC, Russo MW, Ahrens WA, Emerson SU, Engle RE, Purcell RH, Thompson EB, Bonkovsky HL.

Dig Dis Sci. 2013 Aug;58(8):2413-6. doi: 10.1007/s10620-013-2628-7. Epub 2013 Mar 20. No abstract available.


Pathobiology of hepatitis E: lessons learned from primate models.

Purcell RH, Engle RE, Govindarajan S, Herbert R, St Claire M, Elkins WR, Cook A, Shaver C, Beauregard M, Swerczek J, Emerson SU.

Emerg Microbes Infect. 2013 Mar;2(3):e9. doi: 10.1038/emi.2013.9. Epub 2013 Mar 13.


Serological evidence for a hepatitis e virus-related agent in goats in the United States.

Sanford BJ, Emerson SU, Purcell RH, Engle RE, Dryman BA, Cecere TE, Buechner-Maxwell V, Sponenberg DP, Meng XJ.

Transbound Emerg Dis. 2013 Dec;60(6):538-45. doi: 10.1111/tbed.12001. Epub 2012 Aug 22.


Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Shukla P, Nguyen HT, Faulk K, Mather K, Torian U, Engle RE, Emerson SU.

J Virol. 2012 May;86(10):5697-707. doi: 10.1128/JVI.00146-12. Epub 2012 Mar 7.


Hepatitis E virus in rats, Los Angeles, California, USA.

Purcell RH, Engle RE, Rood MP, Kabrane-Lazizi Y, Nguyen HT, Govindarajan S, St Claire M, Emerson SU.

Emerg Infect Dis. 2011 Dec;17(12):2216-22. doi: 10.3201/eid1712.110482.


A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture.

Nguyen HT, Torian U, Faulk K, Mather K, Engle RE, Thompson E, Bonkovsky HL, Emerson SU.

J Gen Virol. 2012 Mar;93(Pt 3):526-30. doi: 10.1099/vir.0.037259-0. Epub 2011 Nov 23.


Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus.

Meunier JC, Gottwein JM, Houghton M, Russell RS, Emerson SU, Bukh J, Purcell RH.

J Infect Dis. 2011 Oct 15;204(8):1186-90. doi: 10.1093/infdis/jir511.


Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.

Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN).

Gastroenterology. 2011 Nov;141(5):1665-72.e1-9. doi: 10.1053/j.gastro.2011.07.051. Epub 2011 Aug 16.


Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation.

Córdoba L, Huang YW, Opriessnig T, Harral KK, Beach NM, Finkielstein CV, Emerson SU, Meng XJ.

J Virol. 2011 Jun;85(11):5338-49. doi: 10.1128/JVI.02278-10. Epub 2011 Mar 30.


Hepatitis C virus receptors claudin-1 and occludin after liver transplantation and influence on early viral kinetics.

Mensa L, Crespo G, Gastinger MJ, Kabat J, Pérez-del-Pulgar S, Miquel R, Emerson SU, Purcell RH, Forns X.

Hepatology. 2011 May;53(5):1436-45. doi: 10.1002/hep.24110. Epub 2011 Feb 3.


Reproduction in vitro of a quasispecies from a hepatitis C virus-infected patient and determination of factors that influence selection of a dominant species.

Kawaguchi K, Faulk K, Purcell RH, Emerson SU.

J Virol. 2011 Apr;85(7):3408-14. doi: 10.1128/JVI.02554-10. Epub 2011 Jan 26.


Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.

Shukla P, Nguyen HT, Torian U, Engle RE, Faulk K, Dalton HR, Bendall RP, Keane FE, Purcell RH, Emerson SU.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2438-43. doi: 10.1073/pnas.1018878108. Epub 2011 Jan 24.


Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.

Feagins AR, Córdoba L, Sanford BJ, Dryman BA, Huang YW, LeRoith T, Emerson SU, Meng XJ.

Virus Res. 2011 Mar;156(1-2):141-6. doi: 10.1016/j.virusres.2010.12.011. Epub 2010 Dec 30.


Spatial configuration of hepatitis E virus antigenic domain.

Xing L, Wang JC, Li TC, Yasutomi Y, Lara J, Khudyakov Y, Schofield D, Emerson SU, Purcell RH, Takeda N, Miyamura T, Cheng RH.

J Virol. 2011 Jan;85(2):1117-24. doi: 10.1128/JVI.00657-10. Epub 2010 Nov 10.


Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: similarities and differences.

Yu C, Boon D, McDonald SL, Myers TG, Tomioka K, Nguyen H, Engle RE, Govindarajan S, Emerson SU, Purcell RH.

J Virol. 2010 Nov;84(21):11264-78. doi: 10.1128/JVI.01205-10. Epub 2010 Aug 25.


Hidden danger: the raw facts about hepatitis E virus.

Purcell RH, Emerson SU.

J Infect Dis. 2010 Sep 15;202(6):819-21. doi: 10.1086/655900. No abstract available.


Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif.

Emerson SU, Nguyen HT, Torian U, Burke D, Engle R, Purcell RH.

J Virol. 2010 Sep;84(18):9059-69. doi: 10.1128/JVI.00593-10. Epub 2010 Jul 7.


The entire core protein of HCV JFH1 is required for efficient formation of infectious JFH1 pseudoparticles.

Shukla P, Faulk KN, Emerson SU.

J Med Virol. 2010 May;82(5):783-90. doi: 10.1002/jmv.21660.


Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins.

Takikawa S, Engle RE, Faulk KN, Emerson SU, Purcell RH, Bukh J.

J Gen Virol. 2010 Mar;91(Pt 3):727-33. doi: 10.1099/vir.0.015750-0. Epub 2009 Nov 11.


Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress.

Boudreau HE, Emerson SU, Korzeniowska A, Jendrysik MA, Leto TL.

J Virol. 2009 Dec;83(24):12934-46. doi: 10.1128/JVI.01059-09. Epub 2009 Oct 7.


Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt.

Blackard JT, Rouster SD, Nady S, Galal G, Marzuuk N, Rafaat MM, Daef E, El Din SS, Purcell RH, Emerson SU, Sherman KE, Shata MT.

J Clin Virol. 2009 Oct;46(2):140-4. doi: 10.1016/j.jcv.2009.07.007. Epub 2009 Aug 3.


Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles.

Russell RS, Kawaguchi K, Meunier JC, Takikawa S, Faulk K, Bukh J, Purcell RH, Emerson SU.

J Viral Hepat. 2009 Sep;16(9):621-32. doi: 10.1111/j.1365-2893.2009.01111.x. Epub 2009 Mar 11.


Apolipoprotein c1 association with hepatitis C virus.

Meunier JC, Russell RS, Engle RE, Faulk KN, Purcell RH, Emerson SU.

J Virol. 2008 Oct;82(19):9647-56. doi: 10.1128/JVI.00914-08. Epub 2008 Jul 30.


Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus.

Russell RS, Meunier JC, Takikawa S, Faulk K, Engle RE, Bukh J, Purcell RH, Emerson SU.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4370-5. doi: 10.1073/pnas.0800422105. Epub 2008 Mar 11.


Hepatitis E: an emerging awareness of an old disease.

Purcell RH, Emerson SU.

J Hepatol. 2008 Mar;48(3):494-503. doi: 10.1016/j.jhep.2007.12.008. Epub 2008 Jan 2. Review.


Hepatitis E.

Emerson SU, Purcell RH.

Pediatr Infect Dis J. 2007 Dec;26(12):1147-8. Review. No abstract available.


Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles.

Graff J, Zhou YH, Torian U, Nguyen H, St Claire M, Yu C, Purcell RH, Emerson SU.

J Virol. 2008 Feb;82(3):1185-94. Epub 2007 Nov 21.


Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus.

Meunier JC, Russell RS, Goossens V, Priem S, Walter H, Depla E, Union A, Faulk KN, Bukh J, Emerson SU, Purcell RH.

J Virol. 2008 Jan;82(2):966-73. Epub 2007 Oct 31.


Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.

Shata MT, Barrett A, Shire NJ, Abdelwahab SF, Sobhy M, Daef E, El-Kamary SS, Hashem M, Engle RE, Purcell RH, Emerson SU, Strickland GT, Sherman KE.

J Immunol Methods. 2007 Dec 1;328(1-2):152-61. Epub 2007 Sep 19.


In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells.

Sakai A, Takikawa S, Thimme R, Meunier JC, Spangenberg HC, Govindarajan S, Farci P, Emerson SU, Chisari FV, Purcell RH, Bukh J.

J Virol. 2007 Jul;81(13):7208-19. Epub 2007 Apr 4.


Using improved technology for filter paper-based blood collection to survey wild Sika deer for antibodies to hepatitis E virus.

Yu C, Zimmerman C, Stone R, Engle RE, Elkins W, Nardone GA, Emerson SU, Purcell RH.

J Virol Methods. 2007 Jun;142(1-2):143-50. Epub 2007 Mar 2.


Positive reactions on Western blots do not necessarily indicate the epitopes on antigens are continuous.

Zhou YH, Chen Z, Purcell RH, Emerson SU.

Immunol Cell Biol. 2007 Jan;85(1):73-8. Epub 2006 Nov 28.


ORF3 protein of hepatitis E virus is not required for replication, virion assembly, or infection of hepatoma cells in vitro.

Emerson SU, Nguyen H, Torian U, Purcell RH.

J Virol. 2006 Nov;80(21):10457-64. Epub 2006 Aug 23.


A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus.

Graff J, Torian U, Nguyen H, Emerson SU.

J Virol. 2006 Jun;80(12):5919-26.


Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein.

Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21.


Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay.

Emerson SU, Clemente-Casares P, Moiduddin N, Arankalle VA, Torian U, Purcell RH.

J Gen Virol. 2006 Mar;87(Pt 3):697-704.


Active surveillance for acute viral hepatitis in rural villages in the Nile Delta.

Meky FA, Stoszek SK, Abdel-Hamid M, Selim S, Abdel-Wahab A, Mikhail N, El-Kafrawy S, El-Daly M, Abdel-Aziz F, Sharaf S, Mohamed MK, Engle RE, Emerson SU, Purcell RH, Fix AD, Strickland GT.

Clin Infect Dis. 2006 Mar 1;42(5):628-33. Epub 2006 Jan 25.


Hepatitis E antibody seroconversion without disease in highly endemic rural Egyptian communities.

Stoszek SK, Engle RE, Abdel-Hamid M, Mikhail N, Abdel-Aziz F, Medhat A, Fix AD, Emerson SU, Purcell RH, Strickland GT.

Trans R Soc Trop Med Hyg. 2006 Feb;100(2):89-94. Epub 2005 Oct 28.


High prevalence of hepatitis E antibodies in pregnant Egyptian women.

Stoszek SK, Abdel-Hamid M, Saleh DA, El Kafrawy S, Narooz S, Hawash Y, Shebl FM, El Daly M, Said A, Kassem E, Mikhail N, Engle RE, Sayed M, Sharaf S, Fix AD, Emerson SU, Purcell RH, Strickland GT.

Trans R Soc Trop Med Hyg. 2006 Feb;100(2):95-101. Epub 2005 Oct 28.


Human monoclonal antibodies that react with the E2 glycoprotein of hepatitis C virus and possess neutralizing activity.

Schofield DJ, Bartosch B, Shimizu YK, Allander T, Alter HJ, Emerson SU, Cosset FL, Purcell RH.

Hepatology. 2005 Nov;42(5):1055-62.


Thermal stability of hepatitis E virus.

Emerson SU, Arankalle VA, Purcell RH.

J Infect Dis. 2005 Sep 1;192(5):930-3. Epub 2005 Jul 12.


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