Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 129


Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.

Colón-Thillet R, Hsieh E, Graf L, McLaughlin RN Jr, Young JM, Kochs G, Emerman M, Malik HS.

PLoS Biol. 2019 Oct 1;17(10):e3000181. doi: 10.1371/journal.pbio.3000181. eCollection 2019 Oct.


Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.

Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J.

PLoS Pathog. 2019 Jul 1;15(7):e1007925. doi: 10.1371/journal.ppat.1007925. eCollection 2019 Jul.


A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.

OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M.

Elife. 2018 Dec 6;7. pii: e39823. doi: 10.7554/eLife.39823.


Recurrent Loss of APOBEC3H Activity during Primate Evolution.

Garcia EI, Emerman M.

J Virol. 2018 Aug 16;92(17). pii: e00971-18. doi: 10.1128/JVI.00971-18. Print 2018 Sep 1.


A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.

Roesch F, OhAinle M, Emerman M.

Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2.


Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.


Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.

Adolph MB, Ara A, Feng Y, Wittkopp CJ, Emerman M, Fraser JS, Chelico L.

Nucleic Acids Res. 2017 Apr 7;45(6):3378-3394. doi: 10.1093/nar/gkx066.


A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.

Wittkopp CJ, Adolph MB, Wu LI, Chelico L, Emerman M.

PLoS Pathog. 2016 Oct 12;12(10):e1005865. doi: 10.1371/journal.ppat.1005865. eCollection 2016 Oct.


Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment.

Fregoso OI, Emerman M.

MBio. 2016 Sep 13;7(5). pii: e01433-16. doi: 10.1128/mBio.01433-16.


Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.

McLaughlin RN Jr, Gable JT, Wittkopp CJ, Emerman M, Malik HS.

Mol Biol Evol. 2016 Aug;33(8):1889-901. doi: 10.1093/molbev/msw070. Epub 2016 Apr 6.


Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction.

Mitchell PS, Young JM, Emerman M, Malik HS.

PLoS Pathog. 2015 Dec 10;11(12):e1005304. doi: 10.1371/journal.ppat.1005304. eCollection 2015 Dec.


The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.

Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M.

PLoS Pathog. 2015 Sep 22;11(9):e1005149. doi: 10.1371/journal.ppat.1005149. eCollection 2015 Sep.


Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.

Refsland EW, Hultquist JF, Luengas EM, Ikeda T, Shaban NM, Law EK, Brown WL, Reilly C, Emerman M, Harris RS.

PLoS Genet. 2014 Nov 20;10(11):e1004761. doi: 10.1371/journal.pgen.1004761. eCollection 2014 Nov.


A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.

Matsen FA 4th, Small CT, Soliven K, Engel GA, Feeroz MM, Wang X, Craig KL, Hasan MK, Emerman M, Linial ML, Jones-Engel L.

PLoS Comput Biol. 2014 Feb 27;10(2):e1003493. doi: 10.1371/journal.pcbi.1003493. eCollection 2014 Feb.


Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.

Spragg CJ, Emerman M.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21136-41. doi: 10.1073/pnas.1316839110. Epub 2013 Dec 9.


An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family.

Malfavon-Borja R, Sawyer SL, Wu LI, Emerman M, Malik HS.

Genome Biol Evol. 2013;5(11):2141-54. doi: 10.1093/gbe/evt163.


The mongoose, the pheasant, the pox, and the retrovirus.

Etienne L, Emerman M.

PLoS Biol. 2013;11(8):e1001641. doi: 10.1371/journal.pbio.1001641. Epub 2013 Aug 27.


Host gene evolution traces the evolutionary history of ancient primate lentiviruses.

Compton AA, Malik HS, Emerman M.

Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120496. doi: 10.1098/rstb.2012.0496. Print 2013 Sep 19. Review.


Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M.

PLoS Pathog. 2013;9(7):e1003496. doi: 10.1371/journal.ppat.1003496. Epub 2013 Jul 18.


Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.

Cell Host Microbe. 2013 Jul 17;14(1):85-92. doi: 10.1016/j.chom.2013.06.002.


Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.

Duggal NK, Fu W, Akey JM, Emerman M.

Virology. 2013 Sep 1;443(2):329-37. doi: 10.1016/j.virol.2013.05.016. Epub 2013 Jun 10.


An evolutionary perspective on the broad antiviral specificity of MxA.

Mitchell PS, Emerman M, Malik HS.

Curr Opin Microbiol. 2013 Aug;16(4):493-9. doi: 10.1016/j.mib.2013.04.005. Epub 2013 May 28. Review.


Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.

Compton AA, Emerman M.

PLoS Pathog. 2013 Jan;9(1):e1003135. doi: 10.1371/journal.ppat.1003135. Epub 2013 Jan 24.


Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes.

Malfavon-Borja R, Wu LI, Emerman M, Malik HS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):E583-92. doi: 10.1073/pnas.1216542110. Epub 2013 Jan 14.


Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.

Mitchell PS, Patzina C, Emerman M, Haller O, Malik HS, Kochs G.

Cell Host Microbe. 2012 Oct 18;12(4):598-604. doi: 10.1016/j.chom.2012.09.005.


Evolutionary conflicts between viruses and restriction factors shape immunity.

Duggal NK, Emerman M.

Nat Rev Immunol. 2012 Oct;12(10):687-95. doi: 10.1038/nri3295. Epub 2012 Sep 14. Review.


The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.

Lim ES, Wu LI, Malik HS, Emerman M.

Retrovirology. 2012 Jun 26;9:55. doi: 10.1186/1742-4690-9-55.


The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M.

Cell Host Microbe. 2012 Feb 16;11(2):194-204. doi: 10.1016/j.chom.2012.01.004. Epub 2012 Jan 26.


The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.

Compton AA, Hirsch VM, Emerman M.

Cell Host Microbe. 2012 Jan 19;11(1):91-8. doi: 10.1016/j.chom.2011.11.010.


The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome.

Yu SF, Lujan P, Jackson DL, Emerman M, Linial ML.

PLoS Pathog. 2011 Oct;7(10):e1002303. doi: 10.1371/journal.ppat.1002303. Epub 2011 Oct 13.


Paleovirology - ghosts and gifts of viruses past.

Patel MR, Emerman M, Malik HS.

Curr Opin Virol. 2011 Oct;1(4):304-9. doi: 10.1016/j.coviro.2011.06.007. Review.


The breadth of antiviral activity of Apobec3DE in chimpanzees has been driven by positive selection.

Duggal NK, Malik HS, Emerman M.

J Virol. 2011 Nov;85(21):11361-71. doi: 10.1128/JVI.05046-11. Epub 2011 Aug 10.


HIV: Going for the watchman.

Lim ES, Emerman M.

Nature. 2011 Jun 29;474(7353):587-8. doi: 10.1038/474587a. No abstract available.


Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity.

Li MM, Emerman M.

J Virol. 2011 Aug;85(16):8197-207. doi: 10.1128/JVI.00624-11. Epub 2011 Jun 8.


Trim5 TAKes on pattern recognition.

Tareen SU, Emerman M.

Cell Host Microbe. 2011 May 19;9(5):349-50. doi: 10.1016/j.chom.2011.05.003.


Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition.

Tareen SU, Emerman M.

Virology. 2011 Jan 5;409(1):113-20. doi: 10.1016/j.virol.2010.09.018. Epub 2010 Oct 28.


Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.

Lim ES, Malik HS, Emerman M.

J Virol. 2010 Jul;84(14):7124-34. doi: 10.1128/JVI.00468-10. Epub 2010 May 5.


Paleovirology--modern consequences of ancient viruses.

Emerman M, Malik HS.

PLoS Biol. 2010 Feb 9;8(2):e1000301. doi: 10.1371/journal.pbio.1000301. No abstract available.


The range of human APOBEC3H sensitivity to lentiviral Vif proteins.

Li MM, Wu LI, Emerman M.

J Virol. 2010 Jan;84(1):88-95. doi: 10.1128/JVI.01344-09.


Cellular restriction targeting viral capsids perturbs human immunodeficiency virus type 1 infection of nondividing cells.

Yamashita M, Emerman M.

J Virol. 2009 Oct;83(19):9835-43. doi: 10.1128/JVI.01084-09. Epub 2009 Jul 22.


Genetic drift of HIV populations in culture.

Voronin Y, Holte S, Overbaugh J, Emerman M.

PLoS Genet. 2009 Mar;5(3):e1000431. doi: 10.1371/journal.pgen.1000431. Epub 2009 Mar 20.


An expanded clade of rodent Trim5 genes.

Tareen SU, Sawyer SL, Malik HS, Emerman M.

Virology. 2009 Mar 15;385(2):473-83. doi: 10.1016/j.virol.2008.12.018. Epub 2009 Jan 15.


Guidelines for naming nonprimate APOBEC3 genes and proteins.

LaRue RS, Andrésdóttir V, Blanchard Y, Conticello SG, Derse D, Emerman M, Greene WC, Jónsson SR, Landau NR, Löchelt M, Malik HS, Malim MH, Münk C, O'Brien SJ, Pathak VK, Strebel K, Wain-Hobson S, Yu XF, Yuhki N, Harris RS.

J Virol. 2009 Jan;83(2):494-7. doi: 10.1128/JVI.01976-08. Epub 2008 Nov 5. No abstract available.


Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells.

Diehl WE, Stansell E, Kaiser SM, Emerman M, Hunter E.

J Virol. 2008 Nov;82(22):11140-51. doi: 10.1128/JVI.00269-08. Epub 2008 Sep 17.


Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.

OhAinle M, Kerns JA, Li MM, Malik HS, Emerman M.

Cell Host Microbe. 2008 Sep 11;4(3):249-59. doi: 10.1016/j.chom.2008.07.005.


Determinants of cyclophilin A-dependent TRIM5 alpha restriction against HIV-1.

Lin TY, Emerman M.

Virology. 2008 Sep 30;379(2):335-41. doi: 10.1016/j.virol.2008.06.037. Epub 2008 Aug 3.


HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

Malim MH, Emerman M.

Cell Host Microbe. 2008 Jun 12;3(6):388-98. doi: 10.1016/j.chom.2008.04.008. Review.


Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals.

Sawyer SL, Emerman M, Malik HS.

PLoS Pathog. 2007 Dec;3(12):e197.

Supplemental Content

Loading ...
Support Center