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Items: 1 to 50 of 185

1.

Author Correction: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.

Chen H, Moreno-Moral A, Pesce F, Devapragash N, Mancini M, Heng EL, Rotival M, Srivastava PK, Harmston N, Shkura K, Rackham OJL, Yu WP, Sun XM, Tee NGZ, Tan ELS, Barton PJR, Felkin LE, Lara-Pezzi E, Angelini G, Beltrami C, Pravenec M, Schafer S, Bottolo L, Hubner N, Emanueli C, Cook SA, Petretto E.

Nat Commun. 2019 Sep 9;10(1):4085. doi: 10.1038/s41467-019-12060-5.

2.

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.

Chen H, Moreno-Moral A, Pesce F, Devapragash N, Mancini M, Heng EL, Rotival M, Srivastava PK, Harmston N, Shkura K, Rackham OJL, Yu WP, Sun XM, Tee NGZ, Tan ELS, Barton PJR, Felkin LE, Lara-Pezzi E, Angelini G, Beltrami C, Pravenec M, Schafer S, Bottolo L, Hubner N, Emanueli C, Cook SA, Petretto E.

Nat Commun. 2019 Aug 9;10(1):3616. doi: 10.1038/s41467-019-11551-9. Erratum in: Nat Commun. 2019 Sep 9;10(1):4085.

3.

miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia.

Besnier M, Shantikumar S, Anwar M, Dixit P, Chamorro-Jorganes A, Sweaad W, Sala-Newby G, Madeddu P, Thomas AC, Howard L, Mushtaq S, Petretto E, Caporali A, Emanueli C.

Mol Ther Nucleic Acids. 2019 Sep 6;17:49-62. doi: 10.1016/j.omtn.2019.05.002. Epub 2019 May 17.

4.

MicroRNAs as potential biomarkers in congenital heart surgery.

Stoica SC, Dorobantu DM, Vardeu A, Biglino G, Ford KL, Bruno DV, Zakkar M, Mumford A, Angelini GD, Caputo M, Emanueli C.

J Thorac Cardiovasc Surg. 2019 Apr 4. pii: S0022-5223(19)30740-8. doi: 10.1016/j.jtcvs.2019.03.062. [Epub ahead of print]

PMID:
31043318
5.

Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia.

Dang Z, Avolio E, Albertario A, Sala-Newby GB, Thomas AC, Wang N, Emanueli C, Madeddu P.

Diabetologia. 2019 Jul;62(7):1297-1311. doi: 10.1007/s00125-019-4860-y. Epub 2019 Apr 24.

6.

Enhanced notch signaling modulates unproductive revascularization in response to nitric oxide-angiopoietin signaling in a mouse model of peripheral ischemia.

Machado MJC, Boardman R, Riu F, Emanueli C, Benest AV, Bates DO.

Microcirculation. 2019 Aug;26(6):e12549. doi: 10.1111/micc.12549. Epub 2019 Jun 19.

PMID:
30974486
7.

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.

Gomes CPC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M, Hoydal MA, Jankovic A, Jusic A, Kardassis D, Kerkelä R, Kuster GM, Lakkisto P, Leszek P, Lustrek M, Maegdefessel L, Martelli F, Novella S, O'Brien T, Papaneophytou C, Pedrazzini T, Pinet F, Popescu O, Potočnjak I, Robinson E, Sasson S, Scholz M, Simionescu M, Stoll M, Varga ZV, Vinciguerra M, Xuereb A, Yilmaz MB, Emanueli C, Devaux Y, on behalf of the EU-CardioRNA COST Action (CA17129).

Noncoding RNA. 2019 Mar 29;5(2). pii: E31. doi: 10.3390/ncrna5020031.

8.

Optimisation of laboratory methods for whole transcriptomic RNA analyses in human left ventricular biopsies and blood samples of clinical relevance.

Ford KL, Anwar M, Heys R, Ahmed EM, Caputo M, Game L, Reeves BC, Punjabi PP, Angelini GD, Petretto E, Emanueli C.

PLoS One. 2019 Mar 14;14(3):e0213685. doi: 10.1371/journal.pone.0213685. eCollection 2019.

9.

Remote ischaemic preconditioning in isolated aortic valve and coronary artery bypass surgery: a randomized trial†.

Moscarelli M, Fiorentino F, Suleiman MS, Emanueli C, Reeves BC, Punjabi PP, Angelini GD.

Eur J Cardiothorac Surg. 2019 May 1;55(5):905-912. doi: 10.1093/ejcts/ezy404.

PMID:
30544237
10.

Exosomes: Basic Biology and Technological Advancements Suggesting Their Potential as Ischemic Heart Disease Therapeutics.

Shanmuganathan M, Vughs J, Noseda M, Emanueli C.

Front Physiol. 2018 Nov 19;9:1159. doi: 10.3389/fphys.2018.01159. eCollection 2018. Review.

11.

Aortic morphological variability in patients with bicuspid aortic valve and aortic coarctation.

Sophocleous F, Biffi B, Milano EG, Bruse J, Caputo M, Rajakaruna C, Schievano S, Emanueli C, Bucciarelli-Ducci C, Biglino G.

Eur J Cardiothorac Surg. 2019 Apr 1;55(4):704-713. doi: 10.1093/ejcts/ezy339.

12.

BDNF (Brain-Derived Neurotrophic Factor) Promotes Embryonic Stem Cells Differentiation to Endothelial Cells Via a Molecular Pathway, Including MicroRNA-214, EZH2 (Enhancer of Zeste Homolog 2), and eNOS (Endothelial Nitric Oxide Synthase).

Descamps B, Saif J, Benest AV, Biglino G, Bates DO, Chamorro-Jorganes A, Emanueli C.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2117-2125. doi: 10.1161/ATVBAHA.118.311400.

13.

miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia.

Besnier M, Gasparino S, Vono R, Sangalli E, Facoetti A, Bollati V, Cantone L, Zaccagnini G, Maimone B, Fuschi P, Da Silva D, Schiavulli M, Aday S, Caputo M, Madeddu P, Emanueli C, Martelli F, Spinetti G.

Mol Ther. 2018 Jul 5;26(7):1694-1705. doi: 10.1016/j.ymthe.2018.06.003. Epub 2018 Jun 15.

14.

Robust Revascularization in Models of Limb Ischemia Using a Clinically Translatable Human Stem Cell-Derived Endothelial Cell Product.

MacAskill MG, Saif J, Condie A, Jansen MA, MacGillivray TJ, Tavares AAS, Fleisinger L, Spencer HL, Besnier M, Martin E, Biglino G, Newby DE, Hadoke PWF, Mountford JC, Emanueli C, Baker AH.

Mol Ther. 2018 Jul 5;26(7):1669-1684. doi: 10.1016/j.ymthe.2018.03.017. Epub 2018 Mar 28.

15.

Enlightening the Association between Bicuspid Aortic Valve and Aortopathy.

Sophocleous F, Milano EG, Pontecorboli G, Chivasso P, Caputo M, Rajakaruna C, Bucciarelli-Ducci C, Emanueli C, Biglino G.

J Cardiovasc Dev Dis. 2018 Apr 19;5(2). pii: E21. doi: 10.3390/jcdd5020021. Review.

16.

Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction.

Alvino VV, Fernández-Jiménez R, Rodriguez-Arabaolaza I, Slater S, Mangialardi G, Avolio E, Spencer H, Culliford L, Hassan S, Sueiro Ballesteros L, Herman A, Ayaon-Albarrán A, Galán-Arriola C, Sánchez-González J, Hennessey H, Delmege C, Ascione R, Emanueli C, Angelini GD, Ibanez B, Madeddu P.

J Am Heart Assoc. 2018 Jan 22;7(2). pii: e006727. doi: 10.1161/JAHA.117.006727.

17.

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition.

Aday S, Zoldan J, Besnier M, Carreto L, Saif J, Fernandes R, Santos T, Bernardino L, Langer R, Emanueli C, Ferreira L.

Nat Commun. 2017 Sep 29;8(1):747. doi: 10.1038/s41467-017-00746-7.

18.

MWASTools: an R/bioconductor package for metabolome-wide association studies.

Rodriguez-Martinez A, Posma JM, Ayala R, Neves AL, Anwar M, Petretto E, Emanueli C, Gauguier D, Nicholson JK, Dumas ME.

Bioinformatics. 2018 Mar 1;34(5):890-892. doi: 10.1093/bioinformatics/btx477.

19.

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease.

Gomes CPC, Spencer H, Ford KL, Michel LYM, Baker AH, Emanueli C, Balligand JL, Devaux Y; Cardiolinc network.

Mol Ther Nucleic Acids. 2017 Sep 15;8:494-507. doi: 10.1016/j.omtn.2017.07.014. Epub 2017 Jul 28. Review.

20.

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA.

Dykes IM, Emanueli C.

Genomics Proteomics Bioinformatics. 2017 Jun;15(3):177-186. doi: 10.1016/j.gpb.2016.12.005. Epub 2017 May 19. Review.

21.

Methodological Guidelines to Study Extracellular Vesicles.

Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R.

Circ Res. 2017 May 12;120(10):1632-1648. doi: 10.1161/CIRCRESAHA.117.309417. Review.

PMID:
28495994
22.

Circulating MicroRNAs to Predict the Risk for Metabolic Diseases in the General Population?

Dumas ME, Emanueli C.

Diabetes. 2017 Mar;66(3):565-567. doi: 10.2337/dbi16-0072. No abstract available.

23.

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

Beltrami C, Besnier M, Shantikumar S, Shearn AI, Rajakaruna C, Laftah A, Sessa F, Spinetti G, Petretto E, Angelini GD, Emanueli C.

Mol Ther. 2017 Mar 1;25(3):679-693. doi: 10.1016/j.ymthe.2016.12.022. Epub 2017 Feb 1.

24.

Extracellular vesicles at the cross-line between basic science and clinical needs.

Sasso L, Hosamuddin H, Emanueli C.

Microcirculation. 2017 Jan;24(1). doi: 10.1111/micc.12333. Review.

PMID:
28135410
25.

Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?

Biglino G, Caputo M, Rajakaruna C, Angelini G, van Rooij E, Emanueli C.

Pharmacol Ther. 2017 Feb;170:192-204. doi: 10.1016/j.pharmthera.2016.11.004. Epub 2016 Nov 27. Review.

PMID:
27902930
26.

Exosomes in Diabetic Cardiomyopathy: The Next-Generation Therapeutic Targets?

Sahoo S, Emanueli C.

Diabetes. 2016 Oct;65(10):2829-31. doi: 10.2337/dbi16-0041. No abstract available.

27.

Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro: tissue engineering implications.

Fortunato TM, Beltrami C, Emanueli C, De Bank PA, Pula G.

Sci Rep. 2016 May 4;6:25326. doi: 10.1038/srep25326.

28.

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery.

Emanueli C, Shearn AI, Laftah A, Fiorentino F, Reeves BC, Beltrami C, Mumford A, Clayton A, Gurney M, Shantikumar S, Angelini GD.

PLoS One. 2016 Apr 29;11(4):e0154274. doi: 10.1371/journal.pone.0154274. eCollection 2016.

29.

A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells.

Boulberdaa M, Scott E, Ballantyne M, Garcia R, Descamps B, Angelini GD, Brittan M, Hunter A, McBride M, McClure J, Miano JM, Emanueli C, Mills NL, Mountford JC, Baker AH.

Mol Ther. 2016 May;24(5):978-90. doi: 10.1038/mt.2016.41. Epub 2016 Feb 22.

30.

MicroRNA transport in cardiovascular complication of diabetes.

Caporali A, Miscianinov V, Saif J, Emanueli C.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2111-2120. doi: 10.1016/j.bbalip.2016.01.010. Epub 2016 Jan 20. Review.

PMID:
26806392
31.

MicroRNAs in congenital heart disease.

Smith T, Rajakaruna C, Caputo M, Emanueli C.

Ann Transl Med. 2015 Dec;3(21):333. doi: 10.3978/j.issn.2305-5839.2015.12.25. Review.

32.

Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress.

Zakkar M, Angelini GD, Emanueli C.

Curr Vasc Pharmacol. 2016;14(2):181-6. Review.

PMID:
26638798
33.

Data supporting the activation of autophagy genes in the diabetic heart.

Munasinghe PE, Riu F, Dixit P, Edamatsu M, Saxena P, Hamer NS, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R.

Data Brief. 2015 Sep 14;5:269-75. doi: 10.1016/j.dib.2015.09.003. eCollection 2015 Dec.

34.

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.

Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T.

Sci Rep. 2015 Oct 6;5:14780. doi: 10.1038/srep14780.

35.

Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway.

Munasinghe PE, Riu F, Dixit P, Edamatsu M, Saxena P, Hamer NS, Galvin IF, Bunton RW, Lequeux S, Jones G, Lamberts RR, Emanueli C, Madeddu P, Katare R.

Int J Cardiol. 2016 Jan 1;202:13-20. doi: 10.1016/j.ijcard.2015.08.111. Epub 2015 Aug 10.

PMID:
26386349
36.

Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes.

Dang Z, Maselli D, Spinetti G, Sangalli E, Carnelli F, Rosa F, Seganfreddo E, Canal F, Furlan A, Paccagnella A, Paiola E, Lorusso B, Specchia C, Albiero M, Cappellari R, Avogaro A, Falco A, Quaini F, Ou K, Rodriguez-Arabaolaza I, Emanueli C, Sambataro M, Fadini GP, Madeddu P.

Diabetologia. 2015 Nov;58(11):2653-62. doi: 10.1007/s00125-015-3735-0. Epub 2015 Sep 10.

37.

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart.

Meloni M, Cesselli D, Caporali A, Mangialardi G, Avolio E, Reni C, Fortunato O, Martini S, Madeddu P, Valgimigli M, Nikolaev E, Kaczmarek L, Angelini GD, Beltrami AP, Emanueli C.

Mol Ther. 2015 Dec;23(12):1854-66. doi: 10.1038/mt.2015.167. Epub 2015 Sep 10.

38.

p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia.

Caporali A, Meloni M, Nailor A, Mitić T, Shantikumar S, Riu F, Sala-Newby GB, Rose L, Besnier M, Katare R, Voellenkle C, Verkade P, Martelli F, Madeddu P, Emanueli C.

Nat Commun. 2015 Aug 13;6:8024. doi: 10.1038/ncomms9024.

39.

Bridging Basic Science with Cardiac Surgery: The Bristol Heart Institute Experience.

Emanueli C, Angelini GD.

Front Surg. 2015 Jul 22;2:31. doi: 10.3389/fsurg.2015.00031. eCollection 2015. Review. No abstract available.

40.

MicroRNAs as clinical biomarkers?

Angelini TG, Emanueli C.

Front Genet. 2015 Jul 14;6:240. doi: 10.3389/fgene.2015.00240. eCollection 2015. No abstract available.

41.

Expansion and characterization of neonatal cardiac pericytes provides a novel cellular option for tissue engineering in congenital heart disease.

Avolio E, Rodriguez-Arabaolaza I, Spencer HL, Riu F, Mangialardi G, Slater SC, Rowlinson J, Alvino VV, Idowu OO, Soyombo S, Oikawa A, Swim MM, Kong CH, Cheng H, Jia H, Ghorbel MT, Hancox JC, Orchard CH, Angelini G, Emanueli C, Caputo M, Madeddu P.

J Am Heart Assoc. 2015 Jun 16;4(6):e002043. doi: 10.1161/JAHA.115.002043.

42.

MicroRNAs in vascular tissue engineering and post-ischemic neovascularization.

Caputo M, Saif J, Rajakaruna C, Brooks M, Angelini GD, Emanueli C.

Adv Drug Deliv Rev. 2015 Jul 1;88:78-91. doi: 10.1016/j.addr.2015.05.003. Epub 2015 May 14. Review.

43.

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction.

Ascione R, Rowlinson J, Avolio E, Katare R, Meloni M, Spencer HL, Mangialardi G, Norris C, Kränkel N, Spinetti G, Emanueli C, Madeddu P.

Stem Cell Res Ther. 2015 Apr 11;6:53. doi: 10.1186/s13287-015-0028-y.

44.

Non coding RNAs in aortic aneurysmal disease.

Duggirala A, Delogu F, Angelini TG, Smith T, Caputo M, Rajakaruna C, Emanueli C.

Front Genet. 2015 Apr 1;6:125. doi: 10.3389/fgene.2015.00125. eCollection 2015. Review.

45.

Exosomes and exosomal miRNAs in cardiovascular protection and repair.

Emanueli C, Shearn AI, Angelini GD, Sahoo S.

Vascul Pharmacol. 2015 Aug;71:24-30. doi: 10.1016/j.vph.2015.02.008. Epub 2015 Apr 11. Review.

46.

Insulin over expression induces heart abnormalities via reactive oxygen species regulation, might be step towards cardiac hypertrophy.

Mushtaq S, Ali T, Gul M, Javed Q, Emanueli C, Murtaza I.

Cell Mol Biol (Noisy-le-grand). 2015 Mar 9;61(1):30-5.

PMID:
25817343
47.

Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair.

Avolio E, Meloni M, Spencer HL, Riu F, Katare R, Mangialardi G, Oikawa A, Rodriguez-Arabaolaza I, Dang Z, Mitchell K, Reni C, Alvino VV, Rowlinson J, Livi U, Cesselli D, Angelini G, Emanueli C, Beltrami AP, Madeddu P.

Circ Res. 2015 May 8;116(10):e81-94. doi: 10.1161/CIRCRESAHA.115.306146. Epub 2015 Mar 23.

PMID:
25801898
48.

Circulating MicroRNAs as new biomarkers of ischaemia/reperfusion injury during cardiac surgery.

Caputo M, Skerritt C, Emanueli C.

Cardiology. 2015;130(4):234-6. doi: 10.1159/000375482. Epub 2015 Mar 18. No abstract available.

PMID:
25791531
49.

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

Floris I, Descamps B, Vardeu A, Mitić T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):664-74. doi: 10.1161/ATVBAHA.114.304730. Epub 2015 Jan 22.

PMID:
25614281
50.

Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia.

Gubernator M, Slater SC, Spencer HL, Spiteri I, Sottoriva A, Riu F, Rowlinson J, Avolio E, Katare R, Mangialardi G, Oikawa A, Reni C, Campagnolo P, Spinetti G, Touloumis A, Tavaré S, Prandi F, Pesce M, Hofner M, Klemens V, Emanueli C, Angelini G, Madeddu P.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):675-88. doi: 10.1161/ATVBAHA.114.304989. Epub 2015 Jan 8.

PMID:
25573856

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