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Items: 28


Cell cycle oscillators underlying orderly proteolysis of E2F8.

Wasserman D, Nachum S, Cohen M, Enrico TP, Noach-Hirsh M, Parasol J, Zomer-Polak S, Auerbach N, Sheinberger-Chorni E, Nevenzal H, Levi-Dadon N, Wang X, Lahmi R, Michaely E, Gerber D, Emanuele MJ, Tzur A.

Mol Biol Cell. 2020 Jan 29:mbcE19120725. doi: 10.1091/mbc.E19-12-0725. [Epub ahead of print]


Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.

McDonald IM, Grant GD, East MP, Gilbert TS, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM.

J Biol Chem. 2020 Jan 2. pii: jbc.RA119.011083. doi: 10.1074/jbc.RA119.011083. [Epub ahead of print]


Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.

Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, Cox AD, Der CJ.

Sci Signal. 2019 Jul 16;12(590). pii: eaav7259. doi: 10.1126/scisignal.aav7259.


Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne.

Bonacci T, Emanuele MJ.

Cell Cycle. 2019 Mar - Apr;18(6-7):652-660. doi: 10.1080/15384101.2019.1593646. Epub 2019 Mar 28.


FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer.

Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ.

Cell Rep. 2019 Mar 12;26(11):3076-3086.e6. doi: 10.1016/j.celrep.2019.02.054.


Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle.

Kernan J, Bonacci T, Emanuele MJ.

Biochim Biophys Acta Mol Cell Res. 2018 Dec;1865(12):1924-1933. doi: 10.1016/j.bbamcr.2018.09.011. Epub 2018 Oct 2. Review.


Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.

Bonacci T, Suzuki A, Grant GD, Stanley N, Cook JG, Brown NG, Emanuele MJ.

EMBO J. 2018 Aug 15;37(16). pii: e98701. doi: 10.15252/embj.201798701. Epub 2018 Jul 4.


Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity.

Dronamraju R, Jha DK, Eser U, Adams AT, Dominguez D, Choudhury R, Chiang YC, Rathmell WK, Emanuele MJ, Churchman LS, Strahl BD.

Nucleic Acids Res. 2018 Feb 16;46(3):1331-1344. doi: 10.1093/nar/gkx1276.


Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron.

Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG.

Mol Biol Cell. 2018 Jan 15;29(2):96-110. doi: 10.1091/mbc.E17-11-0627. Epub 2017 Nov 22.


The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery.

Choudhury R, Bonacci T, Wang X, Truong A, Arceci A, Zhang Y, Mills CA, Kernan JL, Liu P, Emanuele MJ.

Cell Rep. 2017 Sep 26;20(13):3212-3222. doi: 10.1016/j.celrep.2017.08.099.


Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation.

Mills CA, Suzuki A, Arceci A, Mo JY, Duncan A, Salmon ED, Emanuele MJ.

J Biol Chem. 2017 Oct 20;292(42):17178-17189. doi: 10.1074/jbc.M117.796045. Epub 2017 Sep 12.


The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 Jul 28;292(30):12503-12515. doi: 10.1074/jbc.M117.788448. Epub 2017 May 30.


VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.

Wang X, Arceci A, Bird K, Mills CA, Choudhury R, Kernan JL, Zhou C, Bae-Jump V, Bowers A, Emanuele MJ.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00609-16. doi: 10.1128/MCB.00609-16. Print 2017 Jul 1.


APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.

Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ.

Cell Rep. 2016 Sep 20;16(12):3359-3372. doi: 10.1016/j.celrep.2016.08.058.


A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells.

Ly T, Ahmad Y, Shlien A, Soroka D, Mills A, Emanuele MJ, Stratton MR, Lamond AI.

Elife. 2014 Jan 1;3:e01630. doi: 10.7554/eLife.01630.


Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth.

Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN.

Cell Host Microbe. 2014 Jan 15;15(1):113-24. doi: 10.1016/j.chom.2013.12.009.


Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.

Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo J.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3659-67. doi: 10.1073/pnas.1207673110. Epub 2012 Dec 10.


Global identification of modular cullin-RING ligase substrates.

Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.

Cell. 2011 Oct 14;147(2):459-74. doi: 10.1016/j.cell.2011.09.019. Epub 2011 Sep 29. Erratum in: Cell. 2012 Feb 3;148(3):620-2.


Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

Emanuele MJ, Ciccia A, Elia AE, Elledge SJ.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9845-50. doi: 10.1073/pnas.1106136108. Epub 2011 May 31.


A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ.

Cell. 2009 May 29;137(5):835-48. doi: 10.1016/j.cell.2009.05.006.


Probing kinetochore structure and function using Xenopus laevis frog egg extracts.

Emanuele MJ, Stukenberg PT.

Methods Mol Biol. 2009;545:221-32. doi: 10.1007/978-1-60327-993-2_13.


Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly.

Emanuele MJ, Lan W, Jwa M, Miller SA, Chan CS, Stukenberg PT.

J Cell Biol. 2008 Apr 21;181(2):241-54. doi: 10.1083/jcb.200710019.


Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.

Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ.

Chromosoma. 2008 Apr;117(2):169-79. Epub 2007 Dec 4.


Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment.

Emanuele MJ, Stukenberg PT.

Cell. 2007 Sep 7;130(5):893-905.


Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore.

Emanuele MJ, McCleland ML, Satinover DL, Stukenberg PT.

Mol Biol Cell. 2005 Oct;16(10):4882-92. Epub 2005 Aug 3.


Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome.

Wang HW, Putt ME, Emanuele MJ, Shin DB, Glatstein E, Yodh AG, Busch TM.

Cancer Res. 2004 Oct 15;64(20):7553-61.


Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients.

Busch TM, Hahn SM, Wileyto EP, Koch CJ, Fraker DL, Zhang P, Putt M, Gleason K, Shin DB, Emanuele MJ, Jenkins K, Glatstein E, Evans SM.

Clin Cancer Res. 2004 Jul 15;10(14):4630-8.


Photodynamic therapy creates fluence rate-dependent gradients in the intratumoral spatial distribution of oxygen.

Busch TM, Wileyto EP, Emanuele MJ, Del Piero F, Marconato L, Glatstein E, Koch CJ.

Cancer Res. 2002 Dec 15;62(24):7273-9.

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