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Prognostic factors in the progression of intervertebral disc degeneration: Which patient should be targeted with regenerative therapies?

Rustenburg CME, Faraj SSA, Ket JCF, Emanuel KS, Smit TH.

JOR Spine. 2019 Sep 21;2(3):e1063. doi: 10.1002/jsp2.1063. eCollection 2019 Sep. Review.


Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar.

Rustenburg CME, Emanuel KS, Peeters M, Lems WF, Vergroesen PA, Smit TH.

JOR Spine. 2018 Oct 19;1(4):e1033. doi: 10.1002/jsp2.1033. eCollection 2018 Dec. Review.


Climate change exacerbates hurricane flood hazards along US Atlantic and Gulf Coasts in spatially varying patterns.

Marsooli R, Lin N, Emanuel K, Feng K.

Nat Commun. 2019 Aug 22;10(1):3785. doi: 10.1038/s41467-019-11755-z.


The biomechanical effect of single-level laminectomy and posterior instrumentation on spinal stability in degenerative lumbar scoliosis: a human cadaveric study.

Rustenburg CME, Faraj SSA, Holewijn RM, Kingma I, van Royen BJ, Stadhouder A, Emanuel KS.

Neurosurg Focus. 2019 May 1;46(5):E15. doi: 10.3171/2019.2.FOCUS1911.


Advances in weather prediction.

Alley RB, Emanuel KA, Zhang F.

Science. 2019 Jan 25;363(6425):342-344. doi: 10.1126/science.aav7274. Epub 2019 Jan 24. No abstract available.


Early changes in the extracellular matrix of the degenerating intervertebral disc, assessed by Fourier transform infrared imaging.

Emanuel KS, Mader KT, Peeters M, Kingma I, Rustenburg CME, Vergroesen PA, Sammon C, Smit TH.

Osteoarthritis Cartilage. 2018 Oct;26(10):1400-1408. doi: 10.1016/j.joca.2018.06.003. Epub 2018 Jun 20.


Data-driven quantification of the effect of wind on athletics performance.

Moinat M, Fabius O, Emanuel KS.

Eur J Sport Sci. 2018 Oct;18(9):1185-1190. doi: 10.1080/17461391.2018.1480062. Epub 2018 Jun 11.


Changes in Intervertebral Disk Mechanical Behavior During Early Degeneration.

Paul CPL, Emanuel KS, Kingma I, van der Veen AJ, Holewijn RM, Vergroesen PA, van de Ven PM, Mullender MG, Helder MN, Smit TH.

J Biomech Eng. 2018 Sep 1;140(9). doi: 10.1115/1.4039890.


Publisher Correction: Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle.

Beekmans SV, Emanuel KS, Smit TH, Iannuzzi D.

Sci Rep. 2018 Mar 15;8(1):4880. doi: 10.1038/s41598-018-23164-1.


Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study.

Beekmans SV, Emanuel KS, Smit TH, Iannuzzi D.

JOR Spine. 2018 Mar 15;1(1):e1005. doi: 10.1002/jsp2.1005. eCollection 2018 Mar.


Impacts of hemispheric solar geoengineering on tropical cyclone frequency.

Jones AC, Haywood JM, Dunstone N, Emanuel K, Hawcroft MK, Hodges KI, Jones A.

Nat Commun. 2017 Nov 14;8(1):1382. doi: 10.1038/s41467-017-01606-0.


Assessing the present and future probability of Hurricane Harvey's rainfall.

Emanuel K.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12681-12684. doi: 10.1073/pnas.1716222114. Epub 2017 Nov 13.


Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load: A caprine in vitro study.

Emanuel KS, van der Veen AJ, Rustenburg CME, Smit TH, Kingma I.

J Biomech. 2018 Mar 21;70:10-15. doi: 10.1016/j.jbiomech.2017.10.010. Epub 2017 Oct 25.


Impact of climate change on New York City's coastal flood hazard: Increasing flood heights from the preindustrial to 2300 CE.

Garner AJ, Mann ME, Emanuel KA, Kopp RE, Lin N, Alley RB, Horton BP, DeConto RM, Donnelly JP, Pollard D.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11861-11866. doi: 10.1073/pnas.1703568114. Epub 2017 Oct 23.


Minimally Invasive Micro-Indentation: mapping tissue mechanics at the tip of an 18G needle.

Beekmans SV, Emanuel KS, Smit TH, Iannuzzi D.

Sci Rep. 2017 Sep 12;7(1):11364. doi: 10.1038/s41598-017-10526-4. Erratum in: Sci Rep. 2018 Mar 15;8(1):4880.


Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals.

Stauch KL, Emanuel K, Lamberty BG, Morsey B, Fox HS.

J Neurovirol. 2017 Dec;23(6):795-807. doi: 10.1007/s13365-017-0573-5. Epub 2017 Sep 11.


A Novel Spinal Implant for Fusionless Scoliosis Correction: A Biomechanical Analysis of the Motion Preserving Properties of a Posterior Periapical Concave Distraction Device.

Holewijn RM, de Kleuver M, van der Veen AJ, Emanuel KS, Bisschop A, Stadhouder A, van Royen BJ, Kingma I.

Global Spine J. 2017 Aug;7(5):400-409. doi: 10.1177/2192568217699377. Epub 2017 Apr 7.


Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect.

Harrison EB, Emanuel K, Lamberty BG, Morsey BM, Li M, Kelso ML, Yelamanchili SV, Fox HS.

Front Mol Neurosci. 2017 Jul 28;10:228. doi: 10.3389/fnmol.2017.00228. eCollection 2017.


Are axial intervertebral disc biomechanics determined by osmosis?

Vergroesen PA, Emanuel KS, Peeters M, Kingma I, Smit TH.

J Biomech. 2018 Mar 21;70:4-9. doi: 10.1016/j.jbiomech.2017.04.027. Epub 2017 May 8.


Tropical cyclone activity enhanced by Sahara greening and reduced dust emissions during the African Humid Period.

Pausata FSR, Emanuel KA, Chiacchio M, Diro GT, Zhang Q, Sushama L, Stager JC, Donnelly JP.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6221-6226. doi: 10.1073/pnas.1619111114. Epub 2017 May 30.


A novel physiological testing device to study knee biomechanics in vitro.

van de Bunt F, Emanuel KS, Wijffels T, Kooren PN, Kingma I, Smit TH.

Knee. 2017 Aug;24(4):718-725. doi: 10.1016/j.knee.2017.04.006. Epub 2017 Apr 25.


Functioning Without Cartilage: Older People With Radiographic Knee Osteoarthritis Who Self-Report No Functional Limitations Do Score Lower on a Performance Battery.

van Leeuwen DM, van de Bunt F, de Ruiter CJ, van Schoor NM, Deeg DJH, Emanuel KS.

J Aging Phys Act. 2017 Oct 1;25(4):570-575. doi: 10.1123/japa.2016-0112. Epub 2017 Sep 18.


Sex and Racial/Ethnic Differences in Positive Outcomes in Delinquent Youth After Detention: A 12-Year Longitudinal Study.

Abram KM, Azores-Gococo NM, Emanuel KM, Aaby DA, Welty LJ, Hershfield JA, Rosenbaum MS, Teplin LA.

JAMA Pediatr. 2017 Feb 1;171(2):123-132. doi: 10.1001/jamapediatrics.2016.3260.


Global warming-induced upper-ocean freshening and the intensification of super typhoons.

Balaguru K, Foltz GR, Leung LR, Emanuel KA.

Nat Commun. 2016 Nov 25;7:13670. doi: 10.1038/ncomms13670.


Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration.

Stauch KL, Villeneuve LM, Purnell PR, Ottemann BM, Emanuel K, Fox HS.

Proteomics Clin Appl. 2016 Dec;10(12):1205-1217. doi: 10.1002/prca.201600005. Epub 2016 Sep 21.


Response to: 'A dose-response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine'.

Emanuel KS, Kingma I, Helder MN, Smit TH.

Arthritis Res Ther. 2016 Feb 8;18:41. doi: 10.1186/s13075-016-0944-y. No abstract available.


The poro-elastic behaviour of the intervertebral disc: A new perspective on diurnal fluid flow.

Vergroesen PA, van der Veen AJ, Emanuel KS, van Dieën JH, Smit TH.

J Biomech. 2016 Apr 11;49(6):857-863. doi: 10.1016/j.jbiomech.2015.11.041. Epub 2015 Nov 28.


Translational challenges for the development of a novel nucleus pulposus substitute: Experimental results from biomechanical and in vivo studies.

Detiger SE, de Bakker JY, Emanuel KS, Schmitz M, Vergroesen PP, van der Veen AJ, Mazel C, Smit TH.

J Biomater Appl. 2016 Feb;30(7):983-94. doi: 10.1177/0885328215611946. Epub 2015 Oct 21.


Increased threat of tropical cyclones and coastal flooding to New York City during the anthropogenic era.

Reed AJ, Mann ME, Emanuel KA, Lin N, Horton BP, Kemp AC, Donnelly JP.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12610-5. doi: 10.1073/pnas.1513127112. Epub 2015 Sep 28.


Poroelastic behaviour of the degenerating human intervertebral disc: a ten-day study in a loaded disc culture system.

Emanuel KS, Vergroesen PP, Peeters M, Holewijn RM, Kingma I, Smit TH.

Eur Cell Mater. 2015 Jun 20;29:330-40; discussion 340-1.


Mechanics and biology in intervertebral disc degeneration: a vicious circle.

Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, van Royen BJ, van Dieën JH, Smit TH.

Osteoarthritis Cartilage. 2015 Jul;23(7):1057-70. doi: 10.1016/j.joca.2015.03.028. Epub 2015 Mar 27. Review.


A biodegradable glue for annulus closure: evaluation of strength and endurance.

Vergroesen PP, Bochyn Ska AI, Emanuel KS, Sharifi S, Kingma I, Grijpma DW, Smit TH.

Spine (Phila Pa 1976). 2015 May 1;40(9):622-8. doi: 10.1097/BRS.0000000000000792.


CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system.

Marcondes MC, Morsey B, Emanuel K, Lamberty BG, Flynn CT, Fox HS.

J Infect Dis. 2015 Jan 1;211(1):40-4. doi: 10.1093/infdis/jiu401. Epub 2014 Jul 17.


The poleward migration of the location of tropical cyclone maximum intensity.

Kossin JP, Emanuel KA, Vecchi GA.

Nature. 2014 May 15;509(7500):349-52. doi: 10.1038/nature13278.


Climate adaptation. Evaluating flood resilience strategies for coastal megacities.

Aerts JC, Botzen WJ, Emanuel K, Lin N, de Moel H, Michel-Kerjan EO.

Science. 2014 May 2;344(6183):473-5. doi: 10.1126/science.1248222. No abstract available.


The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins.

Yelamanchili SV, Morsey B, Harrison EB, Rennard DA, Emanuel K, Thapa I, Bastola DR, Fox HS.

Cell Death Dis. 2014 Jan 9;5:e982. doi: 10.1038/cddis.2013.498.


Downscaling CMIP5 climate models shows increased tropical cyclone activity over the 21st century.

Emanuel KA.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12219-24. doi: 10.1073/pnas.1301293110. Epub 2013 Jul 8.


Low-probability flood risk modeling for New York City.

Aerts JC, Lin N, Botzen W, Emanuel K, de Moel H.

Risk Anal. 2013 May;33(5):772-88. doi: 10.1111/risa.12008. Epub 2013 Feb 5.


The survival of ultrashort locking-taper implants.

Urdaneta RA, Daher S, Leary J, Emanuel KM, Chuang SK.

Int J Oral Maxillofac Implants. 2012 May-Jun;27(3):644-54.


The effect of implant size 5 × 8 mm on crestal bone levels around single-tooth implants.

Urdaneta RA, Leary J, Lubelski W, Emanuel KM, Chuang SK.

J Periodontol. 2012 Oct;83(10):1235-44. Epub 2012 Feb 6.


Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy.

Mackiewicz U, Czarnowska E, Brudek M, Pająk B, Duda M, Emanuel K, Csanyi G, Fedorowicz A, Grochal E, Tyrankiewicz U, Skórka T, Mende U, Lewartowski B, Chłopicki S.

J Mol Cell Cardiol. 2012 May;52(5):978-87. doi: 10.1016/j.yjmcc.2012.01.008. Epub 2012 Jan 17.


Hurricane modification and adaptation in Miami-Dade County, Florida.

Klima K, Lin N, Emanuel K, Morgan MG, Grossmann I.

Environ Sci Technol. 2012 Jan 17;46(2):636-42. doi: 10.1021/es202640p. Epub 2011 Dec 28.


Factors associated with crestal bone gain on single-tooth locking-taper implants: the effect of nonsteroidal anti-inflammatory drugs.

Urdaneta RA, Daher S, Lery J, Emanuel K, Chuang SK.

Int J Oral Maxillofac Implants. 2011 Sep-Oct;26(5):1063-78.


Does it make sense to modify tropical cyclones? A decision-analytic assessment.

Klima K, Morgan MG, Grossmann I, Emanuel K.

Environ Sci Technol. 2011 May 15;45(10):4242-8. doi: 10.1021/es104336u. Epub 2011 Apr 20.


Short (5.0 × 5.0 mm) implant placements and restoration with integrated abutment crowns.

Yi YS, Emanuel KM, Chuang SK.

Implant Dent. 2011 Apr;20(2):125-30. doi: 10.1097/ID.0b013e31820fb67e.


Climate change and the integrity of science.

Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J Jr, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS 3rd, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB Jr, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE Jr, Wu C, Wunsch C, Zoback ML.

Science. 2010 May 7;328(5979):689-90. doi: 10.1126/science.328.5979.689. No abstract available. Erratum in: Science. 2010 May 14;328(5980):826.


Tropical cyclones and permanent El Niño in the early Pliocene epoch.

Fedorov AV, Brierley CM, Emanuel K.

Nature. 2010 Feb 25;463(7284):1066-70. doi: 10.1038/nature08831.


Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.

Hegde GV, Peterson KJ, Emanuel K, Mittal AK, Joshi AD, Dickinson JD, Kollessery GJ, Bociek RG, Bierman P, Vose JM, Weisenburger DD, Joshi SS.

Mol Cancer Res. 2008 Dec;6(12):1928-36. doi: 10.1158/1541-7786.MCR-08-0142.


Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma.

Hegde GV, Munger CM, Emanuel K, Joshi AD, Greiner TC, Weisenburger DD, Vose JM, Joshi SS.

Mol Cancer Ther. 2008 Jun;7(6):1450-60. doi: 10.1158/1535-7163.MCT-07-2118. Epub 2008 Jun 4.


Retrospective. Edward N. Lorenz (1917-2008).

Emanuel K.

Science. 2008 May 23;320(5879):1025. doi: 10.1126/science.1159438. No abstract available.


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