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Items: 1 to 50 of 77

1.

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

Koltun DO, Parkhill EQ, Kalla R, Perry TD, Elzein E, Li X, Simonovich SP, Ziebenhaus C, Hansen TR, Marchand B, Hung WK, Lagpacan L, Hung M, Aoyama RG, Murray BP, Perry JK, Somoza JR, VillaseƱor AG, Pagratis N, Zablocki JA.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):541-546. doi: 10.1016/j.bmcl.2017.10.040. Epub 2017 Oct 20.

PMID:
29254643
2.

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.

Zablocki JA, Elzein E, Li X, Koltun DO, Parkhill EQ, Kobayashi T, Martinez R, Corkey B, Jiang H, Perry T, Kalla R, Notte GT, Saunders O, Graupe M, Lu Y, Venkataramani C, Guerrero J, Perry J, Osier M, Strickley R, Liu G, Wang WQ, Hu L, Li XJ, El-Bizri N, Hirakawa R, Kahlig K, Xie C, Li CH, Dhalla AK, Rajamani S, Mollova N, Soohoo D, Lepist EI, Murray B, Rhodes G, Belardinelli L, Desai MC.

J Med Chem. 2016 Oct 13;59(19):9005-9017. doi: 10.1021/acs.jmedchem.6b00939. Epub 2016 Oct 3.

PMID:
27690427
3.

The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.

Rajamani S, Liu G, El-Bizri N, Guo D, Li C, Chen XL, Kahlig KM, Mollova N, Elzein E, Zablocki J, Belardinelli L.

Br J Pharmacol. 2016 Nov;173(21):3088-3098. doi: 10.1111/bph.13563. Epub 2016 Sep 14.

4.

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.

Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Notte GT, Kalla R, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Smith-Maxwell C, Dhalla AK, Rajamani S, Stafford B, Tang J, Mollova N, Belardinelli L, Zablocki JA.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3202-3206. doi: 10.1016/j.bmcl.2016.03.101. Epub 2016 Mar 30.

PMID:
27080178
5.

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.

Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Hirakawa R, Smith-Maxwell C, Wu L, Dhalla AK, Rajamani S, Mollova N, Stafford B, Tang J, Belardinelli L, Zablocki JA.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-3211. doi: 10.1016/j.bmcl.2016.03.096. Epub 2016 Mar 26.

PMID:
27038498
6.

Studies on BVD involving establishment of sentinel calves and assessment of herd immunity in a large dairy farm in Saudi Arabia.

Abu Elzein E, Alkhalyifa M.

Trop Anim Health Prod. 2012 Mar;44(3):413-7. doi: 10.1007/s11250-011-9912-3. Epub 2011 Jun 12.

PMID:
21667324
7.

A1 adenosine receptor antagonists, agonists, and allosteric enhancers.

Kiesman WF, Elzein E, Zablocki J.

Handb Exp Pharmacol. 2009;(193):25-58. doi: 10.1007/978-3-540-89615-9_2. Review.

PMID:
19639278
8.

Utilization of protein-A in immuno-histochemical techniques for detection of Peste des Petits Ruminants (PPR) virus antigens in tissues of experimentally infected goats.

Abu Elzein EM, Al-Naeem A.

Trop Anim Health Prod. 2009 Jan;41(1):1-4. doi: 10.1007/s11250-008-9161-2. Epub 2008 Apr 16.

PMID:
19052895
9.

A1 adenosine receptor agonists and their potential therapeutic applications.

Elzein E, Zablocki J.

Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10. doi: 10.1517/13543780802497284 . Review.

PMID:
19012505
10.

In situ detection of PPR virus antigen in skin papules around the mouth of sheep experimentally infected with PPR virus.

Al-Naeem A, Abu-Elzein EM.

Trop Anim Health Prod. 2008 May;40(4):239-41. No abstract available.

PMID:
18557185
11.

Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.

Elzein E, Kalla RV, Li X, Perry T, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J.

J Med Chem. 2008 Apr 10;51(7):2267-78. doi: 10.1021/jm7014815. Epub 2008 Mar 6.

PMID:
18321039
12.

Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.

Kalla RV, Elzein E, Perry T, Li X, Gimbel A, Yang M, Zeng D, Zablocki J.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1397-401. doi: 10.1016/j.bmcl.2008.01.008. Epub 2008 Jan 8.

PMID:
18226896
13.

Severe malformations in calves associated with bovine viral diarrhoea (BVD) virus infection in a dairy cattle herd.

Al-Afaleq AI, Abu-Elzein EM, Al-Khalyfah M.

Trop Anim Health Prod. 2007 Oct;39(7):463-6.

PMID:
17969709
14.

Pseudocowpox virus: the etiological agent of contagious ecthyma (Auzdyk) in camels (Camelus dromedarius) in the Arabian peninsula.

Abubakr MI, Abu-Elzein EM, Housawi FM, Abdelrahman AO, Fadlallah ME, Nayel MN, Adam AS, Moss S, Forrester NL, Coloyan E, Gameel A, Al-Afaleq AI, Gould EA.

Vector Borne Zoonotic Dis. 2007 Summer;7(2):257-60.

PMID:
17627446
15.

A study on bovine ephemeral fever involving sentinel herds and serosurveillance in Saudi Arabia.

Abu-Elzein EM, Al-Afaleq AI, Housawi FM, Al-Basheir AM.

Rev Sci Tech. 2006 Dec;25(3):1147-51.

16.

N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.

Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J.

Bioorg Med Chem Lett. 2007 Jan 1;17(1):161-6. Epub 2006 Oct 11.

PMID:
17045477
17.

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Kalla RV, Elzein E, Perry T, Li X, Palle V, Varkhedkar V, Gimbel A, Maa T, Zeng D, Zablocki J.

J Med Chem. 2006 Jun 15;49(12):3682-92.

PMID:
16759111
18.

Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?

Forrester NL, Abubakr MI, Abu Elzein EM, Al-Afaleq AI, Housawi FM, Moss SR, Turner SL, Gould EA.

Virology. 2006 Jan 20;344(2):277-82. Epub 2005 Nov 9.

19.

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.

Elzein E, Kalla R, Li X, Perry T, Parkhill E, Palle V, Varkhedkar V, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):302-6. Epub 2005 Nov 4.

PMID:
16275090
20.

Abortions, stillbirths and deformities in sheep at the Al-Ahsa oasis in eastern Saudi Arabia: isolation of a bluetongue serogroup virus from the affected lambs.

Housawi FM, Abu Elzein EM, Ramadan RO, Gameel AA, Al-Afaleq AI, Al-Mousa J.

Rev Sci Tech. 2004 Dec;23(3):913-20.

21.

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.

Elzein E, Ibrahim P, Koltun DO, Rehder K, Shenk KD, Marquart TA, Jiang B, Li X, Natero R, Li Y, Nguyen M, Kerwar S, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Zeng D, Leung K, Zablocki JA.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6017-21.

PMID:
15546720
22.

2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.

Elzein E, Palle V, Wu Y, Maa T, Zeng D, Zablocki J.

J Med Chem. 2004 Sep 9;47(19):4766-73.

PMID:
15341491
23.

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.

Morrison CF, Elzein E, Jiang B, Ibrahim PN, Marquart T, Palle V, Shenk KD, Varkhedkar V, Maa T, Wu L, Wu Y, Zeng D, Fong I, Lustig D, Leung K, Zablocki JA.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3793-7.

PMID:
15203164
24.

Severe PPR infection in gazelles kept under semi-free range conditions.

Elzein EM, Housawi FM, Bashareek Y, Gameel AA, Al-Afaleq AI, Anderson E.

J Vet Med B Infect Dis Vet Public Health. 2004 Mar;51(2):68-71.

PMID:
15030603
25.

Novel inhibitors of fatty acid oxidation as potential metabolic modulators.

Elzein E, Shenk K, Ibrahim P, Marquart T, Kerwar S, Meyer S, Ahmed H, Zeng D, Chu N, Soohoo D, Wong S, Leung K, Zablocki J.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):973-7.

PMID:
15013004
26.

A retrospective study of Rift Valley fever in Saudi Arabia.

Al-Afaleq AI, Abu Elzein EM, Mousa SM, Abbas AM.

Rev Sci Tech. 2003 Dec;22(3):867-71.

27.

New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties.

Koltun DO, Marquart TA, Shenk KD, Elzein E, Li Y, Nguyen M, Kerwar S, Zeng D, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Ng KJ, Fraser H, Zablocki JA.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):549-52.

PMID:
14698201
28.

Sheep-associated malignant catarrhal fever involving 3-5-week-old calves in Saudi Arabia.

Abu Elzein EM, Housawi FM, Gameel AA, Al-Afaleq AI, El-Bashir AM.

J Vet Med B Infect Dis Vet Public Health. 2003 Mar;50(2):53-9.

PMID:
12675894
29.

Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.

Palle VP, Elzein EO, Gothe SA, Li Z, Gao Z, Meyer S, Blackburn B, Zablocki JA.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2935-9.

PMID:
12270178
30.

2-substituted pi system derivatives of adenosine that are coronary vasodilators acting via the A2A adenosine receptor.

Zablocki J, Palle V, Blackburn B, Elzein E, Nudelman G, Gothe S, Gao Z, Li Z, Meyer S, Belardinelli L.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):343-60.

PMID:
11563047
31.

Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.

Gao Z, Li Z, Baker SP, Lasley RD, Meyer S, Elzein E, Palle V, Zablocki JA, Blackburn B, Belardinelli L.

J Pharmacol Exp Ther. 2001 Jul;298(1):209-18.

PMID:
11408544
32.

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

Gangjee A, Vidwans A, Elzein E, McGuire JJ, Queener SF, Kisliuk RL.

J Med Chem. 2001 Jun 7;44(12):1993-2003.

PMID:
11384244
33.

Pigeon paramyxovirus-1 (P-group) as the cause of severe outbreaks in fancy Columba livia in Saudi Arabia.

Abu Elzein EM, Manvell R, Alexander D, Alafaleq AI.

Zentralbl Veterinarmed B. 1999 Dec;46(10):689-92.

PMID:
10676146
34.

Contagious ecthyma associated with myiasis in sheep.

Housawi FM, Abu Elzein EM.

Rev Sci Tech. 2000 Dec;19(3):863-6.

35.

Epizootiological aspects of peste des petits ruminants and rinderpest in sheep and goats in Saudi Arabia.

al-Naeem A, Abu Elzein EM, al-Afaleq AI.

Rev Sci Tech. 2000 Dec;19(3):855-8. Review.

36.

An eruptive moderate form of camelpox infection in dromedary camels (Camelus dromedarius) in Saudi Arabia.

Abu Elzein EM, Gameel AA, Ramadan RO, Housawi FM.

Rev Sci Tech. 1999 Dec;18(3):749-52.

37.

Observations on the recent epizootic of bovine ephemeral fever in Saudi Arabia.

Abu Elzein EM, Gameel AA, al-Afaleq AI, al-Gundi O, al-Bashier AM, Zeedan A, al-Mageed HA, Abu Khadra H.

Rev Sci Tech. 1999 Dec;18(3):672-80.

38.

Rabbit haemorrhagic disease in Saudi Arabia.

Abu Elzein EM, al-Afaleq AI.

Vet Rec. 1999 Apr 24;144(17):480-1. No abstract available.

PMID:
10358879
39.

Observations on African horse sickness in Saudi Arabia.

al-Afaleq AI, Abu Elzein EM, Hassanein MM.

Rev Sci Tech. 1998 Dec;17(3):777-80.

40.

Study of Akabane infection in Saudi Arabia by the use of sentinel ruminants.

Abu Elzein EM, al-Afaleq AI, Mellor PS, el-Bashir AM, Hassanein MM.

J Comp Pathol. 1998 Nov;119(4):473-8.

PMID:
9839208
41.

A study on bluetongue virus infection in Saudi Arabia using sentinel ruminants.

Abu Elzein EM, Aitchison H, al-Afaleq AI, al-Bashir AM, Ibrahim AO, Housawi FM.

Onderstepoort J Vet Res. 1998 Dec;65(4):243-51.

PMID:
10192836
42.

Prevalence of neutralizing antibodies to Akabane virus in ruminants in Saudi Arabia.

al-Afaleq AI, Elzein EM, Mellor PS.

Zentralbl Veterinarmed B. 1998 Jun;45(5):257-62.

PMID:
9673576
44.

Arbovirus infections of ruminants in al-Rub al-Khali desert.

Abu Elzein EM, Sandouka MA, al-Afaleq AI, Mohamed OB, Flamand JR.

Vet Rec. 1998 Feb 21;142(8):196-7. No abstract available.

PMID:
9533283
45.

Severe long-lasting contagious ecthyma infection in a goat's kid.

Abu Elzein EM, Housawi FM.

Zentralbl Veterinarmed B. 1997 Nov;44(9):561-4.

PMID:
9451946
46.

Bovine ephemeral fever in Saudi Arabia.

Abu Elzein EM, Gameel AA, al Afaleq AI, al Gundi O, Bukhari A.

Vet Rec. 1997 Jun 14;140(24):630-1. No abstract available.

PMID:
9228697
47.

Clinico-pathological observations on naturally occurring contagious ecthyma in lambs in Saudi Arabia.

Gameel AA, Abu Elzein EM, Housawi FM, Agib A, Ibrahim AO.

Rev Elev Med Vet Pays Trop. 1995;48(3):233-5.

PMID:
8745744
48.

Interference of herbal drinks with urinalysis for drugs of abuse.

Winek CL, Elzein EO, Wahba WW, Feldman JA.

J Anal Toxicol. 1993 Jul-Aug;17(4):246-7.

PMID:
8371557
49.

A close comparative study on the response of sheep and goats to experimental orf infection.

Housawi FM, Abu Elzein EM, Gameel AA, Alafaleq AI.

Zentralbl Veterinarmed B. 1993 Jun;40(4):272-82.

PMID:
8237197
50.

High level agglutination of camel (Camelus dromedarius) erythrocytes by avian paramyxovirus serotype 1.

Elzein EM, Hassanein MM, Afaleq AI.

Avian Pathol. 1993 Mar;22(1):189-92.

PMID:
18671008

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