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Items: 1 to 50 of 52

1.

A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system.

Ruan C, Sun L, Kroshilina A, Beckers L, De Jager P, Bradshaw EM, Hasson SA, Yang G, Elyaman W.

Brain Behav Immun. 2019 Oct 8. pii: S0889-1591(19)30814-1. doi: 10.1016/j.bbi.2019.10.009. [Epub ahead of print]

PMID:
31604143
2.

Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.

Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV.

Circulation. 2019 Sep 9;140(10):846-863. doi: 10.1161/CIRCULATIONAHA.119.040563. Epub 2019 Jul 3.

PMID:
31266349
3.

A transcriptomic atlas of aged human microglia.

Olah M, Patrick E, Villani AC, Xu J, White CC, Ryan KJ, Piehowski P, Kapasi A, Nejad P, Cimpean M, Connor S, Yung CJ, Frangieh M, McHenry A, Elyaman W, Petyuk V, Schneider JA, Bennett DA, De Jager PL, Bradshaw EM.

Nat Commun. 2018 Feb 7;9(1):539. doi: 10.1038/s41467-018-02926-5.

4.

MS AHI1 genetic risk promotes IFNγ+ CD4+ T cells.

Kaskow BJ, Buttrick TS, Klein HU, White C, Bourgeois JR, Ferland RJ, Patsopoulos N, Bradshaw EM, De Jager PL, Elyaman W.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 8;5(1):e414. doi: 10.1212/NXI.0000000000000414. eCollection 2018 Jan.

5.

Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy.

Buttrick TS, Wang W, Yung C, Trieu KG, Patel K, Khoury SJ, Ai X, Elyaman W.

Sci Rep. 2018 Jan 16;8(1):818. doi: 10.1038/s41598-018-19315-z.

6.

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

Ryan KJ, White CC, Patel K, Xu J, Olah M, Replogle JM, Frangieh M, Cimpean M, Winn P, McHenry A, Kaskow BJ, Chan G, Cuerdon N, Bennett DA, Boyd JD, Imitola J, Elyaman W, De Jager PL, Bradshaw EM.

Sci Transl Med. 2017 Dec 20;9(421). pii: eaai7635. doi: 10.1126/scitranslmed.aai7635.

7.

Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.

Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J.

JCI Insight. 2017 Nov 2;2(21). pii: 91599. doi: 10.1172/jci.insight.91599.

8.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. No abstract available.

9.

Innate and adaptive immunity in human epilepsies.

Bauer J, Becker AJ, Elyaman W, Peltola J, Rüegg S, Titulaer MJ, Varley JA, Beghi E.

Epilepsia. 2017 Jul;58 Suppl 3:57-68. doi: 10.1111/epi.13784. Review.

10.

Opposite functions of STAT3 and Smad3 in regulating Tiam1 expression in Th17 cells.

Buttrick T, Khoury SJ, Elyaman W.

Small GTPases. 2017 Jun 13:1-7. doi: 10.1080/21541248.2017.1341365. [Epub ahead of print]

PMID:
28609201
11.

Prediction and Validation of Transcription Factors Binding Sites in the Il9 Locus.

Orent W, Elyaman W.

Methods Mol Biol. 2017;1585:111-125. doi: 10.1007/978-1-4939-6877-0_9.

PMID:
28477191
12.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. No abstract available.

PMID:
28170374
13.

Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.

Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW.

J Leukoc Biol. 2017 Feb;101(2):493-505. doi: 10.1189/jlb.3A1215-546RR. Epub 2016 Dec 13.

14.

Th9 cells in the pathogenesis of EAE and multiple sclerosis.

Elyaman W, Khoury SJ.

Semin Immunopathol. 2017 Jan;39(1):79-87. doi: 10.1007/s00281-016-0604-y. Epub 2016 Nov 14. Review.

PMID:
27844107
15.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Erratum in: Nat Med. 2017 Feb 7;23 (2):264. Nat Med. 2017 Aug 4;23 (8):1004.

16.

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.

Kurdi AT, Bassil R, Olah M, Wu C, Xiao S, Taga M, Frangieh M, Buttrick T, Orent W, Bradshaw EM, Khoury SJ, Elyaman W.

Nat Commun. 2016 Oct 11;7:13048. doi: 10.1038/ncomms13048.

17.

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.

Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK.

Cell Rep. 2016 Jul 12;16(2):392-404. doi: 10.1016/j.celrep.2016.05.088. Epub 2016 Jun 23.

18.

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.

Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN.

Nat Commun. 2015 Dec 18;6:10182. doi: 10.1038/ncomms10182.

19.

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.

Orent W, Mchenry AR, Rao DA, White C, Klein HU, Bassil R, Srivastava G, Replogle JM, Raj T, Frangieh M, Cimpean M, Cuerdon N, Chibnik L, Khoury SJ, Karlson EW, Brenner MB, De Jager P, Bradshaw EM, Elyaman W.

Hum Mol Genet. 2016 Jan 15;25(2):404-17. doi: 10.1093/hmg/ddv474. Epub 2015 Nov 24.

20.

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity.

Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, Brassat D, Benoist C, Patsopoulos NA, Comi G, Elyaman W, Martinelli Boneschi F, De Jager PL.

Ann Neurol. 2015 Jul;78(1):115-27. doi: 10.1002/ana.24429. Epub 2015 May 14.

PMID:
25914168
21.

BCL6 controls Th9 cell development by repressing Il9 transcription.

Bassil R, Orent W, Olah M, Kurdi AT, Frangieh M, Buttrick T, Khoury SJ, Elyaman W.

J Immunol. 2014 Jul 1;193(1):198-207. doi: 10.4049/jimmunol.1303184. Epub 2014 May 30.

22.

Notch signaling and T-helper cells in EAE/MS.

Bassil R, Orent W, Elyaman W.

Clin Dev Immunol. 2013;2013:570731. doi: 10.1155/2013/570731. Epub 2013 Nov 14. Review.

23.

IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.

Zhu B, Buttrick T, Bassil R, Zhu C, Olah M, Wu C, Xiao S, Orent W, Elyaman W, Khoury SJ.

J Immunol. 2013 Sep 15;191(6):3139-51. doi: 10.4049/jimmunol.1300329. Epub 2013 Aug 19.

24.

Jagged2-signaling promotes IL-6-dependent transplant rejection.

Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A.

Eur J Immunol. 2013 Jun;43(6):1449-58. doi: 10.1002/eji.201243151. Epub 2013 May 2.

25.

In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity.

Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS.

J Clin Immunol. 2013 Jan;33 Suppl 1:S43-9. doi: 10.1007/s10875-012-9762-4. Epub 2012 Sep 2. Review.

26.

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration.

Starossom SC, Mascanfroni ID, Imitola J, Cao L, Raddassi K, Hernandez SF, Bassil R, Croci DO, Cerliani JP, Delacour D, Wang Y, Elyaman W, Khoury SJ, Rabinovich GA.

Immunity. 2012 Aug 24;37(2):249-63. doi: 10.1016/j.immuni.2012.05.023. Epub 2012 Aug 9.

27.

Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.

Nat Med. 2012 Aug;18(8):1248-53. doi: 10.1038/nm.2856. Epub 2012 Jul 8.

28.

Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells.

Elyaman W, Bassil R, Bradshaw EM, Orent W, Lahoud Y, Zhu B, Radtke F, Yagita H, Khoury SJ.

Immunity. 2012 Apr 20;36(4):623-34. doi: 10.1016/j.immuni.2012.01.020. Epub 2012 Apr 12.

29.

The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.

Azzi J, Moore RF, Elyaman W, Mounayar M, El Haddad N, Yang S, Jurewicz M, Takakura A, Petrelli A, Fiorina P, Ruckle T, Abdi R.

Diabetes. 2012 Jun;61(6):1509-18. doi: 10.2337/db11-0134. Epub 2012 Mar 8.

30.

Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4⁺ T cells and requires the presence of monocytes.

Boenisch O, Lopez M, Elyaman W, Magee CN, Ahmad U, Najafian N.

Am J Transplant. 2012 Apr;12(4):856-66. doi: 10.1111/j.1600-6143.2011.03978.x. Epub 2012 Mar 5.

31.

Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation.

Riella LV, Ueno T, Batal I, De Serres SA, Bassil R, Elyaman W, Yagita H, Medina-Pestana JO, Chandraker A, Najafian N.

J Immunol. 2011 Nov 1;187(9):4629-38. doi: 10.4049/jimmunol.1004076. Epub 2011 Sep 26.

32.

Potential application of tregitopes as immunomodulating agents in multiple sclerosis.

Elyaman W, Khoury SJ, Scott DW, De Groot AS.

Neurol Res Int. 2011;2011:256460. doi: 10.1155/2011/256460. Epub 2011 Sep 15.

33.

Plasticity of Ly-6C(hi) myeloid cells in T cell regulation.

Zhu B, Kennedy JK, Wang Y, Sandoval-Garcia C, Cao L, Xiao S, Wu C, Elyaman W, Khoury SJ.

J Immunol. 2011 Sep 1;187(5):2418-32. doi: 10.4049/jimmunol.1100403. Epub 2011 Aug 8.

34.

Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development.

Bassil R, Zhu B, Lahoud Y, Riella LV, Yagita H, Elyaman W, Khoury SJ.

J Immunol. 2011 Sep 1;187(5):2322-8. doi: 10.4049/jimmunol.1100725. Epub 2011 Aug 3.

35.

TIM-3: a novel regulatory molecule of alloimmune activation.

Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N.

J Immunol. 2010 Nov 15;185(10):5806-19. doi: 10.4049/jimmunol.0903435. Epub 2010 Oct 18.

36.

TGF-beta induces IL-9 production from human Th17 cells.

Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA.

J Immunol. 2010 Jul 1;185(1):46-54. doi: 10.4049/jimmunol.1000356. Epub 2010 May 24.

37.

CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis.

Liu Y, Bando Y, Vargas-Lowy D, Elyaman W, Khoury SJ, Huang T, Reif K, Chitnis T.

J Neurosci. 2010 Feb 10;30(6):2025-38. doi: 10.1523/JNEUROSCI.4272-09.2010.

38.

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.

Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA.

J Immunol. 2009 Oct 1;183(7):4432-9. doi: 10.4049/jimmunol.0900576. Epub 2009 Sep 11.

39.

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90. doi: 10.1073/pnas.0812530106. Epub 2009 May 11.

40.

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.

Nat Immunol. 2008 Dec;9(12):1347-55. doi: 10.1038/ni.1677. Epub 2008 Nov 9. Erratum in: Nat Immunol. 2009 May;10(5):551.

41.

Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.

Elyaman W, Kivisäkk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ.

Am J Pathol. 2008 Aug;173(2):411-22. doi: 10.2353/ajpath.2008.080142. Epub 2008 Jun 26.

42.

Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis.

Kivisäkk P, Imitola J, Rasmussen S, Elyaman W, Zhu B, Ransohoff RM, Khoury SJ.

Ann Neurol. 2009 Apr;65(4):457-69. doi: 10.1002/ana.21379.

43.

JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis.

Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisäkk P, Chiba S, Yagita H, Khoury SJ.

J Immunol. 2007 Nov 1;179(9):5990-8.

44.

Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration.

Chitnis T, Imitola J, Wang Y, Elyaman W, Chawla P, Sharuk M, Raddassi K, Bronson RT, Khoury SJ.

Am J Pathol. 2007 May;170(5):1695-712.

45.

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway.

Ji JZ, Elyaman W, Yip HK, Lee VW, Yick LW, Hugon J, So KF.

Eur J Neurosci. 2004 Jan;19(2):265-72.

PMID:
14725620
46.

Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity.

Suen KC, Lin KF, Elyaman W, So KF, Chang RC, Hugon J.

J Neurochem. 2003 Dec;87(6):1413-26. Erratum in: J Neurochem. 2004 Feb;88(4):1040.

47.

BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis.

Elyaman W, Terro F, Suen KC, Yardin C, Chang RC, Hugon J.

Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):233-8.

PMID:
12531534
48.
49.

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.

J Neurosci Res. 2002 Aug 15;69(4):530-9.

PMID:
12210846
50.

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