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Items: 24


A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA.

Nat Med. 2018 Jul;24(7):1005-1014. doi: 10.1038/s41591-018-0070-2. Epub 2018 Jun 25.


Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.

Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL Jr, Coughlin SR.

Structure. 2018 Feb 6;26(2):187-198.e4. doi: 10.1016/j.str.2017.12.010. Epub 2018 Jan 11.


The Role of Opportunistic Bilateral Salpingectomy vs Tubal Occlusion or Ligation for Ovarian Cancer Prophylaxis.

Ely LK, Truong M.

J Minim Invasive Gynecol. 2017 Mar - Apr;24(3):371-378. doi: 10.1016/j.jmig.2017.01.001. Epub 2017 Jan 10. Review.


Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis.

David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR.

Sci Transl Med. 2016 Aug 24;8(353):353ra112. doi: 10.1126/scitranslmed.aaf4331.


Combined proximal nerve graft and distal nerve transfer for a posterior cord brachial plexus injury.

Plate JF, Ely LK, Pulley BR, Smith BP, Li Z.

J Neurosurg. 2013 Jan;118(1):155-9. doi: 10.3171/2012.10.JNS12425. Epub 2012 Nov 9.


Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM.

J Immunol. 2011 May 15;186(10):5823-32. doi: 10.4049/jimmunol.1100197. Epub 2011 Apr 13.


Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.


Structural basis of receptor sharing by interleukin 17 cytokines.

Ely LK, Fischer S, Garcia KC.

Nat Immunol. 2009 Dec;10(12):1245-51. doi: 10.1038/ni.1813. Epub 2009 Oct 18.


Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.


The molecular basis of TCR germline bias for MHC is surprisingly simple.

Garcia KC, Adams JJ, Feng D, Ely LK.

Nat Immunol. 2009 Feb;10(2):143-7. doi: 10.1038/ni.f.219. Review.


Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.

Archbold JK, Macdonald WA, Gras S, Ely LK, Miles JJ, Bell MJ, Brennan RM, Beddoe T, Wilce MC, Clements CS, Purcell AW, McCluskey J, Burrows SR, Rossjohn J.

J Exp Med. 2009 Jan 16;206(1):209-19. doi: 10.1084/jem.20082136. Epub 2009 Jan 12.


T-cells behaving badly: structural insights into alloreactivity and autoimmunity.

Ely LK, Burrows SR, Purcell AW, Rossjohn J, McCluskey J.

Curr Opin Immunol. 2008 Oct;20(5):575-80. doi: 10.1016/j.coi.2008.07.006. Epub 2008 Aug 12. Review.


Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.

Hoare HL, Sullivan LC, Clements CS, Ely LK, Beddoe T, Henderson KN, Lin J, Reid HH, Brooks AG, Rossjohn J.

J Mol Biol. 2008 Apr 11;377(5):1297-303. doi: 10.1016/j.jmb.2008.01.098. Epub 2008 Feb 12. Review.


T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?

Archbold JK, Ely LK, Kjer-Nielsen L, Burrows SR, Rossjohn J, McCluskey J, Macdonald WA.

Mol Immunol. 2008 Feb;45(3):583-98. Epub 2007 Sep 14. Review.


Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.

Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC.

Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12.


Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

Ely LK, Beddoe T, Clements CS, Matthews JM, Purcell AW, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6641-6. Epub 2006 Apr 14.


Structural basis for a major histocompatibility complex class Ib-restricted T cell response.

Hoare HL, Sullivan LC, Pietra G, Clements CS, Lee EJ, Ely LK, Beddoe T, Falco M, Kjer-Nielsen L, Reid HH, McCluskey J, Moretta L, Rossjohn J, Brooks AG.

Nat Immunol. 2006 Mar;7(3):256-64. Epub 2006 Feb 12.


Structural studies on the alphabeta T-cell receptor.

Ely LK, Kjer-Nielsen L, McCluskey J, Rossjohn J.

IUBMB Life. 2005 Aug;57(8):575-82. Review.


Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection.

Ely LK, Green KJ, Beddoe T, Clements CS, Miles JJ, Bottomley SP, Zernich D, Kjer-Nielsen L, Purcell AW, McCluskey J, Rossjohn J, Burrows SR.

J Immunol. 2005 May 1;174(9):5593-601.


The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.

Borg NA, Ely LK, Beddoe T, Macdonald WA, Reid HH, Clements CS, Purcell AW, Kjer-Nielsen L, Miles JJ, Burrows SR, McCluskey J, Rossjohn J.

Nat Immunol. 2005 Feb;6(2):171-80. Epub 2005 Jan 9.


Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion.

Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J.

J Exp Med. 2004 Jul 5;200(1):13-24. Epub 2004 Jun 28.


Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10.


A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.

Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J.

J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25.


Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design.

Purcell AW, Zeng W, Mifsud NA, Ely LK, Macdonald WA, Jackson DC.

J Pept Sci. 2003 May;9(5):255-81. Review.


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