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Items: 38

1.

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.

Urbahn MA, Kaup SC, Reusswig F, Krüger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M.

Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y.

2.

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.

Donner L, Gremer L, Ziehm T, Gertzen CGW, Gohlke H, Willbold D, Elvers M.

Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30.

PMID:
29964150
3.

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis.

Klatt C, Krüger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Lückstädt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M, Elvers M.

J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13.

4.

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M.

Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21.

PMID:
28943410
5.

Phospholipase D1 is a regulator of platelet-mediated inflammation.

Klier M, Gowert NS, Jäckel S, Reinhardt C, Elvers M.

Cell Signal. 2017 Oct;38:171-181. doi: 10.1016/j.cellsig.2017.07.007. Epub 2017 Jul 12.

PMID:
28711718
6.

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice.

Gowert NS, Klier M, Reich M, Reusswig F, Donner L, Keitel V, Häussinger D, Elvers M.

Cell Physiol Biochem. 2017;41(6):2133-2149. doi: 10.1159/000475566. Epub 2017 Apr 20.

7.

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.

Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg LU, Lothmann K, Rizzi F, Schaller M, Gohlke H, Willbold D, Grenegard M, Elvers M.

Sci Signal. 2016 May 24;9(429):ra52. doi: 10.1126/scisignal.aaf6240.

PMID:
27221710
8.

Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis.

Niermann C, Gorressen S, Klier M, Gowert NS, Billuart P, Kelm M, Merx MW, Elvers M.

Cell Signal. 2016 Aug;28(8):967-78. doi: 10.1016/j.cellsig.2016.04.008. Epub 2016 Apr 23.

PMID:
27117132
9.

Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.

Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR, Fischer JW.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):e41-50. doi: 10.1161/ATVBAHA.115.306973. Epub 2016 Mar 31.

PMID:
27034473
10.

RhoGAPs and Rho GTPases in platelets.

Elvers M.

Hamostaseologie. 2016 Aug 3;36(3):168-77. doi: 10.5482/HAMO-14-09-0046. Epub 2015 Feb 2. Review.

PMID:
25639730
11.

Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.

Fotinos A, Klier M, Gowert NS, Münzer P, Klatt C, Beck S, Borst O, Billuart P, Schaller M, Lang F, Gawaz M, Elvers M.

J Thromb Haemost. 2015 Apr;13(4):619-30. doi: 10.1111/jth.12834. Epub 2015 Jan 29.

12.

Pivotal role of phospholipase D1 in tumor necrosis factor-α-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice.

Schönberger T, Jürgens T, Müller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer JW, Gawaz M, Elvers M.

Am J Pathol. 2014 Sep;184(9):2450-64. doi: 10.1016/j.ajpath.2014.06.005. Epub 2014 Jul 18.

PMID:
25046692
13.

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease.

Jarre A, Gowert NS, Donner L, Münzer P, Klier M, Borst O, Schaller M, Lang F, Korth C, Elvers M.

Cell Signal. 2014 Sep;26(9):2040-50. doi: 10.1016/j.cellsig.2014.05.019. Epub 2014 Jun 11.

PMID:
24928203
14.

Nadrin GAP activity is isoform- and target-specific regulated by tyrosine phosphorylation.

Beck S, Fotinos A, Gawaz M, Elvers M.

Cell Signal. 2014 Sep;26(9):1975-84. doi: 10.1016/j.cellsig.2014.03.024. Epub 2014 Apr 2.

PMID:
24703939
15.

Blood platelets in the progression of Alzheimer's disease.

Gowert NS, Donner L, Chatterjee M, Eisele YS, Towhid ST, Münzer P, Walker B, Ogorek I, Borst O, Grandoch M, Schaller M, Fischer JW, Gawaz M, Weggen S, Lang F, Jucker M, Elvers M.

PLoS One. 2014 Feb 28;9(2):e90523. doi: 10.1371/journal.pone.0090523. eCollection 2014.

16.

1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.

Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, Walker B, Yang W, Leibrock C, Szteyn K, Schmidt S, Elvers M, Faggio C, Shumilina E, Kuro-o M, Gawaz M, Lang F.

FASEB J. 2014 May;28(5):2108-19. doi: 10.1096/fj.13-239277. Epub 2014 Feb 12.

PMID:
24522202
17.

Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation.

Münzer P, Borst O, Walker B, Schmid E, Feijge MA, Cosemans JM, Chatterjee M, Schmidt EM, Schmidt S, Towhid ST, Leibrock C, Elvers M, Schaller M, Seizer P, Ferlinz K, May AE, Gulbins E, Heemskerk JW, Gawaz M, Lang F.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):61-71. doi: 10.1161/ATVBAHA.112.300210. Epub 2013 Nov 14.

PMID:
24233488
18.

Constraint on 0νββ matrix elements from a novel decay channel of the scissors mode: the case of 154Gd.

Beller J, Pietralla N, Barea J, Elvers M, Endres J, Fransen C, Kotila J, Möller O, Richter A, Rodríguez TR, Romig C, Savran D, Scheck M, Schnorrenberger L, Sonnabend K, Werner V, Zilges A, Zweidinger M.

Phys Rev Lett. 2013 Oct 25;111(17):172501. Epub 2013 Oct 23.

PMID:
24206482
19.

Isoform-specific roles of the GTPase activating protein Nadrin in cytoskeletal reorganization of platelets.

Beck S, Fotinos A, Lang F, Gawaz M, Elvers M.

Cell Signal. 2013 Jan;25(1):236-46. doi: 10.1016/j.cellsig.2012.09.005. Epub 2012 Sep 10.

PMID:
22975681
20.

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.

Schönberger T, Ziegler M, Borst O, Konrad I, Nieswandt B, Massberg S, Ochmann C, Jürgens T, Seizer P, Langer H, Münch G, Ungerer M, Preissner KT, Elvers M, Gawaz M.

Am J Physiol Cell Physiol. 2012 Oct 1;303(7):C757-66. doi: 10.1152/ajpcell.00060.2012. Epub 2012 Jul 18.

21.

Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation.

Elvers M, Herrmann A, Seizer P, Münzer P, Beck S, Schönberger T, Borst O, Martin-Romero FJ, Lang F, May AE, Gawaz M.

Blood. 2012 Aug 9;120(6):1317-26. doi: 10.1182/blood-2011-12-398438. Epub 2012 Jun 27.

22.

A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity.

Elvers M, Grenegård M, Khoshjabinzadeh H, Münzer P, Borst O, Tian H, Di Paolo G, Lang F, Gawaz M, Lindahl TL, Fälker K.

Cell Signal. 2012 Sep;24(9):1743-52. doi: 10.1016/j.cellsig.2012.04.018. Epub 2012 May 3.

PMID:
22579635
23.

The recombinant bifunctional protein αCD133-GPVI promotes repair of the infarcted myocardium in mice.

Baumer Y, Leder C, Ziegler M, Schönberger T, Ochmann C, Perk A, Degen H, Schmid-Horch B, Elvers M, Münch G, Ungerer M, Schlosshauer B, Gawaz M.

J Thromb Haemost. 2012 Jun;10(6):1152-64. doi: 10.1111/j.1538-7836.2012.04710.x.

24.

The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets.

Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M.

Cardiovasc Res. 2012 Jun 1;94(3):526-36. doi: 10.1093/cvr/cvs079. Epub 2012 Feb 1.

PMID:
22298643
25.

The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.

Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M.

Circulation. 2012 Feb 7;125(5):685-96. doi: 10.1161/CIRCULATIONAHA.111.070508. Epub 2012 Jan 5.

PMID:
22223428
26.

The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.

Borst O, Schmidt EM, Münzer P, Schönberger T, Towhid ST, Elvers M, Leibrock C, Schmid E, Eylenstein A, Kuhl D, May AE, Gawaz M, Lang F.

Blood. 2012 Jan 5;119(1):251-61. doi: 10.1182/blood-2011-06-359976. Epub 2011 Oct 26.

27.

Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy.

Bigalke B, Elvers M, Schönberger T, Gawaz M.

Curr Drug Targets. 2011 Nov;12(12):1821-30.

PMID:
21718237
28.

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.

Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B.

Blood. 2010 Sep 9;116(10):1767-75. doi: 10.1182/blood-2010-03-274340. Epub 2010 Jun 7.

29.

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.

Elvers M, Pozgaj R, Pleines I, May F, Kuijpers MJ, Heemskerk JM, Yu P, Nieswandt B.

J Thromb Haemost. 2010 Jun;8(6):1353-63. doi: 10.1111/j.1538-7836.2010.03838.x. Epub 2010 Mar 3.

30.

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B.

Blood. 2010 Apr 22;115(16):3364-73. doi: 10.1182/blood-2009-09-242271. Epub 2010 Feb 4.

31.

Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, Kuijpers ME, Boesl M, Chen Q, Heemskerk JW, Stoll G, Frohman MA, Nieswandt B.

Sci Signal. 2010 Jan 5;3(103):ra1. doi: 10.1126/scisignal.2000551.

32.

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis.

May F, Hagedorn I, Pleines I, Bender M, Vögtle T, Eble J, Elvers M, Nieswandt B.

Blood. 2009 Oct 15;114(16):3464-72. doi: 10.1182/blood-2009-05-222273. Epub 2009 Jul 29.

33.

Integrins in platelet activation.

Nieswandt B, Varga-Szabo D, Elvers M.

J Thromb Haemost. 2009 Jul;7 Suppl 1:206-9. doi: 10.1111/j.1538-7836.2009.03370.x. Review.

34.

Rac1 is essential for phospholipase C-gamma2 activation in platelets.

Pleines I, Elvers M, Strehl A, Pozgajova M, Varga-Szabo D, May F, Chrostek-Grashoff A, Brakebusch C, Nieswandt B.

Pflugers Arch. 2009 Mar;457(5):1173-85. doi: 10.1007/s00424-008-0573-7. Epub 2008 Aug 13.

PMID:
18704487
35.

Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling.

Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B.

BMC Neurosci. 2006 Sep 20;7:64.

36.

Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.

Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Prüllage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C.

Eur J Neurosci. 2006 Jul;24(2):555-63.

PMID:
16903857
37.

TGF-beta2 neutralization inhibits proliferation and activates apoptosis of cerebellar granule cell precurors in the developing cerebellum.

Elvers M, Pfeiffer J, Kaltschmidt C, Kaltschmidt B.

Mech Dev. 2005 Apr;122(4):587-602. Epub 2004 Dec 15.

38.

Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.

Schwamborn J, Lindecke A, Elvers M, Horejschi V, Kerick M, Rafigh M, Pfeiffer J, Prüllage M, Kaltschmidt B, Kaltschmidt C.

BMC Genomics. 2003 Nov 25;4(1):46.

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