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Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking.

Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW.

Am J Physiol Endocrinol Metab. 2020 Feb 11. doi: 10.1152/ajpendo.00218.2019. [Epub ahead of print]


Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion.

Lee JW, Koeppen M, Seo SW, Bowser JL, Yuan X, Li J, Sibilia M, Ambardekar AV, Zhang X, Eckle T, Yoo SH, Eltzschig HK.

Anesthesiology. 2019 Nov 26. doi: 10.1097/ALN.0000000000003037. [Epub ahead of print]


Perioperative Acute Kidney Injury.

Gumbert SD, Kork F, Jackson ML, Vanga N, Ghebremichael SJ, Wang CY, Eltzschig HK.

Anesthesiology. 2020 Jan;132(1):180-204. doi: 10.1097/ALN.0000000000002968.


Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer.

Singh K, Pruski MA, Polireddy K, Jones NC, Chen Q, Yao J, Dar WA, McAllister F, Ju C, Eltzschig HK, Younes M, Moran C, Karmouty-Quintana H, Ying H, Bailey JM.

Oncogene. 2020 Jan;39(5):1152-1164. doi: 10.1038/s41388-019-1031-z. Epub 2019 Sep 30.


Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6.

Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C.

Hepatology. 2019 Sep 17. doi: 10.1002/hep.30954. [Epub ahead of print]


Purinergic Signaling in Pulmonary Inflammation.

Le TT, Berg NK, Harting MT, Li X, Eltzschig HK, Yuan X.

Front Immunol. 2019 Jul 16;10:1633. doi: 10.3389/fimmu.2019.01633. eCollection 2019. Review.


Hypoxia signaling in human diseases and therapeutic targets.

Lee JW, Ko J, Ju C, Eltzschig HK.

Exp Mol Med. 2019 Jun 20;51(6):68. doi: 10.1038/s12276-019-0235-1. Review.


Cigarette smoke-induced reduction of C1q promotes emphysema.

Yuan X, Chang CY, You R, Shan M, Gu BH, Madison MC, Diehl G, Perusich S, Song LZ, Cornwell L, Rossen RD, Wetsel R, Kimal R, Coarfa C, Eltzschig HK, Corry DB, Kheradmand F.

JCI Insight. 2019 May 21;5. pii: 124317. doi: 10.1172/jci.insight.124317.


Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice.

Deng Z, Gao X, Sun X, Amra S, Lu A, Cui Y, Eltzschig HK, Lei G, Huard J.

FASEB J. 2019 Aug;33(8):8809-8821. doi: 10.1096/fj.201802132RR. Epub 2019 May 1.


Perioperative Management of Disruptive Patients.

Berg NK, Eltzschig HK, Vanga N, Love LJ, Nwokolo OO.

Anesth Analg. 2019 Mar;128(3):587-591. doi: 10.1213/ANE.0000000000004008. No abstract available.


Markers of Accelerated Skeletal Muscle Regenerative Response in Murphy Roths Large Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.

Tseng C, Sinha K, Pan H, Cui Y, Guo P, Lin CY, Yang F, Deng Z, Eltzschig HK, Lu A, Huard J.

Stem Cells. 2019 Mar;37(3):357-367. doi: 10.1002/stem.2957. Epub 2019 Jan 14.


Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain.

Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, Skolasky RL, Cao Y, Wu T, Gao B, Yang M, Gao M, Kuliwaba J, Ni S, Wang L, Wu C, Findlay D, Eltzschig HK, Ouyang HW, Crane J, Zhou FQ, Guan Y, Dong X, Cao X.

J Clin Invest. 2019 Mar 1;129(3):1076-1093. doi: 10.1172/JCI121561. Epub 2019 Feb 4.


Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.

Hadi T, Boytard L, Silvestro M, Alebrahim D, Jacob S, Feinstein J, Barone K, Spiro W, Hutchison S, Simon R, Rateri D, Pinet F, Fenyo D, Adelman M, Moore KJ, Eltzschig HK, Daugherty A, Ramkhelawon B.

Nat Commun. 2018 Nov 27;9(1):5022. doi: 10.1038/s41467-018-07495-1.


Assessment of a multimodal analgesia protocol to allow the implementation of enhanced recovery after cardiac surgery: Retrospective analysis of patient outcomes.

Markham T, Wegner R, Hernandez N, Lee JW, Choi W, Eltzschig HK, Zaki J.

J Clin Anesth. 2019 May;54:76-80. doi: 10.1016/j.jclinane.2018.10.035. Epub 2018 Nov 6.


Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.

Aherne CM, Collins CB, Rapp CR, Olli KE, Perrenoud L, Jedlicka P, Bowser JL, Mills TW, Karmouty-Quintana H, Blackburn MR, Eltzschig HK.

JCI Insight. 2018 Oct 18;3(20). pii: 121521. doi: 10.1172/jci.insight.121521.


Elevated ecto-5'-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease.

Liu H, Adebiyi M, Liu RR, Song A, Manalo J, Wen YE, Wen AQ, Weng T, Ko J, Idowu M, Kellems RE, Eltzschig HK, Blackburn MR, Juneja HS, Xia Y.

Blood Adv. 2018 Aug 14;2(15):1957-1968. doi: 10.1182/bloodadvances.2018015784.


Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

Kiers D, Wielockx B, Peters E, van Eijk LT, Gerretsen J, John A, Janssen E, Groeneveld R, Peters M, Damen L, Meneses AM, Krüger A, Langereis JD, Zomer AL, Blackburn MR, Joosten LA, Netea MG, Riksen NP, van der Hoeven JG, Scheffer GJ, Eltzschig HK, Pickkers P, Kox M.

EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.


Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.

Mertens TCJ, Hanmandlu A, Tu L, Phan C, Collum SD, Chen NY, Weng T, Davies J, Liu C, Eltzschig HK, Jyothula SSK, Rajagopal K, Xia Y, Guha A, Bruckner BA, Blackburn MR, Guignabert C, Karmouty-Quintana H.

Front Physiol. 2018 Jun 1;9:555. doi: 10.3389/fphys.2018.00555. eCollection 2018.


Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury.

Hoegl S, Burns N, Angulo M, Francis D, Osborne CM, Mills TW, Blackburn MR, Eltzschig HK, Vohwinkel CU.

Physiol Rep. 2018 Mar;6(6):e13648. doi: 10.14814/phy2.13648.


A Review of the Impact of Obstetric Anesthesia on Maternal and Neonatal Outcomes.

Lim G, Facco FL, Nathan N, Waters JH, Wong CA, Eltzschig HK.

Anesthesiology. 2018 Jul;129(1):192-215. doi: 10.1097/ALN.0000000000002182. Review.


Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.

Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK.

Nat Commun. 2018 Feb 26;9(1):816. doi: 10.1038/s41467-018-03105-2.


The Hypoxia-Adenosine Link during Intestinal Inflammation.

Bowser JL, Phan LH, Eltzschig HK.

J Immunol. 2018 Feb 1;200(3):897-907. doi: 10.4049/jimmunol.1701414. Review.


Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.


Retraction: Hypoxia-Inducible Factor-1α-Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5'-Nucleotidase (CD73) and the A2B Adenosine Receptor.

Hart ML, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK.

J Immunol. 2017 Sep 1;199(5):1942. doi: 10.4049/jimmunol.1700997. No abstract available.


The hypoxia-adenosine link during inflammation.

Bowser JL, Lee JW, Yuan X, Eltzschig HK.

J Appl Physiol (1985). 2017 Nov 1;123(5):1303-1320. doi: 10.1152/japplphysiol.00101.2017. Epub 2017 Aug 10. Review.


Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside.

Neudecker V, Colgan SP, Eltzschig HK.

J Mol Med (Berl). 2017 Sep;95(9):899-903. doi: 10.1007/s00109-017-1574-9. No abstract available.


Targeting Hypoxia Signaling for Perioperative Organ Injury.

Yuan X, Lee JW, Bowser JL, Neudecker V, Sridhar S, Eltzschig HK.

Anesth Analg. 2018 Jan;126(1):308-321. doi: 10.1213/ANE.0000000000002288. Review.


MicroRNAs in mucosal inflammation.

Neudecker V, Yuan X, Bowser JL, Eltzschig HK.

J Mol Med (Berl). 2017 Sep;95(9):935-949. doi: 10.1007/s00109-017-1568-7. Epub 2017 Jul 20. Review.


HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.

Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR.

FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12.


Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury.

Vohwinkel CU, Buchäckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vadász I.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):589-602. doi: 10.1165/rcmb.2016-0358OC.


Erythrocyte purinergic signaling components underlie hypoxia adaptation.

Sun K, Liu H, Song A, Manalo JM, D'Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

J Appl Physiol (1985). 2017 Oct 1;123(4):951-956. doi: 10.1152/japplphysiol.00155.2017. Epub 2017 Jun 1. Review.


Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890. Epub 2017 Jun 1. No abstract available.


A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis.

Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F553-F559. doi: 10.1152/ajprenal.00493.2016. Epub 2017 May 17.


Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN.

J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.


Correction: Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.

Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU.

PLoS One. 2017 Apr 13;12(4):e0176134. doi: 10.1371/journal.pone.0176134. eCollection 2017.


The Devil Is in the Detail: Remote Ischemic Preconditioning for Perioperative Kidney Protection.

Kork F, Eltzschig HK.

Anesthesiology. 2017 May;126(5):763-765. doi: 10.1097/ALN.0000000000001599. No abstract available.


Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome.

Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU.

PLoS One. 2017 Feb 14;12(2):e0172116. doi: 10.1371/journal.pone.0172116. eCollection 2017. Erratum in: PLoS One. 2017 Apr 13;12 (4):e0176134.


Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.

Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y.

Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108.


HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis.

Dehn S, DeBerge M, Yeap XY, Yvan-Charvet L, Fang D, Eltzschig HK, Miller SD, Thorp EB.

J Immunol. 2016 Nov 1;197(9):3639-3649. Epub 2016 Sep 26.


MicroRNAs Modulate the Purinergic Signaling Network.

Ferrari D, Bianchi N, Eltzschig HK, Gambari R.

Trends Mol Med. 2016 Oct;22(10):905-918. doi: 10.1016/j.molmed.2016.08.006. Epub 2016 Sep 10. Review.


NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury.

Hoegl S, Ehrentraut H, Brodsky KS, Victorino F, Golden-Mason L, Eltzschig HK, McNamee EN.

J Leukoc Biol. 2017 Feb;101(2):471-480. doi: 10.1189/jlb.3A0516-227R. Epub 2016 Sep 6.


Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.


Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity.

Kork F, Balzer F, Krannich A, Bernardi MH, Eltzschig HK, Jankowski J, Spies C.

Acta Physiol (Oxf). 2017 Mar;219(3):613-624. doi: 10.1111/apha.12763. Epub 2016 Aug 25.


Transglutaminase is a Critical Link Between Inflammation and Hypertension.

Luo R, Liu C, Elliott SE, Wang W, Parchim N, Iriyama T, Daugherty PS, Tao L, Eltzschig HK, Blackwell SC, Sibai BM, Kellems RE, Xia Y.

J Am Heart Assoc. 2016 Jun 30;5(7). pii: e003730. doi: 10.1161/JAHA.116.003730.


Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y.

Cell Rep. 2016 Jun 28;16(1):106-119. doi: 10.1016/j.celrep.2016.05.080. Epub 2016 Jun 16.


Hydroxylation-independent HIF-1α stabilization through PKA: A new paradigm for hypoxia signaling.

McNamee EN, Vohwinkel C, Eltzschig HK.

Sci Signal. 2016 May 31;9(430):fs11. doi: 10.1126/scisignal.aaf4630. Review.


Immunologic Consequences of Hypoxia during Critical Illness.

Kiers HD, Scheffer GJ, van der Hoeven JG, Eltzschig HK, Pickkers P, Kox M.

Anesthesiology. 2016 Jul;125(1):237-49. doi: 10.1097/ALN.0000000000001163.


Purinergic Signaling During Immune Cell Trafficking.

Ferrari D, McNamee EN, Idzko M, Gambari R, Eltzschig HK.

Trends Immunol. 2016 Jun;37(6):399-411. doi: 10.1016/ Epub 2016 Apr 30. Review.


Hypoxia-inducible factors as molecular targets for liver diseases.

Ju C, Colgan SP, Eltzschig HK.

J Mol Med (Berl). 2016 Jun;94(6):613-27. doi: 10.1007/s00109-016-1408-1. Epub 2016 Apr 20. Review.


C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-κB Activation in Neutrophils.

Baudiß K, de Paula Vieira R, Cicko S, Ayata K, Hossfeld M, Ehrat N, Gómez-Muñoz A, Eltzschig HK, Idzko M.

J Immunol. 2016 Mar 1;196(5):2319-26. doi: 10.4049/jimmunol.1402681. Epub 2016 Jan 22.

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