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Items: 1 to 50 of 159

1.

Steryl ester formation and accumulation in steroid-degrading bacteria.

Holert J, Brown K, Hashimi A, Eltis LD, Mohn WW.

Appl Environ Microbiol. 2019 Nov 8. pii: AEM.02353-19. doi: 10.1128/AEM.02353-19. [Epub ahead of print]

PMID:
31704679
2.

Catabolism of Alkylphenols in Rhodococcus via a Meta-Cleavage Pathway Associated With Genomic Islands.

Levy-Booth DJ, Fetherolf MM, Stewart GR, Liu J, Eltis LD, Mohn WW.

Front Microbiol. 2019 Aug 20;10:1862. doi: 10.3389/fmicb.2019.01862. eCollection 2019.

3.

Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase.

Kuatsjah E, Verstraete MM, Kobylarz MJ, Liu AKN, Murphy MEP, Eltis LD.

J Biol Chem. 2019 Aug 30;294(35):12911-12920. doi: 10.1074/jbc.RA119.009428. Epub 2019 Jul 10.

PMID:
31292192
4.

A thermostable laccase from Thermus sp. 2.9 and its potential for delignification of Eucalyptus biomass.

Navas LE, Martínez FD, Taverna ME, Fetherolf MM, Eltis LD, Nicolau V, Estenoz D, Campos E, Benintende GB, Berretta MF.

AMB Express. 2019 Feb 12;9(1):24. doi: 10.1186/s13568-019-0748-y.

5.

Multiple iron reduction by methoxylated phenolic lignin structures and the generation of reactive oxygen species by lignocellulose surfaces.

Tamaru Y, Yoshida M, Eltis LD, Goodell B.

Int J Biol Macromol. 2019 May 1;128:340-346. doi: 10.1016/j.ijbiomac.2019.01.149. Epub 2019 Jan 27.

PMID:
30699335
6.

Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus.

Alexander JAN, Chatterjee SS, Hamilton SM, Eltis LD, Chambers HF, Strynadka NCJ.

J Biol Chem. 2018 Dec 21;293(51):19854-19865. doi: 10.1074/jbc.RA118.004952. Epub 2018 Oct 26.

PMID:
30366985
7.

Bacterial contributions to delignification and lignocellulose degradation in forest soils with metagenomic and quantitative stable isotope probing.

Wilhelm RC, Singh R, Eltis LD, Mohn WW.

ISME J. 2019 Feb;13(2):413-429. doi: 10.1038/s41396-018-0279-6. Epub 2018 Sep 26.

8.

Bacterial Catabolism of Biphenyls: Synthesis and Evaluation of Analogues.

Nerdinger S, Kuatsjah E, Hurst TE, Schlapp-Hackl I, Kahlenberg V, Wurst K, Eltis LD, Snieckus V.

Chembiochem. 2018 Jun 15. doi: 10.1002/cbic.201800231. [Epub ahead of print]

PMID:
29905982
9.

IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.

Crowe AM, Workman SD, Watanabe N, Worrall LJ, Strynadka NCJ, Eltis LD.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3378-E3387. doi: 10.1073/pnas.1717015115. Epub 2018 Mar 26.

10.

Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.

Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS.

ACS Chem Biol. 2018 Apr 20;13(4):965-974. doi: 10.1021/acschembio.8b00039. Epub 2018 Feb 28.

PMID:
29466666
11.

Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin.

Bowden CFM, Chan ACK, Li EJW, Arrieta AL, Eltis LD, Murphy MEP.

J Biol Chem. 2018 Jan 5;293(1):177-190. doi: 10.1074/jbc.M117.806562. Epub 2017 Nov 6.

12.

The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily.

Kuatsjah E, Chan ACK, Kobylarz MJ, Murphy MEP, Eltis LD.

J Biol Chem. 2017 Nov 3;292(44):18290-18302. doi: 10.1074/jbc.M117.797696. Epub 2017 Sep 20.

13.

A Fatty Acyl Coenzyme A Reductase Promotes Wax Ester Accumulation in Rhodococcus jostii RHA1.

Round J, Roccor R, Li SN, Eltis LD.

Appl Environ Microbiol. 2017 Sep 29;83(20). pii: e00902-17. doi: 10.1128/AEM.00902-17. Print 2017 Oct 15.

14.

Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria.

Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.

MBio. 2017 Apr 4;8(2). pii: e00321-17. doi: 10.1128/mBio.00321-17.

15.

Characterization of an extradiol dioxygenase involved in the catabolism of lignin-derived biphenyl.

Kuatsjah E, Chen HM, Withers SG, Eltis LD.

FEBS Lett. 2017 Apr;591(7):1001-1009. doi: 10.1002/1873-3468.12611. Epub 2017 Mar 19.

16.

Enhanced delignification of steam-pretreated poplar by a bacterial laccase.

Singh R, Hu J, Regner MR, Round JW, Ralph J, Saddler JN, Eltis LD.

Sci Rep. 2017 Feb 7;7:42121. doi: 10.1038/srep42121.

17.

Characterization of key triacylglycerol biosynthesis processes in rhodococci.

Amara S, Seghezzi N, Otani H, Diaz-Salazar C, Liu J, Eltis LD.

Sci Rep. 2016 Apr 29;6:24985. doi: 10.1038/srep24985.

18.

Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase.

Dhindwal S, Gomez-Gil L, Neau DB, Pham TT, Sylvestre M, Eltis LD, Bolin JT, Kumar P.

J Bacteriol. 2016 Apr 28;198(10):1499-512. doi: 10.1128/JB.00952-15. Print 2016 May 15.

19.

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Ho NA, Dawes SS, Crowe AM, Casabon I, Gao C, Kendall SL, Baker EN, Eltis LD, Lott JS.

J Biol Chem. 2016 Apr 1;291(14):7256-66. doi: 10.1074/jbc.M115.707760. Epub 2016 Feb 8.

20.

A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond.

Du YL, Singh R, Alkhalaf LM, Kuatsjah E, He HY, Eltis LD, Ryan KS.

Nat Chem Biol. 2016 Mar;12(3):194-9. doi: 10.1038/nchembio.2009. Epub 2016 Jan 25.

PMID:
26807714
21.

The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism.

Otani H, Stogios PJ, Xu X, Nocek B, Li SN, Savchenko A, Eltis LD.

Nucleic Acids Res. 2016 Jan 29;44(2):595-607. doi: 10.1093/nar/gkv955. Epub 2015 Sep 22.

22.

A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules.

Kulig JK, Spandolf C, Hyde R, Ruzzini AC, Eltis LD, Grönberg G, Hayes MA, Grogan G.

Bioorg Med Chem. 2015 Sep 1;23(17):5603-9. doi: 10.1016/j.bmc.2015.07.025. Epub 2015 Jul 21.

PMID:
26234905
23.

The multihued palette of dye-decolorizing peroxidases.

Singh R, Eltis LD.

Arch Biochem Biophys. 2015 May 15;574:56-65. doi: 10.1016/j.abb.2015.01.014. Epub 2015 Mar 2. Review.

PMID:
25743546
24.

Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, Russell DG.

PLoS Pathog. 2015 Feb 12;11(2):e1004679. doi: 10.1371/journal.ppat.1004679. eCollection 2015 Feb.

25.

Structural and functional characterization of a ketosteroid transcriptional regulator of Mycobacterium tuberculosis.

Crowe AM, Stogios PJ, Casabon I, Evdokimova E, Savchenko A, Eltis LD.

J Biol Chem. 2015 Jan 9;290(2):872-82. doi: 10.1074/jbc.M114.607481. Epub 2014 Nov 18.

26.

Characterization of p-hydroxycinnamate catabolism in a soil Actinobacterium.

Otani H, Lee YE, Casabon I, Eltis LD.

J Bacteriol. 2014 Dec;196(24):4293-303. doi: 10.1128/JB.02247-14. Epub 2014 Sep 29.

27.

The essential role of nitrogen limitation in expression of xplA and degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Gordonia sp. strain KTR9.

Zhu SH, Reuther J, Liu J, Crocker FH, Indest KJ, Eltis LD, Mohn WW.

Appl Microbiol Biotechnol. 2015 Jan;99(1):459-67. doi: 10.1007/s00253-014-6013-z. Epub 2014 Aug 22.

PMID:
25142696
28.

Substrate specificities and conformational flexibility of 3-ketosteroid 9α-hydroxylases.

Penfield JS, Worrall LJ, Strynadka NC, Eltis LD.

J Biol Chem. 2014 Sep 12;289(37):25523-36. doi: 10.1074/jbc.M114.575886. Epub 2014 Jul 21.

29.

Metagenomic scaffolds enable combinatorial lignin transformation.

Strachan CR, Singh R, VanInsberghe D, Ievdokymenko K, Budwill K, Mohn WW, Eltis LD, Hallam SJ.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10143-8. doi: 10.1073/pnas.1401631111. Epub 2014 Jun 30.

30.

Hemoglobin binding and catalytic heme extraction by IsdB near iron transporter domains.

Bowden CF, Verstraete MM, Eltis LD, Murphy ME.

Biochemistry. 2014 Apr 15;53(14):2286-94. doi: 10.1021/bi500230f. Epub 2014 Apr 1.

PMID:
24645787
31.

Functional analyses of three acyl-CoA synthetases involved in bile acid degradation in Pseudomonas putida DOC21.

Barrientos Á, Merino E, Casabon I, Rodríguez J, Crowe AM, Holert J, Philipp B, Eltis LD, Olivera ER, Luengo JM.

Environ Microbiol. 2015 Jan;17(1):47-63. doi: 10.1111/1462-2920.12395. Epub 2014 Mar 13.

PMID:
24428272
32.

Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism.

Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW.

J Bacteriol. 2014 Feb;196(3):579-87. doi: 10.1128/JB.01012-13. Epub 2013 Nov 15.

33.

WhiB7, an Fe-S-dependent transcription factor that activates species-specific repertoires of drug resistance determinants in actinobacteria.

Ramón-García S, Ng C, Jensen PR, Dosanjh M, Burian J, Morris RP, Folcher M, Eltis LD, Grzesiek S, Nguyen L, Thompson CJ.

J Biol Chem. 2013 Nov 29;288(48):34514-28. doi: 10.1074/jbc.M113.516385. Epub 2013 Oct 14.

34.

A substrate-assisted mechanism of nucleophile activation in a Ser-His-Asp containing C-C bond hydrolase.

Ruzzini AC, Bhowmik S, Ghosh S, Yam KC, Bolin JT, Eltis LD.

Biochemistry. 2013 Oct 22;52(42):7428-38. doi: 10.1021/bi401156a. Epub 2013 Oct 9.

35.

Breaking down lignin to high-value chemicals: the conversion of lignocellulose to vanillin in a gene deletion mutant of Rhodococcus jostii RHA1.

Sainsbury PD, Hardiman EM, Ahmad M, Otani H, Seghezzi N, Eltis LD, Bugg TD.

ACS Chem Biol. 2013 Oct 18;8(10):2151-6. doi: 10.1021/cb400505a. Epub 2013 Aug 8.

PMID:
23898824
36.

The lid domain of the MCP hydrolase DxnB2 contributes to the reactivity toward recalcitrant PCB metabolites.

Ruzzini AC, Bhowmik S, Yam KC, Ghosh S, Bolin JT, Eltis LD.

Biochemistry. 2013 Aug 20;52(33):5685-5695. doi: 10.1021/bi400774m. Epub 2013 Aug 9.

37.

Regulation of the KstR2 regulon of Mycobacterium tuberculosis by a cholesterol catabolite.

Casabon I, Zhu SH, Otani H, Liu J, Mohn WW, Eltis LD.

Mol Microbiol. 2013 Sep;89(6):1201-12. doi: 10.1111/mmi.12340. Epub 2013 Aug 14.

38.

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force.

Bocedi A, Fabrini R, Farrotti A, Stella L, Ketterman AJ, Pedersen JZ, Allocati N, Lau PC, Grosse S, Eltis LD, Ruzzini A, Edwards TE, Morici L, Del Grosso E, Guidoni L, Bovi D, Lo Bello M, Federici G, Parker MW, Board PG, Ricci G.

J Biol Chem. 2013 Aug 23;288(34):24936-47. doi: 10.1074/jbc.M113.476135. Epub 2013 Jul 3.

39.

Physiological adaptation of the Rhodococcus jostii RHA1 membrane proteome to steroids as growth substrates.

Haußmann U, Wolters DA, Fränzel B, Eltis LD, Poetsch A.

J Proteome Res. 2013 Mar 1;12(3):1188-98. doi: 10.1021/pr300816n. Epub 2013 Feb 11.

PMID:
23360181
40.

Structural characterization of Pandoraea pnomenusa B-356 biphenyl dioxygenase reveals features of potent polychlorinated biphenyl-degrading enzymes.

Colbert CL, Agar NY, Kumar P, Chakko MN, Sinha SC, Powlowski JB, Eltis LD, Bolin JT.

PLoS One. 2013;8(1):e52550. doi: 10.1371/journal.pone.0052550. Epub 2013 Jan 3.

41.

Improved manganese-oxidizing activity of DypB, a peroxidase from a lignolytic bacterium.

Singh R, Grigg JC, Qin W, Kadla JF, Murphy ME, Eltis LD.

ACS Chem Biol. 2013 Apr 19;8(4):700-6. doi: 10.1021/cb300608x. Epub 2013 Jan 18.

42.

Role of nitrogen limitation in transformation of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) by Gordonia sp. strain KTR9.

Indest KJ, Hancock DE, Jung CM, Eberly JO, Mohn WW, Eltis LD, Crocker FH.

Appl Environ Microbiol. 2013 Mar;79(5):1746-50. doi: 10.1128/AEM.03905-12. Epub 2012 Dec 28.

43.

FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria.

Casabon I, Crowe AM, Liu J, Eltis LD.

Mol Microbiol. 2013 Jan;87(2):269-83. doi: 10.1111/mmi.12095. Epub 2012 Dec 10.

44.

Two transporters essential for reassimilation of novel cholate metabolites by Rhodococcus jostii RHA1.

Swain K, Casabon I, Eltis LD, Mohn WW.

J Bacteriol. 2012 Dec;194(24):6720-7. doi: 10.1128/JB.01167-12. Epub 2012 Sep 28.

45.

Gene cluster encoding cholate catabolism in Rhodococcus spp.

Mohn WW, Wilbrink MH, Casabon I, Stewart GR, Liu J, van der Geize R, Eltis LD.

J Bacteriol. 2012 Dec;194(24):6712-9. doi: 10.1128/JB.01169-12. Epub 2012 Sep 28.

46.

Genomic and transcriptomic studies of an RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine)-degrading actinobacterium.

Chen HP, Zhu SH, Casabon I, Hallam SJ, Crocker FH, Mohn WW, Indest KJ, Eltis LD.

Appl Environ Microbiol. 2012 Nov;78(21):7798-800. doi: 10.1128/AEM.02120-12. Epub 2012 Aug 24.

47.

Proteomic analysis of survival of Rhodococcus jostii RHA1 during carbon starvation.

Patrauchan MA, Miyazawa D, LeBlanc JC, Aiga C, Florizone C, Dosanjh M, Davies J, Eltis LD, Mohn WW.

Appl Environ Microbiol. 2012 Sep;78(18):6714-25. doi: 10.1128/AEM.01293-12. Epub 2012 Jul 13.

48.

The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

Ruzzini AC, Horsman GP, Eltis LD.

Biochemistry. 2012 Jul 24;51(29):5831-40. doi: 10.1021/bi300663r. Epub 2012 Jul 11.

PMID:
22747426
49.

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.

Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD.

J Am Chem Soc. 2012 Mar 14;134(10):4615-24. doi: 10.1021/ja208544g. Epub 2012 Mar 5.

PMID:
22339283
50.

Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.

Singh R, Grigg JC, Armstrong Z, Murphy ME, Eltis LD.

J Biol Chem. 2012 Mar 23;287(13):10623-30. doi: 10.1074/jbc.M111.332171. Epub 2012 Feb 3.

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