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Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges.

De Los Angeles A, Hyun I, Latham SR, Elsworth JD, Redmond DE Jr.

Methods Mol Biol. 2019;2005:221-231. doi: 10.1007/978-1-4939-9524-0_15.


Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity.

Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL.

Mol Metab. 2019 Jun;24:120-138. doi: 10.1016/j.molmet.2019.02.005. Epub 2019 Feb 21.


ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state.

De Los Angeles A, Elsworth JD, Redmond DE Jr.

Biochem Biophys Res Commun. 2019 Feb 26;510(1):78-84. doi: 10.1016/j.bbrc.2019.01.037. Epub 2019 Jan 16.


Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson's Disease.

Curry DW, Stutz B, Andrews ZB, Elsworth JD.

J Parkinsons Dis. 2018;8(2):161-181. doi: 10.3233/JPD-171296.


Molecular and cellular reorganization of neural circuits in the human lineage.

Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N.

Science. 2017 Nov 24;358(6366):1027-1032. doi: 10.1126/science.aan3456.


Cognitive performance of juvenile monkeys after chronic fluoxetine treatment.

Golub MS, Hackett EP, Hogrefe CE, Leranth C, Elsworth JD, Roth RH.

Dev Cogn Neurosci. 2017 Aug;26:52-61. doi: 10.1016/j.dcn.2017.04.008. Epub 2017 May 1.


Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.

Bayliss JA, Lemus MB, Santos VV, Deo M, Davies JS, Kemp BE, Elsworth JD, Andrews ZB.

PLoS One. 2016 Jul 28;11(7):e0159381. doi: 10.1371/journal.pone.0159381. eCollection 2016.


Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.

Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder EY, Redmond DE Jr, Kern RA.

Cell Transplant. 2016 Nov;25(11):1945-1966. doi: 10.3727/096368916X691682.


Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease.

Bayliss JA, Lemus MB, Stark R, Santos VV, Thompson A, Rees DJ, Galic S, Elsworth JD, Kemp BE, Davies JS, Andrews ZB.

J Neurosci. 2016 Mar 9;36(10):3049-63. doi: 10.1523/JNEUROSCI.4373-15.2016.


Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease.

Bayliss JA, Lemus M, Santos VV, Deo M, Elsworth JD, Andrews ZB.

J Neurochem. 2016 May;137(3):460-71. doi: 10.1111/jnc.13576. Epub 2016 Mar 11.


Proof of concept studies exploring the safety and functional activity of human parthenogenetic-derived neural stem cells for the treatment of Parkinson's disease.

Gonzalez R, Garitaonandia I, Crain A, Poustovoitov M, Abramihina T, Noskov A, Jiang C, Morey R, Laurent LC, Elsworth JD, Snyder EY, Redmond DE Jr, Semechkin R.

Cell Transplant. 2015;24(4):681-90. doi: 10.3727/096368915X687769. Epub 2015 Mar 24.


A potential compensatory role for endogenous striatal tyrosine hydroxylase-positive neurons in a nonhuman primate model of Parkinson's disease.

Bubak AN, Redmond DE Jr, Elsworth JD, Roth RH, Collier TJ, Bjugstad KB, Blanchard BC, Sladek JR Jr.

Cell Transplant. 2015;24(4):673-80. doi: 10.3727/096368915X687741. Epub 2015 Mar 24.


Low circulating levels of bisphenol-A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys.

Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED Jr, Leranth C.

J Comp Neurol. 2015 Jun 1;523(8):1248-57. doi: 10.1002/cne.23735. Epub 2015 Feb 17.


Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex.

Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE Jr, Kim JD, Diano S, Roth RH.

Int J Neuropsychopharmacol. 2014 Oct 31;18(6). pii: pyu048. doi: 10.1093/ijnp/pyu048.


In the blink of an eye: relating positive-feedback sensitivity to striatal dopamine D2-like receptors through blink rate.

Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD.

J Neurosci. 2014 Oct 22;34(43):14443-54. doi: 10.1523/JNEUROSCI.3037-14.2014.


Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease.

Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Eugene Redmond D Jr, Taylor HS.

J Cell Mol Med. 2015 Jan;19(1):249-56. doi: 10.1111/jcmm.12433. Epub 2014 Oct 6.


Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.

Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11876-81. doi: 10.1073/pnas.1406000111. Epub 2014 Jul 28. Erratum in: Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):14003.


Pregnancy, a risky time: keep calm, clean, and carry on!

Elsworth JD, Roth RH.

Biol Psychiatry. 2013 Oct 1;74(7):478-9. doi: 10.1016/j.biopsych.2013.07.027. No abstract available.


Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model.

Redmond DE Jr, McEntire CR, Kingsbery JP, Leranth C, Elsworth JD, Bjugstad KB, Roth RH, Samulski RJ, Sladek JR Jr.

Mol Ther. 2013 Dec;21(12):2160-8. doi: 10.1038/mt.2013.180. Epub 2013 Aug 5.


Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates.

Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE.

Cell Transplant. 2014;23(8):981-94. doi: 10.3727/096368913X664865. Epub 2013 Apr 2.


Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development.

Elsworth JD, Redmond DE Jr, Roth RH.

Synapse. 2013 Sep;67(9):580-5. doi: 10.1002/syn.21662. Epub 2013 Apr 18.


Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates.

Elsworth JD, Jentsch JD, Vandevoort CA, Roth RH, Redmond DE Jr, Leranth C.

Neurotoxicology. 2013 Mar;35:113-20. doi: 10.1016/j.neuro.2013.01.001. Epub 2013 Jan 18.


Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys.

Elsworth JD, Leranth C, Redmond DE Jr, Roth RH.

Int J Neuropsychopharmacol. 2013 May;16(4):905-12. doi: 10.1017/S1461145712000892. Epub 2012 Sep 4.


Bicyclic oxygen heterocycles from γ,δ-unsaturated alcohols: synthetic targets inspired by blepharocalyxin D.

Bunt AJ, Bailey CD, Cons BD, Edwards SJ, Elsworth JD, Pheko T, Willis CL.

Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3901-4. doi: 10.1002/anie.201108315. Epub 2012 Mar 5.


Susceptibility to a parkinsonian toxin varies during primate development.

Morrow BA, Roth RH, Redmond DE Jr, Diano S, Elsworth JD.

Exp Neurol. 2012 May;235(1):273-81. doi: 10.1016/j.expneurol.2012.02.005. Epub 2012 Feb 14.


MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3125-30. doi: 10.1073/pnas.1113793109. Epub 2012 Feb 6.


Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.

Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH.

Neuropharmacology. 2012 Mar;62(3):1442-52. doi: 10.1016/j.neuropharm.2011.08.026. Epub 2011 Aug 23.


Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.

Elsworth JD, Hajszan T, Leranth C, Roth RH.

Int J Neuropsychopharmacol. 2011 Nov;14(10):1411-5. doi: 10.1017/S1461145711000939. Epub 2011 Jun 27.


Reduced locomotor responses to cocaine in ghrelin-deficient mice.

Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL.

Neuroscience. 2011 Sep 29;192:500-6. doi: 10.1016/j.neuroscience.2011.06.001. Epub 2011 Jun 12.


Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine.

Elsworth JD, Morrow BA, Hajszan T, Leranth C, Roth RH.

Neuropsychopharmacology. 2011 Sep;36(10):2054-61. doi: 10.1038/npp.2011.96. Epub 2011 Jun 15.


Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease.

Morrow BA, Roth RH, Redmond DE, Elsworth JD.

Neuroscience. 2011 Aug 25;189:277-85. doi: 10.1016/j.neuroscience.2011.05.046. Epub 2011 Jun 1.


Aged monkeys as a partial model for Parkinson's disease.

Hurley PJ, Elsworth JD, Whittaker MC, Roth RH, Redmond DE Jr.

Pharmacol Biochem Behav. 2011 Sep;99(3):324-32. doi: 10.1016/j.pbb.2011.05.007. Epub 2011 May 18.


GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.

Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB.

Neurobiol Dis. 2011 Jul;43(1):152-62. doi: 10.1016/j.nbd.2011.03.005. Epub 2011 Mar 13.


Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model.

Wolff EF, Gao XB, Yao KV, Andrews ZB, Du H, Elsworth JD, Taylor HS.

J Cell Mol Med. 2011 Apr;15(4):747-55. doi: 10.1111/j.1582-4934.2010.01068.x.


Cellular repair in the parkinsonian nonhuman primate brain.

Redmond DE Jr, Weiss S, Elsworth JD, Roth RH, Wakeman DR, Bjugstad KB, Collier TJ, Blanchard BC, Teng YD, Synder EY, Sladek JR Jr.

Rejuvenation Res. 2010 Apr-Jun;13(2-3):188-94. doi: 10.1089/rej.2009.0960. Review.


Chemoenzymatic and enantiodivergent routes to 1,2-ring-fused bicyclo[2.2.2]octane and related tricyclic frameworks.

Austin KA, Elsworth JD, Banwell MG, Willis AC.

Org Biomol Chem. 2010 Feb 21;8(4):751-4. doi: 10.1039/b921600f. Epub 2009 Dec 7. Erratum in: Org Biomol Chem. 2011 Dec 21;9(24):8504.


Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.

Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE Jr.

Mol Ther. 2010 Mar;18(3):588-93. doi: 10.1038/mt.2009.286. Epub 2009 Dec 15.


Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism.

Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL.

J Neurosci. 2009 Nov 11;29(45):14057-65. doi: 10.1523/JNEUROSCI.3890-09.2009.


Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.

Redmond DE Jr, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR Jr.

J Comp Neurol. 2009 Jul 1;515(1):31-40. doi: 10.1002/cne.22028.


Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.

Jentsch JD, Sanchez D, Elsworth JD, Roth RH.

Brain Res. 2008 Dec 30;1246:41-6. doi: 10.1016/j.brainres.2008.10.006. Epub 2008 Oct 18.


Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate.

Sladek JR Jr, Bjugstad KB, Collier TJ, Bundock EA, Blanchard BC, Elsworth JD, Roth RH, Redmond DE Jr.

Cell Transplant. 2008;17(4):427-44.


Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease.

Bjugstad KB, Teng YD, Redmond DE Jr, Elsworth JD, Roth RH, Cornelius SK, Snyder EY, Sladek JR Jr.

Exp Neurol. 2008 Jun;211(2):362-9. doi: 10.1016/j.expneurol.2008.01.025. Epub 2008 Feb 14.


Intramolecular Prins cyclisations for the stereoselective synthesis of bicyclic tetrahydropyrans.

Elsworth JD, Willis CL.

Chem Commun (Camb). 2008 Apr 7;(13):1587-9. doi: 10.1039/b717078e. Epub 2008 Feb 21.


AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.

Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH.

Exp Neurol. 2008 May;211(1):252-8. doi: 10.1016/j.expneurol.2008.01.026. Epub 2008 Feb 15.


Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex.

Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH.

Synapse. 2007 Oct;61(10):862-5.


Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.

Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12175-80. Epub 2007 Jun 22.


Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors.

Elsworth JD, Morrow BA, Nguyen VT, Mitra J, Picciotto MR, Roth RH.

Neuroscience. 2007 Jun 29;147(2):419-27. Epub 2007 Jun 1. Erratum in: Neuroscience. 2008 Oct 15;156(3):800.


Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine.

Elsworth JD, Jentsch JD, Morrow BA, Redmond DE Jr, Roth RH.

Neuropsychopharmacology. 2008 Feb;33(3):491-6. Epub 2007 May 16.


Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation.

Morrow BA, Roth RH, Redmond DE Jr, Sladek JR Jr, Elsworth JD.

Exp Neurol. 2007 Apr;204(2):802-7. Epub 2007 Jan 19.


Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortex.

Morrow BA, Elsworth JD, Roth RH.

Psychopharmacology (Berl). 2007 Jun;192(2):283-90. Epub 2007 Jan 30.


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