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Items: 1 to 50 of 96


EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity.

Zhurikhina A, Qi T, Hahn KM, Elston TC, Tsygankov D.

Methods Mol Biol. 2018;1821:47-56. doi: 10.1007/978-1-4939-8612-5_4.


Principles that govern competition or co-existence in Rho-GTPase driven polarization.

Chiou JG, Ramirez SA, Elston TC, Witelski TP, Schaeffer DG, Lew DJ.

PLoS Comput Biol. 2018 Apr 12;14(4):e1006095. doi: 10.1371/journal.pcbi.1006095. eCollection 2018 Apr.


Particle-based simulations of polarity establishment reveal stochastic promotion of Turing pattern formation.

Pablo M, Ramirez SA, Elston TC.

PLoS Comput Biol. 2018 Mar 12;14(3):e1006016. doi: 10.1371/journal.pcbi.1006016. eCollection 2018 Mar.


An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.

Tajadura-Ortega V, Garg R, Allen R, Owczarek C, Bright MD, Kean S, Mohd-Noor A, Grigoriadis A, Elston TC, Hahn KM, Ridley AJ.

BMC Biol. 2018 Mar 6;16(1):29. doi: 10.1186/s12915-018-0489-4.


Dose-Duration Reciprocity for G protein activation: Modulation of kinase to substrate ratio alters cell signaling.

Liao KL, Melvin CE, Sozzani R, Jones RD, Elston TC, Jones AM.

PLoS One. 2017 Dec 29;12(12):e0190000. doi: 10.1371/journal.pone.0190000. eCollection 2017.


Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis.

Sandefur CI, Boucher RC, Elston TC.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7272-E7281. doi: 10.1073/pnas.1617383114. Epub 2017 Aug 14.


A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.

Mohan K, Nosbisch JL, Elston TC, Bear JE, Haugh JM.

Biophys J. 2017 Jul 11;113(1):185-194. doi: 10.1016/j.bpj.2017.05.035.


Testing the limits of gradient sensing.

Lakhani V, Elston TC.

PLoS Comput Biol. 2017 Feb 16;13(2):e1005386. doi: 10.1371/journal.pcbi.1005386. eCollection 2017 Feb.


A shadow detector for photosynthesis efficiency.

Liao KL, Jones RD, McCarter P, Tunc-Ozdemir M, Draper JA, Elston TC, Kramer D, Jones AM.

J Theor Biol. 2017 Feb 7;414:231-244. doi: 10.1016/j.jtbi.2016.11.027. Epub 2016 Dec 3.


Modeling the Excess Cell Surface Stored in a Complex Morphology of Bleb-Like Protrusions.

Kapustina M, Tsygankov D, Zhao J, Wessler T, Yang X, Chen A, Roach N, Elston TC, Wang Q, Jacobson K, Forest MG.

PLoS Comput Biol. 2016 Mar 25;12(3):e1004841. doi: 10.1371/journal.pcbi.1004841. eCollection 2016 Mar.


Role of Polarized G Protein Signaling in Tracking Pheromone Gradients.

McClure AW, Minakova M, Dyer JM, Zyla TR, Elston TC, Lew DJ.

Dev Cell. 2015 Nov 23;35(4):471-82. doi: 10.1016/j.devcel.2015.10.024.


Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands.

Lakhani VV, Hinde E, Gratton E, Elston TC.

PLoS One. 2015 Nov 25;10(11):e0143753. doi: 10.1371/journal.pone.0143753. eCollection 2015.


Role of competition between polarity sites in establishing a unique front.

Wu CF, Chiou JG, Minakova M, Woods B, Tsygankov D, Zyla TR, Savage NS, Elston TC, Lew DJ.

Elife. 2015 Nov 2;4. pii: e11611. doi: 10.7554/eLife.11611.


Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.

Swanson CI, Meserve JH, McCarter PC, Thieme A, Mathew T, Elston TC, Duronio RJ.

Development. 2015 Dec 15;142(24):4288-98. doi: 10.1242/dev.115006. Epub 2015 Oct 22.


Modulation of receptor dynamics by the regulator of G protein signaling Sst2.

Venkatapurapu SP, Kelley JB, Dixit G, Pena M, Errede B, Dohlman HG, Elston TC.

Mol Biol Cell. 2015 Nov 5;26(22):4124-34. doi: 10.1091/mbc.E14-12-1635. Epub 2015 Aug 26.


Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, Elston TC, Der CJ.

J Biol Chem. 2015 Sep 11;290(37):22851-61. doi: 10.1074/jbc.M115.656710. Epub 2015 Jul 27.


Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα.

Errede B, Vered L, Ford E, Pena MI, Elston TC.

Mol Biol Cell. 2015 Sep 15;26(18):3343-58. doi: 10.1091/mbc.E15-03-0176. Epub 2015 Jul 15.


Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK.

Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG.

Mol Biol Cell. 2015 Sep 15;26(18):3359-71. doi: 10.1091/mbc.E15-01-0037. Epub 2015 Jul 15.


RGS proteins and septins cooperate to promote chemotropism by regulating polar cap mobility.

Kelley JB, Dixit G, Sheetz JB, Venkatapurapu SP, Elston TC, Dohlman HG.

Curr Biol. 2015 Feb 2;25(3):275-285. doi: 10.1016/j.cub.2014.11.047. Epub 2015 Jan 15.


MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast.

English JG, Shellhammer JP, Malahe M, McCarter PC, Elston TC, Dohlman HG.

Sci Signal. 2015 Jan 13;8(359):ra5. doi: 10.1126/scisignal.2005774.


Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.

Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12420-5. doi: 10.1073/pnas.1404487111. Epub 2014 Aug 12.


User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters.

Tsygankov D, Chu PH, Chen H, Elston TC, Hahn KM.

Methods Cell Biol. 2014;123:409-27. doi: 10.1016/B978-0-12-420138-5.00022-7.


Cellular noise suppression by the regulator of G protein signaling Sst2.

Dixit G, Kelley JB, Houser JR, Elston TC, Dohlman HG.

Mol Cell. 2014 Jul 3;55(1):85-96. doi: 10.1016/j.molcel.2014.05.019. Epub 2014 Jun 19.


Dissecting motility signaling through activation of specific Src-effector complexes.

Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM.

Nat Chem Biol. 2014 Apr;10(4):286-90. doi: 10.1038/nchembio.1477. Epub 2014 Mar 9. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.


Reciprocal encoding of signal intensity and duration in a glucose-sensing circuit.

Fu Y, Lim S, Urano D, Tunc-Ozdemir M, Phan NG, Elston TC, Jones AM.

Cell. 2014 Feb 27;156(5):1084-95. doi: 10.1016/j.cell.2014.01.013.


Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo.

Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M.

Dev Cell. 2014 Feb 24;28(4):394-408. doi: 10.1016/j.devcel.2014.01.015.


CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries.

Tsygankov D, Bilancia CG, Vitriol EA, Hahn KM, Peifer M, Elston TC.

J Cell Biol. 2014 Feb 3;204(3):443-60. doi: 10.1083/jcb.201306067.


Automated line scan analysis to quantify biosensor activity at the cell edge.

Allen RJ, Tsygankov D, Zawistowski JS, Elston TC, Hahn KM.

Methods. 2014 Mar 15;66(2):162-7. doi: 10.1016/j.ymeth.2013.08.025. Epub 2013 Aug 30.


Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities.

Garcia GJ, Boucher RC, Elston TC.

Biophys J. 2013 Feb 5;104(3):716-26. doi: 10.1016/j.bpj.2012.12.040. Erratum in: Biophys J. 2014 Apr 1;106(7):1548.


A mechanochemical model for auto-regulation of lung airway surface layer volume.

Herschlag G, Garcia GJ, Button B, Tarran R, Lindley B, Reinhardt B, Elston TC, Forest MG.

J Theor Biol. 2013 May 21;325:42-51. doi: 10.1016/j.jtbi.2013.01.023. Epub 2013 Feb 13.


Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape.

Kapustina M, Elston TC, Jacobson K.

J Cell Biol. 2013 Jan 7;200(1):95-108. doi: 10.1083/jcb.201204157.


A predictive mathematical model of the DNA damage G2 checkpoint.

Kesseler KJ, Blinov ML, Elston TC, Kaufmann WK, Simpson DA.

J Theor Biol. 2013 Mar 7;320:159-69. doi: 10.1016/j.jtbi.2012.12.011. Epub 2012 Dec 22.


Tracking shallow chemical gradients by actin-driven wandering of the polarization site.

Dyer JM, Savage NS, Jin M, Zyla TR, Elston TC, Lew DJ.

Curr Biol. 2013 Jan 7;23(1):32-41. doi: 10.1016/j.cub.2012.11.014. Epub 2012 Nov 29.


An improved short-lived fluorescent protein transcriptional reporter for Saccharomyces cerevisiae.

Houser JR, Ford E, Chatterjea SM, Maleri S, Elston TC, Errede B.

Yeast. 2012 Dec;29(12):519-30. doi: 10.1002/yea.2932. Epub 2012 Nov 21.


Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.

Hao N, Yildirim N, Nagiec MJ, Parnell SC, Errede B, Dohlman HG, Elston TC.

Mol Biol Cell. 2012 Oct;23(19):3899-910. doi: 10.1091/mbc.E12-04-0333. Epub 2012 Aug 8.


Positive roles for negative regulators in the mating response of yeast.

Houser JR, Ford E, Nagiec MJ, Errede B, Elston TC.

Mol Syst Biol. 2012 Jun 5;8:586. doi: 10.1038/msb.2012.18.


Negative feedback enhances robustness in the yeast polarity establishment circuit.

Howell AS, Jin M, Wu CF, Zyla TR, Elston TC, Lew DJ.

Cell. 2012 Apr 13;149(2):322-33. doi: 10.1016/j.cell.2012.03.012.


A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis.

Xu K, Morgan KT, Todd Gehris A, Elston TC, Gomez SM.

PLoS Comput Biol. 2011 Dec;7(12):e1002272. doi: 10.1371/journal.pcbi.1002272. Epub 2011 Dec 1.


Yeast dynamically modify their environment to achieve better mating efficiency.

Jin M, Errede B, Behar M, Mather W, Nayak S, Hasty J, Dohlman HG, Elston TC.

Sci Signal. 2011 Aug 16;4(186):ra54. doi: 10.1126/scisignal.2001763.


A physical model reveals the mechanochemistry responsible for dynein's processive motion.

Tsygankov D, Serohijos AW, Dokholyan NV, Elston TC.

Biophys J. 2011 Jul 6;101(1):144-50. doi: 10.1016/j.bpj.2011.05.043.


Computational model for the regulation of extracellular ATP and adenosine in airway epithelia.

Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC.

Subcell Biochem. 2011;55:51-74. doi: 10.1007/978-94-007-1217-1_3. Review.


From Physics to Pharmacology?

Allen RJ, Elston TC.

Rep Prog Phys. 2011 Jan;74(1). pii: 016601.


RhoA regulates calcium-independent periodic contractions of the cell cortex.

Costigliola N, Kapustina MT, Weinreb GE, Monteith A, Rajfur Z, Elston TC, Jacobson K.

Biophys J. 2010 Aug 9;99(4):1053-63. doi: 10.1016/j.bpj.2010.06.010.


Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics.

Kapustina M, Vitriol E, Elston TC, Loew LM, Jacobson K.

Cytoskeleton (Hoboken). 2010 Aug;67(8):519-34. doi: 10.1002/cm.20463.


A Cut Cell Method for Simulating Spatial Models of Biochemical Reaction Networks in Arbitrary Geometries.

Strychalski W, Adalsteinsson D, Elston TC.

Comm App Math Comp Sci. 2010;5(1):31-53.



Strychalski W, Adalsteinsson D, Elston TC.

SIAM J Sci Comput. 2010;32(5):3039-3070.


A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.

Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16562-7. doi: 10.1073/pnas.0904405106. Epub 2009 Sep 14.


Multiscale approaches for studying energy transduction in dynein.

Serohijos AW, Tsygankov D, Liu S, Elston TC, Dokholyan NV.

Phys Chem Chem Phys. 2009 Jun 28;11(24):4840-50. doi: 10.1039/b902028d. Epub 2009 May 15. Review.


In silico generation of alternative hypotheses using causal mapping (CMAP).

Weinreb GE, Kapustina MT, Jacobson K, Elston TC.

PLoS One. 2009;4(4):e5378. doi: 10.1371/journal.pone.0005378. Epub 2009 Apr 29.


Kinetic models for the coordinated stepping of cytoplasmic dynein.

Tsygankov D, Serohijos AW, Dokholyan NV, Elston TC.

J Chem Phys. 2009 Jan 14;130(2):025101. doi: 10.1063/1.3050098.

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