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Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo.

Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A.

Sci Signal. 2019 Jan 8;12(563). pii: eaau0240. doi: 10.1126/scisignal.aau0240.


Protein tyrosine phosphatase alpha inhibits hypothalamic leptin receptor signaling and regulates body weight in vivo.

Cohen-Sharir Y, Kuperman Y, Apelblat D, den Hertog J, Spiegel I, Knobler H, Elson A.

FASEB J. 2019 Jan 7:fj201800860RR. doi: 10.1096/fj.201800860RR. [Epub ahead of print]


The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts.

Shalev M, Elson A.

Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):114-123. doi: 10.1016/j.bbamcr.2018.07.005. Epub 2018 Jul 17. Review.


Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis.

Buiga P, Elson A, Tabernero L, Schwartz JM.

BMC Syst Biol. 2018 Apr 11;12(Suppl 1):11. doi: 10.1186/s12918-018-0534-5.


Developing a platform system for gene delivery: amplifying virus-like particles (AVLP) as an influenza vaccine.

Wei H, Chen Z, Elson A, Li Z, Abraham M, Phan S, Kristhnamurthy S, McCray PB Jr, Andrews S, Stice S, Sakamoto K, Jones C, Tompkins SM, He B.

NPJ Vaccines. 2017 Nov 20;2:32. doi: 10.1038/s41541-017-0031-7. eCollection 2017.


Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.

Elson A.

Int J Biochem Cell Biol. 2018 Mar;96:135-147. doi: 10.1016/j.biocel.2017.09.013. Epub 2017 Sep 20. Review.


Establishing a small animal model for evaluating protective immunity against mumps virus.

Pickar A, Xu P, Elson A, Zengel J, Sauder C, Rubin S, He B.

PLoS One. 2017 Mar 31;12(3):e0174444. doi: 10.1371/journal.pone.0174444. eCollection 2017.


The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia.

Wakim J, Arman E, Becker-Herman S, Kramer MP, Bakos E, Shachar I, Elson A.

Oncogene. 2017 Jun 29;36(26):3686-3694. doi: 10.1038/onc.2016.523. Epub 2017 Feb 6.


Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains.

Barnea M, Olender T, Bedford MT, Elson A.

Biochem Soc Trans. 2016 Oct 15;44(5):1295-1303. Review.


Production of Osteoclasts for Studying Protein Tyrosine Phosphatase Signaling.

Finkelshtein E, Levy-Apter E, Elson A.

Methods Mol Biol. 2016;1447:283-300. doi: 10.1007/978-1-4939-3746-2_16.


Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.


Developmental specification of metabolic circuitry.

Elson AE, Simerly RB.

Front Neuroendocrinol. 2015 Oct;39:38-51. doi: 10.1016/j.yfrne.2015.09.003. Epub 2015 Sep 25. Review.


Oligomerization of Mumps Virus Phosphoprotein.

Pickar A, Elson A, Yang Y, Xu P, Luo M, He B.

J Virol. 2015 Nov;89(21):11002-10. doi: 10.1128/JVI.01719-15. Epub 2015 Aug 26.


Evaluation of pre-radiotherapy apparent diffusion coefficient (ADC): patterns of recurrence and survival outcomes analysis in patients treated for glioblastoma multiforme.

Elson A, Paulson E, Bovi J, Siker M, Schultz C, Laviolette PS.

J Neurooncol. 2015 May;123(1):179-88. doi: 10.1007/s11060-015-1782-5. Epub 2015 Apr 17.


Taste responsiveness to sweeteners is resistant to elevations in plasma leptin.

Glendinning JI, Elson AE, Kalik S, Sosa Y, Patterson CM, Myers MG Jr, Munger SD.

Chem Senses. 2015 May;40(4):223-31. doi: 10.1093/chemse/bju075. Epub 2015 Mar 4.


Use of Helical TomoTherapy for the Focal Hypofractionated Treatment of Limited Brain Metastases in the Initial and Recurrent Setting.

Elson A, Walker A, Bovi JA, Schultz C.

Front Oncol. 2015 Feb 9;5:27. doi: 10.3389/fonc.2015.00027. eCollection 2015.


Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma.

Elson A, Bovi J, Siker M, Schultz C, Paulson E.

J Neurooncol. 2015 May;122(3):549-58. doi: 10.1007/s11060-015-1743-z. Epub 2015 Feb 21.


Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A.

J Biol Chem. 2014 Dec 26;289(52):36048-58. doi: 10.1074/jbc.M114.603548. Epub 2014 Nov 7.


TAS2R bitter taste receptors regulate thyroid function.

Clark AA, Dotson CD, Elson AE, Voigt A, Boehm U, Meyerhof W, Steinle NI, Munger SD.

FASEB J. 2015 Jan;29(1):164-72. doi: 10.1096/fj.14-262246. Epub 2014 Oct 23.


Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein.

Cox R, Pickar A, Qiu S, Tsao J, Rodenburg C, Dokland T, Elson A, He B, Luo M.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15208-13. doi: 10.1073/pnas.1413268111. Epub 2014 Oct 6.


Metabolic regulation by protein tyrosine phosphatases.

Knobler H, Elson A.

J Biomed Res. 2014 May;28(3):157-68. doi: 10.7555/JBR.28.20140012. Epub 2014 Feb 28.


Effect of treatment modality on the hypothalamic-pituitary function of patients treated with radiation therapy for pituitary adenomas: hypothalamic dose and endocrine outcomes.

Elson A, Bovi J, Kaur K, Maas D, Sinson G, Schultz C.

Front Oncol. 2014 Apr 9;4:73. doi: 10.3389/fonc.2014.00073. eCollection 2014.


Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.

Finkelshtein E, Lotinun S, Levy-Apter E, Arman E, den Hertog J, Baron R, Elson A.

Mol Biol Cell. 2014 Jun;25(11):1808-18. doi: 10.1091/mbc.E14-03-0788. Epub 2014 Apr 2.


Roles of serine and threonine residues of mumps virus P protein in viral transcription and replication.

Pickar A, Xu P, Elson A, Li Z, Zengel J, He B.

J Virol. 2014 Apr;88(8):4414-22. doi: 10.1128/JVI.03673-13. Epub 2014 Feb 5.


Protein tyrosine phosphatases as novel targets in breast cancer therapy.

Nunes-Xavier CE, Martín-Pérez J, Elson A, Pulido R.

Biochim Biophys Acta. 2013 Dec;1836(2):211-26. doi: 10.1016/j.bbcan.2013.06.001. Epub 2013 Jun 10. Review.


Protein tyrosine phosphatases in health and disease.

Hendriks WJ, Elson A, Harroch S, Pulido R, Stoker A, den Hertog J.

FEBS J. 2013 Jan;280(2):708-30. doi: 10.1111/febs.12000. Epub 2012 Oct 1. Review.


Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.

Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK.

Mol Cell Biol. 2012 Oct;32(19):3913-24. doi: 10.1128/MCB.00068-12. Epub 2012 Jul 30.


Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability.

Ebner-Bennatan S, Patrich E, Peretz A, Kornilov P, Tiran Z, Elson A, Attali B.

J Biol Chem. 2012 Aug 10;287(33):27614-28. doi: 10.1074/jbc.M112.342519. Epub 2012 Jun 21.


Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner.

Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, Akepati VR, Klinghoffer RA, Chen A, Elson A.

Cell Metab. 2011 May 4;13(5):562-72. doi: 10.1016/j.cmet.2011.02.017.


Glucagon signaling modulates sweet taste responsiveness.

Elson AE, Dotson CD, Egan JM, Munger SD.

FASEB J. 2010 Oct;24(10):3960-9. doi: 10.1096/fj.10-158105. Epub 2010 Jun 14.


Comment on Steven Rose's opinion article, 'Academic freedom in Israel and Palestine'.

Elson A.

EMBO Rep. 2010 Mar;11(3):150; author reply 151-2. doi: 10.1038/embor.2010.4. No abstract available.


Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src.

Granot-Attas S, Luxenburg C, Finkelshtein E, Elson A.

Mol Biol Cell. 2009 Oct;20(20):4324-34. doi: 10.1091/mbc.E08-11-1158. Epub 2009 Aug 19.


Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses.

Akimoto M, Mishra K, Lim KT, Tani N, Hisanaga SI, Katagiri T, Elson A, Mizuno K, Yakura H.

Scand J Immunol. 2009 May;69(5):401-11. doi: 10.1111/j.1365-3083.2009.02235.x. Epub 2008 Feb 6.


Bitter taste receptors influence glucose homeostasis.

Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AE, Choi HJ, Shaw H, Egan JM, Mitchell BD, Li X, Steinle NI, Munger SD.

PLoS One. 2008;3(12):e3974. doi: 10.1371/journal.pone.0003974. Epub 2008 Dec 18.


PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells.

De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, Brunati AM, Turretta L, Iolascon A, Perrotta S, Elson A, Bulato C, Brugnara C.

Proteomics. 2008 Nov;8(22):4695-708. doi: 10.1002/pmic.200700596.


Protein tyrosine phosphatases in osteoclast differentiation, adhesion, and bone resorption.

Granot-Attas S, Elson A.

Eur J Cell Biol. 2008 Sep;87(8-9):479-90. doi: 10.1016/j.ejcb.2008.01.006. Epub 2008 Mar 14. Review.


Protein tyrosine phosphatases: functional inferences from mouse models and human diseases.

Hendriks WJ, Elson A, Harroch S, Stoker AW.

FEBS J. 2008 Mar;275(5):816-30. doi: 10.1111/j.1742-4658.2008.06249.x. Review.


Protein tyrosine phosphatase epsilon and Neu-induced mammary tumorigenesis.

Berman-Golan D, Granot-Attas S, Elson A.

Cancer Metastasis Rev. 2008 Jun;27(2):193-203. doi: 10.1007/s10555-008-9124-0. Review.


Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle.

Aga-Mizrachi S, Brutman-Barazani T, Jacob AI, Bak A, Elson A, Sampson SR.

Endocrinology. 2008 Feb;149(2):605-14. Epub 2007 Nov 15.


Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor.

Sines T, Granot-Attas S, Weisman-Welcher S, Elson A.

Mol Cell Biol. 2007 Oct;27(20):7102-12. Epub 2007 Aug 20.


Substrate recognition reduces side-chain flexibility for conserved hydrophobic residues in human Pin1.

Namanja AT, Peng T, Zintsmaster JS, Elson AC, Shakour MG, Peng JW.

Structure. 2007 Mar;15(3):313-27.


Protein tyrosine phosphatases in osteoclasts.

Granot-Attas S, Knobler H, Elson A.

Crit Rev Eukaryot Gene Expr. 2007;17(1):49-71. Review.


Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells.

Tiran Z, Peretz A, Sines T, Shinder V, Sap J, Attali B, Elson A.

Mol Biol Cell. 2006 Oct;17(10):4330-42. Epub 2006 Jul 26.


Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.

Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y, Tesio M, Samstein RM, Goichberg P, Spiegel A, Elson A, Lapidot T.

Nat Med. 2006 Jun;12(6):657-64. Epub 2006 May 21.


Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells.

Granot-Attas S, Elson A.

Exp Cell Res. 2004 Mar 10;294(1):236-43.


Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Ostman A, Hellberg C.

Mol Cell Biol. 2004 Mar;24(5):2190-201.

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