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Items: 1 to 50 of 66

1.

Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.

Yellamilli A, Ren Y, McElmurry RT, Lambert JP, Gross P, Mohsin S, Houser SR, Elrod JW, Tolar J, Garry DJ, van Berlo JH.

FASEB J. 2020 Feb 25. doi: 10.1096/fj.201902105R. [Epub ahead of print]

PMID:
32100368
2.

MCUB and mitochondrial calcium uptake - modeling, function, and therapeutic potential.

Lambert JP, Murray EK, Elrod JW.

Expert Opin Ther Targets. 2020 Mar;24(3):163-169. doi: 10.1080/14728222.2020.1732926. Epub 2020 Feb 24. No abstract available.

PMID:
32093523
3.

Nicotinamide riboside kinase-2 alleviates ischemia-induced heart failure through P38 signaling.

Ahmad F, Tomar D, Aryal A C S, Elmoselhi AB, Thomas M, Elrod JW, Tilley DG, Force T.

Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165609. doi: 10.1016/j.bbadis.2019.165609. Epub 2019 Nov 16.

PMID:
31743747
4.

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW.

Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x.

5.

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

Lambert JP, Luongo TS, Tomar D, Jadiya P, Gao E, Zhang X, Lucchese AM, Kolmetzky DW, Shah NS, Elrod JW.

Circulation. 2019 Nov 19;140(21):1720-1733. doi: 10.1161/CIRCULATIONAHA.118.037968. Epub 2019 Sep 19.

PMID:
31533452
6.

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.

Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW.

Nat Commun. 2019 Aug 29;10(1):3885. doi: 10.1038/s41467-019-11813-6.

7.

Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis.

Gibb AA, Elrod JW.

J Clin Invest. 2019 Jan 2;129(1):63-65. doi: 10.1172/JCI125433. Epub 2018 Dec 3.

8.

Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart.

De La Fuente S, Lambert JP, Nichtova Z, Fernandez Sanz C, Elrod JW, Sheu SS, Csordás G.

Cell Rep. 2018 Sep 18;24(12):3099-3107.e4. doi: 10.1016/j.celrep.2018.08.040.

9.

Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency.

Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL.

Cell Rep. 2018 Jun 26;23(13):3710-3720.e8. doi: 10.1016/j.celrep.2018.06.002.

10.

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity.

Natarajaseenivasan K, Cotto B, Shanmughapriya S, Lombardi AA, Datta PK, Madesh M, Elrod JW, Khalili K, Langford D.

Cell Death Dis. 2018 Apr 1;9(4):415. doi: 10.1038/s41419-018-0422-3.

11.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

12.

Mediating ER-mitochondrial cross-talk.

Lombardi AA, Elrod JW.

Science. 2017 Nov 3;358(6363):591-592. doi: 10.1126/science.aaq0141. No abstract available.

13.

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW.

Nature. 2017 May 4;545(7652):93-97. doi: 10.1038/nature22082. Epub 2017 Apr 26.

14.

Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.

Woodall BP, Woodall MC, Luongo TS, Grisanti LA, Tilley DG, Elrod JW, Koch WJ.

J Biol Chem. 2016 Oct 14;291(42):21913-21924. Epub 2016 Aug 26.

15.

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.

Tomar D, Dong Z, Shanmughapriya S, Koch DA, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jaña F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M.

Cell Rep. 2016 May 24;15(8):1673-85. doi: 10.1016/j.celrep.2016.04.050. Epub 2016 May 12.

16.

HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial Pathway.

De Simone FI, Darbinian N, Amini S, Muniswamy M, White MK, Elrod JW, Datta PK, Langford D, Khalili K.

J Neuroimmune Pharmacol. 2016 Jun;11(2):358-68. doi: 10.1007/s11481-016-9669-6. Epub 2016 Mar 31.

17.

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.

Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod JW, Koch WJ.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):360-4. doi: 10.1016/j.yjmcc.2015.10.002. Epub 2015 Oct 23.

18.

Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH.

Cell Metab. 2015 Nov 3;22(5):838-50. doi: 10.1016/j.cmet.2015.08.022. Epub 2015 Sep 24.

19.

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M.

Mol Cell. 2015 Oct 1;60(1):47-62. doi: 10.1016/j.molcel.2015.08.009. Epub 2015 Sep 17.

20.

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW.

Cell Rep. 2015 Jul 7;12(1):23-34. doi: 10.1016/j.celrep.2015.06.017. Epub 2015 Jun 25.

21.

mtDNA damage in the development of heart failure.

Lombardi AA, Elrod JW.

Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H393-5. doi: 10.1152/ajpheart.00475.2015. Epub 2015 Jun 19. No abstract available.

22.

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling.

Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, Rabinowitz JE, Leask A, Molkentin JD.

Mol Cell Biol. 2015 Jun;35(12):2154-64. doi: 10.1128/MCB.00199-15. Epub 2015 Apr 13.

23.

Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.

Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY.

Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H637-50. doi: 10.1152/ajpheart.00720.2014. Epub 2015 Jan 9.

24.

Unraveling the complexities of cardiac remodeling and hypertrophy - high-content screening and computational modeling.

Elrod JW, van Berlo JH.

J Mol Cell Cardiol. 2014 Jul;72:360-3. doi: 10.1016/j.yjmcc.2014.03.014. Epub 2014 Apr 15. No abstract available.

25.

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.

King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7. doi: 10.1073/pnas.1321871111. Epub 2014 Feb 10.

26.

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M.

Mol Biol Cell. 2014 Mar;25(6):936-47. doi: 10.1091/mbc.E13-08-0502. Epub 2014 Jan 15.

27.

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.

Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD.

Elife. 2013 Aug 27;2:e00772. doi: 10.7554/eLife.00772.

28.

Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.

Elrod JW, Molkentin JD.

Circ J. 2013;77(5):1111-22. Epub 2013 Mar 29. Review.

29.

Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease.

Vagnozzi RJ, Hoffman NE, Elrod JW, Madesh M, Force T.

Drug Discov Today Ther Strateg. 2012;9(4):e173-e182.

30.

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.

Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD.

J Clin Invest. 2012 Jan;122(1):280-90. doi: 10.1172/JCI58227. Epub 2011 Dec 1.

31.

Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.

van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12331-6. doi: 10.1073/pnas.1104499108. Epub 2011 Jul 11.

32.

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD.

J Clin Invest. 2010 Oct;120(10):3680-7. doi: 10.1172/JCI43171. Epub 2010 Sep 20.

33.

The transcription factor GATA-6 regulates pathological cardiac hypertrophy.

van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD.

Circ Res. 2010 Oct 15;107(8):1032-40. doi: 10.1161/CIRCRESAHA.110.220764. Epub 2010 Aug 12.

34.

Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice.

Calvert JW, Elston M, Nicholson CK, Gundewar S, Jha S, Elrod JW, Ramachandran A, Lefer DJ.

Circulation. 2010 Jul 6;122(1):11-9. doi: 10.1161/CIRCULATIONAHA.109.920991. Epub 2010 Jun 21.

35.

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.

Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F.

Circulation. 2009 Sep 8;120(10):888-96. doi: 10.1161/CIRCULATIONAHA.108.833491. Epub 2009 Aug 24.

36.

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.

Calvert JW, Jha S, Gundewar S, Elrod JW, Ramachandran A, Pattillo CB, Kevil CG, Lefer DJ.

Circ Res. 2009 Aug 14;105(4):365-74. doi: 10.1161/CIRCRESAHA.109.199919. Epub 2009 Jul 16.

37.

Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.

Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD.

Circ Res. 2009 Jan 2;104(1):e1-7. doi: 10.1161/CIRCRESAHA.108.188649. Epub 2008 Nov 26.

38.

Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide.

Elrod JW, Calvert JW, Gundewar S, Bryan NS, Lefer DJ.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11430-5. doi: 10.1073/pnas.0800700105. Epub 2008 Aug 6.

39.

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ.

Circulation. 2008 Mar 18;117(11):1405-13. doi: 10.1161/CIRCULATIONAHA.107.745539. Epub 2008 Mar 3. Erratum in: Circulation.2008 May 6;117(18):e332.

PMID:
18316485
40.

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury.

Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19144-9. Epub 2007 Nov 19.

41.

Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.

Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Chow CW, Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15560-5. Epub 2007 Sep 18.

42.

Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.

Gundewar S, Calvert JW, Elrod JW, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2462-71. Epub 2007 Jul 13.

43.

Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway.

Elrod JW, Greer JJ, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H342-7. Epub 2006 Sep 1.

44.

Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.

Duranski MR, Elrod JW, Calvert JW, Bryan NS, Feelisch M, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2980-6. Epub 2006 Jul 28.

45.

Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.

Greer JJ, Kakkar AK, Elrod JW, Watson LJ, Jones SP, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2743-51. Epub 2006 Jul 14.

46.

eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.

Elrod JW, Duranski MR, Langston W, Greer JJ, Tao L, Dugas TR, Kevil CG, Champion HC, Lefer DJ.

Circ Res. 2006 Jul 7;99(1):78-85. Epub 2006 Jun 8.

PMID:
16763164
47.

Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury.

Elrod JW, Greer JJ, Bryan NS, Langston W, Szot JF, Gebregzlabher H, Janssens S, Feelisch M, Lefer DJ.

Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1517-23. Epub 2006 Apr 27.

PMID:
16645153
48.

DSS-induced colitis is exacerbated in STAT-6 knockout mice.

Elrod JW, Laroux FS, Houghton J, Carpenter A, Ando T, Jennings MH, Grisham M, Walker N, Alexander JS.

Inflamm Bowel Dis. 2005 Oct;11(10):883-9.

PMID:
16189417
49.

Colonic blood flow responses in experimental colitis: time course and underlying mechanisms.

Mori M, Stokes KY, Vowinkel T, Watanabe N, Elrod JW, Harris NR, Lefer DJ, Hibi T, Granger DN.

Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1024-9. Epub 2005 Aug 4.

50.

The effects of statins on endothelium, inflammation and cardioprotection.

Elrod JW, Lefer DJ.

Drug News Perspect. 2005 May;18(4):229-36. Review.

PMID:
16034478

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