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Items: 1 to 50 of 68


Constitutive splicing and economies of scale in gene expression.

Ding F, Elowitz MB.

Nat Struct Mol Biol. 2019 Jun;26(6):424-432. doi: 10.1038/s41594-019-0226-x. Epub 2019 May 27.


Cis-activation in the Notch signaling pathway.

Nandagopal N, Santat LA, Elowitz MB.

Elife. 2019 Jan 10;8. pii: e37880. doi: 10.7554/eLife.37880.


A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY.

Elife. 2018 Nov 20;7. pii: e37851. doi: 10.7554/eLife.37851.


Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback.

Martinez-Corral R, Raimundez E, Lin Y, Elowitz MB, Garcia-Ojalvo J.

Cell Syst. 2018 Oct 24;7(4):453-462.e1. doi: 10.1016/j.cels.2018.08.012. Epub 2018 Oct 10.


Programmable protein circuits in living cells.

Gao XJ, Chong LS, Kim MS, Elowitz MB.

Science. 2018 Sep 21;361(6408):1252-1258. doi: 10.1126/science.aat5062.


Metabolic interactions between dynamic bacterial subpopulations.

Rosenthal AZ, Qi Y, Hormoz S, Park J, Li SH, Elowitz MB.

Elife. 2018 May 29;7. pii: e33099. doi: 10.7554/eLife.33099.


Morphogen gradient reconstitution reveals Hedgehog pathway design principles.

Li P, Markson JS, Wang S, Chen S, Vachharajani V, Elowitz MB.

Science. 2018 May 4;360(6388):543-548. doi: 10.1126/science.aao0645. Epub 2018 Apr 5.


Molecular Time Sharing through Dynamic Pulsing in Single Cells.

Park J, Dies M, Lin Y, Hormoz S, Smith-Unna SE, Quinodoz S, Hernández-Jiménez MJ, Garcia-Ojalvo J, Locke JCW, Elowitz MB.

Cell Syst. 2018 Feb 28;6(2):216-229.e15. doi: 10.1016/j.cels.2018.01.011. Epub 2018 Feb 14.


Dynamic Ligand Discrimination in the Notch Signaling Pathway.

Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB.

Cell. 2018 Feb 8;172(4):869-880.e19. doi: 10.1016/j.cell.2018.01.002. Epub 2018 Feb 1.


An operational view of intercellular signaling pathways.

Antebi YE, Nandagopal N, Elowitz MB.

Curr Opin Syst Biol. 2017 Feb;1:16-24. doi: 10.1016/j.coisb.2016.12.003. Epub 2017 Feb 24.


Combinatorial Signal Perception in the BMP Pathway.

Antebi YE, Linton JM, Klumpe H, Bintu B, Gong M, Su C, McCardell R, Elowitz MB.

Cell. 2017 Sep 7;170(6):1184-1196.e24. doi: 10.1016/j.cell.2017.08.015.


Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements.

Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB.

Cell Syst. 2016 Nov 23;3(5):419-433.e8. doi: 10.1016/j.cels.2016.10.015.


Synthetic recording and in situ readout of lineage information in single cells.

Frieda KL, Linton JM, Hormoz S, Choi J, Chow KK, Singer ZS, Budde MW, Elowitz MB, Cai L.

Nature. 2017 Jan 5;541(7635):107-111. doi: 10.1038/nature20777. Epub 2016 Nov 21.


Synthetic biology: Precision timing in a cell.

Gao XJ, Elowitz MB.

Nature. 2016 Oct 27;538(7626):462-463. doi: 10.1038/nature19478. Epub 2016 Oct 12. No abstract available.


Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment.

Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV.

Nat Immunol. 2016 Aug;17(8):956-65. doi: 10.1038/ni.3514. Epub 2016 Jul 4.


Central Dogma Goes Digital.

Lin Y, Elowitz MB.

Mol Cell. 2016 Mar 17;61(6):791-2. doi: 10.1016/j.molcel.2016.03.005.


Dynamics of epigenetic regulation at the single-cell level.

Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB.

Science. 2016 Feb 12;351(6274):720-4. doi: 10.1126/science.aab2956.


Combinatorial gene regulation by modulation of relative pulse timing.

Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB.

Nature. 2015 Nov 5;527(7576):54-8. doi: 10.1038/nature15710. Epub 2015 Oct 14.


Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming.

Kim DH, Marinov GK, Pepke S, Singer ZS, He P, Williams B, Schroth GP, Elowitz MB, Wold BJ.

Cell Stem Cell. 2015 Jan 8;16(1):88-101. doi: 10.1016/j.stem.2014.11.005.


Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms.

Markson JS, Elowitz MB.

ACS Synth Biol. 2014 Dec 19;3(12):875-6. doi: 10.1021/sb500358y. No abstract available.


Polyphasic feedback enables tunable cellular timers.

Levine JH, Elowitz MB.

Curr Biol. 2014 Oct 20;24(20):R994-5. doi: 10.1016/j.cub.2014.08.030. Epub 2014 Oct 21.


Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.

LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB.

Elife. 2014 Sep 25;3:e02950. doi: 10.7554/eLife.02950. Erratum in: Elife. 2014;3:e04998.


Pulsatile dynamics in the yeast proteome.

Dalal CK, Cai L, Lin Y, Rahbar K, Elowitz MB.

Curr Biol. 2014 Sep 22;24(18):2189-2194. doi: 10.1016/j.cub.2014.07.076. Epub 2014 Sep 11.


Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB.

Mol Cell. 2014 Jul 17;55(2):319-31. doi: 10.1016/j.molcel.2014.06.029.


Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

Tan FE, Elowitz MB.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1740-8. doi: 10.1073/pnas.1320873111. Epub 2014 Apr 14.


Realizing the potential of synthetic biology.

Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):289-94. doi: 10.1038/nrm3767. Epub 2014 Mar 12. Review.


Functional roles of pulsing in genetic circuits.

Levine JH, Lin Y, Elowitz MB.

Science. 2013 Dec 6;342(6163):1193-200. doi: 10.1126/science.1239999. Review.


Positive feedback between PU.1 and the cell cycle controls myeloid differentiation.

Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV.

Science. 2013 Aug 9;341(6146):670-3. doi: 10.1126/science.1240831. Epub 2013 Jul 18. Erratum in: Science. 2013 Oct 18;342(6156):311. Champhekhar, Ameya [corrected to Champhekar, Ameya].


Rate of environmental change determines stress response specificity.

Young JW, Locke JC, Elowitz MB.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4140-5. doi: 10.1073/pnas.1213060110. Epub 2013 Feb 13.


Pulsed feedback defers cellular differentiation.

Levine JH, Fontes ME, Dworkin J, Elowitz MB.

PLoS Biol. 2012 Jan;10(1):e1001252. doi: 10.1371/journal.pbio.1001252. Epub 2012 Jan 31.


Following evolution of bacterial antibiotic resistance in real time.

Rosenthal AZ, Elowitz MB.

Nat Genet. 2011 Dec 27;44(1):11-3. doi: 10.1038/ng.1048.


Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy.

Young JW, Locke JC, Altinok A, Rosenfeld N, Bacarian T, Swain PS, Mjolsness E, Elowitz MB.

Nat Protoc. 2011 Dec 15;7(1):80-8. doi: 10.1038/nprot.2011.432.


Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay.

Sen S, Garcia-Ojalvo J, Elowitz MB.

PLoS One. 2011;6(9):e25102. doi: 10.1371/journal.pone.0025102. Epub 2011 Sep 29.


Stochastic pulse regulation in bacterial stress response.

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB.

Science. 2011 Oct 21;334(6054):366-9. doi: 10.1126/science.1208144. Epub 2011 Oct 6.


The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM).

Zheng G, Lee SA, Antebi Y, Elowitz MB, Yang C.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16889-94. doi: 10.1073/pnas.1110681108. Epub 2011 Oct 3.


Synthetic biology: integrated gene circuits.

Nandagopal N, Elowitz MB.

Science. 2011 Sep 2;333(6047):1244-8. doi: 10.1126/science.1207084. Review.


Mutual inactivation of Notch receptors and ligands facilitates developmental patterning.

Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB.

PLoS Comput Biol. 2011 Jun;7(6):e1002069. doi: 10.1371/journal.pcbi.1002069. Epub 2011 Jun 9.


Mixed messages: how bacteria resolve conflicting signals.

Young JW, Elowitz MB.

Mol Cell. 2011 May 20;42(4):405-6. doi: 10.1016/j.molcel.2011.05.005.


A general mechanism for network-dosage compensation in gene circuits.

Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A.

Science. 2010 Sep 24;329(5999):1656-60. doi: 10.1126/science.1190544.


Functional roles for noise in genetic circuits.

Eldar A, Elowitz MB.

Nature. 2010 Sep 9;467(7312):167-73. doi: 10.1038/nature09326. Review.


A synthetic three-color scaffold for monitoring genetic regulation and noise.

Cox RS 3rd, Dunlop MJ, Elowitz MB.

J Biol Eng. 2010 Jul 21;4:10. doi: 10.1186/1754-1611-4-10.


Cis-interactions between Notch and Delta generate mutually exclusive signalling states.

Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB.

Nature. 2010 May 6;465(7294):86-90. doi: 10.1038/nature08959. Epub 2010 Apr 25.


Architecture-dependent noise discriminates functionally analogous differentiation circuits.

Cağatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM.

Cell. 2009 Oct 30;139(3):512-22. doi: 10.1016/j.cell.2009.07.046. Epub 2009 Oct 22.


Partial penetrance facilitates developmental evolution in bacteria.

Eldar A, Chary VK, Xenopoulos P, Fontes ME, Losón OC, Dworkin J, Piggot PJ, Elowitz MB.

Nature. 2009 Jul 23;460(7254):510-4. doi: 10.1038/nature08150. Epub 2009 Jul 5.


Using movies to analyse gene circuit dynamics in single cells.

Locke JC, Elowitz MB.

Nat Rev Microbiol. 2009 May;7(5):383-92. doi: 10.1038/nrmicro2056. Review.


Regulatory activity revealed by dynamic correlations in gene expression noise.

Dunlop MJ, Cox RS 3rd, Levine JH, Murray RM, Elowitz MB.

Nat Genet. 2008 Dec;40(12):1493-8. doi: 10.1038/ng.281.


Frequency-modulated nuclear localization bursts coordinate gene regulation.

Cai L, Dalal CK, Elowitz MB.

Nature. 2008 Sep 25;455(7212):485-90. doi: 10.1038/nature07292.


The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication.

Presser A, Elowitz MB, Kellis M, Kishony R.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):950-4. doi: 10.1073/pnas.0707293105. Epub 2008 Jan 16.


Programming gene expression with combinatorial promoters.

Cox RS 3rd, Surette MG, Elowitz MB.

Mol Syst Biol. 2007;3:145. Epub 2007 Nov 13.


Accurate prediction of gene feedback circuit behavior from component properties.

Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB.

Mol Syst Biol. 2007;3:143. Epub 2007 Nov 13.

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