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Items: 1 to 50 of 109

1.

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus.

Almlöf JC, Nystedt S, Leonard D, Eloranta ML, Grosso G, Sjöwall C, Bengtsson AA, Jönsen A, Gunnarsson I, Svenungsson E, Rönnblom L, Sandling JK, Syvänen AC.

Hum Genet. 2019 Feb;138(2):141-150. doi: 10.1007/s00439-018-01966-7. Epub 2019 Feb 1.

2.

A case of systemic lupus erythematosus with C1q deficiency, increased serum interferon-α levels and high serum interferogenic activity.

Bolin K, Eloranta ML, Kozyrev SV, Dahlqvist J, Nilsson B, Knight A, Rönnblom L.

Rheumatology (Oxford). 2019 Jan 3. doi: 10.1093/rheumatology/key419. [Epub ahead of print] No abstract available.

PMID:
30608615
3.

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts.

Farias FHG, Dahlqvist J, Kozyrev SV, Leonard D, Wilbe M, Abramov SN, Alexsson A, Pielberg GR, Hansson-Hamlin H, Andersson G, Tandre K, Bengtsson AA, Sjöwall C, Svenungsson E, Gunnarsson I, Rantapää-Dahlqvist S, Syvänen AC, Sandling JK, Eloranta ML, Rönnblom L, Lindblad-Toh K.

Eur J Hum Genet. 2019 Mar;27(3):432-441. doi: 10.1038/s41431-018-0297-x. Epub 2018 Nov 20.

4.

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor.

Hjorton K, Hagberg N, Israelsson E, Jinton L, Berggren O, Sandling JK, Thörn K, Mo J; DISSECT consortium, Eloranta ML, Rönnblom L.

Arthritis Res Ther. 2018 Oct 24;20(1):238. doi: 10.1186/s13075-018-1702-0.

5.

Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature.

Imgenberg-Kreuz J, Sandling JK, Björk A, Nordlund J, Kvarnström M, Eloranta ML, Rönnblom L, Wahren-Herlenius M, Syvänen AC, Nordmark G.

Scand J Immunol. 2018 May;87(5):e12662. doi: 10.1111/sji.12662.

PMID:
29655283
6.

ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.

Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H.

Sci Rep. 2018 Mar 19;8(1):4852. doi: 10.1038/s41598-018-23034-w.

7.

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis.

Leonard D, Svenungsson E, Dahlqvist J, Alexsson A, Ärlestig L, Taylor KE, Sandling JK, Bengtsson C, Frodlund M, Jönsen A, Eketjäll S, Jensen-Urstad K, Gunnarsson I, Sjöwall C, Bengtsson AA, Eloranta ML, Syvänen AC, Rantapää-Dahlqvist S, Criswell LA, Rönnblom L.

Ann Rheum Dis. 2018 Jul;77(7):1063-1069. doi: 10.1136/annrheumdis-2017-212614. Epub 2018 Mar 7.

8.

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.

Hagberg N, Joelsson M, Leonard D, Reid S, Eloranta ML, Mo J, Nilsson MK, Syvänen AC, Bryceson YT, Rönnblom L.

Ann Rheum Dis. 2018 Jul;77(7):1070-1077. doi: 10.1136/annrheumdis-2017-212794. Epub 2018 Feb 23.

9.

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Imgenberg-Kreuz J, Carlsson Almlöf J, Leonard D, Alexsson A, Nordmark G, Eloranta ML, Rantapää-Dahlqvist S, Bengtsson AA, Jönsen A, Padyukov L, Gunnarsson I, Svenungsson E, Sjöwall C, Rönnblom L, Syvänen AC, Sandling JK.

Ann Rheum Dis. 2018 May;77(5):736-743. doi: 10.1136/annrheumdis-2017-212379. Epub 2018 Feb 1.

10.

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.

Houtman M, Shchetynsky K, Chemin K, Hensvold AH, Ramsköld D, Tandre K, Eloranta ML, Rönnblom L, Uebe S, Catrina AI, Malmström V, Padyukov L.

J Autoimmun. 2018 Jun;90:28-38. doi: 10.1016/j.jaut.2018.01.003. Epub 2018 Feb 3.

11.

Preoperative sentinel lymph node localization in vulvar cancer: preliminary experience with inguinal intradermal contrast-enhanced ultrasound.

Lahtinen O, Eloranta M, Anttila M, Kärkkäinen H, Sironen R, Vanninen R, Rautiainen S.

Eur Radiol. 2018 May;28(5):2089-2095. doi: 10.1007/s00330-017-5155-7. Epub 2017 Nov 30.

PMID:
29189931
12.

Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype.

Berggren O, Hagberg N, Alexsson A, Weber G, Rönnblom L, Eloranta ML.

PLoS One. 2017 Aug 28;12(8):e0183946. doi: 10.1371/journal.pone.0183946. eCollection 2017.

13.

Novel risk genes for systemic lupus erythematosus predicted by random forest classification.

Almlöf JC, Alexsson A, Imgenberg-Kreuz J, Sylwan L, Bäcklin C, Leonard D, Nordmark G, Tandre K, Eloranta ML, Padyukov L, Bengtsson C, Jönsen A, Dahlqvist SR, Sjöwall C, Bengtsson AA, Gunnarsson I, Svenungsson E, Rönnblom L, Sandling JK, Syvänen AC.

Sci Rep. 2017 Jul 24;7(1):6236. doi: 10.1038/s41598-017-06516-1.

14.

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF; for UK Primary Sjögren's Syndrome Registry, Nordmark G, Lessard CJ, Sivils KL.

PLoS Genet. 2017 Jun 22;13(6):e1006820. doi: 10.1371/journal.pgen.1006820. eCollection 2017 Jun.

15.

Validation of the short forms of the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Floor Impact Questionnaire (PFIQ-7), and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) in Finnish.

Mattsson NK, Nieminen K, Heikkinen AM, Jalkanen J, Koivurova S, Eloranta ML, Suvitie P, Tolppanen AM.

Health Qual Life Outcomes. 2017 May 2;15(1):88. doi: 10.1186/s12955-017-0648-2.

16.

Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro.

Wirestam L, Enocsson H, Skogh T, Eloranta ML, Rönnblom L, Sjöwall C, Wetterö J.

Clin Exp Immunol. 2017 Jul;189(1):83-91. doi: 10.1111/cei.12957. Epub 2017 Mar 31.

17.

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Folkersen L, Brynedal B, Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Westerlind H, Sundström Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Rönnblom L, Brunak S, Malmström V, Catrina A, Moerch UG, Klareskog L, Padyukov L, Berg L.

Mol Med. 2016 Sep;22:322-328. doi: 10.2119/molmed.2016.00078. Epub 2016 Aug 15.

18.

Cause and consequences of the activated type I interferon system in SLE.

Eloranta ML, Rönnblom L.

J Mol Med (Berl). 2016 Oct;94(10):1103-1110. Epub 2016 Apr 20. Review.

19.

Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression.

Cavalli M, Pan G, Nord H, Wallerman O, Wallén Arzt E, Berggren O, Elvers I, Eloranta ML, Rönnblom L, Lindblad Toh K, Wadelius C.

Hum Genet. 2016 May;135(5):485-497. doi: 10.1007/s00439-016-1654-x. Epub 2016 Mar 18.

20.

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes.

Imgenberg-Kreuz J, Sandling JK, Almlöf JC, Nordlund J, Signér L, Norheim KB, Omdal R, Rönnblom L, Eloranta ML, Syvänen AC, Nordmark G.

Ann Rheum Dis. 2016 Nov;75(11):2029-2036. doi: 10.1136/annrheumdis-2015-208659. Epub 2016 Feb 8.

21.

Effect of PTPN22 Gene Variant R620W on Type I Interferon Production Stimulated by Different Toll-like Receptor 7 Agonists: Comment on the Article by Wang et al.

Berggren O, Rönnblom L, Eloranta ML.

Arthritis Rheumatol. 2016 Apr;68(4):1045. doi: 10.1002/art.39571. No abstract available.

22.

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes.

Leonard D, Eloranta ML, Hagberg N, Berggren O, Tandre K, Alm G, Rönnblom L.

Ann Rheum Dis. 2016 Sep;75(9):1728-34. doi: 10.1136/annrheumdis-2015-208055. Epub 2015 Oct 22.

PMID:
26493814
23.

IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases.

Berggren O, Alexsson A, Morris DL, Tandre K, Weber G, Vyse TJ, Syvänen AC, Rönnblom L, Eloranta ML.

Hum Mol Genet. 2015 Jun 15;24(12):3571-81. doi: 10.1093/hmg/ddv095. Epub 2015 Mar 16.

PMID:
25779693
24.

Functional anti-CD94/NKG2A and anti-CD94/NKG2C autoantibodies in patients with systemic lupus erythematosus.

Hagberg N, Theorell J, Hjorton K, Spee P, Eloranta ML, Bryceson YT, Rönnblom L.

Arthritis Rheumatol. 2015 Apr;67(4):1000-11. doi: 10.1002/art.38999.

25.

Association of serum C-reactive protein levels with lupus disease activity in the absence of measurable interferon-α and a C-reactive protein gene variant.

Enocsson H, Sjöwall C, Kastbom A, Skogh T, Eloranta ML, Rönnblom L, Wetterö J.

Arthritis Rheumatol. 2014 Jun;66(6):1568-73. doi: 10.1002/art.38408.

26.

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis.

Bolin K, Sandling JK, Zickert A, Jönsen A, Sjöwall C, Svenungsson E, Bengtsson AA, Eloranta ML, Rönnblom L, Syvänen AC, Gunnarsson I, Nordmark G.

PLoS One. 2013 Dec 27;8(12):e84450. doi: 10.1371/journal.pone.0084450. eCollection 2013.

27.

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL.

Nat Genet. 2013 Nov;45(11):1284-92. doi: 10.1038/ng.2792. Epub 2013 Oct 6.

28.

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia.

Nordlund J, Bäcklin CL, Wahlberg P, Busche S, Berglund EC, Eloranta ML, Flaegstad T, Forestier E, Frost BM, Harila-Saari A, Heyman M, Jónsson OG, Larsson R, Palle J, Rönnblom L, Schmiegelow K, Sinnett D, Söderhäll S, Pastinen T, Gustafsson MG, Lönnerholm G, Syvänen AC.

Genome Biol. 2013 Sep 24;14(9):r105. doi: 10.1186/gb-2013-14-9-r105.

29.

Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.

Hagberg N, Theorell J, Schlums H, Eloranta ML, Bryceson YT, Rönnblom L.

J Immunol. 2013 Sep 15;191(6):2989-98. doi: 10.4049/jimmunol.1301022. Epub 2013 Aug 16.

30.

Association of genes in the NF-κB pathway with antibody-positive primary Sjögren's syndrome.

Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad-d'Elia H, Jazebi H, Sjöwall C, Reksten TR, Brun JG, Jonsson MV, Johnsen SJ, Wahren-Herlenius M, Omdal R, Jonsson R, Bowman S, Ng WF, Eloranta ML, Syvänen AC; UK Primary Sjögren’s Syndrome Registry.

Scand J Immunol. 2013 Nov;78(5):447-54. doi: 10.1111/sji.12101.

31.

NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.

Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d'Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Rönnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X.

Sci Transl Med. 2013 Jul 24;5(195):195ra96. doi: 10.1126/scitranslmed.3005727.

32.

Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus.

Hagberg N, Theorell J, Eloranta ML, Pascal V, Bryceson YT, Rönnblom L.

Rheumatology (Oxford). 2013 Oct;52(10):1818-23. doi: 10.1093/rheumatology/ket220. Epub 2013 Jul 3.

PMID:
23825044
33.

Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis.

Balboni I, Niewold TB, Morgan G, Limb C, Eloranta ML, Rönnblom L, Utz PJ, Pachman LM.

Arthritis Rheum. 2013 Sep;65(9):2424-9. doi: 10.1002/art.38038.

34.

Reply: To PMID 22736048.

Eloranta ML, Rönnblom L.

Arthritis Rheum. 2013 Aug;65(8):2216. doi: 10.1002/art.38003. No abstract available.

35.

Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants.

Leonard D, Svenungsson E, Sandling JK, Berggren O, Jönsen A, Bengtsson C, Wang C, Jensen-Urstad K, Granstam SO, Bengtsson AA, Gustafsson JT, Gunnarsson I, Rantapää-Dahlqvist S, Nordmark G, Eloranta ML, Syvänen AC, Rönnblom L.

Circ Cardiovasc Genet. 2013 Jun;6(3):255-63. doi: 10.1161/CIRCGENETICS.113.000044. Epub 2013 May 9.

PMID:
23661672
36.

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility.

Wang C, Ahlford A, Laxman N, Nordmark G, Eloranta ML, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Truedsson L, Rantapää-Dahlqvist S, Sjöwall C, Sandling JK, Rönnblom L, Syvänen AC.

Genes Immun. 2013 Jun;14(4):217-22. doi: 10.1038/gene.2013.9. Epub 2013 Mar 28.

PMID:
23535865
37.

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Rönnblom L, Michel F, Pellegrini S.

J Immunol. 2013 Mar 1;190(5):2335-44. doi: 10.4049/jimmunol.1203118. Epub 2013 Jan 28.

38.

RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.

Stone RC, Du P, Feng D, Dhawan K, Rönnblom L, Eloranta ML, Donnelly R, Barnes BJ.

PLoS One. 2013;8(1):e54487. doi: 10.1371/journal.pone.0054487. Epub 2013 Jan 18.

39.

Disease mechanisms in rheumatology--tools and pathways: plasmacytoid dendritic cells and their role in autoimmune rheumatic diseases.

Eloranta ML, Alm GV, Rönnblom L.

Arthritis Rheum. 2013 Apr;65(4):853-63. doi: 10.1002/art.37821. Review. No abstract available.

40.

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations.

Wang C, Ahlford A, Järvinen TM, Nordmark G, Eloranta ML, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Truedsson L, Eriksson C, Rantapää-Dahlqvist S, Sjöwall C, Julkunen H, Criswell LA, Graham RR, Behrens TW, Kere J, Rönnblom L, Syvänen AC, Sandling JK.

Eur J Hum Genet. 2013 Sep;21(9):994-9. doi: 10.1038/ejhg.2012.277. Epub 2012 Dec 19.

41.

The interferon signature in autoimmune diseases.

Rönnblom L, Eloranta ML.

Curr Opin Rheumatol. 2013 Mar;25(2):248-53. doi: 10.1097/BOR.0b013e32835c7e32. Review.

PMID:
23249830
42.

B lymphocytes enhance interferon-α production by plasmacytoid dendritic cells.

Berggren O, Hagberg N, Weber G, Alm GV, Rönnblom L, Eloranta ML.

Arthritis Rheum. 2012 Oct;64(10):3409-19. doi: 10.1002/art.34599.

43.

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4.

Wang C, Sandling JK, Hagberg N, Berggren O, Sigurdsson S, Karlberg O, Rönnblom L, Eloranta ML, Syvänen AC.

Ann Rheum Dis. 2013 Jan;72(1):96-103. doi: 10.1136/annrheumdis-2012-201364. Epub 2012 Jun 23.

PMID:
22730365
44.

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE.

Ahlin E, Mathsson L, Eloranta ML, Jonsdottir T, Gunnarsson I, Rönnblom L, Rönnelid J.

Lupus. 2012 May;21(6):586-95. doi: 10.1177/0961203311434938. Epub 2012 Feb 2.

PMID:
22300829
45.

Primary Sjögren's syndrome and the type I interferon system.

Nordmark G, Eloranta ML, Ronnblom L.

Curr Pharm Biotechnol. 2012 Aug;13(10):2054-62. Review.

PMID:
22208657
46.

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus.

Jönsen A, Nilsson SC, Ahlqvist E, Svenungsson E, Gunnarsson I, Eriksson KG, Bengtsson A, Zickert A, Eloranta ML, Truedsson L, Rönnblom L, Nordmark G, Sturfelt G, Blom AM.

Arthritis Res Ther. 2011;13(6):R206. doi: 10.1186/ar3539. Epub 2011 Dec 15.

47.

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons.

Stone RC, Feng D, Deng J, Singh S, Yang L, Fitzgerald-Bocarsly P, Eloranta ML, Rönnblom L, Barnes BJ.

Arthritis Rheum. 2012 Mar;64(3):788-98. doi: 10.1002/art.33395.

48.

IFN-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1β and LFA-1.

Hagberg N, Berggren O, Leonard D, Weber G, Bryceson YT, Alm GV, Eloranta ML, Rönnblom L.

J Immunol. 2011 May 1;186(9):5085-94. doi: 10.4049/jimmunol.1003349. Epub 2011 Mar 23.

49.

The type I interferon system in the development of lupus.

Rönnblom L, Alm GV, Eloranta ML.

Semin Immunol. 2011 Apr;23(2):113-21. doi: 10.1016/j.smim.2011.01.009. Epub 2011 Feb 2. Review.

PMID:
21292501
50.

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

Sandling JK, Garnier S, Sigurdsson S, Wang C, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Truedsson L, Eriksson C, Rantapää-Dahlqvist S, Mälarstig A, Strawbridge RJ, Hamsten A, Criswell LA, Graham RR, Behrens TW, Eloranta ML, Alm G, Rönnblom L, Syvänen AC.

Eur J Hum Genet. 2011 Apr;19(4):479-84. doi: 10.1038/ejhg.2010.197. Epub 2010 Dec 22.

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