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Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK.

Mol Metab. 2018 May 23. pii: S2212-8778(18)30014-0. doi: 10.1016/j.molmet.2018.05.015. [Epub ahead of print]


POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels.

Caron A, Dungan Lemko HM, Castorena CM, Fujikawa T, Lee S, Lord CC, Ahmed N, Lee CE, Holland WL, Liu C, Elmquist JK.

Elife. 2018 Mar 12;7. pii: e33710. doi: 10.7554/eLife.33710.


Leptin and brain-adipose crosstalks.

Caron A, Lee S, Elmquist JK, Gautron L.

Nat Rev Neurosci. 2018 Feb 16;19(3):153-165. doi: 10.1038/nrn.2018.7. Review.


Ghrelin mediates exercise endurance and the feeding response post-exercise.

Mani BK, Castorena CM, Osborne-Lawrence S, Vijayaraghavan P, Metzger NP, Elmquist JK, Zigman JM.

Mol Metab. 2018 Mar;9:114-130. doi: 10.1016/j.molmet.2018.01.006. Epub 2018 Jan 31.


Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance.

Mountjoy KG, Caron A, Hubbard K, Shome A, Grey AC, Sun B, Bould S, Middleditch M, Pontré B, McGregor A, Harris PWR, Kowalczyk R, Brimble MA, Botha R, Tan KML, Piper SJ, Buchanan C, Lee S, Coll AP, Elmquist JK.

Mol Metab. 2018 Mar;9:207-216. doi: 10.1016/j.molmet.2017.11.008. Epub 2017 Nov 24.


Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.

Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L.

Mol Metab. 2017 Oct;6(10):1081-1091. doi: 10.1016/j.molmet.2017.07.012. Epub 2017 Aug 4. Review.


Serotonergic Control of Metabolic Homeostasis.

Wyler SC, Lord CC, Lee S, Elmquist JK, Liu C.

Front Cell Neurosci. 2017 Sep 20;11:277. doi: 10.3389/fncel.2017.00277. eCollection 2017. Review.


The hypothalamic regulation of metabolic adaptations to exercise.

Fujikawa T, Castorena CM, Lee S, Elmquist JK.

J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12533. Review.


The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C.

Lord CC, Wyler SC, Wan R, Castorena CM, Ahmed N, Mathew D, Lee S, Liu C, Elmquist JK.

J Clin Invest. 2017 Sep 1;127(9):3402-3406. doi: 10.1172/JCI93362. Epub 2017 Aug 14.


Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice.

Tao C, Holland WL, Wang QA, Shao M, Jia L, Sun K, Lin X, Kuo YC, Johnson JA, Gordillo R, Elmquist JK, Scherer PE.

Endocrinology. 2017 May 1;158(5):1260-1270. doi: 10.1210/en.2017-00024.


An adipo-biliary-uridine axis that regulates energy homeostasis.

Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE.

Science. 2017 Mar 17;355(6330). pii: eaaf5375. doi: 10.1126/science.aaf5375. Epub 2017 Mar 16.


Brain nuclear receptors and body weight regulation.

Xu Y, O'Malley BW, Elmquist JK.

J Clin Invest. 2017 Apr 3;127(4):1172-1180. doi: 10.1172/JCI88891. Epub 2017 Feb 20. Review.


SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise.

Fujikawa T, Castorena CM, Pearson M, Kusminski CM, Ahmed N, Battiprolu PK, Kim KW, Lee S, Hill JA, Scherer PE, Holland WL, Elmquist JK.

Elife. 2016 Nov 22;5. pii: e18206. doi: 10.7554/eLife.18206.


Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons.

Sohn JW, Oh Y, Kim KW, Lee S, Williams KW, Elmquist JK.

Mol Metab. 2016 Jun 14;5(8):669-679. doi: 10.1016/j.molmet.2016.06.004. eCollection 2016 Aug.


Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE.

Cell Metab. 2016 Sep 13;24(3):420-433. doi: 10.1016/j.cmet.2016.08.005.


Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination.

Lee J, Yang DJ, Lee S, Hammer GD, Kim KW, Elmquist JK.

Sci Rep. 2016 Jan 11;6:19143. doi: 10.1038/srep19143.


Development of neuroendocrine systems governing energy homeostasis.

Elmquist JK.

Front Neuroendocrinol. 2015 Oct;39:1-2. doi: 10.1016/j.yfrne.2015.11.002. Epub 2015 Nov 30. No abstract available.


Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.

Mansuy-Aubert V, Gautron L, Lee S, Bookout AL, Kusminski C, Sun K, Zhang Y, Scherer PE, Mangelsdorf DJ, Elmquist JK.

Elife. 2015 Jun 15;4. doi: 10.7554/eLife.06667.


A neural basis for melanocortin-4 receptor-regulated appetite.

Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB.

Nat Neurosci. 2015 Jun;18(6):863-71. doi: 10.1038/nn.4011. Epub 2015 Apr 27.


Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice.

Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO Jr, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y.

Br J Pharmacol. 2015 Jul;172(14):3510-21. doi: 10.1111/bph.13141. Epub 2015 May 11.


Neural control of energy balance: translating circuits to therapies.

Gautron L, Elmquist JK, Williams KW.

Cell. 2015 Mar 26;161(1):133-145. doi: 10.1016/j.cell.2015.02.023. Review.


Hypothalamic POMC neurons promote cannabinoid-induced feeding.

Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL.

Nature. 2015 Mar 5;519(7541):45-50. doi: 10.1038/nature14260. Epub 2015 Feb 18.


Leptin mediates the increase in blood pressure associated with obesity.

Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG Jr, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS, Cowley MA.

Cell. 2014 Dec 4;159(6):1404-16. doi: 10.1016/j.cell.2014.10.058.


Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.

Kohno D, Lee S, Harper MJ, Kim KW, Sone H, Sasaki T, Kitamura T, Fan G, Elmquist JK.

J Neurosci. 2014 Nov 12;34(46):15288-96. doi: 10.1523/JNEUROSCI.1316-14.2014.


Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47. doi: 10.1152/ajpregu.00131.2014. Epub 2014 Oct 22.


MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.

Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13193-8. doi: 10.1073/pnas.1407843111. Epub 2014 Aug 25.


Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.

Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK.

Cell Metab. 2014 Sep 2;20(3):471-82. doi: 10.1016/j.cmet.2014.06.002. Epub 2014 Jul 10.


Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.

Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK.

Nat Neurosci. 2014 Jul;17(7):911-3. doi: 10.1038/nn.3737. Epub 2014 Jun 8.


Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance.

Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK.

Nat Commun. 2014 May 12;5:3878. doi: 10.1038/ncomms4878.


PPARγ in vagal neurons regulates high-fat diet induced thermogenesis.

Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK.

Cell Metab. 2014 Apr 1;19(4):722-30. doi: 10.1016/j.cmet.2014.01.021.


Circuits controlling energy balance and mood: inherently intertwined or just complicated intersections?

Liu C, Lee S, Elmquist JK.

Cell Metab. 2014 Jun 3;19(6):902-9. doi: 10.1016/j.cmet.2014.02.008. Epub 2014 Mar 13. Review.


Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice.

Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE.

Diabetologia. 2014 Jun;57(6):1209-18. doi: 10.1007/s00125-014-3210-3. Epub 2014 Mar 13.


Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.

Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM.

Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb.


Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK.

J Clin Invest. 2013 Dec;123(12):5061-70. doi: 10.1172/JCI70338. Epub 2013 Nov 1. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1868. Dosage error in article text.


Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R.

Cell Metab. 2013 Sep 3;18(3):431-44. doi: 10.1016/j.cmet.2013.08.004.


Mrap2: an accessory protein linked to obesity.

Liu T, Elmquist JK, Williams KW.

Cell Metab. 2013 Sep 3;18(3):309-11. doi: 10.1016/j.cmet.2013.08.016.


FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA.

Nat Med. 2013 Sep;19(9):1147-52. doi: 10.1038/nm.3249. Epub 2013 Aug 11.


Neuronal circuits that regulate feeding behavior and metabolism.

Sohn JW, Elmquist JK, Williams KW.

Trends Neurosci. 2013 Sep;36(9):504-12. doi: 10.1016/j.tins.2013.05.003. Epub 2013 Jun 19. Review.


Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.

Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y, Elmquist JK.

J Comp Neurol. 2013 Nov;521(16):3741-67. doi: 10.1002/cne.23376.


Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.

Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2013 Apr;27(4):598-605. doi: 10.1210/me.2012-1371. Epub 2013 Mar 15.


Discrete melanocortin-sensitive neuroanatomical pathway linking the ventral premmamillary nucleus to the paraventricular hypothalamus.

Gautron L, Cravo RM, Elmquist JK, Elias CF.

Neuroscience. 2013 Jun 14;240:70-82. doi: 10.1016/j.neuroscience.2013.02.024. Epub 2013 Feb 26.


Shift in Kiss1 cell activity requires estrogen receptor α.

Frazão R, Cravo RM, Donato J Jr, Ratra DV, Clegg DJ, Elmquist JK, Zigman JM, Williams KW, Elias CF.

J Neurosci. 2013 Feb 13;33(7):2807-20. doi: 10.1523/JNEUROSCI.1610-12.2013.


Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.

Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK.

Cell. 2013 Jan 31;152(3):612-9. doi: 10.1016/j.cell.2012.12.022.


Adipose tissue biology and cardiomyopathy: translational implications.

Turer AT, Hill JA, Elmquist JK, Scherer PE.

Circ Res. 2012 Dec 7;111(12):1565-77. doi: 10.1161/CIRCRESAHA.111.262493. Review.


Tipping the scales early: probing the long-term effects of obesity.

Liu C, Elmquist JK.

J Clin Invest. 2012 Nov;122(11):3840-2. doi: 10.1172/JCI66409. Epub 2012 Oct 24.


From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior.

Williams KW, Elmquist JK.

Nat Neurosci. 2012 Oct;15(10):1350-5. doi: 10.1038/nn.3217. Epub 2012 Sep 25. Review.


The cover. Neuroendocrine and endocrine pathways of obesity.

Elmquist JK, Scherer PE.

JAMA. 2012 Sep 19;308(11):1070-1. No abstract available.


Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

Scott MM, Perello M, Chuang JC, Sakata I, Gautron L, Lee CE, Lauzon D, Elmquist JK, Zigman JM.

PLoS One. 2012;7(8):e44089. doi: 10.1371/journal.pone.0044089. Epub 2012 Aug 31.


Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.

Vianna CR, Donato J Jr, Rossi J, Scott M, Economides K, Gautron L, Pierpont S, Elias CF, Elmquist JK.

J Neurosci. 2012 Jul 25;32(30):10331-7. doi: 10.1523/JNEUROSCI.4507-11.2012.


FOXO1 in the ventromedial hypothalamus regulates energy balance.

Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK.

J Clin Invest. 2012 Jul;122(7):2578-89. doi: 10.1172/JCI62848. Epub 2012 Jun 1.

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