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Items: 1 to 50 of 81

1.

Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions.

Elmaleh DR, Farlow MR, Conti PS, Tompkins RG, Kundakovic L, Tanzi RE.

J Alzheimers Dis. 2019;71(3):715-732. doi: 10.3233/JAD-190507. Review.

2.

Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis.

Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE.

Sci Rep. 2018 Jan 18;8(1):1144. doi: 10.1038/s41598-018-19641-2.

3.

Pharmacokinetics of Cromolyn and Ibuprofen in Healthy Elderly Volunteers.

Brazier D, Perry R, Keane J, Barrett K, Elmaleh DR.

Clin Drug Investig. 2017 Nov;37(11):1025-1034. doi: 10.1007/s40261-017-0549-5.

4.

A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.

Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E.

J Biol Chem. 2015 Jan 23;290(4):1966-78. doi: 10.1074/jbc.M114.586602. Epub 2014 Dec 2.

5.

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.

Tian Y, Zhang X, Li Y, Shoup TM, Teng X, Elmaleh DR, Moore A, Ran C.

Chem Commun (Camb). 2014 Dec 25;50(99):15792-5. doi: 10.1039/c4cc06029f. Epub 2014 Nov 5.

6.

Membrane potential-dependent uptake of 18F-triphenylphosphonium--a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.

Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ.

J Surg Res. 2014 May 15;188(2):473-9. doi: 10.1016/j.jss.2014.01.011. Epub 2014 Jan 11.

7.

Mannose-binding lectin binds to amyloid β protein and modulates inflammation.

Larvie M, Shoup T, Chang WC, Chigweshe L, Hartshorn K, White MR, Stahl GL, Elmaleh DR, Takahashi K.

J Biomed Biotechnol. 2012;2012:929803. doi: 10.1155/2012/929803. Epub 2012 Mar 27.

8.

4-[18F]-tetraphenylphosphonium as a PET tracer for myocardial mitochondrial membrane potential.

Gurm GS, Danik SB, Shoup TM, Weise S, Takahashi K, Laferrier S, Elmaleh DR, Gewirtz H.

JACC Cardiovasc Imaging. 2012 Mar;5(3):285-92. doi: 10.1016/j.jcmg.2011.11.017.

9.

Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET.

Shoup TM, Elmaleh DR, Brownell AL, Zhu A, Guerrero JL, Fischman AJ.

Mol Imaging Biol. 2011 Jun;13(3):511-517. doi: 10.1007/s11307-010-0349-2.

PMID:
20563755
10.

Imaging amyloid deposition in Lewy body diseases.

Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA.

Neurology. 2008 Sep 16;71(12):903-10. doi: 10.1212/01.wnl.0000326146.60732.d6.

11.

Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography.

Elmaleh DR, Fischman AJ, Tawakol A, Zhu A, Shoup TM, Hoffmann U, Brownell AL, Zamecnik PC.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15992-6. Epub 2006 Oct 12.

12.

Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.

Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ.

J Pharmacol Exp Ther. 2006 Nov;319(2):570-85. Epub 2006 Aug 2.

PMID:
16885433
13.

Anti-viral activity of human antithrombin III.

Elmaleh DR, Brown NV, Geiben-Lynn R.

Int J Mol Med. 2005 Aug;16(2):191-200.

PMID:
16012749
14.
15.

Novel (bisarylmethoxy)butylpiperidine analogues as neurotransmitter transporter inhibitors with activity at dopamine receptor sites.

Choi SW, Elmaleh DR, Hanson RN, Shoup TM, Fischman AJ.

Bioorg Med Chem. 2002 Dec;10(12):4091-102.

PMID:
12413863
16.

Novel monoamine transporter ligands reduce cocaine-induced enhancement of brain stimulation reward.

Trzcińska M, Pimentel P, Stellar JR, Hanson RN, Choi SW, Elmaleh DR, Zhang J, Prakash KR, Tamiz AP, Kozikowski AP, Johnson KM, Smith MP, Babich JW.

Pharmacol Biochem Behav. 2001 Jan;68(1):171-80.

PMID:
11274722
19.

Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease.

Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O.

Nat Med. 1998 Nov;4(11):1308-12.

PMID:
9809556
20.

Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters.

Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK.

Synapse. 1998 Jun;29(2):128-41.

PMID:
9593103
21.

Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain.

Madras BK, Gracz LM, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ.

Synapse. 1998 Jun;29(2):105-15.

PMID:
9593101
22.

Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.

Madras BK, Meltzer PC, Liang AY, Elmaleh DR, Babich J, Fischman AJ.

Synapse. 1998 Jun;29(2):93-104.

PMID:
9593100
23.

Rapid noninvasive detection of experimental atherosclerotic lesions with novel 99mTc-labeled diadenosine tetraphosphates.

Elmaleh DR, Narula J, Babich JW, Petrov A, Fischman AJ, Khaw BA, Rapaport E, Zamecnik PC.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):691-5.

24.

SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys.

Fischman AJ, Babich JW, Elmaleh DR, Barrow SA, Meltzer P, Hanson RN, Madras BK.

J Nucl Med. 1997 Jan;38(1):144-50.

25.

Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.

Fischman AJ, Bonab AA, Babich JW, Alpert NM, Rauch SL, Elmaleh DR, Shoup TM, Williams SA, Rubin RH.

J Pharmacol Exp Ther. 1996 Nov;279(2):939-47.

PMID:
8930203
26.

Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.

Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK.

J Nucl Med. 1996 Jul;37(7):1197-202.

27.

Cocaine congeners as PET imaging probes for dopamine terminals.

Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK.

J Nucl Med. 1996 Jul;37(7):1186-92.

28.

Effect of monounsaturation of a branched fatty acid on organ selectivity.

Zaknun J, Elmaleh DR, Guan JH, Fischman AJ.

J Nucl Med. 1995 Nov;36(11):2062-8.

29.

The use of pentafluorophenyl derivatives for the 18F labelling of proteins.

Herman LW, Fischman AJ, Tompkins RG, Hanson RN, Byon C, Strauss HW, Elmaleh DR.

Nucl Med Biol. 1994 Oct;21(7):1005-10.

PMID:
9234356
30.

Synthesis of fluorine-18-labeled biotin derivatives: biodistribution and infection localization.

Shoup TM, Fischman AJ, Jaywook S, Babich JW, Strauss HW, Elmaleh DR.

J Nucl Med. 1994 Oct;35(10):1685-90.

31.

Synthesis of 2-[18F]fluoro-2-deoxy-L-glucose and positron emission tomography studies in monkeys.

Meng J, Elmaleh DR, Jyawook S, Weiss S, Alpert NM, Babich JW, Tompkins RG, Fischman AJ.

Nucl Med Biol. 1994 May;21(4):633-40.

PMID:
9234321
32.

Myocardial extraction of 1-[11C] betamethylheptadecanoic acid.

Elmaleh DR, Livni E, Alpert NM, Strauss HW, Buxton R, Fischman AJ.

J Nucl Med. 1994 Mar;35(3):496-503.

33.

Synthesis and biodistribution of a new 99mtechnetium fatty acid.

Jones GS Jr, Elmaleh DR, Strauss HW, Fischman AJ.

Nucl Med Biol. 1994 Jan;21(1):117-23.

PMID:
9234273
34.

PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates.

Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al.

Exp Neurol. 1994 Jan;125(1):41-51.

PMID:
7905836
35.

Positron emission tomography of cocaine binding sites on the dopamine transporter.

Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL.

NIDA Res Monogr. 1994;138:57-69. Review. No abstract available.

PMID:
7603545
36.

Myocardial substrate utilization and left ventricular function in adriamycin cardiomyopathy.

Wakasugi S, Fischman AJ, Babich JW, Callahan RJ, Elmaleh DR, Wilkinson R, Strauss HW.

J Nucl Med. 1993 Sep;34(9):1529-35.

37.

Serial course of left ventricular function, perfusion and fatty acid uptake in the cardiomyopathic hamster.

Nakai K, Ahmad M, Nakaki M, Wilkinson R, Callahan RJ, Elmaleh DR, Fischman AJ, Strauss HW.

J Nucl Med. 1993 Aug;34(8):1309-15.

38.

Synthesis and evaluation of 1-[11C]methyl-4-aryl-piperazinium salts as myocardial imaging agents.

Elmaleh DR, Padmanabhan S, Hassan MA, Correia JA, Herman LW, Hanson RN, Strauss HW.

Nucl Med Biol. 1993 May;20(4):427-33.

PMID:
8504285
39.

Structure-localization relationships of 11C-labeled phentermine derivatives: effect of aromatic substitution.

Elmaleh DR, Kizuka H, Hanson RN, Jones GS Jr, Herman LW, Strauss HW.

Appl Radiat Isot. 1993 May;44(5):821-9.

PMID:
8485509
40.
42.

Synthesis of 18F-labeled fluconazole and positron emission tomography studies in rabbits.

Livni E, Fischman AJ, Ray S, Sinclair I, Elmaleh DR, Alpert NM, Weiss S, Correia JA, Webb D, Dahl R, et al.

Int J Rad Appl Instrum B. 1992 Feb;19(2):191-9.

PMID:
1601672
43.

A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures.

Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O.

Cell Transplant. 1992;1(4):313-22.

PMID:
1344304
44.

Pharmacokinetics of 18F-labeled fluconazole in rabbits with candidal infections studied with positron emission tomography.

Fischman AJ, Alpert NM, Livni E, Ray S, Sinclair I, Elmaleh DR, Weiss S, Correia JA, Webb D, Liss R, et al.

J Pharmacol Exp Ther. 1991 Dec;259(3):1351-9.

PMID:
1762083
45.

Enhanced in vitro uptake and retention of 3H-tetraphenylphosphonium by nervous system tumor cells.

Steichen JD, Weiss MJ, Elmaleh DR, Martuza RL.

J Neurosurg. 1991 Jan;74(1):116-22.

PMID:
1984490
46.

(3H/14C)beta-methylheptadecanoic acid subcellular distribution and lipid incorporation in mouse heart.

Livni E, Ito S, Kassis AI, Elmaleh DR.

Lipids. 1990 Apr;25(4):238-40.

PMID:
2345498
47.

Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.

Miller DD, Gill JB, Livni E, Elmaleh DR, Aretz T, Boucher CA, Strauss HW.

Circ Res. 1988 Oct;63(4):681-92.

PMID:
3048774
48.

Synthesis and biologic evaluation of 1-[11C]-3,3-dimethylheptadecanoic acid.

Jones GS Jr, Livni E, Strauss HW, Hanson RN, Elmaleh DR.

J Nucl Med. 1988 Jan;29(1):68-72.

49.

Comparative evaluation of [123I]14-p-iodophenyl-beta-methyltetradecanoic acid and thallium-201 in the detection of infarcted areas in the dog heart using SPECT.

Kairento AL, Livni E, Mattila S, Harjula A, Porkka L, Lindroth L, Elmaleh DR.

Int J Rad Appl Instrum B. 1988;15(3):333-8.

PMID:
3260230
50.

Hepatobiliary MR contrast agents: 5-substituted iron-EHPG derivatives.

Lauffer RB, Vincent AC, Padmanabhan S, Villringer A, Saini S, Elmaleh DR, Brady TJ.

Magn Reson Med. 1987 Jun;4(6):582-90.

PMID:
3613958

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