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Items: 34


The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.

Aki D, Li H, Zhang W, Zheng M, Elly C, Lee JH, Zou W, Liu YC.

Nat Immunol. 2018 Jul;19(7):766-775. doi: 10.1038/s41590-018-0137-8. Epub 2018 Jun 20.


E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, Zou L, Elly C, Lee JH, Liu YC.

Immunity. 2018 Feb 20;48(2):258-270.e5. doi: 10.1016/j.immuni.2017.12.013. Epub 2018 Feb 13.


SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex.

Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC.

Nat Immunol. 2016 Mar;17(3):286-96. doi: 10.1038/ni.3352. Epub 2016 Feb 1.


Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.


E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.

Lee JH, Elly C, Park Y, Liu YC.

Immunity. 2015 Jun 16;42(6):1062-74. doi: 10.1016/j.immuni.2015.05.016.


The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.

Xiao N, Eto D, Elly C, Peng G, Crotty S, Liu YC.

Nat Immunol. 2014 Jul;15(7):657-66. doi: 10.1038/ni.2912. Epub 2014 May 25.


TSC1 regulates the balance between effector and regulatory T cells.

Park Y, Jin HS, Lopez J, Elly C, Kim G, Murai M, Kronenberg M, Liu YC.

J Clin Invest. 2013 Dec;123(12):5165-78. doi: 10.1172/JCI69751. Epub 2013 Nov 25.


Itch expression by Treg cells controls Th2 inflammatory responses.

Jin HS, Park Y, Elly C, Liu YC.

J Clin Invest. 2013 Nov;123(11):4923-34. doi: 10.1172/JCI69355. Epub 2013 Oct 25.


K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling.

Huang H, Jeon MS, Liao L, Yang C, Elly C, Yates JR 3rd, Liu YC.

Immunity. 2010 Jul 23;33(1):60-70. doi: 10.1016/j.immuni.2010.07.002. Erratum in: Immunity. 2010 Nov 24;33(5):830.


Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.

Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC.

J Exp Med. 2010 Jul 5;207(7):1381-91. doi: 10.1084/jem.20100004. Epub 2010 May 3.


Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.

Kojo S, Elly C, Harada Y, Langdon WY, Kronenberg M, Liu YC.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17847-51. doi: 10.1073/pnas.0904078106. Epub 2009 Oct 7.


The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.

Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC.

Nat Immunol. 2008 Mar;9(3):245-53. doi: 10.1038/ni1564. Epub 2008 Feb 17.


Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation.

Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC.

J Clin Invest. 2006 Apr;116(4):1117-26. Epub 2006 Mar 23.


Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.

Bai Y, Yang C, Hu K, Elly C, Liu YC.

Mol Cell. 2004 Sep 10;15(5):825-31.


Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, Bloom D, Fathman CG, Liu YC, Penninger JM.

Immunity. 2004 Aug;21(2):167-77.


Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.

Shao Y, Yang C, Elly C, Liu YC.

J Biol Chem. 2004 Oct 15;279(42):43646-53. Epub 2004 Aug 10.


Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.

Shao Y, Elly C, Liu YC.

EMBO Rep. 2003 Apr;4(4):425-31.


Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity.

Kaminuma O, Elly C, Tanaka Y, Mori A, Liu YC, Altman A, Miyatake S.

FEBS Lett. 2002 Mar 13;514(2-3):153-8.


Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

Fang D, Elly C, Gao B, Fang N, Altman Y, Joazeiro C, Hunter T, Copeland N, Jenkins N, Liu YC.

Nat Immunol. 2002 Mar;3(3):281-7. Epub 2002 Feb 4.


Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

Wang HY, Altman Y, Fang D, Elly C, Dai Y, Shao Y, Liu YC.

J Biol Chem. 2001 Jul 13;276(28):26004-11. Epub 2001 May 15.


Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC.

J Biol Chem. 2001 Feb 16;276(7):4872-8. Epub 2000 Nov 21.


Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.

Qiu L, Joazeiro C, Fang N, Wang HY, Elly C, Altman Y, Fang D, Hunter T, Liu YC.

J Biol Chem. 2000 Nov 17;275(46):35734-7.


Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.

Liu Y, Witte S, Liu YC, Doyle M, Elly C, Altman A.

J Biol Chem. 2000 Feb 4;275(5):3603-9.


Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.

Liu Y, Liu YC, Meller N, Giampa L, Elly C, Doyle M, Altman A.

J Immunol. 1999 Jun 15;162(12):7095-101.


Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC.

Oncogene. 1999 Feb 4;18(5):1147-56.


Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.

Zhang Z, Elly C, Altman A, Liu YC.

J Biol Chem. 1999 Feb 19;274(8):4883-9.


Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

Deckert M, Elly C, Altman A, Liu YC.

J Biol Chem. 1998 Apr 10;273(15):8867-74.


Activation-modulated association of 14-3-3 proteins with Cbl in T cells.

Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A.

J Biol Chem. 1996 Jun 14;271(24):14591-5.


Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.

Bonnefoy-Bérard N, Liu YC, von Willebrand M, Sung A, Elly C, Mustelin T, Yoshida H, Ishizaka K, Altman A.

Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10142-6.


Requirement of posttranslational modifications for the generation of biologic activity of glycosylation-inhibiting factor.

Liu YC, Nakano T, Elly C, Ishizaka K.

Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11227-31.

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