Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 58

1.

A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants.

Kingsmore SF, Cakici JA, Clark MM, Gaughran M, Feddock M, Batalov S, Bainbridge MN, Carroll J, Caylor SA, Clarke C, Ding Y, Ellsworth K, Farnaes L, Hildreth A, Hobbs C, James K, Kint CI, Lenberg J, Nahas S, Prince L, Reyes I, Salz L, Sanford E, Schols P, Sweeney N, Tokita M, Veeraraghavan N, Watkins K, Wigby K, Wong T, Chowdhury S, Wright MS, Dimmock D; RCIGM Investigators.

Am J Hum Genet. 2019 Oct 3;105(4):719-733. doi: 10.1016/j.ajhg.2019.08.009. Epub 2019 Sep 26.

PMID:
31564432
2.

Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation.

Clark MM, Hildreth A, Batalov S, Ding Y, Chowdhury S, Watkins K, Ellsworth K, Camp B, Kint CI, Yacoubian C, Farnaes L, Bainbridge MN, Beebe C, Braun JJA, Bray M, Carroll J, Cakici JA, Caylor SA, Clarke C, Creed MP, Friedman J, Frith A, Gain R, Gaughran M, George S, Gilmer S, Gleeson J, Gore J, Grunenwald H, Hovey RL, Janes ML, Lin K, McDonagh PD, McBride K, Mulrooney P, Nahas S, Oh D, Oriol A, Puckett L, Rady Z, Reese MG, Ryu J, Salz L, Sanford E, Stewart L, Sweeney N, Tokita M, Van Der Kraan L, White S, Wigby K, Williams B, Wong T, Wright MS, Yamada C, Schols P, Reynders J, Hall K, Dimmock D, Veeraraghavan N, Defay T, Kingsmore SF.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaat6177. doi: 10.1126/scitranslmed.aat6177.

PMID:
31019026
3.

Birth Size and Gestational Age Specific Outcomes of Inhaled Nitric Oxide Therapy in Preterm Neonates with Clinically Diagnosed Pulmonary Hypertension.

Udland CJ, Carey WA, Weaver AL, Mara KC, Clark RH, Ellsworth KR.

Am J Perinatol. 2019 Jan 23. doi: 10.1055/s-0039-1677799. [Epub ahead of print]

PMID:
30674051
4.

Potential Benefits of Inhaled Nitric Oxide in Pulmonary Hypertension With Hypoplasia in Premature Neonates-Reply.

Ellsworth KR, Weaver AL, Carey WA.

JAMA Pediatr. 2018 Nov 1;172(11):1103-1104. doi: 10.1001/jamapediatrics.2018.2895. No abstract available.

PMID:
30242326
5.

Unilateral Phrenic Nerve Palsy in Infants with Congenital Zika Syndrome.

Rajapakse NS, Ellsworth K, Liesman RM, Ho ML, Henry N, Theel ES, Wallace A, Alvino ACI, Medeiros de Mello L, Meneses J.

Emerg Infect Dis. 2018 Aug;24(8). doi: 10.3201/eid2408.180057.

6.

Association of Early Inhaled Nitric Oxide With the Survival of Preterm Neonates With Pulmonary Hypoplasia.

Ellsworth KR, Ellsworth MA, Weaver AL, Mara KC, Clark RH, Carey WA.

JAMA Pediatr. 2018 Jul 2;172(7):e180761. doi: 10.1001/jamapediatrics.2018.0761. Epub 2018 Jul 2.

7.

Survey of Nutrition Management Practices in Centers for Pediatric Intestinal Rehabilitation.

Nucci AM, Ellsworth K, Michalski A, Nagel E, Wessel J; ASPEN Pediatric Intestinal Failure Section.

Nutr Clin Pract. 2018 Aug;33(4):528-538. doi: 10.1177/0884533617719670. Epub 2017 Dec 18.

PMID:
28731841
8.

Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.

Wang X, Kurowski S, Wu W, Castriota GA, Zhou X, Chu L, Ellsworth KP, Chu D, Edmondson S, Ali A, Andre P, Seiffert D, Erion M, Gutstein DE, Chen Z.

J Pharmacol Exp Ther. 2017 Mar;360(3):476-483. doi: 10.1124/jpet.116.238600. Epub 2016 Dec 29.

PMID:
28035007
9.
10.

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

Zhang T, Liu Y, Yang X, Martin GE, Yao H, Shang J, Bugianesi RM, Ellsworth KP, Sonatore LM, Nizner P, Sherer EC, Hill SE, Knemeyer IW, Geissler WM, Dandliker PJ, Helmy R, Wood HB.

J Med Chem. 2016 Mar 10;59(5):1818-29. doi: 10.1021/acs.jmedchem.5b01293. Epub 2016 Feb 22.

PMID:
26871940
11.

Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Natural Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum.

Clark TN, Ellsworth KT, Jean S, Webster D, Robichaud GA, Johnson JA, Gray CA.

Nat Prod Commun. 2015 Oct;10(10):1647-8. Erratum in: Nat Prod Commun. 2015 Nov;10(11):2017. Webste, Duncan [corrected to Webster, Duncan].

PMID:
26669094
12.

Development of a novel tricyclic class of potent and selective FIXa inhibitors.

Meng D, Andre P, Bateman TJ, Berger R, Chen YH, Desai K, Dewnani S, Ellsworth K, Feng D, Geissler WM, Guo L, Hruza A, Jian T, Li H, Metzger J, Parker DL, Reichert P, Sherer EC, Smith CJ, Sonatore LM, Tschirret-Guth R, Wu J, Xu J, Zhang T, Campeau LC, Orr R, Poirier M, McCabe-Dunn J, Araki K, Nishimura T, Sakurada I, Hirabayashi T, Wood HB.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5437-43. doi: 10.1016/j.bmcl.2015.07.078. Epub 2015 Jul 31.

PMID:
26318999
13.

Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.

Chobanian HR, Pio B, Guo Y, Shen H, Huffman MA, Madeira M, Salituro G, Terebetski JL, Ormes J, Jochnowitz N, Hoos L, Zhou Y, Lewis D, Hawes B, Mitnaul L, O'Neill K, Ellsworth K, Wang L, Biftu T, Duffy JL.

ACS Med Chem Lett. 2015 Mar 13;6(5):553-7. doi: 10.1021/acsmedchemlett.5b00047. eCollection 2015 May 14.

14.

Development of a novel class of potent and selective FIXa inhibitors.

Zhang T, Andre P, Bateman TJ, Chen YH, Desai K, Ellsworth K, Geissler WM, Guo L, Hruza A, Jian T, Meng D, Parker DL Jr, Qian X, Reichert P, Sherer EC, Shu M, Smith CJ, Sonatore LM, Tschirret-Guth R, Nolting AF, Orr R, Campeau LC, Araki K, Nishimura T, Sakurada I, Wood HB.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4945-4949. doi: 10.1016/j.bmcl.2015.04.057. Epub 2015 Apr 29.

PMID:
25978966
15.

Rapid development of two factor IXa inhibitors from hit to lead.

Parker DL Jr, Walsh S, Li B, Kim E, Sharipour A, Smith C, Chen YH, Berger R, Harper B, Zhang T, Park M, Shu M, Wu J, Xu J, Dewnani S, Sherer EC, Hruza A, Reichert P, Geissler W, Sonatore L, Ellsworth K, Balkovec J, Greenlee W, Wood HB.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2321-5. doi: 10.1016/j.bmcl.2015.04.025. Epub 2015 Apr 13.

PMID:
25937013
16.

Isolation of the plant hormone (+)-abscisic acid as an antimycobacterial constituent of the medicinal plant endophyte Nigrospora sp.

Clark TN, Ellsworth K, Li H, Johnson JA, Gray CA.

Nat Prod Commun. 2013 Dec;8(12):1673-4.

PMID:
24555269
17.

Macroalgal Endophytes from the Atlantic Coast of Canada: A Potential Source of Antibiotic Natural Products?

Flewelling AJ, Ellsworth KT, Sanford J, Forward E, Johnson JA, Gray CA.

Microorganisms. 2013 Dec 13;1(1):175-187.

18.

Isolation and bioassay screening of medicinal plant endophytes from eastern Canada.

Ellsworth KT, Clark TN, Gray CA, Johnson JA.

Can J Microbiol. 2013 Nov;59(11):761-5. doi: 10.1139/cjm-2013-0639. Epub 2013 Oct 15.

PMID:
24206359
19.

Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma.

Ellsworth KA, Eckloff BW, Li L, Moon I, Fridley BL, Jenkins GD, Carlson E, Brisbin A, Abo R, Bamlet W, Petersen G, Wieben ED, Wang L.

PLoS One. 2013 Aug 1;8(8):e70216. doi: 10.1371/journal.pone.0070216. Print 2013.

20.

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.

Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A, Biernacka JM, Abo R, Brisbin A, Ji Y, Hebbring S, Wieben ED, Mrazek DA, Weinshilboum RM, Wang L.

Pharmacogenet Genomics. 2013 Mar;23(3):156-66. doi: 10.1097/FPC.0b013e32835dc133.

21.

Localization of association signal from risk and protective variants in sequencing studies.

Brisbin A, Jenkins GD, Ellsworth KA, Wang L, Fridley BL.

Front Genet. 2012 Sep 6;3:173. doi: 10.3389/fgene.2012.00173. eCollection 2012.

22.

α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.

Liu Y, Hu J, Wu J, Zhu C, Hui Y, Han Y, Huang Z, Ellsworth K, Fan W.

J Neuroinflammation. 2012 May 24;9:98. doi: 10.1186/1742-2094-9-98.

23.

Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices.

Kimura R, Ma LY, Wu C, Turner D, Shen JX, Ellsworth K, Wakui M, Maalouf M, Wu J.

CNS Neurosci Ther. 2012 Aug;18(8):641-6. doi: 10.1111/j.1755-5949.2012.00337.x. Epub 2012 May 22.

24.

Synthesis of β-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.

Zhang J, Ellsworth K, Ma PX.

Macromol Rapid Commun. 2012 Apr 23;33(8):664-71. doi: 10.1002/marc.201100814. Epub 2012 Feb 9.

25.

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.

Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5378-83. doi: 10.1073/pnas.1002588108. Epub 2011 Mar 9.

26.

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.

Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA, Doebber TW, Ellsworth KP, Lassman ME, Li C, Wu MS, Zhang BB, Chapman KT, Mills SG, Berger JP, Pasternak A.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6088-92. doi: 10.1016/j.bmcl.2010.08.047. Epub 2010 Aug 20.

PMID:
20832306
27.

RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice.

Yang R, Castriota G, Chen Y, Cleary MA, Ellsworth K, Shin MK, Tran JL, Vogt TF, Wu M, Xu S, Yang X, Zhang BB, Berger JP, Qureshi SA.

Int J Obes (Lond). 2011 Feb;35(2):217-25. doi: 10.1038/ijo.2010.128. Epub 2010 Jul 6.

28.

Hydrophobic pharmaceuticals mediated self-assembly of beta-cyclodextrin containing hydrophilic copolymers: novel chemical responsive nano-vehicles for drug delivery.

Zhang J, Ellsworth K, Ma PX.

J Control Release. 2010 Jul 14;145(2):116-23. doi: 10.1016/j.jconrel.2010.04.019. Epub 2010 Apr 24.

29.

Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors.

Wang L, Ellsworth KA, Moon I, Pelleymounter LL, Eckloff BW, Martin YN, Fridley BL, Jenkins GD, Batzler A, Suman VJ, Ravi S, Dixon JM, Miller WR, Wieben ED, Buzdar A, Weinshilboum RM, Ingle JN.

Cancer Res. 2010 Jan 1;70(1):319-28. doi: 10.1158/0008-5472.CAN-09-3224.

30.

Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.

Zhou HH, Chin CN, Wu M, Ni W, Quan S, Liu F, Dallas-Yang Q, Ellsworth K, Ho T, Zhang A, Natasha T, Li J, Chapman K, Strohl W, Li C, Wang IM, Berger J, An Z, Zhang BB, Jiang G.

Eur J Pharmacol. 2009 Aug 15;616(1-3):346-52. doi: 10.1016/j.ejphar.2009.06.057. Epub 2009 Jul 3.

PMID:
19577557
31.

Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.

Chin CN, Dallas-Yang Q, Liu F, Ho T, Ellsworth K, Fischer P, Natasha T, Ireland C, Lu P, Li C, Wang IM, Strohl W, Berger JP, An Z, Zhang BB, Jiang G.

Eur J Pharmacol. 2009 Mar 15;606(1-3):17-24. doi: 10.1016/j.ejphar.2009.01.016. Epub 2009 Jan 22.

PMID:
19374858
32.

GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas.

Wu J, DeChon J, Xue F, Li G, Ellsworth K, Gao M, Liu Q, Yang K, Zheng C, He P, Tu J, Kim DY, Rho JM, Rekate H, Kerrigan JF, Chang Y.

Exp Neurol. 2008 Oct;213(2):397-404. doi: 10.1016/j.expneurol.2008.07.004. Epub 2008 Jul 15.

33.

alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices.

Wang K, Zheng C, Wu C, Gao M, Liu Q, Yang K, Ellsworth K, Xu L, Wu J.

Neurosci Lett. 2008 Aug 15;441(1):66-71. doi: 10.1016/j.neulet.2008.06.014. Epub 2008 Jun 8.

PMID:
18597935
34.

Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma.

Wu J, Chang Y, Li G, Xue F, DeChon J, Ellsworth K, Liu Q, Yang K, Bahadroani N, Zheng C, Zhang J, Rekate H, Rho JM, Kerrigan JF.

J Neurophysiol. 2007 Jul;98(1):5-15. Epub 2007 Apr 11.

35.

Electrophysiological properties of human hypothalamic hamartomas.

Wu J, Xu L, Kim DY, Rho JM, St John PA, Lue LF, Coons S, Ellsworth K, Nowak L, Johnson E, Rekate H, Kerrigan JF.

Ann Neurol. 2005 Sep;58(3):371-82.

PMID:
16130091
36.

Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models.

Yang YL, Meng CH, Ding JH, He HR, Ellsworth K, Wu J, Hu G.

Brain Res. 2005 Jul 5;1049(1):80-8.

PMID:
15932749
37.

Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices.

Song C, Murray TA, Kimura R, Wakui M, Ellsworth K, Javedan SP, Marxer-Miller S, Lukas RJ, Wu J.

Neuropharmacology. 2005 May;48(6):869-80.

PMID:
15829257
38.

Modeling aided design of potent glycogen phosphorylase inhibitors.

Deng Q, Lu Z, Bohn J, Ellsworth KP, Myers RW, Geissler WM, Harris G, Willoughby CA, Chapman K, McKeever B, Mosley R.

J Mol Graph Model. 2005 Apr;23(5):457-64.

PMID:
15781188
39.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB.

J Clin Invest. 2005 Apr;115(4):1030-8. Epub 2005 Mar 10. Erratum in: J Clin Invest. 2005 Aug;115(8):2297.

40.

Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model.

Wu J, Ellsworth K, Ellsworth M, Schroeder KM, Smith K, Fisher RS.

Brain Res. 2004 Jul 9;1013(2):230-40.

PMID:
15193533
41.

Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

Rosauer KG, Ogawa AK, Willoughby CA, Ellsworth KP, Geissler WM, Myers RW, Deng Q, Chapman KT, Harris G, Moller DE.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4385-8.

PMID:
14643331
42.

A new class of glycogen phosphorylase inhibitors.

Lu Z, Bohn J, Bergeron R, Deng Q, Ellsworth KP, Geissler WM, Harris G, McCann PE, McKeever B, Myers RW, Saperstein R, Willoughby CA, Yao J, Chapman K.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):4125-8.

PMID:
14592521
43.

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.

Ogawa AK, Willoughby CA, Bergeron R, Ellsworth KP, Geissler WM, Myers RW, Yao J, Harris G, Chapman KT.

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3405-8.

PMID:
14505637
44.

Intracellular energy failure does not underlie hyperthermic spreading depressions in immature rat hippocampal slice.

Wu J, Takeo T, Wakui M, Ellsworth K, Fisher RS.

Brain Res. 2003 Oct 17;987(2):240-3.

PMID:
14499969
45.

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.

Ali A, Taylor GE, Ellsworth K, Harris G, Painter R, Silver LL, Young K.

J Med Chem. 2003 May 8;46(10):1824-30.

PMID:
12723946
46.
47.

Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

Wu J, Javedan SP, Ellsworth K, Smith K, Fisher RS.

BMC Neurosci. 2001;2:18. Epub 2001 Nov 28.

48.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

Ali A, Aster SD, Graham DW, Patel GF, Taylor GE, Tolman RL, Painter RE, Silver LL, Young K, Ellsworth K, Geissler W, Harris GS.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2185-8.

PMID:
11514166
49.

Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-reductase: evidence for mechanism-based inhibition by finasteride.

Ellsworth KP, Azzolina BA, Cimis G, Bull HG, Harris GS.

J Steroid Biochem Mol Biol. 1998 Sep;66(5-6):271-9.

PMID:
9749833
50.

Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition.

Azzolina B, Ellsworth K, Andersson S, Geissler W, Bull HG, Harris GS.

J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.

PMID:
9328210

Supplemental Content

Loading ...
Support Center