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A Parsimonious Host Inflammatory Biomarker Signature Predicts Incident TB and Mortality in Advanced HIV.

Manabe YC, Andrade BB, Gupte N, Leong S, Kintali M, Matoga M, Riviere C, Sameneka W, Lama JR, Naidoo K, Zhao Y, Johnson WE, Ellner JJ, Hosseinipour MC, Bisson GP, Salgame P, Gupta A; ACTG A5274 REMEMBER and NWCS 408 Study Team.

Clin Infect Dis. 2019 Nov 25. pii: ciz1147. doi: 10.1093/cid/ciz1147. [Epub ahead of print]


Partitioning the risk of tuberculosis transmission in household contact studies.

McIntosh AI, Jenkins HE, Horsburgh CR, Jones-López EC, Whalen CC, Gaeddert M, Marques-Rodrigues P, Ellner JJ, Dietze R, White LF.

PLoS One. 2019 Oct 22;14(10):e0223966. doi: 10.1371/journal.pone.0223966. eCollection 2019.


Interaction of nutritional status and diabetes on active and latent tuberculosis: a cross-sectional analysis.

Kubiak RW, Sarkar S, Horsburgh CR, Roy G, Kratz M, Reshma A, Knudsen S, Salgame P, Ellner JJ, Drain PK, Hochberg NS.

BMC Infect Dis. 2019 Jul 16;19(1):627. doi: 10.1186/s12879-019-4244-4.


Host Determinants of Infectiousness in Smear-Positive Patients With Pulmonary Tuberculosis.

Acuña-Villaorduña C, Ayakaka I, Schmidt-Castellani LG, Mumbowa F, Marques-Rodrigues P, Gaeddert M, White LF, Palaci M, Ellner JJ, Dietze R, Joloba M, Fennelly KP, Jones-López EC.

Open Forum Infect Dis. 2019 Apr 11;6(6):ofz184. doi: 10.1093/ofid/ofz184. eCollection 2019 Jun.


Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis.

Hoyt KJ, Sarkar S, White L, Joseph NM, Salgame P, Lakshminarayanan S, Muthaiah M, Vinod Kumar S, Ellner JJ, Roy G, Horsburgh CR Jr, Hochberg NS.

PLoS One. 2019 Mar 27;14(3):e0214011. doi: 10.1371/journal.pone.0214011. eCollection 2019.


Transmission phenotype of Mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology.

Verma S, Bhatt K, Lovey A, Ribeiro-Rodrigues R, Durbin J, Jones-López EC, Palaci M, Vinhas SA, Alland D, Dietze R, Ellner JJ, Salgame P.

PLoS Pathog. 2019 Mar 6;15(3):e1007613. doi: 10.1371/journal.ppat.1007613. eCollection 2019 Mar.


Cough-aerosol cultures of Mycobacterium tuberculosis in the prediction of outcomes after exposure. A household contact study in Brazil.

Acuña-Villaorduña C, Schmidt-Castellani LG, Marques-Rodrigues P, White LF, Hadad DJ, Gaeddert M, Ellner JJ, Fennelly KP, Palaci M, Dietze R, Jones-López EC.

PLoS One. 2018 Oct 29;13(10):e0206384. doi: 10.1371/journal.pone.0206384. eCollection 2018.


Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans.

Olson A, Ragan EJ, Nakiyingi L, Lin N, Jacobson KR, Ellner JJ, Manabe YC, Sagar M.

J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):407-411. doi: 10.1097/QAI.0000000000001823.


Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.

Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e01019-18. doi: 10.1128/AAC.01019-18. Print 2018 Sep.


FDG-PET/CT activity leads to the diagnosis of unsuspected TB: a retrospective study.

Geadas C, Acuna-Villaorduna C, Mercier G, Kleinman MB, Horsburgh CR Jr, Ellner JJ, Jacobson KR.

BMC Res Notes. 2018 Jul 13;11(1):464. doi: 10.1186/s13104-018-3564-6.


Sex and age differences in Mycobacterium tuberculosis infection in Brazil.

Fernandes P, Ma Y, Gaeddert M, Tsacogianis T, Marques-Rodrigues P, Fregona G, Loomans A, Jones-López EC, Dietze R, Ellner JJ, White LF, Hochberg NS.

Epidemiol Infect. 2018 Sep;146(12):1503-1510. doi: 10.1017/S0950268818001450. Epub 2018 Jun 8.


"Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets".

Verma S, Du P, Nakanjako D, Hermans S, Briggs J, Nakiyingi L, Ellner JJ, Manabe YC, Salgame P.

BMC Infect Dis. 2018 May 15;18(1):220. doi: 10.1186/s12879-018-3127-4.


Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India.

Leong S, Zhao Y, Joseph NM, Hochberg NS, Sarkar S, Pleskunas J, Hom D, Lakshminarayanan S, Horsburgh CR Jr, Roy G, Ellner JJ, Johnson WE, Salgame P.

Tuberculosis (Edinb). 2018 Mar;109:41-51. doi: 10.1016/ Epub 2018 Jan 31.


Intensity of exposure to pulmonary tuberculosis determines risk of tuberculosis infection and disease.

Acuña-Villaorduña C, Jones-López EC, Fregona G, Marques-Rodrigues P, Gaeddert M, Geadas C, Hadad DJ, White LF, Pereira Dutra Molina L, Vinhas S, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

Eur Respir J. 2018 Jan 18;51(1). pii: 1701578. doi: 10.1183/13993003.01578-2017. Print 2018 Jan.


Isoniazid Preventive Therapy for People With HIV Who Are Heavy Alcohol Drinkers in High TB-/HIV-Burden Countries: A Risk-Benefit Analysis.

Freiman JM, Jacobson KR, Muyindike WR, Horsburgh CR, Ellner JJ, Hahn JA, Linas BP.

J Acquir Immune Defic Syndr. 2018 Apr 1;77(4):405-412. doi: 10.1097/QAI.0000000000001610.


Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study.

Dorman SE, Schumacher SG, Alland D, Nabeta P, Armstrong DT, King B, Hall SL, Chakravorty S, Cirillo DM, Tukvadze N, Bablishvili N, Stevens W, Scott L, Rodrigues C, Kazi MI, Joloba M, Nakiyingi L, Nicol MP, Ghebrekristos Y, Anyango I, Murithi W, Dietze R, Lyrio Peres R, Skrahina A, Auchynka V, Chopra KK, Hanif M, Liu X, Yuan X, Boehme CC, Ellner JJ, Denkinger CM; study team.

Lancet Infect Dis. 2018 Jan;18(1):76-84. doi: 10.1016/S1473-3099(17)30691-6. Epub 2017 Nov 30. Erratum in: Lancet Infect Dis. 2018 Feb 21;:.


Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis.

Xie YL, Chakravorty S, Armstrong DT, Hall SL, Via LE, Song T, Yuan X, Mo X, Zhu H, Xu P, Gao Q, Lee M, Lee J, Smith LE, Chen RY, Joh JS, Cho Y, Liu X, Ruan X, Liang L, Dharan N, Cho SN, Barry CE 3rd, Ellner JJ, Dorman SE, Alland D.

N Engl J Med. 2017 Sep 14;377(11):1043-1054. doi: 10.1056/NEJMoa1614915.


An Unsuspected Zoonotic Infection Presenting as Sepsis.

Epstein R, Ristau J, Ellner JJ.

Am J Med. 2018 Jan;131(1):e17-e18. doi: 10.1016/j.amjmed.2017.07.040. Epub 2017 Aug 30. No abstract available.


Comorbidities in pulmonary tuberculosis cases in Puducherry and Tamil Nadu, India: Opportunities for intervention.

Hochberg NS, Sarkar S, Horsburgh CR Jr, Knudsen S, Pleskunas J, Sahu S, Kubiak RW, Govindarajan S, Salgame P, Lakshminarayanan S, Sivaprakasam A, White LF, Joseph NM, Ellner JJ, Roy G.

PLoS One. 2017 Aug 23;12(8):e0183195. doi: 10.1371/journal.pone.0183195. eCollection 2017.


Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil.

Jones-López EC, Acuña-Villaorduña C, Fregona G, Marques-Rodrigues P, White LF, Hadad DJ, Dutra-Molina LP, Vinhas S, McIntosh AI, Gaeddert M, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

BMC Infect Dis. 2017 Aug 18;17(1):576. doi: 10.1186/s12879-017-2675-3.


Predictors of delayed care seeking for tuberculosis in southern India: an observational study.

Van Ness SE, Chandra A, Sarkar S, Pleskunas J, Ellner JJ, Roy G, Lakshminarayanan S, Sahu S, Horsburgh CR Jr, Jenkins HE, Hochberg NS.

BMC Infect Dis. 2017 Aug 15;17(1):567. doi: 10.1186/s12879-017-2629-9.


A Comparative Analysis of Pulmonary and Critical Care Medicine Guideline Development Methodologies.

Schoenberg NC, Barker AF, Bernardo J, Deterding RR, Ellner JJ, Hess DR, MacIntyre NR, Martinez FJ, Wilson KC.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):621-627. doi: 10.1164/rccm.201705-0926OC.


Serologic Responses in Childhood Pulmonary Tuberculosis.

Nonyane BAS, Nicol MP, Andreas NJ, Rimmele S, Schneiderhan-Marra N, Workman LJ, Perkins MD, Joos T, Broger T, Ellner JJ, Alland D, Kampmann B, Dorman SE, Zar HJ.

Pediatr Infect Dis J. 2018 Jan;37(1):1-9. doi: 10.1097/INF.0000000000001683.


Strains of Mycobacterium tuberculosis transmitting infection in Brazilian households and those associated with community transmission of tuberculosis.

Vinhas SA, Jones-López EC, Ribeiro Rodrigues R, Gaeddert M, Peres RL, Marques-Rodrigues P, de Aguiar PPL, White LF, Alland D, Salgame P, Hom D, Ellner JJ, Dietze R, Collins LF, Shashkina E, Kreiswirth B, Palaci M.

Tuberculosis (Edinb). 2017 May;104:79-86. doi: 10.1016/ Epub 2017 Mar 16.


Extensions to Bayesian generalized linear mixed effects models for household tuberculosis transmission.

McIntosh AI, Doros G, Jones-López EC, Gaeddert M, Jenkins HE, Marques-Rodrigues P, Ellner JJ, Dietze R, White LF.

Stat Med. 2017 Jul 20;36(16):2522-2532. doi: 10.1002/sim.7303. Epub 2017 Mar 29.


Diagnosis of Latent Tuberculous Infection.

Collins LF, Geadas C, Ellner JJ.

Ann Intern Med. 2016 Sep 20;165(6):448. doi: 10.7326/L16-0192. No abstract available.


The complexity of diagnosing latent tuberculosis infection in older adults in long-term care facilities.

Hochberg NS, Rekhtman S, Burns J, Ganley-Leal L, Helbig S, Watts NS, Brandeis GH, Ellner JJ, Horsburgh CR Jr.

Int J Infect Dis. 2016 Mar;44:37-43. doi: 10.1016/j.ijid.2016.01.007. Epub 2016 Jan 21.


Diagnosis of Latent Tuberculosis Infection: Too Soon to Pull the Plug on the Tuberculin Skin Test.

Collins LF, Geadas C, Ellner JJ.

Ann Intern Med. 2016 Jan 19;164(2):122-4. doi: 10.7326/M15-1522. Epub 2016 Dec 8. No abstract available.


Predictors for MTB Culture-Positivity among HIV-Infected Smear-Negative Presumptive Tuberculosis Patients in Uganda: Application of New Tuberculosis Diagnostic Technology.

Nakiyingi L, Nonyane BA, Ssengooba W, Kirenga BJ, Nakanjako D, Lubega G, Byakika-Kibwika P, Joloba ML, Ellner JJ, Dorman SE, Mayanja-Kizza H, Manabe YC.

PLoS One. 2015 Jul 29;10(7):e0133756. doi: 10.1371/journal.pone.0133756. eCollection 2015.


Latent tuberculosis infection--Revisiting and revising concepts.

Salgame P, Geadas C, Collins L, Jones-López E, Ellner JJ.

Tuberculosis (Edinb). 2015 Jul;95(4):373-84. doi: 10.1016/ Epub 2015 May 15. Review.


Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda.

Nakiyingi L, Ssengooba W, Nakanjako D, Armstrong D, Holshouser M, Kirenga BJ, Shah M, Mayanja-Kizza H, Joloba ML, Ellner JJ, Dorman SE, Manabe YC.

BMC Infect Dis. 2015 Feb 15;15:62. doi: 10.1186/s12879-015-0812-4.


Improving the sensitivity of the Xpert MTB/RIF assay on sputum pellets by decreasing the amount of added sample reagent: a laboratory and clinical evaluation.

Dharan NJ, Amisano D, Mboowa G, Ssengooba W, Blakemore R, Kubiak RW, Armstrong DT, Jones M, Manabe YC, Joloba ML, Ellner JJ, Dorman SE, Alland D.

J Clin Microbiol. 2015 Apr;53(4):1258-63. doi: 10.1128/JCM.03619-14. Epub 2015 Feb 4.


Quest for correlates of protection against tuberculosis.

Bhatt K, Verma S, Ellner JJ, Salgame P.

Clin Vaccine Immunol. 2015 Mar;22(3):258-66. doi: 10.1128/CVI.00721-14. Epub 2015 Jan 14. Review.


Clinical utility of a novel molecular assay in various combination strategies with existing methods for diagnosis of HIV-related tuberculosis in Uganda.

Ssengooba W, Nakiyingi L, Armstrong DT, Cobelens FG, Alland D, Manabe YC, Dorman SE, Ellner JJ, Joloba ML.

PLoS One. 2014 Sep 15;9(9):e107595. doi: 10.1371/journal.pone.0107595. eCollection 2014.


Importance of cough and M. tuberculosis strain type as risks for increased transmission within households.

Jones-López EC, Kim S, Fregona G, Marques-Rodrigues P, Hadad DJ, Molina LP, Vinhas S, Reilly N, Moine S, Chakravorty S, Gaeddert M, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

PLoS One. 2014 Jul 2;9(7):e100984. doi: 10.1371/journal.pone.0100984. eCollection 2014.


Discordance of tuberculin skin test and interferon gamma release assay in recently exposed household contacts of pulmonary TB cases in Brazil.

Ribeiro-Rodrigues R, Kim S, Coelho da Silva FD, Uzelac A, Collins L, Palaci M, Alland D, Dietze R, Ellner JJ, Jones-López E, Salgame P.

PLoS One. 2014 May 12;9(5):e96564. doi: 10.1371/journal.pone.0096564. eCollection 2014.


Prospective cross-sectional evaluation of the small membrane filtration method for diagnosis of pulmonary tuberculosis.

Jones-López E, Manabe YC, Palaci M, Kayiza C, Armstrong D, Nakiyingi L, Ssengooba W, Gaeddert M, Kubiak R, Almeida Júnior P, Alland D, Dietze R, Joloba M, Ellner JJ, Dorman SE.

J Clin Microbiol. 2014 Jul;52(7):2513-20. doi: 10.1128/JCM.00642-14. Epub 2014 May 7.


Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults.

Nakiyingi L, Moodley VM, Manabe YC, Nicol MP, Holshouser M, Armstrong DT, Zemanay W, Sikhondze W, Mbabazi O, Nonyane BA, Shah M, Joloba ML, Alland D, Ellner JJ, Dorman SE.

J Acquir Immune Defic Syndr. 2014 Jul 1;66(3):270-9. doi: 10.1097/QAI.0000000000000151.


Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals.

Shah M, Ssengooba W, Armstrong D, Nakiyingi L, Holshouser M, Ellner JJ, Joloba M, Manabe YC, Dorman SE.

AIDS. 2014 Jun 1;28(9):1307-14. doi: 10.1097/QAD.0000000000000264.


Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study.

Kirenga BJ, Levin J, Ayakaka I, Worodria W, Reilly N, Mumbowa F, Nabanjja H, Nyakoojo G, Fennelly K, Nakubulwa S, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Mugerwa RD, Smith PG, Ellner JJ, Jones-López EC.

PLoS One. 2014 Mar 7;9(3):e90614. doi: 10.1371/journal.pone.0090614. eCollection 2014.


Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing.

Clark TG, Mallard K, Coll F, Preston M, Assefa S, Harris D, Ogwang S, Mumbowa F, Kirenga B, O'Sullivan DM, Okwera A, Eisenach KD, Joloba M, Bentley SD, Ellner JJ, Parkhill J, Jones-López EC, McNerney R.

PLoS One. 2013 Dec 11;8(12):e83012. doi: 10.1371/journal.pone.0083012. eCollection 2013.


Sensititre MYCOTB MIC plate for testing Mycobacterium tuberculosis susceptibility to first- and second-line drugs.

Lee J, Armstrong DT, Ssengooba W, Park JA, Yu Y, Mumbowa F, Namaganda C, Mboowa G, Nakayita G, Armakovitch S, Chien G, Cho SN, Via LE, Barry CE 3rd, Ellner JJ, Alland D, Dorman SE, Joloba ML.

Antimicrob Agents Chemother. 2014;58(1):11-8. doi: 10.1128/AAC.01209-13. Epub 2013 Oct 7.


Variability of infectious aerosols produced during coughing by patients with pulmonary tuberculosis.

Fennelly KP, Jones-López EC, Ayakaka I, Kim S, Menyha H, Kirenga B, Muchwa C, Joloba M, Dryden-Peterson S, Reilly N, Okwera A, Elliott AM, Smith PG, Mugerwa RD, Eisenach KD, Ellner JJ.

Am J Respir Crit Care Med. 2012 Sep 1;186(5):450-7. doi: 10.1164/rccm.201203-0444OC. Epub 2012 Jul 12.


Ten challenges for TB biomarkers.

Ottenhoff TH, Ellner JJ, Kaufmann SH.

Tuberculosis (Edinb). 2012 Mar;92 Suppl 1:S17-20. doi: 10.1016/S1472-9792(12)70007-0.


'Coinfection-helminthes and tuberculosis'.

Rafi W, Ribeiro-Rodrigues R, Ellner JJ, Salgame P.

Curr Opin HIV AIDS. 2012 May;7(3):239-44. doi: 10.1097/COH.0b013e3283524dc5. Review.


Effectiveness of the standard WHO recommended retreatment regimen (category II) for tuberculosis in Kampala, Uganda: a prospective cohort study.

Jones-López EC, Ayakaka I, Levin J, Reilly N, Mumbowa F, Dryden-Peterson S, Nyakoojo G, Fennelly K, Temple B, Nakubulwa S, Joloba ML, Okwera A, Eisenach KD, McNerney R, Elliott AM, Ellner JJ, Smith PG, Mugerwa RD.

PLoS Med. 2011 Mar;8(3):e1000427. doi: 10.1371/journal.pmed.1000427. Epub 2011 Mar 15.


Immunoregulation in TB: observations and implications.

Ellner JJ.

Clin Transl Sci. 2010 Feb;3(1):23-8. doi: 10.1111/j.1752-8062.2010.00180.x. Review.


Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes.

Juarez E, Nuñez C, Sada E, Ellner JJ, Schwander SK, Torres M.

Respir Res. 2010 Jan 5;11:2. doi: 10.1186/1465-9921-11-2.


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