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Items: 1 to 50 of 386

1.

Verifying, Challenging, and Discovering New Synapses Among Fully EM-Reconstructed Neurons in the Leech Ganglion.

Pipkin JE, Bushong EA, Ellisman MH, Kristan WB Jr.

Front Neuroanat. 2018 Nov 14;12:95. doi: 10.3389/fnana.2018.00095. eCollection 2018.

2.

Nano-structural analysis of engrafted human induced pluripotent stem cell-derived cardiomyocytes in mouse hearts using a genetic-probe APEX2.

Hatani T, Funakoshi S, Deerinck TJ, Bushong EA, Kimura T, Takeshima H, Ellisman MH, Hoshijima M, Yoshida Y.

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1251-1256. doi: 10.1016/j.bbrc.2018.10.020. Epub 2018 Oct 15.

PMID:
30333092
3.

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K.

Nat Immunol. 2018 Nov;19(11):1212-1223. doi: 10.1038/s41590-018-0232-x. Epub 2018 Oct 15.

PMID:
30323343
4.

CDeep3M-Plug-and-Play cloud-based deep learning for image segmentation.

Haberl MG, Churas C, Tindall L, Boassa D, Phan S, Bushong EA, Madany M, Akay R, Deerinck TJ, Peltier ST, Ellisman MH.

Nat Methods. 2018 Sep;15(9):677-680. doi: 10.1038/s41592-018-0106-z. Epub 2018 Aug 31.

PMID:
30171236
5.

Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories.

Zerbi V, Ielacqua GD, Markicevic M, Haberl MG, Ellisman MH, A-Bhaskaran A, Frick A, Rudin M, Wenderoth N.

Cereb Cortex. 2018 Jul 1;28(7):2495-2506. doi: 10.1093/cercor/bhy046.

6.

Iron-specific Signal Separation from within Heavy Metal Stained Biological Samples Using X-Ray Microtomography with Polychromatic Source and Energy-Integrating Detectors.

Katchalski T, Case T, Kim KY, Ramachandra R, Bushong EA, Deerinck TJ, Haberl MG, Mackey MR, Peltier S, Castillon GA, Fujikawa N, Lawrence AR, Ellisman MH.

Sci Rep. 2018 May 15;8(1):7553. doi: 10.1038/s41598-018-25099-z.

7.

High-quality ultrastructural preservation using cryofixation for 3D electron microscopy of genetically labeled tissues.

Tsang TK, Bushong EA, Boassa D, Hu J, Romoli B, Phan S, Dulcis D, Su CY, Ellisman MH.

Elife. 2018 May 11;7. pii: e35524. doi: 10.7554/eLife.35524.

8.

Subgroup characteristics of marine methane-oxidizing ANME-2 archaea and their syntrophic partners revealed by integrated multimodal analytical microscopy.

McGlynn SE, Chadwick GL, O'Neill A, Mackey M, Thor A, Deerinck TJ, Ellisman MH, Orphan VJ.

Appl Environ Microbiol. 2018 Apr 6. pii: AEM.00399-18. doi: 10.1128/AEM.00399-18. [Epub ahead of print]

9.

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes.

Shim MS, Kim KY, Bu JH, Nam HS, Jeong SW, Park TL, Ellisman MH, Weinreb RN, Ju WK.

Cell Death Dis. 2018 Feb 19;9(3):285. doi: 10.1038/s41419-017-0171-8.

10.

Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis.

Lee JK, Enciso GA, Boassa D, Chander CN, Lou TH, Pairawan SS, Guo MC, Wan FYM, Ellisman MH, Sütterlin C, Tan M.

Nat Commun. 2018 Jan 3;9(1):45. doi: 10.1038/s41467-017-02432-0.

11.

High-performance serial block-face SEM of nonconductive biological samples enabled by focal gas injection-based charge compensation.

Deerinck TJ, Shone TM, Bushong EA, Ramachandra R, Peltier ST, Ellisman MH.

J Microsc. 2018 May;270(2):142-149. doi: 10.1111/jmi.12667. Epub 2017 Dec 1.

PMID:
29194648
12.

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K.

Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2.

13.

Probability Map Viewer: near real-time probability map generator of serial block electron microscopy collections.

Churas C, Perez AJ, Hakozaki H, Wong W, Lee D, Peltier ST, Ellisman MH.

Bioinformatics. 2017 Oct 1;33(19):3145-3147. doi: 10.1093/bioinformatics/btx376.

14.

Correlative Microscopy Combining Secondary Ion Mass Spectrometry and Electron Microscopy: Comparison of Intensity-Hue-Saturation and Laplacian Pyramid Methods for Image Fusion.

Vollnhals F, Audinot JN, Wirtz T, Mercier-Bonin M, Fourquaux I, Schroeppel B, Kraushaar U, Lev-Ram V, Ellisman MH, Eswara S.

Anal Chem. 2017 Oct 17;89(20):10702-10710. doi: 10.1021/acs.analchem.7b01256. Epub 2017 Sep 29.

PMID:
28901122
15.

Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.

Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA.

J Cell Sci. 2017 Oct 1;130(19):3248-3260. doi: 10.1242/jcs.201400. Epub 2017 Aug 14.

16.

Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells.

Martell JD, Deerinck TJ, Lam SS, Ellisman MH, Ting AY.

Nat Protoc. 2017 Sep;12(9):1792-1816. doi: 10.1038/nprot.2017.065. Epub 2017 Aug 10.

17.

Microtubule-dependent ribosome localization in C. elegans neurons.

Noma K, Goncharov A, Ellisman MH, Jin Y.

Elife. 2017 Aug 2;6. pii: e26376. doi: 10.7554/eLife.26376.

18.

ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells.

Ou HD, Phan S, Deerinck TJ, Thor A, Ellisman MH, O'Shea CC.

Science. 2017 Jul 28;357(6349). pii: eaag0025. doi: 10.1126/science.aag0025.

19.

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging.

Koehler CL, Perkins GA, Ellisman MH, Jones DL.

J Cell Biol. 2017 Aug 7;216(8):2315-2327. doi: 10.1083/jcb.201610036. Epub 2017 Jun 29.

20.

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines.

Goo MS, Sancho L, Slepak N, Boassa D, Deerinck TJ, Ellisman MH, Bloodgood BL, Patrick GN.

J Cell Biol. 2017 Aug 7;216(8):2499-2513. doi: 10.1083/jcb.201704068. Epub 2017 Jun 19.

21.

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.

Oncotarget. 2017 Jul 18;8(29):47206-47215. doi: 10.18632/oncotarget.17589.

22.

Electron tomography simulator with realistic 3D phantom for evaluation of acquisition, alignment and reconstruction methods.

Wan X, Katchalski T, Churas C, Ghosh S, Phan S, Lawrence A, Hao Y, Zhou Z, Chen R, Chen Y, Zhang F, Ellisman MH.

J Struct Biol. 2017 May;198(2):103-115. doi: 10.1016/j.jsb.2017.04.002. Epub 2017 Apr 6.

23.

Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

Falkenberg CV, Azeloglu EU, Stothers M, Deerinck TJ, Chen Y, He JC, Ellisman MH, Hone JC, Iyengar R, Loew LM.

PLoS Comput Biol. 2017 Mar 16;13(3):e1005433. doi: 10.1371/journal.pcbi.1005433. eCollection 2017 Mar.

24.

Proximity Biotinylation as a Method for Mapping Proteins Associated with mtDNA in Living Cells.

Han S, Udeshi ND, Deerinck TJ, Svinkina T, Ellisman MH, Carr SA, Ting AY.

Cell Chem Biol. 2017 Mar 16;24(3):404-414. doi: 10.1016/j.chembiol.2017.02.002. Epub 2017 Feb 23.

25.

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.

Cao M, Wu Y, Ashrafi G, McCartney AJ, Wheeler H, Bushong EA, Boassa D, Ellisman MH, Ryan TA, De Camilli P.

Neuron. 2017 Feb 22;93(4):882-896.e5. doi: 10.1016/j.neuron.2017.01.019.

26.

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.

de Vivo L, Bellesi M, Marshall W, Bushong EA, Ellisman MH, Tononi G, Cirelli C.

Science. 2017 Feb 3;355(6324):507-510. doi: 10.1126/science.aah5982.

27.

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.

Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW II, Sadoshima J, Ellisman MH, Gustafsson ÅB.

Nat Commun. 2017 Jan 30;8:14050. doi: 10.1038/ncomms14050.

28.

Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain.

Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg JL, Ellisman MH, Taylor SS.

Elife. 2017 Jan 12;6. pii: e17681. doi: 10.7554/eLife.17681.

29.

Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling.

Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD.

J Cell Biol. 2016 Nov 21;215(4):531-542.

30.

High resolution three-dimensional reconstruction of fibrotic skeletal muscle extracellular matrix.

Gillies AR, Chapman MA, Bushong EA, Deerinck TJ, Ellisman MH, Lieber RL.

J Physiol. 2017 Feb 15;595(4):1159-1171. doi: 10.1113/JP273376. Epub 2016 Dec 14.

31.

Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.

Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY.

Cell Chem Biol. 2016 Nov 17;23(11):1417-1427. doi: 10.1016/j.chembiol.2016.10.006. Epub 2016 Nov 3.

32.

Consequences of excessive plasticity in the hippocampus induced by perinatal asphyxia.

Saraceno GE, Caceres LG, Guelman LR, Castilla R, Udovin LD, Ellisman MH, Brocco MA, Capani F.

Exp Neurol. 2016 Dec;286:116-123. doi: 10.1016/j.expneurol.2016.08.017. Epub 2016 Aug 27.

PMID:
27578426
33.

Deceleration of probe beam by stage bias potential improves resolution of serial block-face scanning electron microscopic images.

Bouwer JC, Deerinck TJ, Bushong E, Astakhov V, Ramachandra R, Peltier ST, Ellisman MH.

Adv Struct Chem Imaging. 2017;2(1):11. Epub 2016 Sep 15.

34.
35.

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY.

Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.

36.

3D reconstruction of biological structures: automated procedures for alignment and reconstruction of multiple tilt series in electron tomography.

Phan S, Boassa D, Nguyen P, Wan X, Lanman J, Lawrence A, Ellisman MH.

Adv Struct Chem Imaging. 2017;2:8. doi: 10.1186/s40679-016-0021-2. Epub 2016 Jun 28.

37.

A split horseradish peroxidase for the detection of intercellular protein-protein interactions and sensitive visualization of synapses.

Martell JD, Yamagata M, Deerinck TJ, Phan S, Kwa CG, Ellisman MH, Sanes JR, Ting AY.

Nat Biotechnol. 2016 Jul;34(7):774-80. doi: 10.1038/nbt.3563. Epub 2016 May 30.

38.

Corrigendum to 'Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy' [Methods 90 (2015) 39-48].

Ou HD, Deerinck TJ, Bushong E, Ellisman MH, O'Shea CC.

Methods. 2016 Jul 15;104:206. doi: 10.1016/j.ymeth.2016.05.005. Epub 2016 May 21. No abstract available.

PMID:
27221672
39.

Click-EM for imaging metabolically tagged nonprotein biomolecules.

Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY.

Nat Chem Biol. 2016 Jun;12(6):459-65. doi: 10.1038/nchembio.2076. Epub 2016 Apr 25.

40.

Fine processes of Nestin-GFP-positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature.

Moss J, Gebara E, Bushong EA, Sánchez-Pascual I, O'Laoi R, El M'Ghari I, Kocher-Braissant J, Ellisman MH, Toni N.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2536-45. doi: 10.1073/pnas.1514652113. Epub 2016 Apr 18.

41.

Design and synthesis of a minimal bacterial genome.

Hutchison CA 3rd, Chuang RY, Noskov VN, Assad-Garcia N, Deerinck TJ, Ellisman MH, Gill J, Kannan K, Karas BJ, Ma L, Pelletier JF, Qi ZQ, Richter RA, Strychalski EA, Sun L, Suzuki Y, Tsvetanova B, Wise KS, Smith HO, Glass JI, Merryman C, Gibson DG, Venter JC.

Science. 2016 Mar 25;351(6280):aad6253. doi: 10.1126/science.aad6253. Erratum in: ACS Chem Biol. 2016 May 20;11(5):1463.

PMID:
27013737
42.

Structural analysis of the tongue and hyoid apparatus in a woodpecker.

Jung JY, Naleway SE, Yaraghi NA, Herrera S, Sherman VR, Bushong EA, Ellisman MH, Kisailus D, McKittrick J.

Acta Biomater. 2016 Jun;37:1-13. doi: 10.1016/j.actbio.2016.03.030. Epub 2016 Mar 18.

43.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M.

Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057.

44.

Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1.

Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D.

J Biol Chem. 2016 Mar 11;291(11):5788-802. doi: 10.1074/jbc.M115.705681. Epub 2015 Dec 31.

45.

RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.

Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH.

Neoplasia. 2015 Oct;17(10):776-88. doi: 10.1016/j.neo.2015.10.002.

46.

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.

Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6166-74. doi: 10.1073/pnas.1519384112. Epub 2015 Oct 28.

47.

Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity.

Komin N, Moein M, Ellisman MH, Skupin A.

Neural Plast. 2015;2015:683490. doi: 10.1155/2015/683490. Epub 2015 Aug 4.

48.

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes.

Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin EJ, Soeller C.

PLoS Comput Biol. 2015 Sep 3;11(9):e1004417. doi: 10.1371/journal.pcbi.1004417. eCollection 2015 Sep.

49.

DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.

Kim KY, Perkins GA, Shim MS, Bushong E, Alcasid N, Ju S, Ellisman MH, Weinreb RN, Ju WK.

Cell Death Dis. 2015 Aug 6;6:e1839. doi: 10.1038/cddis.2015.180.

50.

Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis.

Mills EA, Davis CH, Bushong EA, Boassa D, Kim KY, Ellisman MH, Marsh-Armstrong N.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10509-14. doi: 10.1073/pnas.1506486112. Epub 2015 Aug 3.

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