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Items: 24

1.

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.

Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M, Halls ML.

Sci Signal. 2018 Oct 9;11(551). pii: eaan1188. doi: 10.1126/scisignal.aan1188.

PMID:
30301787
2.

Homodimerization attenuates the anti-inflammatory activity of interleukin-37.

Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF.

Sci Immunol. 2017 Feb 10;2(8). pii: eaaj1548. doi: 10.1126/sciimmunol.aaj1548.

PMID:
28783685
3.

P-Rex1 and P-Rex2 RacGEFs and cancer.

Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA.

Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Review.

PMID:
28710285
4.

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice.

Yang ASP, O'Neill MT, Jennison C, Lopaticki S, Allison CC, Armistead JS, Erickson SM, Rogers KL, Ellisdon AM, Whisstock JC, Tweedell RE, Dinglasan RR, Douglas DN, Kneteman NM, Boddey JA.

Cell Rep. 2017 Mar 28;18(13):3105-3116. doi: 10.1016/j.celrep.2017.03.017.

5.

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease.

Lucato CM, Lupton CJ, Halls ML, Ellisdon AM.

J Mol Biol. 2017 May 5;429(9):1289-1304. doi: 10.1016/j.jmb.2017.03.021. Epub 2017 Mar 22. Review.

PMID:
28342736
6.

Compartmentalization of GPCR signalling controls unique cellular responses.

Ellisdon AM, Halls ML.

Biochem Soc Trans. 2016 Apr 15;44(2):562-7. doi: 10.1042/BST20150236. Review.

PMID:
27068970
7.

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1.

8.

Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.

Lupton CJ, Steer DL, Wintrode PL, Bottomley SP, Hughes VA, Ellisdon AM.

J Biol Chem. 2015 Oct 2;290(40):24190-200. doi: 10.1074/jbc.M115.659532. Epub 2015 Aug 10.

9.

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

Halls ML, Poole DP, Ellisdon AM, Nowell CJ, Canals M.

Methods Mol Biol. 2015;1335:131-61. doi: 10.1007/978-1-4939-2914-6_10.

PMID:
26260599
10.

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.

11.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.

PMID:
25729923
12.

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.

Ellisdon AM, Zhang Q, Henstridge MA, Johnson TK, Warr CG, Law RH, Whisstock JC.

BMC Struct Biol. 2014 Apr 24;14:14. doi: 10.1186/1472-6807-14-14.

13.

Structural biology of the PCI-protein fold.

Ellisdon AM, Stewart M.

Bioarchitecture. 2012 Jul-Aug;2(4):118-23. doi: 10.4161/bioa.21131. Epub 2012 Jul 1. Review.

14.

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.

Ellisdon AM, Dimitrova L, Hurt E, Stewart M.

Nat Struct Mol Biol. 2012 Feb 19;19(3):328-36. doi: 10.1038/nsmb.2235.

15.

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

Ellisdon AM, Jani D, Köhler A, Hurt E, Stewart M.

J Biol Chem. 2010 Feb 5;285(6):3850-6. doi: 10.1074/jbc.M109.070839. Epub 2009 Dec 9.

16.

Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export.

Jani D, Lutz S, Marshall NJ, Fischer T, Köhler A, Ellisdon AM, Hurt E, Stewart M.

Mol Cell. 2009 Mar 27;33(6):727-37. doi: 10.1016/j.molcel.2009.01.033.

17.

The structural impact of a polyglutamine tract is location-dependent.

Robertson AL, Horne J, Ellisdon AM, Thomas B, Scanlon MJ, Bottomley SP.

Biophys J. 2008 Dec 15;95(12):5922-30. doi: 10.1529/biophysj.108.138487. Epub 2008 Oct 10.

18.

A common fold mediates vertebrate defense and bacterial attack.

Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC.

Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23.

19.

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Pearce MC, Cabrita LD, Ellisdon AM, Bottomley SP.

FEBS J. 2007 Jul;274(14):3622-3632. doi: 10.1111/j.1742-4658.2007.05897.x. Epub 2007 Jul 3.

20.

Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.

Ellisdon AM, Pearce MC, Bottomley SP.

J Mol Biol. 2007 Apr 27;368(2):595-605. Epub 2007 Feb 22.

PMID:
17362987
21.

Purification of polyglutamine proteins.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP.

Methods Enzymol. 2006;413:1-19.

PMID:
17046388
22.

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

Ellisdon AM, Thomas B, Bottomley SP.

J Biol Chem. 2006 Jun 23;281(25):16888-96. Epub 2006 Apr 19.

23.

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP.

J Biol Chem. 2004 Nov 12;279(46):47643-51. Epub 2004 Sep 1.

24.

The role of protein misfolding in the pathogenesis of human diseases.

Ellisdon AM, Bottomley SP.

IUBMB Life. 2004 Mar;56(3):119-23. Review.

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