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Items: 36

1.

Ceragenins are active against drug-resistant Candida auris clinical isolates in planktonic and biofilm forms.

Hashemi MM, Rovig J, Holden BS, Taylor MF, Weber S, Wilson J, Hilton B, Zaugg AL, Ellis SW, Yost CD, Finnegan PM, Kistler CK, Berkow EL, Deng S, Lockhart SR, Peterson M, Savage PB.

J Antimicrob Chemother. 2018 Jun 1;73(6):1537-1545. doi: 10.1093/jac/dky085.

PMID:
29635279
2.

Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

Allorge D, Bréant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW.

Proteins. 2005 May 1;59(2):339-46.

PMID:
15726636
3.

Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

Heydari A, Yeo KR, Lennard MS, Ellis SW, Tucker GT, Rostami-Hodjegan A.

Drug Metab Dispos. 2004 Nov;32(11):1213-7. Epub 2004 Aug 24.

4.

Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19.

Hichiya H, Kuramoto S, Yamamoto S, Shinoda S, Hanioka N, Narimatsu S, Asaoka K, Miyata A, Iwata S, Nomoto M, Satoh T, Kiryu K, Ueda N, Naito S, Tucker GT, Ellis SW.

Biochem Pharmacol. 2004 Jul 1;68(1):165-75.

PMID:
15183128
5.

Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver.

Wilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW, Tucker GT.

Br J Clin Pharmacol. 2003 Oct;56(4):433-40. Erratum in: Br J Clin Pharmacol. 2004 Dec;58(6):680.

6.

A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.

Shiran MR, Chowdry J, Rostami-Hodjegan A, Ellis SW, Lennard MS, Iqbal MZ, Lagundoye O, Seivewright N, Tucker GT.

Br J Clin Pharmacol. 2003 Aug;56(2):220-4.

7.

In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism.

Allorge D, Harlow J, Boulet O, Hayhurst GP, Chowdry J, Roth E, Crewe K, Lo-Guidice JM, Lhermitte M, Broly F, Tucker GT, Ellis SW.

Pharmacogenetics. 2001 Nov;11(8):739-41. Review.

PMID:
11692084
8.

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.

Hayhurst GP, Harlow J, Chowdry J, Gross E, Hilton E, Lennard MS, Tucker GT, Ellis SW.

Biochem J. 2001 Apr 15;355(Pt 2):373-9.

9.

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling.

Lightfoot T, Ellis SW, Mahling J, Ackland MJ, Blaney FE, Bijloo GJ, De Groot MJ, Vermeulen NP, Blackburn GM, Lennard MS, Tucker GT.

Xenobiotica. 2000 Mar;30(3):219-33.

PMID:
10752638
10.

Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Lightfoot T, Smith G, Harlow J, Rowland-Yeo K, Larsson C, Mahling J, Lim CK, Wolf CR, Blackburn MG, Lennard MS, Tucker GT.

Biochem J. 2000 Feb 1;345 Pt 3:565-71.

11.

A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype.

Marez-Allorge D, Ellis SW, Lo Guidice JM, Tucker GT, Broly F.

Pharmacogenetics. 1999 Jun;9(3):393-6. No abstract available.

PMID:
10471072
12.

Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression.

Schulz-Utermoehl T, Bennett AJ, Ellis SW, Tucker GT, Boobis AR, Edwards RJ.

Pharmacogenetics. 1999 Jun;9(3):357-66.

PMID:
10471068
13.

First principles investigation of singly reduced cytochrome P450.

Segall MD, Payne MC, Ellis SW, Tucker GT, Eddershaw PJ.

Xenobiotica. 1999 Jun;29(6):561-71.

PMID:
10426555
14.

Study of the association between cytochromes P450 2D6 and 2E1 genotypes and the risk of drug and chemical induced idiosyncratic aplastic anaemia.

Marsh JC, Chowdry J, Parry-Jones N, Ellis SW, Muir KR, Gordon-Smith EC, Tucker GT.

Br J Haematol. 1999 Feb;104(2):266-70.

PMID:
10050706
15.

Ab initio molecular modeling in the study of drug metabolism.

Segall MD, Payne MC, Ellis SW, Tucker GT, Boyes RN.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):283-9.

PMID:
9512922
16.

An ab initio approach to the understanding of cytochrome P450-ligand interactions.

Segall MD, Payne MC, Ellis SW, Tucker GT, Boyes RN.

Xenobiotica. 1998 Jan;28(1):15-20.

PMID:
9493315
17.

Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6.

Lin LY, Di Stefano EW, Schmitz DA, Hsu L, Ellis SW, Lennard MS, Tucker GT, Cho AK.

Drug Metab Dispos. 1997 Sep;25(9):1059-64.

18.

Cytochromes P450 mediating the N-demethylation of amitriptyline.

Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT.

Br J Clin Pharmacol. 1997 Feb;43(2):137-44.

19.

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.

Crewe HK, Ellis SW, Lennard MS, Tucker GT.

Biochem Pharmacol. 1997 Jan 24;53(2):171-8.

PMID:
9037249
20.

Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell division.

Beresford AP, Taylor RJ, Ashcroft JA, Ayrton J, Tucker GT, Ellis SW.

Xenobiotica. 1996 Oct;26(10):1013-23.

PMID:
8905916
21.

Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes.

Rowland K, Ellis SW, Lennard MS, Tucker GT.

Br J Clin Pharmacol. 1996 Sep;42(3):390-3.

22.

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Mackman R, Tschirret-Guth RA, Smith G, Hayhurst GP, Ellis SW, Lennard MS, Tucker GT, Wolf CR, Ortiz de Montellano PR.

Arch Biochem Biophys. 1996 Jul 1;331(1):134-40.

PMID:
8660692
23.

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol.

Ellis SW, Rowland K, Ackland MJ, Rekka E, Simula AP, Lennard MS, Wolf CR, Tucker GT.

Biochem J. 1996 Jun 1;316 ( Pt 2):647-54.

24.
25.

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Smith G, Lightfoot T, Wong MM, Simula AP, Ackland MJ, Sternberg MJ, Lennard MS, Tucker GT, et al.

J Biol Chem. 1995 Dec 8;270(49):29055-8.

26.

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites.

Ching MS, Blake CL, Ghabrial H, Ellis SW, Lennard MS, Tucker GT, Smallwood RA.

Biochem Pharmacol. 1995 Sep 7;50(6):833-7.

PMID:
7575645
27.

Inhibition of CYP2D6 activity by treatment with propranolol and the role of 4-hydroxy propranolol.

Rowland K, Yeo WW, Ellis SW, Chadwick IG, Haq I, Lennard MS, Jackson PR, Ramsay LE, Tucker GT.

Br J Clin Pharmacol. 1994 Jul;38(1):9-14.

28.

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).

Tucker GT, Lennard MS, Ellis SW, Woods HF, Cho AK, Lin LY, Hiratsuka A, Schmitz DA, Chu TY.

Biochem Pharmacol. 1994 Mar 29;47(7):1151-6.

PMID:
7909223
29.

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast.

Ellis SW, Ching MS, Watson PF, Henderson CJ, Simula AP, Lennard MS, Tucker GT, Woods HF.

Biochem Pharmacol. 1992 Aug 18;44(4):617-20.

PMID:
1510710
30.

The metabolism of tamoxifen by human liver microsomes is not mediated by cytochrome P450IID6.

Blankson EA, Ellis SW, Lennard MS, Tucker GT, Rogers K.

Biochem Pharmacol. 1991 Dec 11;42 Suppl:S209-12. No abstract available.

PMID:
1768279
31.

Identification of a sterol mutant of Neurospora crassa deficient in delta 14,15-reductase activity.

Ellis SW, Rose ME, Grindle M.

J Gen Microbiol. 1991 Nov;137(11):2627-30.

32.
33.

Interaction of microsomal cytochrome P-450 isolated from Aspergillus fumigatus with fluconazole and itraconazole.

Ballard SA, Kelly SL, Ellis SW, Troke PF.

J Med Vet Mycol. 1990;28(4):327-34.

PMID:
2176687
34.

Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals.

Watson PF, Rose ME, Ellis SW, England H, Kelly SL.

Biochem Biophys Res Commun. 1989 Nov 15;164(3):1170-5.

PMID:
2556119
35.

Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons.

Phillis JW, Edstrom JP, Ellis SW, Kirkpatrick JR.

Can J Physiol Pharmacol. 1979 Aug;57(8):917-20.

PMID:
497904
36.

Recent anterior and posterior colporrhaphy. Sturmdorf amputation of cervix and perineorrhaphy.

BEAVER DC, ELLIS SW.

Am J Clin Pathol. 1947 Nov;17(11):866-73. No abstract available.

PMID:
20269993

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