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Items: 26

1.

Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities.

Dcona MM, Damle PK, Zarate-Perez F, Morris BL, Nawaz Z, Dennis MJ, Deng X, Korwar S, Singh SJ, Ellis KC, Royer WE, Bandyopadhyay D, Escalante C, Grossman SR.

Mol Pharmacol. 2019 Jul;96(1):99-108. doi: 10.1124/mol.118.114363. Epub 2019 Apr 29.

PMID:
31036695
2.

An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition.

Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Ellis KC, Patel BB, Grossman SR.

Oncotarget. 2018 Aug 21;9(65):32408-32418. doi: 10.18632/oncotarget.25784. eCollection 2018 Aug 21.

3.

Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.

Luzi NM, Lyons CE, Peterson DL, Ellis KC.

FEBS Open Bio. 2018 Mar 11;8(4):606-613. doi: 10.1002/2211-5463.12396. eCollection 2018 Apr.

4.

Chelation-directed C-H activation/C-C bond forming reactions catalyzed by Pd(ii) nanoparticles supported on multiwalled carbon nanotubes.

Korwar S, Burkholder M, Gilliland SE, Brinkley K, Gupton BF, Ellis KC.

Chem Commun (Camb). 2017 Jun 27;53(52):7022-7025. doi: 10.1039/c7cc02122d.

PMID:
28613290
5.

Characterization of PKACα enzyme kinetics and inhibition in an HPLC assay with a chromophoric substrate.

Luzi NM, Lyons CE, Peterson DL, Ellis KC.

Anal Biochem. 2017 Sep 1;532:45-52. doi: 10.1016/j.ab.2017.06.001. Epub 2017 Jun 5.

6.

CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.

Dcona MM, Morris BL, Ellis KC, Grossman SR.

Cancer Biol Ther. 2017 Jun 3;18(6):379-391. doi: 10.1080/15384047.2017.1323586. Epub 2017 May 22. Review.

7.

Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia.

Sumner ET, Chawla AT, Cororaton AD, Koblinski JE, Kovi RC, Love IM, Szomju BB, Korwar S, Ellis KC, Grossman SR.

Oncogene. 2017 Aug 17;36(33):4810-4816. doi: 10.1038/onc.2017.106. Epub 2017 Apr 17.

8.

Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).

Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE Jr, Kellogg GE, Grossman SR, Ellis KC.

Bioorg Med Chem. 2016 Jun 15;24(12):2707-15. doi: 10.1016/j.bmc.2016.04.037. Epub 2016 Apr 20.

9.

Design, synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα).

Coover RA, Luzi NM, Korwar S, Casile ME, Lyons CE, Peterson DL, Ellis KC.

Org Biomol Chem. 2016 May 18;14(20):4576-81. doi: 10.1039/c6ob00529b.

PMID:
27126273
10.

Selective N-chelation-directed C-H activation reactions catalyzed by Pd(II) nanoparticles supported on multiwalled carbon nanotubes.

Korwar S, Brinkley K, Siamaki AR, Gupton BF, Ellis KC.

Org Lett. 2015 Apr 3;17(7):1782-5. doi: 10.1021/acs.orglett.5b00566. Epub 2015 Mar 19.

PMID:
25789562
11.

Structure-guided design of a high affinity inhibitor to human CtBP.

Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE Jr.

ACS Chem Biol. 2015 Apr 17;10(4):1118-27. doi: 10.1021/cb500820b. Epub 2015 Jan 30.

12.

Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.

Nguyen T, Coover RA, Verghese J, Moran RG, Ellis KC.

ACS Med Chem Lett. 2014 Mar 7;5(5):462-7. doi: 10.1021/ml500088x. eCollection 2014 May 8.

13.

Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad.

Jennings GK, Modi A, Elenewski JE, Ritchie CM, Nguyen T, Ellis KC, Hackett JC.

J Inorg Biochem. 2014 Jul;136:81-91. doi: 10.1016/j.jinorgbio.2014.03.017. Epub 2014 Apr 12.

14.

Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors.

Korwar S, Nguyen T, Ellis KC.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):271-4. doi: 10.1016/j.bmcl.2013.11.020. Epub 2013 Nov 20.

PMID:
24321345
15.

Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.

Verghese J, Nguyen T, Oppegard LM, Seivert LM, Hiasa H, Ellis KC.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5874-7. doi: 10.1016/j.bmcl.2013.08.094. Epub 2013 Sep 5.

PMID:
24060488
16.

Inhibition of human topoisomerases I and II by simocyclinone D8.

Oppegard LM, Nguyen T, Ellis KC, Hiasa H.

J Nat Prod. 2012 Aug 24;75(8):1485-9. doi: 10.1021/np300299y. Epub 2012 Aug 6.

PMID:
22867097
17.

Understanding failure of visual paired associate learning in amnestic mild cognitive impairment.

O'Donnell J, Pietrzak RH, Ellis KC, Snyder PJ, Maruff P.

J Clin Exp Neuropsychol. 2011 Dec;33(10):1069-78. doi: 10.1080/13803395.2011.596821. Epub 2011 Sep 19.

PMID:
21929324
18.

The differential diagnosis and management of asthma in the preschool-aged child.

Ellis KC.

J Am Acad Nurse Pract. 2009 Sep;21(9):463-73. doi: 10.1111/j.1745-7599.2009.00423.x. Review.

PMID:
19845803
19.

In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.

Oppegard LM, Hamann BL, Streck KR, Ellis KC, Fiedler HP, Khodursky AB, Hiasa H.

Antimicrob Agents Chemother. 2009 May;53(5):2110-9. doi: 10.1128/AAC.01440-08. Epub 2009 Mar 9.

20.

Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers.

Kimball FS, Turunen BJ, Ellis KC, Himes RH, Georg GI.

Bioorg Med Chem. 2008 Apr 15;16(8):4367-77. doi: 10.1016/j.bmc.2008.02.073. Epub 2008 Mar 4.

21.

The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy.

Wright NT, Varney KM, Ellis KC, Markowitz J, Gitti RK, Zimmer DB, Weber DJ.

J Mol Biol. 2005 Oct 21;353(2):410-26.

PMID:
16169012
22.

Total synthesis of (-)- and (+)-membrenone C.

Marshall JA, Ellis KC.

Org Lett. 2003 May 15;5(10):1729-32.

PMID:
12735763
23.

Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy.

Vallely KM, Rustandi RR, Ellis KC, Varlamova O, Bresnick AR, Weber DJ.

Biochemistry. 2002 Oct 22;41(42):12670-80.

PMID:
12379109
24.

Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A).

Ellis KC, Tenenholz TC, Jerng H, Hayhurst M, Dudlak CS, Gilly WF, Blaustein MP, Weber DJ.

Biochemistry. 2001 May 22;40(20):5942-53.

PMID:
11352729
25.
26.

Resistance of Cotton to the Root-Knot Nematode, Meloidogyne incognita.

McClure MA, Ellis KC, Nigh EL.

J Nematol. 1974 Jan;6(1):17-20.

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