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Items: 1 to 50 of 166


Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration.

Zhang C, Gullbrand SE, Schaer TP, Lau YK, Jiang Z, Dodge GR, Elliott DM, Mauck RL, Malhotra NR, Smith LJ.

J Orthop Res. 2020 Feb 24. doi: 10.1002/jor.24639. [Epub ahead of print]


Helical fibrillar microstructure of tendon using serial block-face scanning electron microscopy and a mechanical model for interfibrillar load transfer.

Safa BN, Peloquin JM, Natriello JR, Caplan JL, Elliott DM.

J R Soc Interface. 2019 Nov 29;16(160):20190547. doi: 10.1098/rsif.2019.0547. Epub 2019 Nov 20.


Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss.

Bonnevie ED, Gullbrand SE, Ashinsky BG, Tsinman TK, Elliott DM, Chao PG, Smith HE, Mauck RL.

Nat Biomed Eng. 2019 Dec;3(12):998-1008. doi: 10.1038/s41551-019-0458-4. Epub 2019 Oct 14.


Off-axis response due to mechanical coupling across all six degrees of freedom in the human disc.

DeLucca JF, Amin D, Peloquin JM, Vresilovic EJ, Costi JJ, Elliott DM.

JOR Spine. 2019 Mar 22;2(1):e1047. doi: 10.1002/jsp2.1047. eCollection 2019 Mar.


Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model.

Ashinsky BG, Gullbrand SE, Bonnevie ED, Mandalapu SA, Wang C, Elliott DM, Han L, Mauck RL, Smith HE.

Osteoarthritis Cartilage. 2019 Dec;27(12):1860-1869. doi: 10.1016/j.joca.2019.07.016. Epub 2019 Aug 13.


Human Disc Nucleotomy Alters Annulus Fibrosus Mechanics at Both Reference and Compressed Loads.

Claeson AA, Vresilovic EJ, Showalter BL, Wright AC, Gee JC, Malhotra NR, Elliott DM.

J Biomech Eng. 2019 May 29. doi: 10.1115/1.4043874. [Epub ahead of print]


Evaluating Plastic Deformation and Damage as Potential Mechanisms for Tendon Inelasticity using a Reactive Modeling Framework.

Safa B, Lee A, Santare MH, Elliott DM.

J Biomech Eng. 2019 Apr 20. doi: 10.1115/1.4043520. [Epub ahead of print]


Multi-Scale Loading and Damage Mechanisms of Plantaris and Rat Tail Tendons.

Lee AH, Elliott DM.

J Orthop Res. 2019 Aug;37(8):1827-1837. doi: 10.1002/jor.24309. Epub 2019 May 2.


Short cracks in knee meniscus tissue cause strain concentrations, but do not reduce ultimate stress, in single-cycle uniaxial tension.

Peloquin JM, Santare MH, Elliott DM.

R Soc Open Sci. 2018 Nov 14;5(11):181166. doi: 10.1098/rsos.181166. eCollection 2018 Nov.


Comparative multi-scale hierarchical structure of the tail, plantaris, and Achilles tendons in the rat.

Lee AH, Elliott DM.

J Anat. 2019 Feb;234(2):252-262. doi: 10.1111/joa.12913. Epub 2018 Nov 28.


Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Engiles JB, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaau0670. doi: 10.1126/scitranslmed.aau0670.


Challenges Faced by Family Caregivers: Multiple Perspectives on Eldercare.

Strommen J, Fuller H, Sanders GF, Elliott DM.

J Appl Gerontol. 2020 Apr;39(4):347-356. doi: 10.1177/0733464818813466. Epub 2018 Nov 19.


A Reactive Inelasticity Theoretical Framework for Modeling Viscoelasticity, Plastic Deformation, and Damage in Soft Tissue.

Safa B, Santare MH, Elliott DM.

J Biomech Eng. 2018 Sep 26. doi: 10.1115/1.4041575. [Epub ahead of print]


Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells.

Elliott DM, Singh N, Nagarkatti M, Nagarkatti PS.

Front Immunol. 2018 Aug 3;9:1782. doi: 10.3389/fimmu.2018.01782. eCollection 2018.


Towards the scale up of tissue engineered intervertebral discs for clinical application.

Gullbrand SE, Kim DH, Bonnevie E, Ashinsky BG, Smith LJ, Elliott DM, Mauck RL, Smith HE.

Acta Biomater. 2018 Apr 1;70:154-164. doi: 10.1016/j.actbio.2018.01.050. Epub 2018 Feb 8.


In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty.

Martin JT, Gullbrand SE, Kim DH, Ikuta K, Pfeifer CG, Ashinsky BG, Smith LJ, Elliott DM, Smith HE, Mauck RL.

Sci Rep. 2017 Nov 17;7(1):15765. doi: 10.1038/s41598-017-15887-4.


Freezing does not alter multiscale tendon mechanics and damage mechanisms in tension.

Lee AH, Elliott DM.

Ann N Y Acad Sci. 2017 Dec;1409(1):85-94. doi: 10.1111/nyas.13460. Epub 2017 Oct 25.


Strain Distribution of Intact Rat Rotator Cuff Tendon-to-Bone Attachments and Attachments With Defects.

Locke RC, Peloquin JM, Lemmon EA, Szostek A, Elliott DM, Killian ML.

J Biomech Eng. 2017 Nov 1;139(11). doi: 10.1115/1.4038111.


Special Issue: Spotlight on the Future of Musculoskeletal Biomechanics: Frontiers and Challenges in Musculoskeletal Biomechanics.

Elliott DM, Allen K.

J Biomech Eng. 2017 Nov 1;139(11). doi: 10.1115/1.4038049. No abstract available.


Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model.

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge GR, Chen W, Elliott DM, Mauck RL, Malhotra NR, Smith LJ.

Acta Biomater. 2017 Sep 15;60:201-209. doi: 10.1016/j.actbio.2017.07.025. Epub 2017 Jul 19.


Exposure to buffer solution alters tendon hydration and mechanics.

Safa BN, Meadows KD, Szczesny SE, Elliott DM.

J Biomech. 2017 Aug 16;61:18-25. doi: 10.1016/j.jbiomech.2017.06.045. Epub 2017 Jul 6.


The ultra-structural organization of the elastic network in the intra- and inter-lamellar matrix of the intervertebral disc.

Tavakoli J, Elliott DM, Costi JJ.

Acta Biomater. 2017 Aug;58:269-277. doi: 10.1016/j.actbio.2017.05.036. Epub 2017 May 17.


Investigating mechanisms of tendon damage by measuring multi-scale recovery following tensile loading.

Lee AH, Szczesny SE, Santare MH, Elliott DM.

Acta Biomater. 2017 Jul 15;57:363-372. doi: 10.1016/j.actbio.2017.04.011. Epub 2017 Apr 21.


* Optimization of Preculture Conditions to Maximize the In Vivo Performance of Cell-Seeded Engineered Intervertebral Discs.

Martin JT, Gullbrand SE, Mohanraj B, Ashinsky BG, Kim DH, Ikuta K, Elliott DM, Smith LJ, Mauck RL, Smith HE.

Tissue Eng Part A. 2017 Sep;23(17-18):923-934. doi: 10.1089/ten.tea.2016.0491. Epub 2017 Apr 19.


Evidence that interfibrillar load transfer in tendon is supported by small diameter fibrils and not extrafibrillar tissue components.

Szczesny SE, Fetchko KL, Dodge GR, Elliott DM.

J Orthop Res. 2017 Oct;35(10):2127-2134. doi: 10.1002/jor.23517. Epub 2017 Jan 31.


A large animal model that recapitulates the spectrum of human intervertebral disc degeneration.

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo JR, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ.

Osteoarthritis Cartilage. 2017 Jan;25(1):146-156. doi: 10.1016/j.joca.2016.08.006. Epub 2016 Aug 26.


Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells.

Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL.

Biophys J. 2016 Aug 23;111(4):864-874. doi: 10.1016/j.bpj.2016.07.006.


Quantifying Cartilage Contact Modulus, Tension Modulus, and Permeability With Hertzian Biphasic Creep.

Moore AC, DeLucca JF, Elliott DM, Burris DL.

J Tribol. 2016 Oct;138(4):0414051-414057. Epub 2016 Jul 26.


MRI quantification of human spine cartilage endplate geometry: Comparison with age, degeneration, level, and disc geometry.

DeLucca JF, Peloquin JM, Smith LJ, Wright AC, Vresilovic EJ, Elliott DM.

J Orthop Res. 2016 Aug;34(8):1410-7. doi: 10.1002/jor.23315. Epub 2016 Jun 19.


In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model.

Martin JT, Kim DH, Milby AH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL.

J Orthop Res. 2017 Jan;35(1):23-31. doi: 10.1002/jor.23310. Epub 2016 Jun 14.


Structure and mechanical function of the inter-lamellar matrix of the annulus fibrosus in the disc.

Tavakoli J, Elliott DM, Costi JJ.

J Orthop Res. 2016 Aug;34(8):1307-15. doi: 10.1002/jor.23306. Epub 2016 Jun 14. Review.


Human cartilage endplate permeability varies with degeneration and intervertebral disc site.

DeLucca JF, Cortes DH, Jacobs NT, Vresilovic EJ, Duncan RL, Elliott DM.

J Biomech. 2016 Feb 29;49(4):550-7. doi: 10.1016/j.jbiomech.2016.01.007. Epub 2016 Jan 14.


Theory of MRI contrast in the annulus fibrosus of the intervertebral disc.

Wright AC, Yoder JH, Vresilovic EJ, Elliott DM.

MAGMA. 2016 Aug;29(4):711-22. doi: 10.1007/s10334-015-0522-3. Epub 2016 Jan 11.


A comparison of stress in cracked fibrous tissue specimens with varied crack location, loading, and orientation using finite element analysis.

Peloquin JM, Elliott DM.

J Mech Behav Biomed Mater. 2016 Apr;57:260-8. doi: 10.1016/j.jmbbm.2015.12.004. Epub 2015 Dec 12.


Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage.

Han WM, Heo SJ, Driscoll TP, Delucca JF, McLeod CM, Smith LJ, Duncan RL, Mauck RL, Elliott DM.

Nat Mater. 2016 Apr;15(4):477-84. doi: 10.1038/nmat4520. Epub 2016 Jan 4.


Advances in Quantification of Meniscus Tensile Mechanics Including Nonlinearity, Yield, and Failure.

Peloquin JM, Santare MH, Elliott DM.

J Biomech Eng. 2016 Feb;138(2):021002. doi: 10.1115/1.4032354.


Novel human intervertebral disc strain template to quantify regional three-dimensional strains in a population and compare to internal strains predicted by a finite element model.

Showalter BL, DeLucca JF, Peloquin JM, Cortes DH, Yoder JH, Jacobs NT, Wright AC, Gee JC, Vresilovic EJ, Elliott DM.

J Orthop Res. 2016 Jul;34(7):1264-73. doi: 10.1002/jor.23137. Epub 2016 Jan 8.


Quantification of Interfibrillar Shear Stress in Aligned Soft Collagenous Tissues via Notch Tension Testing.

Szczesny SE, Caplan JL, Pedersen P, Elliott DM.

Sci Rep. 2015 Oct 15;5:14649. doi: 10.1038/srep14649.


A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications.

Martin JT, Milby AH, Ikuta K, Poudel S, Pfeifer CG, Elliott DM, Smith HE, Mauck RL.

Acta Biomater. 2015 Oct;26:97-104. doi: 10.1016/j.actbio.2015.08.001. Epub 2015 Aug 3.


Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery.

Showalter BL, Elliott DM, Chen W, Malhotra NR.

J Biomech Eng. 2015 Aug;137(8):081008. doi: 10.1115/1.4030530. Epub 2015 Jun 16.


Viscoelastic properties of healthy achilles tendon are independent of isometric plantar flexion strength and cross-sectional area.

Suydam SM, Soulas EM, Elliott DM, Silbernagel KG, Buchanan TS, Cortes DH.

J Orthop Res. 2015 Jun;33(6):926-31. doi: 10.1002/jor.22878. Epub 2015 Apr 27.


Continuous Shear Wave Elastography: A New Method to Measure Viscoelastic Properties of Tendons in Vivo.

Cortes DH, Suydam SM, Silbernagel KG, Buchanan TS, Elliott DM.

Ultrasound Med Biol. 2015 Jun;41(6):1518-29. doi: 10.1016/j.ultrasmedbio.2015.02.001. Epub 2015 Mar 19.


Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture.

Gorth DJ, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ.

J Orthop Res. 2015 May;33(5):747-54. doi: 10.1002/jor.22821. Epub 2015 Mar 8.


Phenotypic stability, matrix elaboration and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels.

Kim DH, Martin JT, Elliott DM, Smith LJ, Mauck RL.

Acta Biomater. 2015 Jan;12:21-29. doi: 10.1016/j.actbio.2014.10.030. Epub 2014 Oct 29.


In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation.

Gorth DJ, Martin JT, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ.

J Exp Orthop. 2014 Dec;1(1):15. doi: 10.1186/s40634-014-0015-8. Epub 2014 Nov 21.


Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level.

Martin JT, Collins CM, Ikuta K, Mauck RL, Elliott DM, Zhang Y, Anderson DG, Vaccaro AR, Albert TJ, Arlet V, Smith HE.

J Orthop Res. 2015 Jan;33(1):140-8. doi: 10.1002/jor.22737. Epub 2014 Oct 1.


Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles.

Szczesny SE, Elliott DM.

J Mech Behav Biomed Mater. 2014 Dec;40:325-338. doi: 10.1016/j.jmbbm.2014.09.005. Epub 2014 Sep 16.


Internal three-dimensional strains in human intervertebral discs under axial compression quantified noninvasively by magnetic resonance imaging and image registration.

Yoder JH, Peloquin JM, Song G, Tustison NJ, Moon SM, Wright AC, Vresilovic EJ, Gee JC, Elliott DM.

J Biomech Eng. 2014 Nov;136(11). doi: 10.1115/1.4028250.


Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent.

Jacobs NT, Cortes DH, Peloquin JM, Vresilovic EJ, Elliott DM.

J Biomech. 2014 Aug 22;47(11):2540-6. doi: 10.1016/j.jbiomech.2014.06.008. Epub 2014 Jun 17.

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