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Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library.

Ertesvåg H, Sletta H, Senneset M, Sun YQ, Klinkenberg G, Konradsen TA, Ellingsen TE, Valla S.

BMC Genomics. 2017 Jan 3;18(1):11. doi: 10.1186/s12864-016-3467-7.


Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids.

Aasen IM, Ertesvåg H, Heggeset TM, Liu B, Brautaset T, Vadstein O, Ellingsen TE.

Appl Microbiol Biotechnol. 2016 May;100(10):4309-21. doi: 10.1007/s00253-016-7498-4. Epub 2016 Apr 4. Review.


Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.

Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjærvik E, Zahlsen K, Brunsvik A, Nygaard G, Aachmann FL, Ellingsen TE, Døskeland SO, Zotchev SB.

Appl Microbiol Biotechnol. 2014 Jan;98(2):603-10. doi: 10.1007/s00253-013-5320-0. Epub 2013 Oct 26.


Functional characterization of key enzymes involved in L-glutamate synthesis and degradation in the thermotolerant and methylotrophic bacterium Bacillus methanolicus.

Krog A, Heggeset TM, Ellingsen TE, Brautaset T.

Appl Environ Microbiol. 2013 Sep;79(17):5321-8. doi: 10.1128/AEM.01382-13. Epub 2013 Jun 28.


Mannuronan C-5 epimerases suited for tailoring of specific alginate structures obtained by high-throughput screening of an epimerase mutant library.

Tøndervik A, Klinkenberg G, Aachmann FL, Svanem BI, Ertesvåg H, Ellingsen TE, Valla S, Skjåk-Bræk G, Sletta H.

Biomacromolecules. 2013 Aug 12;14(8):2657-66. doi: 10.1021/bm4005194. Epub 2013 Jun 28.


Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties.

Krog A, Heggeset TM, Müller JE, Kupper CE, Schneider O, Vorholt JA, Ellingsen TE, Brautaset T.

PLoS One. 2013;8(3):e59188. doi: 10.1371/journal.pone.0059188. Epub 2013 Mar 19.


Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling.

Borgos SE, Bordel S, Sletta H, Ertesvåg H, Jakobsen Ø, Bruheim P, Ellingsen TE, Nielsen J, Valla S.

BMC Syst Biol. 2013 Mar 11;7:19. doi: 10.1186/1752-0509-7-19.


Combinatorial mutagenesis and selection of improved signal sequences and their application for high-level production of translocated heterologous proteins in Escherichia coli.

Heggeset TM, Kucharova V, Naerdal I, Valla S, Sletta H, Ellingsen TE, Brautaset T.

Appl Environ Microbiol. 2013 Jan;79(2):559-68. doi: 10.1128/AEM.02407-12. Epub 2012 Nov 9.


Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2).

Wentzel A, Bruheim P, Øverby A, Jakobsen ØM, Sletta H, Omara WA, Hodgson DA, Ellingsen TE.

BMC Syst Biol. 2012 Jun 7;6:59. doi: 10.1186/1752-0509-6-59.


Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor.

Martín JF, Santos-Beneit F, Rodríguez-García A, Sola-Landa A, Smith MC, Ellingsen TE, Nieselt K, Burroughs NJ, Wellington EM.

Appl Microbiol Biotechnol. 2012 Jul;95(1):61-75. doi: 10.1007/s00253-012-4129-6. Epub 2012 May 24. Review.


Genome sequence of thermotolerant Bacillus methanolicus: features and regulation related to methylotrophy and production of L-lysine and L-glutamate from methanol.

Heggeset TM, Krog A, Balzer S, Wentzel A, Ellingsen TE, Brautaset T.

Appl Environ Microbiol. 2012 Aug;78(15):5170-81. doi: 10.1128/AEM.00703-12. Epub 2012 May 18.


Rapid reagentless quantification of alginate biosynthesis in Pseudomonas fluorescens bacteria mutants using FT-IR spectroscopy coupled to multivariate partial least squares regression.

Correa E, Sletta H, Ellis DI, Hoel S, Ertesvåg H, Ellingsen TE, Valla S, Goodacre R.

Anal Bioanal Chem. 2012 Jul;403(9):2591-9. doi: 10.1007/s00216-012-6068-6. Epub 2012 May 15.


Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor.

Wentzel A, Sletta H; Stream Consortium, Ellingsen TE, Bruheim P.

Metabolites. 2012 Feb 17;2(1):178-94. doi: 10.3390/metabo2010178.


Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture.

Thomas L, Hodgson DA, Wentzel A, Nieselt K, Ellingsen TE, Moore J, Morrissey ER, Legaie R; STREAM Consortium, Wohlleben W, Rodríguez-García A, Martín JF, Burroughs NJ, Wellington EM, Smith MC.

Mol Cell Proteomics. 2012 Feb;11(2):M111.013797. doi: 10.1074/mcp.M111.013797. Epub 2011 Dec 6.


Ralstonia sp. U2 naphthalene dioxygenase and Comamonas sp. JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.

Tøndervik A, Bruheim P, Berg L, Ellingsen TE, Kotlar HK, Valla S, Throne-Holst M.

J Biosci Bioeng. 2012 Feb;113(2):173-8. doi: 10.1016/j.jbiosc.2011.10.001. Epub 2011 Oct 28.


The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor.

Waldvogel E, Herbig A, Battke F, Amin R, Nentwich M, Nieselt K, Ellingsen TE, Wentzel A, Hodgson DA, Wohlleben W, Mast Y.

Appl Microbiol Biotechnol. 2011 Dec;92(6):1219-36. doi: 10.1007/s00253-011-3644-1. Epub 2011 Oct 28.


Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.

Heia S, Borgos SE, Sletta H, Escudero L, Seco EM, Malpartida F, Ellingsen TE, Zotchev SB.

Appl Environ Microbiol. 2011 Oct;77(19):6982-90. doi: 10.1128/AEM.05781-11. Epub 2011 Aug 5.


New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei.

Brautaset T, Sletta H, Degnes KF, Sekurova ON, Bakke I, Volokhan O, Andreassen T, Ellingsen TE, Zotchev SB.

Appl Environ Microbiol. 2011 Sep;77(18):6636-43. doi: 10.1128/AEM.05780-11. Epub 2011 Jul 15.


Analysis and manipulation of aspartate pathway genes for L-lysine overproduction from methanol by Bacillus methanolicus.

Nærdal I, Netzer R, Ellingsen TE, Brautaset T.

Appl Environ Microbiol. 2011 Sep;77(17):6020-6. doi: 10.1128/AEM.05093-11. Epub 2011 Jul 1.


A technical platform for generating reproducible expression data from Streptomyces coelicolor batch cultivations.

Battke F, Herbig A, Wentzel A, Jakobsen OM, Bonin M, Hodgson DA, Wohlleben W, Ellingsen TE; STREAM Consortium, Nieselt K.

Adv Exp Med Biol. 2011;696:3-15. doi: 10.1007/978-1-4419-7046-6_1.


Isolation of mutant alginate lyases with cleavage specificity for di-guluronic acid linkages.

Tøndervik A, Klinkenberg G, Aarstad OA, Drabløs F, Ertesvåg H, Ellingsen TE, Skjåk-Bræk G, Valla S, Sletta H.

J Biol Chem. 2010 Nov 12;285(46):35284-92. doi: 10.1074/jbc.M110.162800. Epub 2010 Sep 7.


Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.

Engelhardt K, Degnes KF, Kemmler M, Bredholt H, Fjaervik E, Klinkenberg G, Sletta H, Ellingsen TE, Zotchev SB.

Appl Environ Microbiol. 2010 Aug;76(15):4969-76. doi: 10.1128/AEM.00741-10. Epub 2010 Jun 18.


Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50 degrees C.

Brautaset T, Jakobsen ØM, Degnes KF, Netzer R, Naerdal I, Krog A, Dillingham R, Flickinger MC, Ellingsen TE.

Appl Microbiol Biotechnol. 2010 Jul;87(3):951-64. doi: 10.1007/s00253-010-2559-6. Epub 2010 Apr 7.


Isolation and characterization of marine pigmented bacteria from Norwegian coastal waters and screening for carotenoids with UVA-blue light absorbing properties.

Stafsnes MH, Josefsen KD, Kildahl-Andersen G, Valla S, Ellingsen TE, Bruheim P.

J Microbiol. 2010 Feb;48(1):16-23. doi: 10.1007/s12275-009-0118-6. Epub 2010 Mar 11.


Violacein-producing Collimonas sp. from the sea surface microlayer of costal waters in Trøndelag, Norway.

Hakvåg S, Fjaervik E, Klinkenberg G, Borgos SE, Josefsen KD, Ellingsen TE, Zotchev SB.

Mar Drugs. 2009 Nov 12;7(4):576-88. doi: 10.3390/md7040576.


The dynamic architecture of the metabolic switch in Streptomyces coelicolor.

Nieselt K, Battke F, Herbig A, Bruheim P, Wentzel A, Jakobsen ØM, Sletta H, Alam MT, Merlo ME, Moore J, Omara WA, Morrissey ER, Juarez-Hermosillo MA, Rodríguez-García A, Nentwich M, Thomas L, Iqbal M, Legaie R, Gaze WH, Challis GL, Jansen RC, Dijkhuizen L, Rand DA, Wild DL, Bonin M, Reuther J, Wohlleben W, Smith MC, Burroughs NJ, Martín JF, Hodgson DA, Takano E, Breitling R, Ellingsen TE, Wellington EM.

BMC Genomics. 2010 Jan 6;11:10. doi: 10.1186/1471-2164-11-10.


Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.

Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB.

Chem Biol. 2009 Oct 30;16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014.


A plasmid RK2-based broad-host-range cloning vector useful for transfer of metagenomic libraries to a variety of bacterial species.

Aakvik T, Degnes KF, Dahlsrud R, Schmidt F, Dam R, Yu L, Völker U, Ellingsen TE, Valla S.

FEMS Microbiol Lett. 2009 Jun;296(2):149-58. doi: 10.1111/j.1574-6968.2009.01639.x. Epub 2009 May 4.


Candicidin biosynthesis gene cluster is widely distributed among Streptomyces spp. isolated from the sediments and the neuston layer of the Trondheim fjord, Norway.

Jørgensen H, Fjaervik E, Hakvåg S, Bruheim P, Bredholt H, Klinkenberg G, Ellingsen TE, Zotchev SB.

Appl Environ Microbiol. 2009 May;75(10):3296-303. doi: 10.1128/AEM.02730-08. Epub 2009 Mar 13.


Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.

Hakvåg S, Fjaervik E, Josefsen KD, Ian E, Ellingsen TE, Zotchev SB.

Mar Drugs. 2008;6(4):620-35. doi: 10.3390/md6040620. Epub 2008 Dec 1.


Overexpression of wild-type aspartokinase increases L-lysine production in the thermotolerant methylotrophic bacterium Bacillus methanolicus.

Jakobsen OM, Brautaset T, Degnes KF, Heggeset TM, Balzer S, Flickinger MC, Valla S, Ellingsen TE.

Appl Environ Microbiol. 2009 Feb;75(3):652-61. doi: 10.1128/AEM.01176-08. Epub 2008 Dec 5.


Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei.

Brautaset T, Sletta H, Nedal A, Borgos SE, Degnes KF, Bakke I, Volokhan O, Sekurova ON, Treshalin ID, Mirchink EP, Dikiy A, Ellingsen TE, Zotchev SB.

Chem Biol. 2008 Nov 24;15(11):1198-206. doi: 10.1016/j.chembiol.2008.08.009.


The Azotobacter vinelandii AlgE mannuronan C-5-epimerase family is essential for the in vivo control of alginate monomer composition and for functional cyst formation.

Steigedal M, Sletta H, Moreno S, Maerk M, Christensen BE, Bjerkan T, Ellingsen TE, Espìn G, Ertesvåg H, Valla S.

Environ Microbiol. 2008 Jul;10(7):1760-70. doi: 10.1111/j.1462-2920.2008.01597.x. Epub 2008 Mar 28.


Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.

Nedal A, Sletta H, Brautaset T, Borgos SE, Sekurova ON, Ellingsen TE, Zotchev SB.

Appl Environ Microbiol. 2007 Nov;73(22):7400-7. Epub 2007 Sep 28.


Bacterial metabolism of long-chain n-alkanes.

Wentzel A, Ellingsen TE, Kotlar HK, Zotchev SB, Throne-Holst M.

Appl Microbiol Biotechnol. 2007 Oct;76(6):1209-21. Epub 2007 Aug 3. Review.


Identification of novel genes involved in long-chain n-alkane degradation by Acinetobacter sp. strain DSM 17874.

Throne-Holst M, Wentzel A, Ellingsen TE, Kotlar HK, Zotchev SB.

Appl Environ Microbiol. 2007 May;73(10):3327-32. Epub 2007 Mar 30.


Bacillus methanolicus: a candidate for industrial production of amino acids from methanol at 50 degrees C.

Brautaset T, Jakobsen ØM, Josefsen KD, Flickinger MC, Ellingsen TE.

Appl Microbiol Biotechnol. 2007 Feb;74(1):22-34. Epub 2007 Jan 11. Review.


The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Escherichia coli.

Sletta H, Tøndervik A, Hakvåg S, Aune TE, Nedal A, Aune R, Evensen G, Valla S, Ellingsen TE, Brautaset T.

Appl Environ Microbiol. 2007 Feb;73(3):906-12. Epub 2006 Dec 1.


[Comparative analysis of in vitro antifungal activity and in vivo acute toxicity of the nystatin analogue S44HP produced via genetic engineering].

Treshchalin ID, Sletta H, Borgos SE, Pereverzeva EP, Voeĭkova TA, Ellingsen TE, Zotchev SB.

Antibiot Khimioter. 2005;50(7):18-22. Russian.


Probing the structure-function relationship of polyene macrolides: engineered biosynthesis of soluble nystatin analogues.

Borgos SE, Tsan P, Sletta H, Ellingsen TE, Lancelin JM, Zotchev SB.

J Med Chem. 2006 Apr 20;49(8):2431-9.


Utilization of n-alkanes by a newly isolated strain of Acinetobacter venetianus: the role of two AlkB-type alkane hydroxylases.

Throne-Holst M, Markussen S, Winnberg A, Ellingsen TE, Kotlar HK, Zotchev SB.

Appl Microbiol Biotechnol. 2006 Sep;72(2):353-60. Epub 2006 Mar 7.


Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis.

Borgos SE, Sletta H, Fjaervik E, Brautaset T, Ellingsen TE, Gulliksen OM, Zotchev SB.

Arch Microbiol. 2006 Apr;185(3):165-71. Epub 2006 Jan 14.


Role of the Pseudomonas fluorescens alginate lyase (AlgL) in clearing the periplasm of alginates not exported to the extracellular environment.

Bakkevig K, Sletta H, Gimmestad M, Aune R, Ertesvåg H, Degnes K, Christensen BE, Ellingsen TE, Valla S.

J Bacteriol. 2005 Dec;187(24):8375-84.


Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.

Sletta H, Borgos SE, Bruheim P, Sekurova ON, Grasdalen H, Aune R, Ellingsen TE, Zotchev SB.

Antimicrob Agents Chemother. 2005 Nov;49(11):4576-83.


Broad-host-range plasmid pJB658 can be used for industrial-level production of a secreted host-toxic single-chain antibody fragment in Escherichia coli.

Sletta H, Nedal A, Aune TE, Hellebust H, Hakvåg S, Aune R, Ellingsen TE, Valla S, Brautaset T.

Appl Environ Microbiol. 2004 Dec;70(12):7033-9.


Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.

Bruheim P, Borgos SE, Tsan P, Sletta H, Ellingsen TE, Lancelin JM, Zotchev SB.

Antimicrob Agents Chemother. 2004 Nov;48(11):4120-9.


Plasmid-dependent methylotrophy in thermotolerant Bacillus methanolicus.

Brautaset T, Jakobsen M ØM, Flickinger MC, Valla S, Ellingsen TE.

J Bacteriol. 2004 Mar;186(5):1229-38.

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