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Items: 1 to 50 of 73


Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.

Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG.

PLoS One. 2018 Sep 24;13(9):e0198464. doi: 10.1371/journal.pone.0198464. eCollection 2018.


Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

Ireland L, Santos A, Campbell F, Figueiredo C, Hammond D, Ellies LG, Weyer-Czernilofsky U, Bogenrieder T, Schmid M, Mielgo A.

Oncogene. 2018 Apr;37(15):2022-2036. doi: 10.1038/s41388-017-0115-x. Epub 2018 Jan 25.


Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis.

Gross ET, Han S, Vemu P, Peinado CD, Marsala M, Ellies LG, Bui JD.

Oncoimmunology. 2016 Dec 14;6(2):e1268310. doi: 10.1080/2162402X.2016.1268310. eCollection 2017.


Reprogramming the immunological microenvironment through radiation and targeting Axl.

Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ.

Nat Commun. 2016 Dec 23;7:13898. doi: 10.1038/ncomms13898.


Collagen and fibronectin: threads linking obesity and breast cancer.

Ellies LG.

Ann Transl Med. 2016 Oct;4(Suppl 1):S50. No abstract available.


Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity.

Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG.

Metabolism. 2016 Dec;65(12):1743-1754. doi: 10.1016/j.metabol.2016.09.006. Epub 2016 Sep 22.


Obesity-associated NLRC4 inflammasome activation drives breast cancer progression.

Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W.

Nat Commun. 2016 Oct 6;7:13007. doi: 10.1038/ncomms13007.


Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies.

Spilker ME, Chung H, Visswanathan R, Bagrodia S, Gernhardt S, Fantin VR, Ellies LG.

Xenobiotica. 2017 Jul;47(7):600-606. doi: 10.1080/00498254.2016.1207112. Epub 2016 Jul 20.


Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.

Cimen Bozkus C, Elzey BD, Crist SA, Ellies LG, Ratliff TL.

J Immunol. 2015 Dec 1;195(11):5237-50. doi: 10.4049/jimmunol.1500959. Epub 2015 Oct 21.


Multipotent luminal mammary cancer stem cells model tumor heterogeneity.

Bao L, Cardiff RD, Steinbach P, Messer KS, Ellies LG.

Breast Cancer Res. 2015 Oct 14;17(1):137. doi: 10.1186/s13058-015-0615-y.


Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer.

Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG.

Oncogene. 2015 Jul;34(27):3504-13. doi: 10.1038/onc.2014.283. Epub 2014 Sep 15.


Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. Epub 2014 Sep 4.


Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound.

Liberman A, Wu Z, Barback CV, Viveros RD, Wang J, Ellies LG, Mattrey RF, Trogler WC, Kummel AC, Blair SL.

J Surg Res. 2014 Aug;190(2):391-8. doi: 10.1016/j.jss.2014.05.009. Epub 2014 May 10.


Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis.

Zhou JZ, Riquelme MA, Gao X, Ellies LG, Sun LZ, Jiang JX.

Oncogene. 2015 Apr 2;34(14):1831-42. doi: 10.1038/onc.2014.113. Epub 2014 May 19.


Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery.

Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY.

Mol Cancer Ther. 2014 Jun;13(6):1514-25. doi: 10.1158/1535-7163.MCT-13-1067. Epub 2014 Apr 15.


Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model.

Biswas T, Gu X, Yang J, Ellies LG, Sun LZ.

Cancer Lett. 2014 Apr 28;346(1):129-38. doi: 10.1016/j.canlet.2013.12.018. Epub 2013 Dec 22.


Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice.

Yokota N, Zarpellon A, Chakrabarty S, Bogdanov VY, Gruber A, Castellino FJ, Mackman N, Ellies LG, Weiler H, Ruggeri ZM, Ruf W.

J Thromb Haemost. 2014 Jan;12(1):71-81. doi: 10.1111/jth.12442.


Correlation of transcription of MALAT-1, a novel noncoding RNA, with deregulated expression of tumor suppressor p53 in small DNA tumor virus models.

Jeffers LK, Duan K, Ellies LG, Seaman WT, Burger-Calderon RA, Diatchenko LB, Webster-Cyriaque J.

J Cancer Ther. 2013 May;4(3). doi: 10.4236/jct.2013.43094.


Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells.

Liberman A, Wu Z, Barback CV, Viveros R, Blair SL, Ellies LG, Vera DR, Mattrey RF, Kummel AC, Trogler WC.

ACS Nano. 2013 Jul 23;7(7):6367-77. doi: 10.1021/nn402507d. Epub 2013 Jul 1.


Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10.

Burkart C, Arimoto K, Tang T, Cong X, Xiao N, Liu YC, Kotenko SV, Ellies LG, Zhang DE.

EMBO Mol Med. 2013 Jul;5(7):1035-50. doi: 10.1002/emmm.201201864. Epub 2013 May 16.


PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes.

Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9042-7. doi: 10.1073/pnas.1219603110. Epub 2013 May 13.


Fluorescent ligand for human progesterone receptor imaging in live cells.

Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY.

Bioconjug Chem. 2013 May 15;24(5):766-71. doi: 10.1021/bc3006418. Epub 2013 Apr 29.


Nicotine promotes acquisition of stem cell and epithelial-to-mesenchymal properties in head and neck squamous cell carcinoma.

Yu MA, Kiang A, Wang-Rodriguez J, Rahimy E, Haas M, Yu V, Ellies LG, Chen J, Fan JB, Brumund KT, Weisman RA, Ongkeko WM.

PLoS One. 2012;7(12):e51967. doi: 10.1371/journal.pone.0051967. Epub 2012 Dec 26.


Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides.

Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT.

Cancer Res. 2013 Jan 15;73(2):855-64. doi: 10.1158/0008-5472.CAN-12-2969. Epub 2012 Nov 27.


Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan.

Gibby K, You WK, Kadoya K, Helgadottir H, Young LJ, Ellies LG, Chang Y, Cardiff RD, Stallcup WB.

Breast Cancer Res. 2012 Apr 24;14(2):R67.


Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT.

PLoS One. 2011;6(12):e29046. doi: 10.1371/journal.pone.0029046. Epub 2011 Dec 14.


Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA.

Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016.


Spiers Memorial Lecture. Breeding and building molecular spies.

Shu X, Lev-Ram V, Olson ES, Aguilera TA, Jiang T, Whitney M, Crisp JL, Steinbach P, Deerinck T, Ellisman MH, Ellies LG, Nguyen QT, Tsien RY.

Faraday Discuss. 2011;149:9; discussion 63-77.


Control of mammary tumor differentiation by SKI-606 (bosutinib).

Hebbard L, Cecena G, Golas J, Sawada J, Ellies LG, Charbono A, Williams R, Jimenez RE, Wankell M, Arndt KT, DeJoy SQ, Rollins RA, Diesl V, Follettie M, Chen L, Rosfjord E, Cardiff RD, Komatsu M, Boschelli F, Oshima RG.

Oncogene. 2011 Jan 20;30(3):301-12. doi: 10.1038/onc.2010.412. Epub 2010 Sep 6.


The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis.

Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N.

Respir Res. 2010 Jun 24;11:87. doi: 10.1186/1465-9921-11-87.


Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides.

Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY.

J Biol Chem. 2010 Jul 16;285(29):22532-41. doi: 10.1074/jbc.M110.138297. Epub 2010 May 11.


Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.

Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA.

Cancer Res. 2010 Apr 15;70(8):3042-51. doi: 10.1158/0008-5472.CAN-09-3761. Epub 2010 Apr 13.


Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival.

Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4317-22. doi: 10.1073/pnas.0910261107. Epub 2010 Feb 16.


Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases.

Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4311-6. doi: 10.1073/pnas.0910283107. Epub 2010 Feb 16.


In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer.

Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY.

Integr Biol (Camb). 2009 Jun;1(5-6):382-93. doi: 10.1039/b904890a. Epub 2009 May 11.


Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice.

Versteeg HH, Schaffner F, Kerver M, Ellies LG, Andrade-Gordon P, Mueller BM, Ruf W.

Cancer Res. 2008 Sep 1;68(17):7219-27. doi: 10.1158/0008-5472.CAN-08-0419.


Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.

Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M.

J Exp Med. 2008 Jun 9;205(6):1435-46. doi: 10.1084/jem.20070846. Epub 2008 Jun 2.


Epidermal sensing of oxygen is essential for systemic hypoxic response.

Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS.

Cell. 2008 Apr 18;133(2):223-34. doi: 10.1016/j.cell.2008.02.038.


Cationic amino acid transporter-2 regulates immunity by modulating arginase activity.

Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA.

PLoS Pathog. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023.


L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages.

Wanasen N, MacLeod CL, Ellies LG, Soong L.

Infect Immun. 2007 Jun;75(6):2802-10. Epub 2007 Mar 26.


Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice.

Davie SA, Maglione JE, Manner CK, Young D, Cardiff RD, MacLeod CL, Ellies LG.

Transgenic Res. 2007 Apr;16(2):193-201. Epub 2007 Jan 6.


Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation.

Sperandio M, Frommhold D, Babushkina I, Ellies LG, Olson TS, Smith ML, Fritzsching B, Pauly E, Smith DF, Nobiling R, Linderkamp O, Marth JD, Ley K.

Eur J Immunol. 2006 Dec;36(12):3207-15.


Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.

Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG, Zimmermann N.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14895-900. Epub 2006 Sep 26.


A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.

Underhill GH, Zisoulis DG, Kolli KP, Ellies LG, Marth JD, Kansas GS.

Blood. 2005 Dec 1;106(12):3867-73. Epub 2005 Aug 11.


Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes.

Maglione JE, McGoldrick ET, Young LJ, Namba R, Gregg JP, Liu L, Moghanaki D, Ellies LG, Borowsky AD, Cardiff RD, MacLeod CL.

Mol Cancer Ther. 2004 Aug;3(8):941-53.


Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

Ellies LG, Fishman M, Hardison J, Kleeman J, Maglione JE, Manner CK, Cardiff RD, MacLeod CL.

Int J Cancer. 2003 Aug 10;106(1):1-7.


Sialyltransferase specificity in selectin ligand formation.

Ellies LG, Sperandio M, Underhill GH, Yousif J, Smith M, Priatel JJ, Kansas GS, Ley K, Marth JD.

Blood. 2002 Nov 15;100(10):3618-25. Epub 2002 Jul 25.


Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.

Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10042-7. Epub 2002 Jul 3.


Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment.

Broide DH, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies LG, Sriramarao P.

Am J Physiol Lung Cell Mol Physiol. 2002 Feb;282(2):L259-66.

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