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Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome.

Wallen JR, Zhang H, Weis C, Cui W, Foster BM, Ho CMW, Hammel M, Tainer JA, Gross ML, Ellenberger T.

Structure. 2017 Jan 3;25(1):157-166. doi: 10.1016/j.str.2016.11.019.


Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.

Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA.

Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3.


Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities.

Cheruiyot A, Paudyal SC, Kim IK, Sparks M, Ellenberger T, Piwnica-Worms H, You Z.

DNA Repair (Amst). 2015 Nov;35:106-15. doi: 10.1016/j.dnarep.2015.09.021. Epub 2015 Sep 30.


Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.

Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T.

Nucleic Acids Res. 2015 Aug 18;43(14):7021-31. doi: 10.1093/nar/gkv652. Epub 2015 Jun 29.


The rise and fall of poly(ADP-ribose): An enzymatic perspective.

Pascal JM, Ellenberger T.

DNA Repair (Amst). 2015 Aug;32:10-16. doi: 10.1016/j.dnarep.2015.04.008. Epub 2015 May 1. Review.


14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.

Chen X, Kim IK, Honaker Y, Paudyal SC, Koh WK, Sparks M, Li S, Piwnica-Worms H, Ellenberger T, You Z.

J Biol Chem. 2015 May 8;290(19):12300-12. doi: 10.1074/jbc.M115.644005. Epub 2015 Apr 1.


The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.

Ghisays F, Brace CS, Yackly SM, Kwon HJ, Mills KF, Kashentseva E, Dmitriev IP, Curiel DT, Imai SI, Ellenberger T.

Cell Rep. 2015 Mar 17;10(10):1665-1673. doi: 10.1016/j.celrep.2015.02.036. Epub 2015 Mar 12.


Discrete interactions between bacteriophage T7 primase-helicase and DNA polymerase drive the formation of a priming complex containing two copies of DNA polymerase.

Wallen JR, Majka J, Ellenberger T.

Biochemistry. 2013 Jun 11;52(23):4026-36. doi: 10.1021/bi400284j. Epub 2013 May 31.


The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.

Della-Maria J, Hegde ML, McNeill DR, Matsumoto Y, Tsai MS, Ellenberger T, Wilson DM 3rd, Mitra S, Tomkinson AE.

J Biol Chem. 2012 Nov 9;287(46):39233-44. doi: 10.1074/jbc.M112.369975. Epub 2012 Sep 19.


Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.

Kim IK, Kiefer JR, Ho CM, Stegeman RA, Classen S, Tainer JA, Ellenberger T.

Nat Struct Mol Biol. 2012 May 20;19(6):653-6. doi: 10.1038/nsmb.2305.


An arresting development in transcription.

Ellenberger T.

Mol Cell. 2012 Apr 13;46(1):3-4. doi: 10.1016/j.molcel.2012.03.025.


Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes.

Sperry JB, Smith CL, Caparon MG, Ellenberger T, Gross ML.

Biochemistry. 2011 May 17;50(19):4038-45. doi: 10.1021/bi200244k. Epub 2011 Apr 19.


Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.

Smith CL, Ghosh J, Elam JS, Pinkner JS, Hultgren SJ, Caparon MG, Ellenberger T.

Structure. 2011 Feb 9;19(2):192-202. doi: 10.1016/j.str.2010.12.013.


Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.

Cotner-Gohara E, Kim IK, Hammel M, Tainer JA, Tomkinson AE, Ellenberger T.

Biochemistry. 2010 Jul 27;49(29):6165-76. doi: 10.1021/bi100503w.


Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.

J Med Chem. 2010 Jun 24;53(12):4779-92. doi: 10.1021/jm100438s.


Structural dynamics in DNA damage signaling and repair.

Perry JJ, Cotner-Gohara E, Ellenberger T, Tainer JA.

Curr Opin Struct Biol. 2010 Jun;20(3):283-94. doi: 10.1016/ Epub 2010 May 1. Review.


The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.

Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2010 Feb 5;285(6):3705-12. doi: 10.1074/jbc.M109.067538. Epub 2009 Nov 23.


Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

Antony E, Tomko EJ, Xiao Q, Krejci L, Lohman TM, Ellenberger T.

Mol Cell. 2009 Jul 10;35(1):105-15. doi: 10.1016/j.molcel.2009.05.026.


An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages.

Etzion Y, Hackett A, Proctor BM, Ren J, Nolan B, Ellenberger T, Muslin AJ.

Circ Res. 2009 Jul 17;105(2):148-57. doi: 10.1161/CIRCRESAHA.109.195818. Epub 2009 Jun 18.


The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

Song W, Pascal JM, Ellenberger T, Tomkinson AE.

DNA Repair (Amst). 2009 Aug 6;8(8):912-9. doi: 10.1016/j.dnarep.2009.05.002. Epub 2009 Jun 11.


Mechanism of replication-coupled DNA interstrand crosslink repair.

Räschle M, Knipscheer P, Enoiu M, Angelov T, Sun J, Griffith JD, Ellenberger TE, Schärer OD, Walter JC.

Cell. 2008 Sep 19;134(6):969-80. doi: 10.1016/j.cell.2008.08.030. Erratum in: Cell.2009 May 29;137(5):972. Knipsheer, Puck [corrected to Knipscheer, Puck].


Identification and validation of human DNA ligase inhibitors using computer-aided drug design.

Zhong S, Chen X, Zhu X, Dziegielewska B, Bachman KE, Ellenberger T, Ballin JD, Wilson GM, Tomkinson AE, MacKerell AD Jr.

J Med Chem. 2008 Aug 14;51(15):4553-62. doi: 10.1021/jm8001668. Epub 2008 Jul 17.


Eukaryotic DNA ligases: structural and functional insights.

Ellenberger T, Tomkinson AE.

Annu Rev Biochem. 2008;77:313-38. doi: 10.1146/annurev.biochem.77.061306.123941. Review.


Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.

Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD Jr, Tomkinson AE.

Cancer Res. 2008 May 1;68(9):3169-77. doi: 10.1158/0008-5472.CAN-07-6636.


Two DNA-binding and nick recognition modules in human DNA ligase III.

Cotner-Gohara E, Kim IK, Tomkinson AE, Ellenberger T.

J Biol Chem. 2008 Apr 18;283(16):10764-72. doi: 10.1074/jbc.M708175200. Epub 2008 Jan 30.


Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.

Tsodikov OV, Ivanov D, Orelli B, Staresincic L, Shoshani I, Oberman R, Schärer OD, Wagner G, Ellenberger T.

EMBO J. 2007 Nov 14;26(22):4768-76. Epub 2007 Oct 18.


Domain-swapped dimerization of the HIV-1 capsid C-terminal domain.

Ivanov D, Tsodikov OV, Kasanov J, Ellenberger T, Wagner G, Collins T.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4353-8. Epub 2007 Mar 5.


Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.

Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D'Andrea AD.

Mol Cell Biol. 2007 Apr;27(8):3098-108. Epub 2007 Feb 12.


RNA ligase does the AMP shuffle.

Pascal JM, Ellenberger T.

Nat Struct Mol Biol. 2006 Nov;13(11):950-1. No abstract available.


Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.

Kowal P, Gurtan AM, Stuckert P, D'Andrea AD, Ellenberger T.

J Biol Chem. 2007 Jan 19;282(3):2047-55. Epub 2006 Nov 1.


A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T.

Mol Cell. 2006 Oct 20;24(2):279-91.


Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes.

Chen X, Pascal J, Vijayakumar S, Wilson GM, Ellenberger T, Tomkinson AE.

Methods Enzymol. 2006;409:39-52.


Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments.

King DA, Hall BE, Iwamoto MA, Win KZ, Chang JF, Ellenberger T.

J Biol Chem. 2006 Jul 21;281(29):20107-19. Epub 2006 May 22.


DNA ligases: structure, reaction mechanism, and function.

Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T.

Chem Rev. 2006 Feb;106(2):687-99. Review. No abstract available.


DNA arms do the legwork to ensure the directionality of lambda site-specific recombination.

Radman-Livaja M, Biswas T, Ellenberger T, Landy A, Aihara H.

Curr Opin Struct Biol. 2006 Feb;16(1):42-50. Epub 2005 Dec 20. Review.


Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs.

Kim TW, Brieba LG, Ellenberger T, Kool ET.

J Biol Chem. 2006 Jan 27;281(4):2289-95. Epub 2005 Nov 27.


A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.

Brieba LG, Kokoska RJ, Bebenek K, Kunkel TA, Ellenberger T.

Structure. 2005 Nov;13(11):1653-9.


Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman A.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17308-13. Epub 2005 Oct 31.


Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo.

Chan B, Greenan G, McKeon F, Ellenberger T.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13075-80. Epub 2005 Aug 30.


Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1.

Tsodikov OV, Enzlin JH, Schärer OD, Ellenberger T.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11236-41. Epub 2005 Aug 2.


A structural basis for allosteric control of DNA recombination by lambda integrase.

Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T.

Nature. 2005 Jun 23;435(7045):1059-66.


Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.

Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T.

Biochemistry. 2005 Jun 14;44(23):8312-25.


A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.

Rudner AD, Hall BE, Ellenberger T, Moazed D.

Mol Cell Biol. 2005 Jun;25(11):4514-28.


Non-equivalent interactions between amino-terminal domains of neighboring lambda integrase protomers direct Holliday junction resolution.

Lee SY, Radman-Livaja M, Warren D, Aihara H, Ellenberger T, Landy A.

J Mol Biol. 2005 Jan 21;345(3):475-85.


Human DNA ligase I completely encircles and partially unwinds nicked DNA.

Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T.

Nature. 2004 Nov 25;432(7016):473-8.


Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.

Dutta S, Li Y, Johnson D, Dzantiev L, Richardson CC, Romano LJ, Ellenberger T.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16186-91. Epub 2004 Nov 4.


Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54.

Raschle M, Van Komen S, Chi P, Ellenberger T, Sung P.

J Biol Chem. 2004 Dec 10;279(50):51973-80. Epub 2004 Sep 30.


Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.

Brieba LG, Eichman BF, Kokoska RJ, Doublié S, Kunkel TA, Ellenberger T.

EMBO J. 2004 Sep 1;23(17):3452-61. Epub 2004 Aug 5.

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