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Items: 1 to 50 of 329

1.

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C.

Cell Rep. 2019 Sep 24;28(13):3435-3449.e5. doi: 10.1016/j.celrep.2019.08.060.

2.

Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.

Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J.

Genomics Proteomics Bioinformatics. 2019 Sep 5. pii: S1672-0229(18)30126-8. doi: 10.1016/j.gpb.2018.12.010. [Epub ahead of print]

3.

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.

Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.

Cell. 2019 Aug 8;178(4):1016-1028.e13. doi: 10.1016/j.cell.2019.07.009.

PMID:
31398327
4.

Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.

Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LB.

Nat Ecol Evol. 2019 Aug;3(8):1253-1264. doi: 10.1038/s41559-019-0947-6. Epub 2019 Jul 29.

PMID:
31358949
5.

Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia.

Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LF.

Cell Mol Life Sci. 2019 Jul 27. doi: 10.1007/s00018-019-03242-x. [Epub ahead of print]

PMID:
31352533
6.

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.

Timms RT, Zhang Z, Rhee DY, Harper JW, Koren I, Elledge SJ.

Science. 2019 Jul 5;365(6448). pii: eaaw4912. doi: 10.1126/science.aaw4912.

PMID:
31273098
7.

Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.

Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon N.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14614-14619. doi: 10.1073/pnas.1821863116. Epub 2019 Jul 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17128.

PMID:
31262815
8.

Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation.

Bender Ignacio RA, Dasgupta S, Stevens-Ayers T, Kula T, Hill JA, Lee SJ, Mielcarek M, Duerr A, Elledge SJ, Boeckh M.

Blood. 2019 Aug 8;134(6):503-514. doi: 10.1182/blood.2019897405. Epub 2019 Jun 11.

PMID:
31186276
9.

Temporal virus serological profiling of kidney graft recipients using VirScan.

Isnard P, Kula T, Avettand Fenoel V, Anglicheau D, Terzi F, Legendre C, Elledge SJ, Canaud G.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10899-10904. doi: 10.1073/pnas.1821166116. Epub 2019 May 13.

PMID:
31085644
10.

Comprehensive Profiling of HIV Antibody Evolution.

Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB.

Cell Rep. 2019 Apr 30;27(5):1422-1433.e4. doi: 10.1016/j.celrep.2019.03.097.

11.

Tissue-specificity in cancer: The rule, not the exception.

Haigis KM, Cichowski K, Elledge SJ.

Science. 2019 Mar 15;363(6432):1150-1151. doi: 10.1126/science.aaw3472. No abstract available.

PMID:
30872507
12.

Sequencer Hacking Unlocks Quantitative Protein Studies.

Barber KW, Elledge SJ.

Mol Cell. 2019 Mar 7;73(5):863-865. doi: 10.1016/j.molcel.2019.01.039.

PMID:
30849392
13.

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.

Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.

Cancer Discov. 2019 Apr;9(4):526-545. doi: 10.1158/2159-8290.CD-18-0879. Epub 2019 Feb 1.

PMID:
30709805
14.

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ.

Mol Cell. 2019 Mar 7;73(5):885-899.e6. doi: 10.1016/j.molcel.2018.12.008. Epub 2019 Jan 24.

PMID:
30686591
15.

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.

Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajić A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY.

J Neurosci. 2018 Oct 24;38(43):9286-9301. doi: 10.1523/JNEUROSCI.0254-18.2018. Epub 2018 Sep 24.

16.

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.

Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL.

J Exp Med. 2018 Oct 1;215(10):2567-2585. doi: 10.1084/jem.20180628. Epub 2018 Aug 24.

17.

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.

Liao S, Maertens O, Cichowski K, Elledge SJ.

Genes Dev. 2018 Sep 1;32(17-18):1188-1200. doi: 10.1101/gad.315648.118. Epub 2018 Aug 22.

18.

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ.

Cell. 2018 Jun 14;173(7):1622-1635.e14. doi: 10.1016/j.cell.2018.04.028. Epub 2018 May 17.

19.

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.

Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS.

Mol Cell. 2018 May 17;70(4):602-613.e3. doi: 10.1016/j.molcel.2018.04.006.

20.

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ.

Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22.

21.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 25;172(3):629-631. doi: 10.1016/j.cell.2017.12.035. No abstract available.

22.

Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ.

Genes Dev. 2017 Nov 15;31(22):2310. doi: 10.1101/gad.309864.117. No abstract available.

23.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 11;172(1-2):106-120.e21. doi: 10.1016/j.cell.2017.11.023. Epub 2017 Dec 14. Erratum in: Cell. 2018 Jan 25;172(3):629-631.

24.

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ.

Genes Dev. 2017 Oct 1;31(19):1933-1938. doi: 10.1101/gad.304857.117. Erratum in: Genes Dev. 2017 Nov 15;31(22):2310.

25.

Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown!

Watson EV, Elledge SJ.

Trends Genet. 2017 Oct;33(10):662-664. doi: 10.1016/j.tig.2017.07.007. Epub 2017 Aug 8.

PMID:
28800914
26.

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ.

Cell Rep. 2017 Jul 11;20(2):427-438. doi: 10.1016/j.celrep.2017.06.061.

27.

Origins of lymphatic and distant metastases in human colorectal cancer.

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK.

Science. 2017 Jul 7;357(6346):55-60. doi: 10.1126/science.aai8515.

28.

Reply.

Shah AA, Rosen A, Hummers LK, Wigley FM, Xu G, Elledge SJ, Casciola-Rosen L.

Arthritis Rheumatol. 2017 Sep;69(9):1915-1916. doi: 10.1002/art.40132. Epub 2017 Jul 11. No abstract available.

29.

Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma.

Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L.

Arthritis Rheumatol. 2017 Jun;69(6):1306-1312. doi: 10.1002/art.40065.

30.

A genetic interaction analysis identifies cancer drivers that modify EGFR dependency.

Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ.

Genes Dev. 2017 Jan 15;31(2):184-196. doi: 10.1101/gad.291948.116. Epub 2017 Feb 6.

31.

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.

Davoli T, Uno H, Wooten EC, Elledge SJ.

Science. 2017 Jan 20;355(6322). pii: eaaf8399. doi: 10.1126/science.aaf8399.

32.

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ.

Genes Dev. 2016 Dec 15;30(24):2684-2695. doi: 10.1101/gad.290122.116.

33.

Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer.

Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7526-E7534. Epub 2016 Nov 7.

34.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.

Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986.

35.

Sources of Error in Mammalian Genetic Screens.

Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJ.

G3 (Bethesda). 2016 Sep 8;6(9):2781-90. doi: 10.1534/g3.116.030973.

36.

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3667-75. doi: 10.1073/pnas.1602827113. Epub 2016 Jun 13.

37.

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3676-85. doi: 10.1073/pnas.1525620113. Epub 2016 Jun 13.

38.

How autophagy both activates and inhibits cellular senescence.

Kang C, Elledge SJ.

Autophagy. 2016 May 3;12(5):898-9. doi: 10.1080/15548627.2015.1121361. Review.

39.

A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.

Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K.

Stem Cell Reports. 2016 May 10;6(5):704-716. doi: 10.1016/j.stemcr.2016.02.004. Epub 2016 Mar 3.

40.

A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

Wang Y, Xu Q, Sack L, Kang C, Elledge SJ.

Genes Dev. 2016 Feb 1;30(3):293-306. doi: 10.1101/gad.271445.115.

41.

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ.

Mol Cell. 2015 Oct 15;60(2):280-93. doi: 10.1016/j.molcel.2015.09.011.

42.

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ.

Science. 2015 Sep 25;349(6255):aaa5612. doi: 10.1126/science.aaa5612.

43.

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.

Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu J.

J Biol Chem. 2015 Nov 6;290(45):27297-310. doi: 10.1074/jbc.M115.652339. Epub 2015 Sep 16.

44.

Accidents and Damage Control.

Elledge SJ.

Cell. 2015 Sep 10;162(6):1196-200. doi: 10.1016/j.cell.2015.08.042. No abstract available.

45.

The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award.

Elledge SJ.

JAMA. 2015 Sep 15;314(11):1111-2. doi: 10.1001/jama.2015.10387. No abstract available.

PMID:
26348099
46.

Taking the brakes off telomerase.

Naxerova K, Elledge SJ.

Elife. 2015 Jul 21;4. doi: 10.7554/eLife.09519.

47.

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ.

Mol Cell. 2015 Sep 3;59(5):867-81. doi: 10.1016/j.molcel.2015.05.006. Epub 2015 Jun 4.

48.

Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.

Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ.

Science. 2015 Jun 5;348(6239):aaa0698. doi: 10.1126/science.aaa0698.

49.

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.

Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ.

Cell Rep. 2015 Jun 9;11(9):1486-500. doi: 10.1016/j.celrep.2015.04.053. Epub 2015 May 21.

50.

NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.

Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP.

PLoS Genet. 2015 Mar 13;11(3):e1005029. doi: 10.1371/journal.pgen.1005029. eCollection 2015 Mar.

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