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Items: 1 to 50 of 315

1.

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.

Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajić A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY.

J Neurosci. 2018 Oct 24;38(43):9286-9301. doi: 10.1523/JNEUROSCI.0254-18.2018. Epub 2018 Sep 24.

PMID:
30249792
2.

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.

Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL.

J Exp Med. 2018 Oct 1;215(10):2567-2585. doi: 10.1084/jem.20180628. Epub 2018 Aug 24.

PMID:
30143481
3.

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.

Liao S, Maertens O, Cichowski K, Elledge SJ.

Genes Dev. 2018 Sep 1;32(17-18):1188-1200. doi: 10.1101/gad.315648.118. Epub 2018 Aug 22.

PMID:
30135075
4.

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ.

Cell. 2018 Jun 14;173(7):1622-1635.e14. doi: 10.1016/j.cell.2018.04.028. Epub 2018 May 17.

PMID:
29779948
5.

C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.

Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS.

Mol Cell. 2018 May 17;70(4):602-613.e3. doi: 10.1016/j.molcel.2018.04.006.

PMID:
29775578
6.

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ.

Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22.

PMID:
29576454
7.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 25;172(3):629-631. doi: 10.1016/j.cell.2017.12.035. No abstract available.

8.

Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ.

Genes Dev. 2017 Nov 15;31(22):2310. doi: 10.1101/gad.309864.117. No abstract available.

9.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 11;172(1-2):106-120.e21. doi: 10.1016/j.cell.2017.11.023. Epub 2017 Dec 14. Erratum in: Cell. 2018 Jan 25;172(3):629-631.

PMID:
29249356
10.

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.

Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ.

Genes Dev. 2017 Oct 1;31(19):1933-1938. doi: 10.1101/gad.304857.117. Erratum in: Genes Dev. 2017 Nov 15;31(22):2310.

11.

Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown!

Watson EV, Elledge SJ.

Trends Genet. 2017 Oct;33(10):662-664. doi: 10.1016/j.tig.2017.07.007. Epub 2017 Aug 8.

PMID:
28800914
12.

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ.

Cell Rep. 2017 Jul 11;20(2):427-438. doi: 10.1016/j.celrep.2017.06.061.

13.

Origins of lymphatic and distant metastases in human colorectal cancer.

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK.

Science. 2017 Jul 7;357(6346):55-60. doi: 10.1126/science.aai8515.

14.

Reply.

Shah AA, Rosen A, Hummers LK, Wigley FM, Xu G, Elledge SJ, Casciola-Rosen L.

Arthritis Rheumatol. 2017 Sep;69(9):1915-1916. doi: 10.1002/art.40132. Epub 2017 Jul 11. No abstract available.

15.

Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma.

Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L.

Arthritis Rheumatol. 2017 Jun;69(6):1306-1312. doi: 10.1002/art.40065.

16.

A genetic interaction analysis identifies cancer drivers that modify EGFR dependency.

Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ.

Genes Dev. 2017 Jan 15;31(2):184-196. doi: 10.1101/gad.291948.116. Epub 2017 Feb 6.

17.

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.

Davoli T, Uno H, Wooten EC, Elledge SJ.

Science. 2017 Jan 20;355(6322). pii: eaaf8399. doi: 10.1126/science.aaf8399.

18.

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ.

Genes Dev. 2016 Dec 15;30(24):2684-2695. doi: 10.1101/gad.290122.116.

19.

Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer.

Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7526-E7534. Epub 2016 Nov 7.

20.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.

Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986.

21.

Sources of Error in Mammalian Genetic Screens.

Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJ.

G3 (Bethesda). 2016 Sep 8;6(9):2781-90. doi: 10.1534/g3.116.030973.

22.

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3667-75. doi: 10.1073/pnas.1602827113. Epub 2016 Jun 13.

23.

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3676-85. doi: 10.1073/pnas.1525620113. Epub 2016 Jun 13.

24.

How autophagy both activates and inhibits cellular senescence.

Kang C, Elledge SJ.

Autophagy. 2016 May 3;12(5):898-9. doi: 10.1080/15548627.2015.1121361. Review.

25.

A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.

Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K.

Stem Cell Reports. 2016 May 10;6(5):704-716. doi: 10.1016/j.stemcr.2016.02.004. Epub 2016 Mar 3.

26.

A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

Wang Y, Xu Q, Sack L, Kang C, Elledge SJ.

Genes Dev. 2016 Feb 1;30(3):293-306. doi: 10.1101/gad.271445.115.

27.

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ.

Mol Cell. 2015 Oct 15;60(2):280-93. doi: 10.1016/j.molcel.2015.09.011.

28.

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ.

Science. 2015 Sep 25;349(6255):aaa5612. doi: 10.1126/science.aaa5612.

29.

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.

Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu J.

J Biol Chem. 2015 Nov 6;290(45):27297-310. doi: 10.1074/jbc.M115.652339. Epub 2015 Sep 16.

30.

Accidents and Damage Control.

Elledge SJ.

Cell. 2015 Sep 10;162(6):1196-200. doi: 10.1016/j.cell.2015.08.042. No abstract available.

31.

The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award.

Elledge SJ.

JAMA. 2015 Sep 15;314(11):1111-2. doi: 10.1001/jama.2015.10387. No abstract available.

PMID:
26348099
32.

Taking the brakes off telomerase.

Naxerova K, Elledge SJ.

Elife. 2015 Jul 21;4. doi: 10.7554/eLife.09519.

33.

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ.

Mol Cell. 2015 Sep 3;59(5):867-81. doi: 10.1016/j.molcel.2015.05.006. Epub 2015 Jun 4.

34.

Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.

Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ.

Science. 2015 Jun 5;348(6239):aaa0698. doi: 10.1126/science.aaa0698.

35.

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.

Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ.

Cell Rep. 2015 Jun 9;11(9):1486-500. doi: 10.1016/j.celrep.2015.04.053. Epub 2015 May 21.

36.

NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.

Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP.

PLoS Genet. 2015 Mar 13;11(3):e1005029. doi: 10.1371/journal.pgen.1005029. eCollection 2015 Mar.

37.

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD.

Nature. 2015 Feb 12;518(7538):258-62. doi: 10.1038/nature14184. Epub 2015 Feb 2.

38.

Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.

Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18631-6. doi: 10.1073/pnas.1422488112. Epub 2014 Dec 15.

39.

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP.

Science. 2014 Nov 28;346(6213):1127-30. doi: 10.1126/science.1258973.

40.

Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL.

Cell Rep. 2014 Oct 23;9(2):752-66. doi: 10.1016/j.celrep.2014.09.031. Epub 2014 Oct 16.

41.

RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways.

Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K.

Nat Commun. 2014 Oct 28;5:5217. doi: 10.1038/ncomms6217.

PMID:
25347953
42.

When noise makes music: HIV reactivation with transcriptional noise enhancers.

Tan X, Elledge SJ.

Genome Med. 2014 Jul 29;6(7):55. doi: 10.1186/s13073-014-0055-9. eCollection 2014.

43.

Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10.

Finton KA, Friend D, Jaffe J, Gewe M, Holmes MA, Larman HB, Stuart A, Larimore K, Greenberg PD, Elledge SJ, Stamatatos L, Strong RK.

PLoS Pathog. 2014 Sep 25;10(9):e1004403. doi: 10.1371/journal.ppat.1004403. eCollection 2014 Sep.

44.

Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling.

Airik R, Slaats GG, Guo Z, Weiss AC, Khan N, Ghosh A, Hurd TW, Bekker-Jensen S, Schrøder JM, Elledge SJ, Andersen JS, Kispert A, Castelli M, Boletta A, Giles RH, Hildebrandt F.

J Am Soc Nephrol. 2014 Nov;25(11):2573-83. doi: 10.1681/ASN.2013050565. Epub 2014 Apr 10.

45.

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6. doi: 10.1073/pnas.1400705111. Epub 2014 Feb 20.

46.

Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth.

Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN.

Cell Host Microbe. 2014 Jan 15;15(1):113-24. doi: 10.1016/j.chom.2013.12.009.

47.

Discovery of protein interactions using parallel analysis of translated ORFs (PLATO).

Larman HB, Liang AC, Elledge SJ, Zhu J.

Nat Protoc. 2014 Jan;9(1):90-103. doi: 10.1038/nprot.2013.167. Epub 2013 Dec 12.

48.

Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction.

Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL.

Cell Rep. 2013 Nov 27;5(4):895-908. doi: 10.1016/j.celrep.2013.10.033. Epub 2013 Nov 21.

49.

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.

Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ.

Cell. 2013 Nov 7;155(4):948-62. doi: 10.1016/j.cell.2013.10.011. Epub 2013 Oct 31.

50.

Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10.

Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK.

PLoS Pathog. 2013;9(9):e1003639. doi: 10.1371/journal.ppat.1003639. Epub 2013 Sep 26.

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