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Items: 15

1.

Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease.

Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H.

Dis Model Mech. 2019 Jul 26;12(7). pii: dmm038737. doi: 10.1242/dmm.038737.

2.

Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.

Smatlikova P, Askeland G, Vaskovicova M, Klima J, Motlik J, Eide L, Ellederová Z.

Neurodegener Dis. 2019;19(1):22-34. doi: 10.1159/000500091. Epub 2019 Jun 5.

PMID:
31167196
3.

CKS1 Germ Line Exclusion Is Essential for the Transition from Meiosis to Early Embryonic Development.

Ellederova Z, Del Rincon S, Koncicka M, Susor A, Kubelka M, Sun D, Spruck C.

Mol Cell Biol. 2019 Jun 13;39(13). pii: e00590-18. doi: 10.1128/MCB.00590-18. Print 2019 Jul 1.

PMID:
30988159
4.

Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin.

Smatlikova P, Juhas S, Juhasova J, Suchy T, Hubalek Kalbacova M, Ellederova Z, Motlik J, Klima J.

J Huntingtons Dis. 2019;8(1):33-51. doi: 10.3233/JHD-180303.

PMID:
30584151
5.

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies.

Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L.

Dis Model Mech. 2018 Oct 24;11(10). pii: dmm035949. doi: 10.1242/dmm.035949.

6.

AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.

Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, Lubelski J, Kovarova H, Ellederova Z, van Deventer SJ, Petry H, Motlik J, Konstantinova P.

Mol Ther. 2018 Sep 5;26(9):2163-2177. doi: 10.1016/j.ymthe.2018.06.021. Epub 2018 Jun 25.

7.

Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age.

Vidinská D, Vochozková P, Šmatlíková P, Ardan T, Klíma J, Juhás Š, Juhásová J, Bohuslavová B, Baxa M, Valeková I, Motlík J, Ellederová Z.

Neurodegener Dis. 2018;18(2-3):107-119. doi: 10.1159/000488592. Epub 2018 Jun 5.

PMID:
29870995
8.

Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs.

Krizova J, Stufkova H, Rodinova M, Macakova M, Bohuslavova B, Vidinska D, Klima J, Ellederova Z, Pavlok A, Howland DS, Zeman J, Motlik J, Hansikova H.

Neurodegener Dis. 2017;17(4-5):213-226. doi: 10.1159/000475467. Epub 2017 Jun 21.

PMID:
28633139
9.

Revelation of the IFNα, IL-10, IL-8 and IL-1β as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model.

Valekova I, Jarkovska K, Kotrcova E, Bucci J, Ellederova Z, Juhas S, Motlik J, Gadher SJ, Kovarova H.

J Neuroimmunol. 2016 Apr 15;293:71-81. doi: 10.1016/j.jneuroim.2016.02.012. Epub 2016 Feb 20.

PMID:
27049565
10.

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Talkowski M, Gusella JF, Howland DS, DiFiglia M, Motlik J.

Neurodegener Dis. 2016;16(3-4):245-59. doi: 10.1159/000443665. Epub 2016 Mar 10.

PMID:
26959244
11.

Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.

del Rincón SV, Widschwendter M, Sun D, Ekholm-Reed S, Tat J, Teixeira LK, Ellederova Z, Grolieres E, Reed SI, Spruck C.

Oncogene. 2015 Apr 9;34(15):1961-7. doi: 10.1038/onc.2014.137. Epub 2014 May 26.

12.

Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1.

Susor A, Ellederova Z, Jelinkova L, Halada P, Kavan D, Kubelka M, Kovarova H.

Reproduction. 2007 Oct;134(4):559-68.

PMID:
17890291
13.

ERK1/2 map kinase metabolic pathway is responsible for phosphorylation of translation initiation factor eIF4E during in vitro maturation of pig oocytes.

Ellederová Z, Cais O, Susor A, Uhlírová K, Kovárová H, Jelínková L, Tomek W, Kubelka M.

Mol Reprod Dev. 2008 Feb;75(2):309-17.

PMID:
17290414
14.

Suppression of translation during in vitro maturation of pig oocytes despite enhanced formation of cap-binding protein complex eIF4F and 4E-BP1 hyperphosphorylation.

Ellederova Z, Kovarova H, Melo-Sterza F, Livingstone M, Tomek W, Kubelka M.

Mol Reprod Dev. 2006 Jan;73(1):68-76.

PMID:
16211600
15.

Protein patterns of pig oocytes during in vitro maturation.

Ellederova Z, Halada P, Man P, Kubelka M, Motlik J, Kovarova H.

Biol Reprod. 2004 Nov;71(5):1533-9. Epub 2004 Jun 30.

PMID:
15229143

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