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Items: 1 to 50 of 53

1.

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice.

Ziv Y, Rahamim N, Lezmy N, Even-Chen O, Shaham O, Malishkevich A, Giladi E, Elkon R, Gozes I, Barak S.

Neuropsychopharmacology. 2018 Jun 27. doi: 10.1038/s41386-018-0132-7. [Epub ahead of print]

PMID:
30008470
2.

Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.

Cohen-Tayar Y, Cohen H, Mitiagin Y, Abravanel Z, Levy C, Idelson M, Reubinoff B, Itzkovitz S, Raviv S, Kaestner KH, Blinder P, Elkon R, Ashery-Padan R.

Development. 2018 Aug 9;145(15). pii: dev163691. doi: 10.1242/dev.163691.

PMID:
29986868
3.

FOCS: a novel method for analyzing enhancer and gene activity patterns infers an extensive enhancer-promoter map.

Hait TA, Amar D, Shamir R, Elkon R.

Genome Biol. 2018 May 1;19(1):56. doi: 10.1186/s13059-018-1432-2.

4.

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS.

Li L, van Breugel PC, Loayza-Puch F, Ugalde AP, Korkmaz G, Messika-Gold N, Han R, Lopes R, Barbera EP, Teunissen H, de Wit E, Soares RJ, Nielsen BS, Holmstrøm K, Martínez-Herrera DJ, Huarte M, Louloupi A, Drost J, Elkon R, Agami R.

Nucleic Acids Res. 2018 May 4;46(8):4213-4227. doi: 10.1093/nar/gky087.

5.

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.

Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2018 Jan 25;46(2):730-747. doi: 10.1093/nar/gkx1240.

6.

Characterization of noncoding regulatory DNA in the human genome.

Elkon R, Agami R.

Nat Biotechnol. 2017 Aug 8;35(8):732-746. doi: 10.1038/nbt.3863. Review.

PMID:
28787426
7.

Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis.

Aviner R, Hofmann S, Elman T, Shenoy A, Geiger T, Elkon R, Ehrlich M, Elroy-Stein O.

Nucleic Acids Res. 2017 Jun 2;45(10):5945-5957. doi: 10.1093/nar/gkx326.

8.

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Slobodin B, Han R, Calderone V, Vrielink JAFO, Loayza-Puch F, Elkon R, Agami R.

Cell. 2017 Apr 6;169(2):326-337.e12. doi: 10.1016/j.cell.2017.03.031.

9.

Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells.

Matern M, Vijayakumar S, Margulies Z, Milon B, Song Y, Elkon R, Zhang X, Jones SM, Hertzano R.

Sci Rep. 2017 Feb 9;7:42079. doi: 10.1038/srep42079.

10.

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.

Drost R, Dhillon KK, van der Gulden H, van der Heijden I, Brandsma I, Cruz C, Chondronasiou D, Castroviejo-Bermejo M, Boon U, Schut E, van der Burg E, Wientjens E, Pieterse M, Klijn C, Klarenbeek S, Loayza-Puch F, Elkon R, van Deemter L, Rottenberg S, van de Ven M, Dekkers DH, Demmers JA, van Gent DC, Agami R, Balmaña J, Serra V, Taniguchi T, Bouwman P, Jonkers J.

J Clin Invest. 2016 Aug 1;126(8):2903-18. doi: 10.1172/JCI70196. Epub 2016 Jul 25.

11.

3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

Hoffman Y, Bublik DR, Ugalde AP, Elkon R, Biniashvili T, Agami R, Oren M, Pilpel Y.

PLoS Genet. 2016 Feb 23;12(2):e1005879. doi: 10.1371/journal.pgen.1005879. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006254.

12.

Redifferentiation of expanded human islet β cells by inhibition of ARX.

Friedman-Mazursky O, Elkon R, Efrat S.

Sci Rep. 2016 Feb 9;6:20698. doi: 10.1038/srep20698.

13.

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R.

Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11.

PMID:
26751173
14.

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Creemers EE, Bawazeer A, Ugalde AP, van Deutekom HW, van der Made I, de Groot NE, Adriaens ME, Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, Pinto YM.

Circ Res. 2016 Feb 5;118(3):433-8. doi: 10.1161/CIRCRESAHA.115.307082. Epub 2015 Dec 15. Erratum in: Circ Res. 2016 Oct 14;119(9):e139.

PMID:
26671978
15.

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.

EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717. Epub 2015 Nov 4.

16.

RFX transcription factors are essential for hearing in mice.

Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R.

Nat Commun. 2015 Oct 15;6:8549. doi: 10.1038/ncomms9549.

17.

Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.

Rashi-Elkeles S, Warnatz HJ, Elkon R, Kupershtein A, Chobod Y, Paz A, Amstislavskiy V, Sultan M, Safer H, Nietfeld W, Lehrach H, Shamir R, Yaspo ML, Shiloh Y.

Sci Signal. 2014 May 13;7(325):rs3. doi: 10.1126/scisignal.2005032.

PMID:
24825921
18.

Alternative cleavage and polyadenylation: extent, regulation and function.

Elkon R, Ugalde AP, Agami R.

Nat Rev Genet. 2013 Jul;14(7):496-506. doi: 10.1038/nrg3482. Review.

PMID:
23774734
19.

p53 induces transcriptional and translational programs to suppress cell proliferation and growth.

Loayza-Puch F, Drost J, Rooijers K, Lopes R, Elkon R, Agami R.

Genome Biol. 2013 Apr 17;14(4):R32. doi: 10.1186/gb-2013-14-4-r32.

20.

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Melo CA, Drost J, Wijchers PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Léveillé N, Kalluri R, de Laat W, Agami R.

Mol Cell. 2013 Feb 7;49(3):524-35. doi: 10.1016/j.molcel.2012.11.021. Epub 2012 Dec 27.

21.

Alternative cleavage and polyadenylation during colorectal cancer development.

Morris AR, Bos A, Diosdado B, Rooijers K, Elkon R, Bolijn AS, Carvalho B, Meijer GA, Agami R.

Clin Cancer Res. 2012 Oct 1;18(19):5256-66. doi: 10.1158/1078-0432.CCR-12-0543. Epub 2012 Aug 8.

22.

E2F mediates enhanced alternative polyadenylation in proliferation.

Elkon R, Drost J, van Haaften G, Jenal M, Schrier M, Oude Vrielink JA, Agami R.

Genome Biol. 2012 Jul 2;13(7):R59. doi: 10.1186/gb-2012-13-7-r59.

23.

High throughput gene expression analysis of the inner ear.

Hertzano R, Elkon R.

Hear Res. 2012 Jun;288(1-2):77-88. doi: 10.1016/j.heares.2012.01.002. Epub 2012 Feb 8.

PMID:
22710153
24.

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kühn U, Menzies FM, Oude Vrielink JA, Bos AJ, Drost J, Rooijers K, Rubinsztein DC, Agami R.

Cell. 2012 Apr 27;149(3):538-53. doi: 10.1016/j.cell.2012.03.022. Epub 2012 Apr 12.

25.

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.

Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R.

Nat Commun. 2011 Oct 25;2:513. doi: 10.1038/ncomms1519.

26.

Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis.

Hertzano R, Elkon R, Kurima K, Morrisson A, Chan SL, Sallin M, Biedlingmaier A, Darling DS, Griffith AJ, Eisenman DJ, Strome SE.

PLoS Genet. 2011 Sep;7(9):e1002309. doi: 10.1371/journal.pgen.1002309. Epub 2011 Sep 29.

27.

Matrin 3 binds and stabilizes mRNA.

Salton M, Elkon R, Borodina T, Davydov A, Yaspo ML, Halperin E, Shiloh Y.

PLoS One. 2011;6(8):e23882. doi: 10.1371/journal.pone.0023882. Epub 2011 Aug 17.

28.

Transcriptional modulation induced by ionizing radiation: p53 remains a central player.

Rashi-Elkeles S, Elkon R, Shavit S, Lerenthal Y, Linhart C, Kupershtein A, Amariglio N, Rechavi G, Shamir R, Shiloh Y.

Mol Oncol. 2011 Aug;5(4):336-48. doi: 10.1016/j.molonc.2011.06.004. Epub 2011 Jul 7. Review.

29.

Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear.

Elkan-Miller T, Ulitsky I, Hertzano R, Rudnicki A, Dror AA, Lenz DR, Elkon R, Irmler M, Beckers J, Shamir R, Avraham KB.

PLoS One. 2011 Apr 5;6(4):e18195. doi: 10.1371/journal.pone.0018195.

30.

ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.

Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang SY, Chen DJ, Aebersold R, Shiloh Y.

Sci Signal. 2010 Dec 7;3(151):rs3. doi: 10.1126/scisignal.2001034.

31.

SPIKE: a database of highly curated human signaling pathways.

Paz A, Brownstein Z, Ber Y, Bialik S, David E, Sagir D, Ulitsky I, Elkon R, Kimchi A, Avraham KB, Shiloh Y, Shamir R.

Nucleic Acids Res. 2011 Jan;39(Database issue):D793-9. doi: 10.1093/nar/gkq1167. Epub 2010 Nov 19.

32.

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

Kedde M, van Kouwenhove M, Zwart W, Oude Vrielink JA, Elkon R, Agami R.

Nat Cell Biol. 2010 Oct;12(10):1014-20. doi: 10.1038/ncb2105. Epub 2010 Sep 5.

PMID:
20818387
33.

Major role for mRNA stability in shaping the kinetics of gene induction.

Elkon R, Zlotorynski E, Zeller KI, Agami R.

BMC Genomics. 2010 Apr 21;11:259. doi: 10.1186/1471-2164-11-259.

34.

BRD7 is a candidate tumour suppressor gene required for p53 function.

Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R, Del Sal G.

Nat Cell Biol. 2010 Apr;12(4):380-9. doi: 10.1038/ncb2038. Epub 2010 Mar 14.

PMID:
20228809
35.

Expander: from expression microarrays to networks and functions.

Ulitsky I, Maron-Katz A, Shavit S, Sagir D, Linhart C, Elkon R, Tanay A, Sharan R, Shiloh Y, Shamir R.

Nat Protoc. 2010 Feb;5(2):303-22. doi: 10.1038/nprot.2009.230. Epub 2010 Jan 28.

PMID:
20134430
36.

Removal of AU bias from microarray mRNA expression data enhances computational identification of active microRNAs.

Elkon R, Agami R.

PLoS Comput Biol. 2008 Oct 3;4(10):e1000189. doi: 10.1371/journal.pcbi.1000189.

37.

SPIKE--a database, visualization and analysis tool of cellular signaling pathways.

Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, Assa J, Shiloh Y, Shamir R.

BMC Bioinformatics. 2008 Feb 20;9:110. doi: 10.1186/1471-2105-9-110.

38.

Functional genomic delineation of TLR-induced transcriptional networks.

Elkon R, Linhart C, Halperin Y, Shiloh Y, Shamir R.

BMC Genomics. 2007 Oct 29;8:394.

39.

Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).

Blum R, Elkon R, Yaari S, Zundelevich A, Jacob-Hirsch J, Rechavi G, Shamir R, Kloog Y.

Cancer Res. 2007 Apr 1;67(7):3320-8.

40.

Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage.

Zhou T, Chou J, Mullen TE, Elkon R, Zhou Y, Simpson DA, Bushel PR, Paules RS, Lobenhofer EK, Hurban P, Kaufmann WK.

Cell Cycle. 2007 Apr 15;6(8):972-81. Epub 2007 Apr 19.

41.

Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells.

Scafoglio C, Ambrosino C, Cicatiello L, Altucci L, Ardovino M, Bontempo P, Medici N, Molinari AM, Nebbioso A, Facchiano A, Calogero RA, Elkon R, Menini N, Ponzone R, Biglia N, Sismondi P, De Bortoli M, Weisz A.

J Cell Biochem. 2006 Aug 1;98(5):1163-84.

PMID:
16514628
42.

E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition.

Blum R, Nakdimon I, Goldberg L, Elkon R, Shamir R, Rechavi G, Kloog Y.

Int J Cancer. 2006 Aug 1;119(3):527-38.

43.

Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.

Rashi-Elkeles S, Elkon R, Weizman N, Linhart C, Amariglio N, Sternberg G, Rechavi G, Barzilai A, Shamir R, Shiloh Y.

Oncogene. 2006 Mar 9;25(10):1584-92.

PMID:
16314843
44.

Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis.

Linhart C, Elkon R, Shiloh Y, Shamir R.

Cell Cycle. 2005 Dec;4(12):1788-97. Epub 2005 Dec 13.

PMID:
16294034
45.

EXPANDER--an integrative program suite for microarray data analysis.

Shamir R, Maron-Katz A, Tanay A, Linhart C, Steinfeld I, Sharan R, Shiloh Y, Elkon R.

BMC Bioinformatics. 2005 Sep 21;6:232.

46.

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A.

Hum Mol Genet. 2005 Oct 1;14(19):2929-43. Epub 2005 Sep 8.

PMID:
16150740
47.

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade.

Ophir G, Amariglio N, Jacob-Hirsch J, Elkon R, Rechavi G, Michaelson DM.

Neurobiol Dis. 2005 Dec;20(3):709-18. Epub 2005 Jun 23.

PMID:
15979312
48.

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.

Elkon R, Rashi-Elkeles S, Lerenthal Y, Linhart C, Tenne T, Amariglio N, Rechavi G, Shamir R, Shiloh Y.

Genome Biol. 2005;6(5):R43. Epub 2005 Apr 13.

49.

In silico identification of transcriptional regulators associated with c-Myc.

Elkon R, Zeller KI, Linhart C, Dang CV, Shamir R, Shiloh Y.

Nucleic Acids Res. 2004 Sep 23;32(17):4955-61. Print 2004.

50.

Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene.

Hertzano R, Montcouquiol M, Rashi-Elkeles S, Elkon R, Yücel R, Frankel WN, Rechavi G, Möröy T, Friedman TB, Kelley MW, Avraham KB.

Hum Mol Genet. 2004 Sep 15;13(18):2143-53. Epub 2004 Jul 14.

PMID:
15254021

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