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Items: 1 to 50 of 216

1.

High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients.

Wang T, Marken J, Chen J, Tran VB, Li QZ, Li M, Cerosaletti K, Elkon KB, Zeng X, Giltiay NV.

Front Immunol. 2019 Jun 4;10:1243. doi: 10.3389/fimmu.2019.01243. eCollection 2019.

2.

Aspirin meets cGAS.

Elkon KB.

Nat Rev Rheumatol. 2019 May;15(5):254-255. doi: 10.1038/s41584-019-0205-y. No abstract available.

PMID:
30914774
3.

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.

Akilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA.

Science. 2019 Jan 11;363(6423). pii: eaao5213. doi: 10.1126/science.aao5213.

PMID:
30630901
4.

Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice.

An J, Woodward JJ, Lai W, Minie M, Sun X, Tanaka L, Snyder JM, Sasaki T, Elkon KB.

Arthritis Rheumatol. 2018 Nov;70(11):1807-1819. doi: 10.1002/art.40559. Epub 2018 Sep 14.

PMID:
29781188
5.

Review: Cell Death, Nucleic Acids, and Immunity: Inflammation Beyond the Grave.

Elkon KB.

Arthritis Rheumatol. 2018 Jun;70(6):805-816. doi: 10.1002/art.40452. Epub 2018 Apr 18. Review.

6.

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA.

Lood C, Arve S, Ledbetter J, Elkon KB.

J Exp Med. 2017 Jul 3;214(7):2103-2119. doi: 10.1084/jem.20161512. Epub 2017 Jun 12.

7.

Ribosomal P antibody: 30 years on the road.

Viana VT, Durcan L, Bonfa E, Elkon KB.

Lupus. 2017 Apr;26(5):453-462. doi: 10.1177/0961203317690243.

PMID:
28394227
8.

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus.

An J, Durcan L, Karr RM, Briggs TA, Rice GI, Teal TH, Woodward JJ, Elkon KB.

Arthritis Rheumatol. 2017 Apr;69(4):800-807. doi: 10.1002/art.40002. Epub 2017 Mar 7.

9.
10.

Citrullination in Rheumatoid Arthritis-A Process Promoted by Neutrophil Lysis?

Gazitt T, Lood C, Elkon KB.

Rambam Maimonides Med J. 2016 Oct 31;7(4). doi: 10.5041/RMMJ.10254. Review.

11.

Antimalarial Drugs as Immune Modulators: New Mechanisms for Old Drugs.

An J, Minie M, Sasaki T, Woodward JJ, Elkon KB.

Annu Rev Med. 2017 Jan 14;68:317-330. doi: 10.1146/annurev-med-043015-123453. Epub 2016 Oct 21. Review.

PMID:
27813878
12.

Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus.

Doedens JR, Jones WD, Hill K, Mason MJ, Gersuk VH, Mease PJ, Dall'Era M, Aranow C, Martin RW, Cohen SB, Fleischmann RM, Kivitz AJ, Burge DJ, Chaussabel D, Elkon KB, Posada JA.

J Immunol. 2016 Oct 1;197(7):2854-63. doi: 10.4049/jimmunol.1601142. Epub 2016 Aug 17.

13.

Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus.

An J, Briggs TA, Dumax-Vorzet A, Alarcón-Riquelme ME, Belot A, Beresford M, Bruce IN, Carvalho C, Chaperot L, Frostegård J, Plumas J, Rice GI, Vyse TJ, Wiedeman A, Crow YJ, Elkon KB.

Arthritis Rheumatol. 2017 Jan;69(1):131-142. doi: 10.1002/art.39810. Epub 2016 Dec 2.

14.

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.

Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçınkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B.

Cell. 2016 Jun 30;166(1):88-101. doi: 10.1016/j.cell.2016.05.034. Epub 2016 Jun 9.

15.

Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Feb;126(2):796. doi: 10.1172/JCI86401. Epub 2016 Feb 1. No abstract available.

16.

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.

Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ.

Nat Med. 2016 Feb;22(2):146-53. doi: 10.1038/nm.4027. Epub 2016 Jan 18.

17.

Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity.

Colonna L, Parry GC, Panicker S, Elkon KB.

Clin Immunol. 2016 Feb;163:84-90. doi: 10.1016/j.clim.2015.12.017. Epub 2016 Jan 6.

18.

Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Jan;126(1):266-81. doi: 10.1172/JCI83475. Epub 2015 Dec 7. Erratum in: J Clin Invest. 2016 Feb;126(2):796.

19.

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.

Barrat FJ, Elkon KB, Fitzgerald KA.

Annu Rev Med. 2016;67:323-36. doi: 10.1146/annurev-med-052814-023338. Epub 2015 Nov 2. Review.

PMID:
26526766
20.

IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fcα/μ Receptor.

Weinstein JR, Quan Y, Hanson JF, Colonna L, Iorga M, Honda S, Shibuya K, Shibuya A, Elkon KB, Möller T.

J Immunol. 2015 Dec 1;195(11):5309-17. doi: 10.4049/jimmunol.1401195. Epub 2015 Oct 23.

21.

Cutting edge: Antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction.

An J, Woodward JJ, Sasaki T, Minie M, Elkon KB.

J Immunol. 2015 May 1;194(9):4089-93. doi: 10.4049/jimmunol.1402793. Epub 2015 Mar 27.

22.

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus.

Sisirak V, Ganguly D, Lewis KL, Couillault C, Tanaka L, Bolland S, D'Agati V, Elkon KB, Reizis B.

J Exp Med. 2014 Sep 22;211(10):1969-76. doi: 10.1084/jem.20132522. Epub 2014 Sep 1.

23.

Beyond apoptosis in lupus.

Colonna L, Lood C, Elkon KB.

Curr Opin Rheumatol. 2014 Sep;26(5):459-66. doi: 10.1097/BOR.0000000000000083. Review.

24.

Reply: To PMID 23840006.

Wiedeman AE, Elkon KB.

Arthritis Rheumatol. 2014 Aug;66(8):2309-10. doi: 10.1002/art.38684. No abstract available.

25.

Editorial: toll-like receptor 7: more than skin deep?

Elkon KB, Sontheimer C.

Arthritis Rheumatol. 2014 Mar;66(3):481-4. doi: 10.1002/art.38301. No abstract available.

26.

Poking holes in rheumatoid joints.

Elkon KB.

Sci Transl Med. 2013 Oct 30;5(209):209fs39. doi: 10.1126/scitranslmed.3007515.

PMID:
24174325
27.

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.

Giltiay NV, Chappell CP, Sun X, Kolhatkar N, Teal TH, Wiedeman AE, Kim J, Tanaka L, Buechler MB, Hamerman JA, Imanishi-Kari T, Clark EA, Elkon KB.

J Exp Med. 2013 Nov 18;210(12):2773-89. doi: 10.1084/jem.20122798. Epub 2013 Oct 21.

28.

Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists.

Wiedeman AE, Santer DM, Yan W, Miescher S, Käsermann F, Elkon KB.

Arthritis Rheum. 2013 Oct;65(10):2713-23. doi: 10.1002/art.38082.

29.

Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.

Sun X, Wiedeman A, Agrawal N, Teal TH, Tanaka L, Hudkins KL, Alpers CE, Bolland S, Buechler MB, Hamerman JA, Ledbetter JA, Liggitt D, Elkon KB.

J Immunol. 2013 Mar 15;190(6):2536-43. doi: 10.4049/jimmunol.1202689. Epub 2013 Feb 4.

30.

Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling.

Buechler MB, Teal TH, Elkon KB, Hamerman JA.

J Immunol. 2013 Feb 1;190(3):886-91. doi: 10.4049/jimmunol.1202739. Epub 2013 Jan 9.

31.

Complement, interferon and lupus.

Elkon KB, Santer DM.

Curr Opin Immunol. 2012 Dec;24(6):665-70. doi: 10.1016/j.coi.2012.08.004. Epub 2012 Sep 20. Review.

PMID:
22999705
32.

Naturally occurring autoantibodies to apoptotic cells.

Elkon KB, Silverman GJ.

Adv Exp Med Biol. 2012;750:14-26. doi: 10.1007/978-1-4614-3461-0_2.

PMID:
22903663
33.

Type I IFN system in the development and manifestations of SLE.

Elkon KB, Wiedeman A.

Curr Opin Rheumatol. 2012 Sep;24(5):499-505. doi: 10.1097/BOR.0b013e3283562c3e. Review.

PMID:
22832823
34.

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB.

Immunity. 2012 Jan 27;36(1):120-31. doi: 10.1016/j.immuni.2011.11.018.

35.

Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes.

Santer DM, Wiedeman AE, Teal TH, Ghosh P, Elkon KB.

J Immunol. 2012 Jan 15;188(2):902-15. doi: 10.4049/jimmunol.1102797. Epub 2011 Dec 5.

36.

Type I interferon and systemic lupus erythematosus.

Elkon KB, Stone VV.

J Interferon Cytokine Res. 2011 Nov;31(11):803-12. doi: 10.1089/jir.2011.0045. Epub 2011 Aug 22. Review.

37.

Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens.

Peng Y, Elkon KB.

J Clin Invest. 2011 Jun;121(6):2221-41. doi: 10.1172/JCI43254. Epub 2011 May 2. Erratum in: J Clin Invest. 2012 Feb 1;122(2):782.

38.

Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation.

Kim J, Gross JA, Dillon SR, Min JK, Elkon KB.

Autoimmunity. 2011 Mar;44(2):69-81. doi: 10.3109/08916934.2010.509122. Epub 2011 Jan 20.

PMID:
21250838
39.

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

Briggs TA, Rice GI, Daly S, Urquhart J, Gornall H, Bader-Meunier B, Baskar K, Baskar S, Baudouin V, Beresford MW, Black GC, Dearman RJ, de Zegher F, Foster ES, Francès C, Hayman AR, Hilton E, Job-Deslandre C, Kulkarni ML, Le Merrer M, Linglart A, Lovell SC, Maurer K, Musset L, Navarro V, Picard C, Puel A, Rieux-Laucat F, Roifman CM, Scholl-Bürgi S, Smith N, Szynkiewicz M, Wiedeman A, Wouters C, Zeef LA, Casanova JL, Elkon KB, Janckila A, Lebon P, Crow YJ.

Nat Genet. 2011 Feb;43(2):127-31. doi: 10.1038/ng.748. Epub 2011 Jan 9.

41.

C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes.

Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB.

J Immunol. 2010 Oct 15;185(8):4738-49. doi: 10.4049/jimmunol.1001731. Epub 2010 Sep 15.

42.

Cytokines as therapeutic targets in SLE.

Rönnblom L, Elkon KB.

Nat Rev Rheumatol. 2010 Jun;6(6):339-47. doi: 10.1038/nrrheum.2010.64. Epub 2010 May 4. Review.

PMID:
20440285
43.

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin.

Dillon SR, Harder B, Lewis KB, Moore MD, Liu H, Bukowski TR, Hamacher NB, Lantry MM, Maurer M, Krejsa CM, Ellsworth JL, Pederson S, Elkon KB, Wener MH, Dall'Era M, Gross JA.

Arthritis Res Ther. 2010;12(2):R48. doi: 10.1186/ar2959. Epub 2010 Mar 19.

44.

Autoimmunity: apoptotic fats grease transcription.

Elkon KB.

Nat Med. 2009 Nov;15(11):1246-8. doi: 10.1038/nm1109-1246. No abstract available.

PMID:
19893553
45.

Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW mice.

Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB.

Arthritis Rheum. 2009 Jun;60(6):1775-84. doi: 10.1002/art.24548.

46.

Ly6C(low) monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1.

Peng Y, Latchman Y, Elkon KB.

J Immunol. 2009 Mar 1;182(5):2777-85. doi: 10.4049/jimmunol.0803172.

47.
48.

Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.

Okamoto A, Fujio K, van Rooijen N, Tsuno NH, Takahashi K, Tsurui H, Hirose S, Elkon KB, Yamamoto K.

J Immunol. 2008 Oct 15;181(8):5264-71.

49.

Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis.

Kim D, Peck A, Santer D, Patole P, Schwartz SM, Molitor JA, Arnett FC, Elkon KB.

Arthritis Rheum. 2008 Jul;58(7):2163-73. doi: 10.1002/art.23486.

50.

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma.

Duan H, Fleming J, Pritchard DK, Amon LM, Xue J, Arnett HA, Chen G, Breen P, Buckner JH, Molitor JA, Elkon KB, Schwartz SM.

Arthritis Rheum. 2008 May;58(5):1465-74. doi: 10.1002/art.23451.

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