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Items: 1 to 50 of 259

1.

Impact of informative censoring on the treatment effect estimate of disability worsening in multiple sclerosis clinical trials.

Riester K, Kappos L, Selmaj K, Lindborg S, Lipkovich I, Elkins J.

Mult Scler Relat Disord. 2019 Nov 23;39:101865. doi: 10.1016/j.msard.2019.101865. [Epub ahead of print]

2.

Integrated Proteomics and Lipidomics Reveal That the Swarming Motility of Paenibacillus polymyxa Is Characterized by Phospholipid Modification, Surfactant Deployment, and Flagellar Specialization Relative to Swimming Motility.

Poudel S, Giannone RJ, Farmer AT, Campagna SR, Bible AN, Morrell-Falvey JL, Elkins JG, Hettich RL.

Front Microbiol. 2019 Nov 19;10:2594. doi: 10.3389/fmicb.2019.02594. eCollection 2019.

3.

Iwankapiya American Indian pilot clinical trial: Historical trauma and group interpersonal psychotherapy.

Brave Heart MYH, Chase J, Myers O, Elkins J, Skipper B, Schmitt C, Mootz J, Waldorf VA.

Psychotherapy (Chic). 2019 Dec 2. doi: 10.1037/pst0000267. [Epub ahead of print]

PMID:
31789541
4.

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Profeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM.

Sci Rep. 2019 Nov 11;9(1):16452. doi: 10.1038/s41598-019-52795-1.

5.

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Bennett JM, Su L, Laitinen T, Elkins JM, Pickett JE, Wells CI, Li Z, Willson TM, Zuercher WJ.

Molecules. 2019 Nov 6;24(22). pii: E4016. doi: 10.3390/molecules24224016.

6.

Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.

Asquith CRM, Laitinen T, Bennett JM, Wells CI, Elkins JM, Zuercher WJ, Tizzard GJ, Poso A.

ChemMedChem. 2020 Jan 7;15(1):26-49. doi: 10.1002/cmdc.201900521. Epub 2019 Nov 26.

PMID:
31675459
7.

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.

Righetto GL, Sriranganadane D, Halabelian L, Chiodi CG, Elkins JM, Massirer KB, Gileadi O, Menossi M, Couñago RM.

Front Plant Sci. 2019 Sep 17;10:1105. doi: 10.3389/fpls.2019.01105. eCollection 2019.

8.

Addressing a Need: A Clinical Lipidology Subspecialty Postgraduate Certificate.

Elkins JC.

Nurs Educ Perspect. 2019 Oct 11. doi: 10.1097/01.NEP.0000000000000587. [Epub ahead of print]

PMID:
31609819
9.

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.

Serafim RAM, de Souza Gama FH, Dutra LA, Dos Reis CV, Vasconcelos SNS, da Silva Santiago A, Takarada JE, Di Pillo F, Azevedo H, Mascarello A, Elkins JM, Massirer KB, Gileadi O, Guimarães CRW, Couñago RM.

ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271. doi: 10.1021/acsmedchemlett.9b00082. eCollection 2019 Sep 12.

10.

Total Joint Arthroplasty in the Morbidly Obese: How Body Mass Index ≥40 Influences Patient Retention, Treatment Decisions, and Treatment Outcomes.

Foreman CW, Callaghan JJ, Brown TS, Elkins JM, Otero JE.

J Arthroplasty. 2020 Jan;35(1):39-44. doi: 10.1016/j.arth.2019.08.019. Epub 2019 Aug 17.

PMID:
31530460
11.

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.

Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB.

Science. 2019 Aug 30;365(6456). pii: eaau1682. doi: 10.1126/science.aau1682.

PMID:
31467193
12.

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors.

de Toledo I, Grigolo TA, Bennett JM, Elkins JM, Pilli RA.

J Org Chem. 2019 Nov 1;84(21):14187-14201. doi: 10.1021/acs.joc.9b01844. Epub 2019 Sep 30.

13.

Complete Genome Sequence of Caloramator sp. Strain E03, a Novel Ethanologenic, Thermophilic, Obligately Anaerobic Bacterium.

Hatmaker EA, Klingeman DM, Martin RK, Guss AM, Elkins JG.

Microbiol Resour Announc. 2019 Aug 8;8(32). pii: e00708-19. doi: 10.1128/MRA.00708-19.

14.

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

Abdul Azeez KR, Chatterjee S, Yu C, Golub TR, Sobott F, Elkins JM.

Nat Commun. 2019 Jul 18;10(1):3166. doi: 10.1038/s41467-019-11085-0.

15.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S.

J Med Chem. 2019 Jun 27;62(12):5810-5831. doi: 10.1021/acs.jmedchem.9b00136. Epub 2019 Jun 12.

PMID:
31136173
16.

Associations between Adverse Childhood Experiences, Major Depressive Episode and Chronic Physical Health in Adolescents: Moderation of Race/Ethnicity.

Elkins J, Miller KM, Briggs HE, Kim I, Mowbray O, Orellana ER.

Soc Work Public Health. 2019;34(5):444-456. doi: 10.1080/19371918.2019.1617216. Epub 2019 May 22.

PMID:
31117927
17.

Crystal structure of human RIOK2 bound to a specific inhibitor.

Wang J, Varin T, Vieth M, Elkins JM.

Open Biol. 2019 Apr 26;9(4):190037. doi: 10.1098/rsob.190037.

18.

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons.

Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH.

Mol Psychiatry. 2019 Jun;24(6):808-818. doi: 10.1038/s41380-019-0377-5. Epub 2019 Mar 22.

PMID:
30903001
19.

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.

Sorrell FJ, Kilian LM, Elkins JM.

Biochem J. 2019 Apr 4;476(7):1037-1051. doi: 10.1042/BCJ20180867.

20.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ.

J Med Chem. 2019 Mar 14;62(5):2830-2836. doi: 10.1021/acs.jmedchem.8b01213. Epub 2019 Feb 26.

21.

"I Couldn't Just Sit There": Leadership Learning Through Activism.

Elkins B, Elkins J.

New Dir Stud Leadersh. 2019 Mar;2019(161):37-49. doi: 10.1002/yd.20319.

PMID:
30729740
22.

Hypokalemic Periodic Paralysis Secondary to Dexamethasone Injection.

Elkins JC.

J Emerg Nurs. 2019 Jan;45(1):79-81. doi: 10.1016/j.jen.2018.09.012. No abstract available.

PMID:
30616767
23.

Early diagnosis and treatment of familial hypercholesterolemia.

Elkins JC, Fruh S.

Nurse Pract. 2019 Feb;44(2):18-24. doi: 10.1097/01.NPR.0000552677.31028.57.

PMID:
30614895
24.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.

25.

Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine.

Hobart J, Ziemssen T, Feys P, Linnebank M, Goodman AD, Farrell R, Hupperts R, Blight AR, Englishby V, McNeill M, Chang I, Lima G, Elkins J; ENHANCE study investigators.

CNS Drugs. 2019 Jan;33(1):61-79. doi: 10.1007/s40263-018-0586-5.

26.

A family affair: Supporting children with chronic illnesses.

Nabors L, Liddle M, Graves ML, Kamphaus A, Elkins J.

Child Care Health Dev. 2019 Mar;45(2):227-233. doi: 10.1111/cch.12635. Epub 2018 Dec 19.

PMID:
30474877
27.

General Assembly, Diagnosis, Definitions: Proceedings of International Consensus on Orthopedic Infections.

Elkins JM, Kates S, Lange J, Lange J, Lichstein P, Otero J, Soriano A, Wagner C, Wouthuyzen-Bakker M.

J Arthroplasty. 2019 Feb;34(2S):S181-S185. doi: 10.1016/j.arth.2018.09.069. Epub 2018 Oct 19. No abstract available.

PMID:
30348558
28.

Far Cortical Locking Fixation of Distal Femur Fractures is Dominated by Shear at Clinically Relevant Bridge Spans.

Habet N, Elkins J, Peindl R, Killen C, Lack WD.

J Orthop Trauma. 2019 Feb;33(2):92-96. doi: 10.1097/BOT.0000000000001341.

PMID:
30299380
29.

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

Santiago ADS, Couñago RM, Ramos PZ, Godoi PHC, Massirer KB, Gileadi O, Elkins JM.

Sci Rep. 2018 Oct 4;8(1):14800. doi: 10.1038/s41598-018-33043-4.

30.

Development and characterization of stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass at decreasing residence times.

Liang X, Whitham JM, Holwerda EK, Shao X, Tian L, Wu YW, Lombard V, Henrissat B, Klingeman DM, Yang ZK, Podar M, Richard TL, Elkins JG, Brown SD, Lynd LR.

Biotechnol Biofuels. 2018 Sep 6;11:243. doi: 10.1186/s13068-018-1238-1. eCollection 2018.

31.

An unexpected and persistent increase in global emissions of ozone-depleting CFC-11.

Montzka SA, Dutton GS, Yu P, Ray E, Portmann RW, Daniel JS, Kuijpers L, Hall BD, Mondeel D, Siso C, Nance JD, Rigby M, Manning AJ, Hu L, Moore F, Miller BR, Elkins JW.

Nature. 2018 May;557(7705):413-417. doi: 10.1038/s41586-018-0106-2. Epub 2018 May 16.

PMID:
29769666
32.

Lower Extremity Geometry in Morbid Obesity-Considerations for Total Knee Arthroplasty.

Elkins JM, Simoens KJ, Callaghan JJ.

J Arthroplasty. 2018 Oct;33(10):3304-3312. doi: 10.1016/j.arth.2018.03.060. Epub 2018 Mar 30.

PMID:
29705683
33.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

34.

The Impact of Stressful Life Events on the Incidence of Type 2 Diabetes in U.S. Adults from the Health and Retirement Study.

Smith BE, Miles TP, Elkins J, Barkin JL, Ebell MH, Ezeamama AE.

J Gerontol B Psychol Sci Soc Sci. 2018 Apr 7. doi: 10.1093/geronb/gby040. [Epub ahead of print]

PMID:
29635530
35.

Complications and Obesity in Arthroplasty-A Hip is Not a Knee.

DeMik DE, Bedard NA, Dowdle SB, Elkins JM, Brown TS, Gao Y, Callaghan JJ.

J Arthroplasty. 2018 Oct;33(10):3281-3287. doi: 10.1016/j.arth.2018.02.073. Epub 2018 Feb 26.

PMID:
29631859
36.

Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.

Moustakim M, Riedel K, Schuller M, Gehring AP, Monteiro OP, Martin SP, Fedorov O, Heer J, Dixon DJ, Elkins JM, Knapp S, Bracher F, Brennan PE.

Bioorg Med Chem. 2018 Jul 15;26(11):2965-2972. doi: 10.1016/j.bmc.2018.03.020. Epub 2018 Mar 12.

37.

Insights into the Evolution of Host Association through the Isolation and Characterization of a Novel Human Periodontal Pathobiont, Desulfobulbus oralis.

Cross KL, Chirania P, Xiong W, Beall CJ, Elkins JG, Giannone RJ, Griffen AL, Guss AM, Hettich RL, Joshi SS, Mokrzan EM, Martin RK, Zhulin IB, Leys EJ, Podar M.

mBio. 2018 Mar 13;9(2). pii: e02061-17. doi: 10.1128/mBio.02061-17.

38.

Genus-Wide Assessment of Lignocellulose Utilization in the Extremely Thermophilic Genus Caldicellulosiruptor by Genomic, Pangenomic, and Metagenomic Analyses.

Lee LL, Blumer-Schuette SE, Izquierdo JA, Zurawski JV, Loder AJ, Conway JM, Elkins JG, Podar M, Clum A, Jones PC, Piatek MJ, Weighill DA, Jacobson DA, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e02694-17. doi: 10.1128/AEM.02694-17. Print 2018 May 1.

39.

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E.

PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018.

40.

Seventeen years of human trafficking research in social work: A review of the literature.

Okech D, Choi YJ, Elkins J, Burns AC.

J Evid Inf Soc Work. 2018 Mar-Apr;15(2):102-121. doi: 10.1080/23761407.2017.1415177. Epub 2017 Dec 21. Review.

PMID:
29265959
41.

Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

Sansook S, Ocasio CA, Day IJ, Tizzard GJ, Coles SJ, Fedorov O, Bennett JM, Elkins JM, Spencer J.

Org Biomol Chem. 2018 Jan 3;16(2):336. doi: 10.1039/c7ob90195j.

PMID:
29256564
42.

The effect of switchgrass loadings on feedstock solubilization and biofuel production by Clostridium thermocellum.

Verbeke TJ, Garcia GM, Elkins JG.

Biotechnol Biofuels. 2017 Nov 30;10:233. doi: 10.1186/s13068-017-0917-7. eCollection 2017.

43.

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.

Asquith CRM, Laitinen T, Bennett JM, Godoi PH, East MP, Tizzard GJ, Graves LM, Johnson GL, Dornsife RE, Wells CI, Elkins JM, Willson TM, Zuercher WJ.

ChemMedChem. 2018 Jan 8;13(1):48-66. doi: 10.1002/cmdc.201700663. Epub 2017 Nov 27.

44.

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S.

ACS Chem Biol. 2017 Nov 17;12(11):2866-2874. doi: 10.1021/acschembio.7b00445. Epub 2017 Oct 19.

45.

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

Sansook S, Ocasio CA, Day IJ, Tizzard GJ, Coles SJ, Fedorov O, Bennett JM, Elkins JM, Spencer J.

Org Biomol Chem. 2017 Oct 18;15(40):8655-8660. doi: 10.1039/c7ob02289a. Erratum in: Org Biomol Chem. 2018 Jan 3;16(2):336.

46.

2017 IOJ Editors' Note.

Gholson JJ, Elkins JM.

Iowa Orthop J. 2017;37:i. No abstract available.

47.

The Scarcity of Orthopaedic Physician Scientists.

Buckwalter JA 5th, Elkins JM.

Iowa Orthop J. 2017;37:219-224.

48.

Bacillus subtilis Lipid Extract, A Branched-Chain Fatty Acid Model Membrane.

Nickels JD, Chatterjee S, Mostofian B, Stanley CB, Ohl M, Zolnierczuk P, Schulz R, Myles DAA, Standaert RF, Elkins JG, Cheng X, Katsaras J.

J Phys Chem Lett. 2017 Sep 7;8(17):4214-4217. doi: 10.1021/acs.jpclett.7b01877. Epub 2017 Aug 23.

PMID:
28825491
49.

Progress towards a public chemogenomic set for protein kinases and a call for contributions.

Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM.

PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.

50.

Corrigendum: Pentose sugars inhibit metabolism and increase expression of an AgrD-type cyclic pentapeptide in Clostridium thermocellum.

Verbeke TJ, Giannone RJ, Klingeman DM, Engle NL, Rydzak T, Guss AM, Tschaplinski TJ, Brown SD, Hettich RL, Elkins JG.

Sci Rep. 2017 Jul 27;7:46875. doi: 10.1038/srep46875.

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