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Items: 1 to 50 of 63

1.

Invariant Natural Killer T cell dynamics in HIV-associated tuberculosis.

Walker NF, Opondo C, Meintjes G, Jhilmeet N, Friedland JS, Elkington PT, Wilkinson RJ, Wilkinson KA.

Clin Infect Dis. 2019 Jun 12. pii: ciz501. doi: 10.1093/cid/ciz501. [Epub ahead of print]

2.

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

Rohlwink UK, Walker NF, Ordonez AA, Li YJ, Tucker EW, Elkington PT, Wilkinson RJ, Wilkinson KA.

Int J Mol Sci. 2019 Mar 18;20(6). pii: E1350. doi: 10.3390/ijms20061350. Review.

3.

Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition.

Elkington PT, Bateman AC, Thomas GJ, Ottensmeier CH.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1451-1453. doi: 10.1164/rccm.201807-1250LE. No abstract available.

4.

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis.

Ong CWM, Fox K, Ettorre A, Elkington PT, Friedland JS.

Sci Rep. 2018 Jul 31;8(1):11475. doi: 10.1038/s41598-018-29659-1.

5.

Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology.

Ordonez AA, Pokkali S, Sanchez-Bautista J, Klunk MH, Urbanowski ME, Kübler A, Bishai WR, Elkington PT, Jain SK.

J Infect Dis. 2019 Jan 29;219(4):633-636. doi: 10.1093/infdis/jiy373.

PMID:
29920600
6.

Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction.

Urbanowski ME, Ihms EA, Bigelow K, Kübler A, Elkington PT, Bishai WR.

J Infect Dis. 2018 Jun 5;218(1):53-63. doi: 10.1093/infdis/jiy127.

7.

Cytokine diagnosis of pleural TB: will it stand the test of time?

Tebruegge M, Elkington PT.

Thorax. 2018 Mar;73(3):206-207. doi: 10.1136/thoraxjnl-2017-210918. Epub 2017 Dec 20. No abstract available.

PMID:
29263234
8.

Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis.

Singh S, Maniakis-Grivas G, Singh UK, Asher RM, Mauri F, Elkington PT, Friedland JS.

J Pathol. 2018 Mar;244(3):311-322. doi: 10.1002/path.5013. Epub 2018 Jan 18.

9.

Bioelectrospray Methodology for Dissection of the Host-pathogen Interaction in Human Tuberculosis.

Tezera LB, Bielecka MK, Elkington PT.

Bio Protoc. 2017 Jul 20;7(14). pii: e2418. doi: 10.21769/BioProtoc.2418.

10.

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection.

Moores RC, Brilha S, Schutgens F, Elkington PT, Friedland JS.

Front Immunol. 2017 May 24;8:602. doi: 10.3389/fimmu.2017.00602. eCollection 2017.

11.

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.

Brace PT, Tezera LB, Bielecka MK, Mellows T, Garay D, Tian S, Rand L, Green J, Jogai S, Steele AJ, Millar TM, Sanchez-Elsner T, Friedland JS, Proud CG, Elkington PT.

PLoS Pathog. 2017 Jun 1;13(6):e1006367. doi: 10.1371/journal.ppat.1006367. eCollection 2017 Jun.

12.

Matrix Degradation in Human Immunodeficiency Virus Type 1-Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study.

Walker NF, Wilkinson KA, Meintjes G, Tezera LB, Goliath R, Peyper JM, Tadokera R, Opondo C, Coussens AK, Wilkinson RJ, Friedland JS, Elkington PT.

Clin Infect Dis. 2017 Jul 1;65(1):121-132. doi: 10.1093/cid/cix231.

13.

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis.

Ong CW, Pabisiak PJ, Brilha S, Singh P, Roncaroli F, Elkington PT, Friedland JS.

J Neuroinflammation. 2017 Feb 7;14(1):31. doi: 10.1186/s12974-017-0801-1.

14.

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model.

Tezera LB, Bielecka MK, Chancellor A, Reichmann MT, Shammari BA, Brace P, Batty A, Tocheva A, Jogai S, Marshall BG, Tebruegge M, Jayasinghe SN, Mansour S, Elkington PT.

Elife. 2017 Jan 7;6. pii: e21283. doi: 10.7554/eLife.21283.

15.

Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis.

Brilha S, Sathyamoorthy T, Stuttaford LH, Walker NF, Wilkinson RJ, Singh S, Moores RC, Elkington PT, Friedland JS.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):223-232. doi: 10.1165/rcmb.2016-0162OC.

16.

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases.

Ostridge K, Williams N, Kim V, Harden S, Bourne S, Coombs NA, Elkington PT, Estepar RS, Washko G, Staples KJ, Wilkinson TM.

Respir Res. 2016 Jul 26;17(1):92. doi: 10.1186/s12931-016-0402-z.

17.

Hypoxia and tissue destruction in pulmonary TB.

Belton M, Brilha S, Manavaki R, Mauri F, Nijran K, Hong YT, Patel NH, Dembek M, Tezera L, Green J, Moores R, Aigbirhio F, Al-Nahhas A, Fryer TD, Elkington PT, Friedland JS.

Thorax. 2016 Dec;71(12):1145-1153. doi: 10.1136/thoraxjnl-2015-207402. Epub 2016 May 31.

18.

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

Mansour S, Tocheva AS, Cave-Ayland C, Machelett MM, Sander B, Lissin NM, Molloy PE, Baird MS, Stübs G, Schröder NW, Schumann RR, Rademann J, Postle AD, Jakobsen BK, Marshall BG, Gosain R, Elkington PT, Elliott T, Skylaris CK, Essex JW, Tews I, Gadola SD.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75. doi: 10.1073/pnas.1519246113. Epub 2016 Feb 16.

19.

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD.

Ostridge K, Williams N, Kim V, Bennett M, Harden S, Welch L, Bourne S, Coombs NA, Elkington PT, Staples KJ, Wilkinson TM.

Thorax. 2016 Feb;71(2):126-32. doi: 10.1136/thoraxjnl-2015-207428. Epub 2015 Dec 8.

PMID:
26645414
20.

Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis.

Mansour S, Tocheva AS, Sanderson JP, Goulston LM, Platten H, Serhal L, Parsons C, Edwards MH, Woelk CH, Elkington PT, Elliott T, Cooper C, Edwards CJ, Gadola SD.

J Immunol. 2015 Dec 15;195(12):5582-91. doi: 10.4049/jimmunol.1501092. Epub 2015 Nov 9.

21.

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.

Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR.

J Infect Dis. 2016 Feb 15;213(4):618-27. doi: 10.1093/infdis/jiv458. Epub 2015 Sep 27.

22.

Permutations of time and place in tuberculosis.

Elkington PT, Friedland JS.

Lancet Infect Dis. 2015 Nov;15(11):1357-60. doi: 10.1016/S1473-3099(15)00135-8. Epub 2015 Aug 28. Review.

23.

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.

Sathyamoorthy T, Tezera LB, Walker NF, Brilha S, Saraiva L, Mauri FA, Wilkinson RJ, Friedland JS, Elkington PT.

J Immunol. 2015 Aug 1;195(3):882-91. doi: 10.4049/jimmunol.1403110. Epub 2015 Jun 19.

24.

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.

Ong CW, Elkington PT, Brilha S, Ugarte-Gil C, Tome-Esteban MT, Tezera LB, Pabisiak PJ, Moores RC, Sathyamoorthy T, Patel V, Gilman RH, Porter JC, Friedland JS.

PLoS Pathog. 2015 May 21;11(5):e1004917. doi: 10.1371/journal.ppat.1004917. eCollection 2015 May.

25.

The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis.

Al Shammari B, Shiomi T, Tezera L, Bielecka MK, Workman V, Sathyamoorthy T, Mauri F, Jayasinghe SN, Robertson BD, D'Armiento J, Friedland JS, Elkington PT.

J Infect Dis. 2015 Aug 1;212(3):463-73. doi: 10.1093/infdis/jiv076. Epub 2015 Feb 12.

26.

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.

Sathyamoorthy T, Sandhu G, Tezera LB, Thomas R, Singhania A, Woelk CH, Dimitrov BD, Agranoff D, Evans CA, Friedland JS, Elkington PT.

PLoS One. 2015 Jan 30;10(1):e0117605. doi: 10.1371/journal.pone.0117605. eCollection 2015.

27.

Induced sputum is safe and well-tolerated for TB diagnosis in a resource-poor primary healthcare setting.

Ugarte-Gil C, Elkington PT, Gotuzzo E, Friedland JS, Moore DAJ.

Am J Trop Med Hyg. 2015 Mar;92(3):633-635. doi: 10.4269/ajtmh.14-0583. Epub 2014 Dec 22.

28.

Controlled Generation of Microspheres Incorporating Extracellular Matrix Fibrils for Three-Dimensional Cell Culture.

Workman VL, Tezera LB, Elkington PT, Jayasinghe SN.

Adv Funct Mater. 2014 May 14;24(18):2648-2657.

29.

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.

Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR.

J Pathol. 2015 Feb;235(3):431-44. doi: 10.1002/path.4432. Epub 2014 Oct 6.

30.

Antimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis.

Singh S, Kubler A, Singh UK, Singh A, Gardiner H, Prasad R, Elkington PT, Friedland JS.

Antimicrob Agents Chemother. 2014 Aug;58(8):4657-65. doi: 10.1128/AAC.02141-13. Epub 2014 Jun 2.

31.

Tuberculosis and TNF-inhibitors: history of exposure should outweigh investigations.

Reichmann MT, Marshall BG, Cummings F, Elkington PT.

BMJ Case Rep. 2014 May 5;2014. pii: bcr2013202127. doi: 10.1136/bcr-2013-202127.

32.

Tuberculosis, pulmonary cavitation, and matrix metalloproteinases.

Ong CW, Elkington PT, Friedland JS.

Am J Respir Crit Care Med. 2014 Jul 1;190(1):9-18. doi: 10.1164/rccm.201311-2106PP.

33.

HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10.

Tomlinson GS, Bell LC, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz DR, Miller RF, Chain BM, Elkington PT, Noursadeghi M.

J Infect Dis. 2014 Apr 1;209(7):1055-65. doi: 10.1093/infdis/jit621. Epub 2013 Nov 21.

34.

Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome.

Tadokera R, Meintjes GA, Wilkinson KA, Skolimowska KH, Walker N, Friedland JS, Maartens G, Elkington PT, Wilkinson RJ.

Eur J Immunol. 2014 Jan;44(1):127-36. doi: 10.1002/eji.201343593. Epub 2013 Oct 30.

35.

Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70(S6K) cascade.

Singh S, Saraiva L, Elkington PT, Friedland JS.

FASEB J. 2014 Jan;28(1):85-93. doi: 10.1096/fj.13-235507. Epub 2013 Sep 27.

PMID:
24076964
36.

In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.

Green JA, Rand L, Moores R, Dholakia S, Pezas T, Elkington PT, Friedland JS.

J Neuroinflammation. 2013 Aug 26;10:107. doi: 10.1186/1742-2094-10-107.

37.

Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis.

Seddon J, Kasprowicz V, Walker NF, Yuen HM, Sunpath H, Tezera L, Meintjes G, Wilkinson RJ, Bishai WR, Friedland JS, Elkington PT.

J Infect Dis. 2013 Nov 15;208(10):1571-9. doi: 10.1093/infdis/jit343. Epub 2013 Aug 6.

38.

Ethnic variation in inflammatory profile in tuberculosis.

Coussens AK, Wilkinson RJ, Nikolayevskyy V, Elkington PT, Hanifa Y, Islam K, Timms PM, Bothamley GH, Claxton AP, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Drobniewski FA, Mein CA, Bhaw-Rosun L, Nuamah RA, Griffiths CJ, Martineau AR.

PLoS Pathog. 2013;9(7):e1003468. doi: 10.1371/journal.ppat.1003468. Epub 2013 Jul 4.

39.

Tuberculosis: time for a new perspective?

Elkington PT.

J Infect. 2013 Apr;66(4):299-302. doi: 10.1016/j.jinf.2013.02.002. Epub 2013 Feb 12.

40.

Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.

Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Martineau AR.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15449-54. Epub 2012 Sep 4.

41.

Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases.

Walker NF, Clark SO, Oni T, Andreu N, Tezera L, Singh S, Saraiva L, Pedersen B, Kelly DL, Tree JA, D'Armiento JM, Meintjes G, Mauri FA, Williams A, Wilkinson RJ, Friedland JS, Elkington PT.

Am J Respir Crit Care Med. 2012 May 1;185(9):989-97. doi: 10.1164/rccm.201110-1769OC. Epub 2012 Feb 16.

42.

Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.

Tomlinson GS, Cashmore TJ, Elkington PT, Yates J, Lehloenya RJ, Tsang J, Brown M, Miller RF, Dheda K, Katz DR, Chain BM, Noursadeghi M.

Eur J Immunol. 2011 Nov;41(11):3253-60. doi: 10.1002/eji.201141841. Epub 2011 Aug 30.

43.

Matrix metalloproteinases in tuberculosis.

Elkington PT, Ugarte-Gil CA, Friedland JS.

Eur Respir J. 2011 Aug;38(2):456-64. doi: 10.1183/09031936.00015411. Epub 2011 Jun 9. Review.

44.

Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.

Green JA, Dholakia S, Janczar K, Ong CW, Moores R, Fry J, Elkington PT, Roncaroli F, Friedland JS.

J Neuroinflammation. 2011 May 11;8:46. doi: 10.1186/1742-2094-8-46.

45.

Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.

Elkington PT, D'Armiento JM, Friedland JS.

Sci Transl Med. 2011 Feb 23;3(71):71ps6. doi: 10.1126/scitranslmed.3001847.

46.

Optimisation of bioluminescent reporters for use with mycobacteria.

Andreu N, Zelmer A, Fletcher T, Elkington PT, Ward TH, Ripoll J, Parish T, Bancroft GJ, Schaible U, Robertson BD, Wiles S.

PLoS One. 2010 May 24;5(5):e10777. doi: 10.1371/journal.pone.0010777.

47.

Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.

Green JA, Elkington PT, Pennington CJ, Roncaroli F, Dholakia S, Moores RC, Bullen A, Porter JC, Agranoff D, Edwards DR, Friedland JS.

J Immunol. 2010 Jun 1;184(11):6492-503. doi: 10.4049/jimmunol.0903811. Epub 2010 May 5.

48.

MMP12, lung function, and COPD in high-risk populations.

Elkington PT, Cooke GS.

N Engl J Med. 2010 Apr 1;362(13):1241; author reply 1242. doi: 10.1056/NEJMc1000959. No abstract available.

PMID:
20357289
49.

STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.

O'Kane CM, Elkington PT, Jones MD, Caviedes L, Tovar M, Gilman RH, Stamp G, Friedland JS.

Am J Respir Cell Mol Biol. 2010 Oct;43(4):465-74. doi: 10.1165/rcmb.2009-0211OC. Epub 2009 Nov 13.

50.

Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade.

Rand L, Green JA, Saraiva L, Friedland JS, Elkington PT.

J Immunol. 2009 May 1;182(9):5865-72. doi: 10.4049/jimmunol.0801935.

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