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Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.

Elkahloun AG, Saavedra JM.

Mol Neurobiol. 2019 Dec 7. doi: 10.1007/s12035-019-01800-9. [Epub ahead of print]


Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors.

Kaur S, Schwartz AL, Jordan DG, Soto-Pantoja DR, Kuo B, Elkahloun AG, Mathews Griner L, Thomas CJ, Ferrer M, Thomas A, Tang SW, Rajapakse VN, Pommier Y, Roberts DD.

Front Oncol. 2019 Oct 1;9:994. doi: 10.3389/fonc.2019.00994. eCollection 2019.


Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome.

Bernstock JD, Totten AH, Elkahloun AG, Johnson KR, Hurst AC, Goldman F, Groves AK, Mikhail FM, Atkinson TP.

J Allergy Clin Immunol. 2020 Jan;145(1):358-367.e2. doi: 10.1016/j.jaci.2019.09.020. Epub 2019 Oct 7.


FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.

Manoli I, Sysol JR, Epping MW, Li L, Wang C, Sloan JL, Pass A, Gagné J, Ktena YP, Li L, Trivedi NS, Ouattara B, Zerfas PM, Hoffmann V, Abu-Asab M, Tsokos MG, Kleiner DE, Garone C, Cusmano-Ozog K, Enns GM, Vernon HJ, Andersson HC, Grunewald S, Elkahloun AG, Girard CL, Schnermann J, DiMauro S, Andres-Mateos E, Vandenberghe LH, Chandler RJ, Venditti CP.

JCI Insight. 2018 Dec 6;3(23). pii: 124351. doi: 10.1172/jci.insight.124351.


RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.

Arafeh R, Di Pizio A, Elkahloun AG, Dym O, Niv MY, Samuels Y.

Oncogene. 2019 Mar;38(13):2432-2434. doi: 10.1038/s41388-018-0578-4. Epub 2018 Nov 26. No abstract available.


Telmisartan Protects a Microglia Cell Line from LPS Injury Beyond AT1 Receptor Blockade or PPARγ Activation.

Elkahloun AG, Rodriguez Y, Alaiyed S, Wenzel E, Saavedra JM.

Mol Neurobiol. 2019 May;56(5):3193-3210. doi: 10.1007/s12035-018-1300-9. Epub 2018 Aug 13.


Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility.

Lehmann ML, Weigel TK, Cooper HA, Elkahloun AG, Kigar SL, Herkenham M.

Sci Rep. 2018 Jul 26;8(1):11240. doi: 10.1038/s41598-018-28737-8.


CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs.

Kaur S, Elkahloun AG, Arakelyan A, Young L, Myers TG, Otaizo-Carrasquero F, Wu W, Margolis L, Roberts DD.

Sci Rep. 2018 Feb 7;8(1):2577. doi: 10.1038/s41598-018-20936-7.


A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells.

Kaur S, Elkahloun AG, Singh SP, Arakelyan A, Roberts DD.

J Cell Commun Signal. 2018 Mar;12(1):157-170. doi: 10.1007/s12079-017-0428-0. Epub 2017 Nov 29.


Chronic social defeat reduces myelination in the mouse medial prefrontal cortex.

Lehmann ML, Weigel TK, Elkahloun AG, Herkenham M.

Sci Rep. 2017 Apr 18;7:46548. doi: 10.1038/srep46548.


Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.

Pandya H, Shen MJ, Ichikawa DM, Sedlock AB, Choi Y, Johnson KR, Kim G, Brown MA, Elkahloun AG, Maric D, Sweeney CL, Gossa S, Malech HL, McGavern DB, Park JK.

Nat Neurosci. 2017 May;20(5):753-759. doi: 10.1038/nn.4534. Epub 2017 Mar 2.


Dopamine is Required for Activity-Dependent Amplification of Arc mRNA in Developing Postnatal Frontal Cortex.

Ye Y, Mastwal S, Cao VY, Ren M, Liu Q, Zhang W, Elkahloun AG, Wang KH.

Cereb Cortex. 2017 Jul 1;27(7):3600-3608. doi: 10.1093/cercor/bhw181.


A heterogeneous population of nuclear-encoded mitochondrial mRNAs is present in the axons of primary sympathetic neurons.

Aschrafi A, Kar AN, Gale JR, Elkahloun AG, Vargas JN, Sales N, Wilson G, Tompkins M, Gioio AE, Kaplan BB.

Mitochondrion. 2016 Sep;30:18-23. doi: 10.1016/j.mito.2016.06.002. Epub 2016 Jun 15.


miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.

Jiang X, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, Chen P, Huang H, Ulrich B, Gurbuxani S, Weng H, Strong J, Wang Y, Li Y, Salat J, Li S, Elkahloun AG, Yang Y, Neilly MB, Larson RA, Le Beau MM, Herold T, Bohlander SK, Liu PP, Zhang J, Li Z, He C, Jin J, Hong S, Chen J.

Nat Commun. 2016 Apr 26;7:11452. doi: 10.1038/ncomms11452.


A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer.

Kaur S, Elkahloun AG, Singh SP, Chen QR, Meerzaman DM, Song T, Manu N, Wu W, Mannan P, Garfield SH, Roberts DD.

Oncotarget. 2016 Mar 1;7(9):10133-52. doi: 10.18632/oncotarget.7100.


An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease.

Elkahloun AG, Hafko R, Saavedra JM.

Alzheimers Res Ther. 2016 Jan 28;8:5. doi: 10.1186/s13195-015-0167-5.


PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.

Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J.

Cancer Res. 2016 Feb 1;76(3):619-29. doi: 10.1158/0008-5472.CAN-15-1566. Epub 2016 Jan 8.


Overexpression and knockout of miR-126 both promote leukemogenesis.

Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J.

Blood. 2015 Oct 22;126(17):2005-15. doi: 10.1182/blood-2015-04-639062. Epub 2015 Sep 11.


Rescue of CD8+ T cell vaccine memory following sublethal γ irradiation.

McFarland HI, Berkson JD, Lee JP, Elkahloun AG, Mason KP, Rosenberg AS.

Vaccine. 2015 Jul 31;33(32):3865-72. doi: 10.1016/j.vaccine.2015.06.070. Epub 2015 Jun 26.


Novel integrative genomic tool for interrogating lithium response in bipolar disorder.

Hunsberger JG, Chibane FL, Elkahloun AG, Henderson R, Singh R, Lawson J, Cruceanu C, Nagarajan V, Turecki G, Squassina A, Medeiros CD, Del Zompo M, Rouleau GA, Alda M, Chuang DM.

Transl Psychiatry. 2015 Feb 3;5:e504. doi: 10.1038/tp.2014.139.


Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.

Chandler RJ, LaFave MC, Varshney GK, Trivedi NS, Carrillo-Carrasco N, Senac JS, Wu W, Hoffmann V, Elkahloun AG, Burgess SM, Venditti CP.

J Clin Invest. 2015 Feb;125(2):870-80. doi: 10.1172/JCI79213. Epub 2015 Jan 20.


Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes.

Yong RL, Yang C, Lu J, Wang H, Schlaff CD, Tandle A, Graves CA, Elkahloun AG, Chen X, Zhuang Z, Lonser RR.

Nat Commun. 2014 Dec 17;5:5799. doi: 10.1038/ncomms6799.


Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

Yang C, Zhuang Z, Fliedner SM, Shankavaram U, Sun MG, Bullova P, Zhu R, Elkahloun AG, Kourlas PJ, Merino M, Kebebew E, Pacak K.

J Mol Med (Berl). 2015 Jan;93(1):93-104. doi: 10.1007/s00109-014-1205-7. Epub 2014 Sep 30.


Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

Connelly JP, Kwon EM, Gao Y, Trivedi NS, Elkahloun AG, Horwitz MS, Cheng L, Liu PP.

Blood. 2014 Sep 18;124(12):1926-30.


CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells.

Kaur S, Singh SP, Elkahloun AG, Wu W, Abu-Asab MS, Roberts DD.

Matrix Biol. 2014 Jul;37:49-59. doi: 10.1016/j.matbio.2014.05.007. Epub 2014 Jun 2.


Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.

Fliedner SM, Engel T, Lendvai NK, Shankavaram U, Nölting S, Wesley R, Elkahloun AG, Ungefroren H, Oldoerp A, Lampert G, Lehnert H, Timmers H, Pacak K.

PLoS One. 2014 May 20;9(5):e97712. doi: 10.1371/journal.pone.0097712. eCollection 2014.


Identification of candidate genes involved in coronary artery calcification by transcriptome sequencing of cell lines.

Sen SK, Barb JJ, Cherukuri PF, Accame DS, Elkahloun AG, Singh LN, Lee-Lin SQ; NISC Comparative Sequencing Program, Kolodgie FD, Cheng Q, Zhao X, Chen MY, Arai AE, Green ED, Mullikin JC, Munson PJ, Biesecker LG.

BMC Genomics. 2014 Mar 14;15:198. doi: 10.1186/1471-2164-15-198.


Derivation of neural stem cells from human adult peripheral CD34+ cells for an autologous model of neuroinflammation.

Wang T, Choi E, Monaco MC, Campanac E, Medynets M, Do T, Rao P, Johnson KR, Elkahloun AG, Von Geldern G, Johnson T, Subramaniam S, Hoffman DA, Major E, Nath A.

PLoS One. 2013 Nov 26;8(11):e81720. doi: 10.1371/journal.pone.0081720. eCollection 2013. Erratum in: PLoS One. 2014;9(3):e91277. Hoffman, Dax [corrected to Hoffman, Dax A].


Frequent truncating mutations of STAG2 in bladder cancer.

Solomon DA, Kim JS, Bondaruk J, Shariat SF, Wang ZF, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips JJ, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PC, Netto G, Theodorescu D, James CD, Czerniak B, Miettinen M, Waldman T.

Nat Genet. 2013 Dec;45(12):1428-30. doi: 10.1038/ng.2800. Epub 2013 Oct 13.


Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia.

Manoli I, Sysol JR, Li L, Houillier P, Garone C, Wang C, Zerfas PM, Cusmano-Ozog K, Young S, Trivedi NS, Cheng J, Sloan JL, Chandler RJ, Abu-Asab M, Tsokos M, Elkahloun AG, Rosen S, Enns GM, Berry GT, Hoffmann V, DiMauro S, Schnermann J, Venditti CP.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13552-7. doi: 10.1073/pnas.1302764110. Epub 2013 Jul 29.


Pharmacogenomics, ancestry and clinical decision making for global populations.

Ramos E, Doumatey A, Elkahloun AG, Shriner D, Huang H, Chen G, Zhou J, McLeod H, Adeyemo A, Rotimi CN.

Pharmacogenomics J. 2014 Jun;14(3):217-22. doi: 10.1038/tpj.2013.24. Epub 2013 Jul 9.


TET1 plays an essential oncogenic role in MLL-rearranged leukemia.

Huang H, Jiang X, Li Z, Li Y, Song CX, He C, Sun M, Chen P, Gurbuxani S, Wang J, Hong GM, Elkahloun AG, Arnovitz S, Wang J, Szulwach K, Lin L, Street C, Wunderlich M, Dawlaty M, Neilly MB, Jaenisch R, Yang FC, Mulloy JC, Jin P, Liu PP, Rowley JD, Xu M, He C, Chen J.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9. doi: 10.1073/pnas.1310656110. Epub 2013 Jul 1.


miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.

Chen P, Price C, Li Z, Li Y, Cao D, Wiley A, He C, Gurbuxani S, Kunjamma RB, Huang H, Jiang X, Arnovitz S, Xu M, Hong GM, Elkahloun AG, Neilly MB, Wunderlich M, Larson RA, Le Beau MM, Mulloy JC, Liu PP, Rowley JD, Chen J.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11511-6. doi: 10.1073/pnas.1310144110. Epub 2013 Jun 24.


Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions.

Hunsberger JG, Fessler EB, Chibane FL, Leng Y, Maric D, Elkahloun AG, Chuang DM.

Am J Transl Res. 2013 May 24;5(4):450-64. Print 2013.


Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors.

Kaur S, Soto-Pantoja DR, Stein EV, Liu C, Elkahloun AG, Pendrak ML, Nicolae A, Singh SP, Nie Z, Levens D, Isenberg JS, Roberts DD.

Sci Rep. 2013;3:1673. doi: 10.1038/srep01673.


Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.

Shankavaram U, Fliedner SM, Elkahloun AG, Barb JJ, Munson PJ, Huynh TT, Matro JC, Turkova H, Linehan WM, Timmers HJ, Tischler AS, Powers JF, de Krijger R, Baysal BE, Takacova M, Pastorekova S, Gius D, Lehnert H, Camphausen K, Pacak K.

Neoplasia. 2013 Apr;15(4):435-47.


PBX3 is an important cofactor of HOXA9 in leukemogenesis.

Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJ, Döhner K, Neilly MB, Bullinger L, Delwel R, Löwenberg B, Liu PP, Morgan R, Rowley JD, Yuan CS, Chen J.

Blood. 2013 Feb 21;121(8):1422-31. doi: 10.1182/blood-2012-07-442004. Epub 2012 Dec 20.


A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest.

Xu L, Elkahloun AG, Candotti F, Grajkowski A, Beaucage SL, Petricoin EF, Calvert V, Juhl H, Mills F, Mason K, Shastri N, Chik J, Xu C, Rosenberg AS.

J Virol. 2013 Jan;87(1):25-36. doi: 10.1128/JVI.01648-12. Epub 2012 Oct 24.


Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia.

Hunsberger JG, Fessler EB, Wang Z, Elkahloun AG, Chuang DM.

Am J Transl Res. 2012;4(3):316-32. Epub 2012 Jul 25.


Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells.

Lin S, Yang J, Elkahloun AG, Bandyopadhyay A, Wang L, Cornell JE, Yeh IT, Agyin J, Tomlinson G, Sun LZ.

Mol Biol Cell. 2012 Apr;23(8):1569-81. doi: 10.1091/mbc.E11-10-0849. Epub 2012 Feb 22.


Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.

Oskvig DB, Elkahloun AG, Johnson KR, Phillips TM, Herkenham M.

Brain Behav Immun. 2012 May;26(4):623-34. doi: 10.1016/j.bbi.2012.01.015. Epub 2012 Jan 30.


Temporal dynamics and genetic control of transcription in the human prefrontal cortex.

Colantuoni C, Lipska BK, Ye T, Hyde TM, Tao R, Leek JT, Colantuoni EA, Elkahloun AG, Herman MM, Weinberger DR, Kleinman JE.

Nature. 2011 Oct 26;478(7370):519-23. doi: 10.1038/nature10524.


Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.

Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG, Anderson SM, Wei L, Sun H, O'Shea JJ, Schwartzberg PL.

Immunity. 2011 Oct 28;35(4):622-32. doi: 10.1016/j.immuni.2011.07.015. Epub 2011 Oct 20.


Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance.

Zhang C, Elkahloun AG, Robertson M, Gills JJ, Tsurutani J, Shih JH, Fukuoka J, Hollander MC, Harris CC, Travis WD, Jen J, Dennis PA.

PLoS One. 2011;6(8):e23849. doi: 10.1371/journal.pone.0023849. Epub 2011 Aug 24.


Mutational inactivation of STAG2 causes aneuploidy in human cancer.

Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, Toretsky JA, Rosenberg SA, Shukla N, Ladanyi M, Samuels Y, James CD, Yu H, Kim JS, Waldman T.

Science. 2011 Aug 19;333(6045):1039-43. doi: 10.1126/science.1203619.


Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice.

Li X, Johnson KR, Bryant M, Elkahloun AG, Amar M, Remaley AT, De Silva R, Hallenbeck JM, Quandt JA.

PLoS One. 2011;6(6):e20620. doi: 10.1371/journal.pone.0020620. Epub 2011 Jun 20.


Isolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrow.

Mukhopadhyay KD, Bandyopadhyay A, Chang TT, Elkahloun AG, Cornell JE, Yang J, Goins BA, Yeh IT, Sun LZ.

PLoS One. 2011;6(6):e20473. doi: 10.1371/journal.pone.0020473. Epub 2011 Jun 1.


The expression of REG 1A and REG 1B is increased during acute amebic colitis.

Peterson KM, Guo X, Elkahloun AG, Mondal D, Bardhan PK, Sugawara A, Duggal P, Haque R, Petri WA Jr.

Parasitol Int. 2011 Sep;60(3):296-300. doi: 10.1016/j.parint.2011.04.005. Epub 2011 May 6.


Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.

Zhang C, Elkahloun AG, Liao H, Delaney S, Saber B, Morrow B, Prendergast GC, Hollander MC, Gills JJ, Dennis PA.

Mol Cancer Ther. 2011 Jul;10(7):1137-48. doi: 10.1158/1535-7163.MCT-10-1028. Epub 2011 May 6.


A simple genetic architecture underlies morphological variation in dogs.

Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA.

PLoS Biol. 2010 Aug 10;8(8):e1000451. doi: 10.1371/journal.pbio.1000451.

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