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Items: 1 to 50 of 81

1.

Social Inequalities in Palliative Care for Cancer Patients in the United States: A Structured Review.

Elk R, Felder TM, Cayir E, Samuel CA.

Semin Oncol Nurs. 2018 Aug;34(3):303-315. doi: 10.1016/j.soncn.2018.06.011. Epub 2018 Aug 23. Review.

PMID:
30146346
2.

Our Differences Make Us Stronger.

Periyakoil VS, O'Mahony S, Elk R, Quill T.

J Pain Symptom Manage. 2018 May;55(5):1398-1399. doi: 10.1016/j.jpainsymman.2018.02.008. Epub 2018 Feb 24. No abstract available.

PMID:
29481962
3.

Culture and Palliative Care: Preferences, Communication, Meaning, and Mutual Decision Making.

Cain CL, Surbone A, Elk R, Kagawa-Singer M.

J Pain Symptom Manage. 2018 May;55(5):1408-1419. doi: 10.1016/j.jpainsymman.2018.01.007. Epub 2018 Jan 31.

PMID:
29366913
4.

The potential of palliative care for patients with respiratory diseases.

Narsavage GL, Chen YJ, Korn B, Elk R.

Breathe (Sheff). 2017 Dec;13(4):278-289. doi: 10.1183/20734735.014217.

5.

Opioid Prescription Drug Use and Expenditures in US Outpatient Physician Offices: Evidence from Two Nationally Representative Surveys.

Qureshi ZP, Haider MR, Rodriguez-Monguio R, Wooten NR, Nikitin RV, Ball S, Barth K, Elk R, Horner R, Bennett C.

Cancer Ther Oncol Int J. 2017;3(3). pii: 555611. doi: 10.19080/CTOIJ.2017.03.555611. Epub 2017 Feb 22.

7.

Full Collection of Personal Narratives.

Bravo RL, Gutierrez A, Young ME, Farrar H, Saksena J, McMorrow S, Raynor L, Penkin A, Pallai E, Schuch JC, Shirazi M, Ward TS, Mazul M, Berry M, Amy H, Gay T, Betty K, Kaitlin S, Mason S, Wilbricht J, Elk R.

Narrat Inq Bioeth. 2017;7(1):4-40. doi: 10.1353/nib.2017.0029. No abstract available.

PMID:
28713130
8.

The First Step Is Recognizing, Acknowledging, and Respecting the Inequity, Disrespect, and Disregard Our African American Patients Have Experienced.

Elk R.

J Palliat Med. 2016 Feb;19(2):124-5. doi: 10.1089/jpm.2015.0524. No abstract available.

PMID:
26840843
9.

LGBT Populations and Cancer: Is It an Ignored Epidemic?

Boehmer U, Elk R.

LGBT Health. 2016 Feb;3(1):1-2. Epub 2015 Dec 24. No abstract available.

PMID:
26698385
10.

Systematic Review of Palliative Care in the Rural Setting.

Bakitas MA, Elk R, Astin M, Ceronsky L, Clifford KN, Dionne-Odom JN, Emanuel LL, Fink RM, Kvale E, Levkoff S, Ritchie C, Smith T.

Cancer Control. 2015 Oct;22(4):450-64. Review.

PMID:
26678972
11.

Feeling Heard and Understood: A Patient-Reported Quality Measure for the Inpatient Palliative Care Setting.

Gramling R, Stanek S, Ladwig S, Gajary-Coots E, Cimino J, Anderson W, Norton SA; AAHPM Research Committee Writing Group, Aslakson RA, Ast K, Elk R, Garner KK, Gramling R, Grudzen C, Kamal AH, Lamba S, LeBlanc TW, Rhodes RL, Roeland E, Schulman-Green D, Unroe KT.

J Pain Symptom Manage. 2016 Feb;51(2):150-4. doi: 10.1016/j.jpainsymman.2015.10.018. Epub 2015 Nov 17.

PMID:
26596879
12.

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Otvos RA, Iyer JK, van Elk R, Ulens C, Niessen WM, Somsen GW, Kini RM, Smit AB, Kool J.

Toxins (Basel). 2015 Jun 24;7(7):2336-53. doi: 10.3390/toxins7072336.

13.

National Institutes of Health Pathways to Prevention Workshop: Advancing the Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Green CR, Cowan P, Elk R, O'Neil KM, Rasmussen AL.

Ann Intern Med. 2015 Jun 16;162(12):860-5. doi: 10.7326/M15-0338.

PMID:
26075757
14.

Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail.

Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J.

Biology (Basel). 2014 Feb 13;3(1):139-56. doi: 10.3390/biology3010139.

15.

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

Stornaiuolo M, De Kloe GE, Rucktooa P, Fish A, van Elk R, Edink ES, Bertrand D, Smit AB, de Esch IJ, Sixma TK.

Nat Commun. 2013;4:1875. doi: 10.1038/ncomms2900.

16.

Structural basis of ligand recognition in 5-HT3 receptors.

Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C.

EMBO Rep. 2013 Jan;14(1):49-56. doi: 10.1038/embor.2012.189. Epub 2012 Nov 30.

17.

Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.

Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, Kozikowski AP.

J Med Chem. 2012 Sep 27;55(18):8028-37. Epub 2012 Sep 7.

18.

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.

Billen B, Spurny R, Brams M, van Elk R, Valera-Kummer S, Yakel JL, Voets T, Bertrand D, Smit AB, Ulens C.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9173-8. doi: 10.1073/pnas.1116397109. Epub 2012 May 22.

19.

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

Rucktooa P, Haseler CA, van Elk R, Smit AB, Gallagher T, Sixma TK.

J Biol Chem. 2012 Jul 6;287(28):23283-93. doi: 10.1074/jbc.M112.360347. Epub 2012 May 2.

20.

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

Edink E, Akdemir A, Jansen C, van Elk R, Zuiderveld O, de Kanter FJ, van Muijlwijk-Koezen JE, Smit AB, Leurs R, de Esch IJ.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1448-54. doi: 10.1016/j.bmcl.2011.12.008. Epub 2011 Dec 9.

PMID:
22243960
21.

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

Akdemir A, Rucktooa P, Jongejan A, Elk Rv, Bertrand S, Sixma TK, Bertrand D, Smit AB, Leurs R, de Graaf C, de Esch IJ.

Bioorg Med Chem. 2011 Oct 15;19(20):6107-19. doi: 10.1016/j.bmc.2011.08.028. Epub 2011 Aug 27.

PMID:
21920761
22.

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C.

PLoS Biol. 2011 Mar;9(3):e1001034. doi: 10.1371/journal.pbio.1001034. Epub 2011 Mar 29.

23.

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Edink E, Rucktooa P, Retra K, Akdemir A, Nahar T, Zuiderveld O, van Elk R, Janssen E, van Nierop P, van Muijlwijk-Koezen J, Smit AB, Sixma TK, Leurs R, de Esch IJ.

J Am Chem Soc. 2011 Apr 13;133(14):5363-71. doi: 10.1021/ja110571r. Epub 2011 Feb 15.

PMID:
21322593
24.

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.

Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C.

J Biol Chem. 2011 Feb 11;286(6):4420-8. doi: 10.1074/jbc.M110.188730. Epub 2010 Nov 29.

25.

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ.

J Med Chem. 2010 Oct 14;53(19):7192-201. doi: 10.1021/jm100834y.

PMID:
20828128
26.

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H.

J Med Chem. 2010 Jun 24;53(12):4720-30. doi: 10.1021/jm100230k.

PMID:
20518527
27.

Modeling healthcare expenditures: overview of the literature and evidence from a panel time-series model.

van Elk R, Mot E, Franses PH.

Expert Rev Pharmacoecon Outcomes Res. 2010 Feb;10(1):25-35. doi: 10.1586/erp.09.72. Review.

PMID:
20121562
28.

Current status of palliative care--clinical implementation, education, and research.

Grant M, Elk R, Ferrell B, Morrison RS, von Gunten CF.

CA Cancer J Clin. 2009 Sep-Oct;59(5):327-35. doi: 10.3322/caac.20032.

29.

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ.

J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g.

PMID:
19331415
30.

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ.

EMBO J. 2007 Aug 22;26(16):3858-67. Epub 2007 Jul 26.

31.

Alpha-conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors.

Kasheverov IE, Zhmak MN, Vulfius CA, Gorbacheva EV, Mordvintsev DY, Utkin YN, van Elk R, Smit AB, Tsetlin VI.

FEBS J. 2006 Oct;273(19):4470-81. Epub 2006 Sep 5.

32.

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB.

Nat Struct Mol Biol. 2005 Jul;12(7):582-8. Epub 2005 Jun 12.

PMID:
15951818
33.

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

Celie PH, Klaassen RV, van Rossum-Fikkert SE, van Elk R, van Nierop P, Smit AB, Sixma TK.

J Biol Chem. 2005 Jul 15;280(28):26457-66. Epub 2005 May 16.

34.

Granularin, a novel molluscan opsonin comprising a single vWF type C domain is up-regulated during parasitation.

Smit AB, De Jong-Brink M, Li KW, Sassen MM, Spijker S, Van Elk R, Buijs S, Van Minnen J, Van Kesteren RE.

FASEB J. 2004 May;18(7):845-7. Epub 2004 Mar 19.

PMID:
15033923
35.

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

Smit AB, Syed NI, Schaap D, van Minnen J, Klumperman J, Kits KS, Lodder H, van der Schors RC, van Elk R, Sorgedrager B, Brejc K, Sixma TK, Geraerts WP.

Nature. 2001 May 17;411(6835):261-8.

PMID:
11357121
36.

Use of monetary reinforcers by cocaine-dependent outpatients.

Rothfleisch J, Elk R, Rhoades H, Schmitz J.

J Subst Abuse Treat. 1999 Oct;17(3):229-36.

PMID:
10531629
37.

Family of prohormone convertases in Lymnaea: characterization of two alternatively spliced furin-like transcripts and cell-specific regulation of their expression.

Spijker S, Smit AB, Sharp-Baker HE, Van Elk R, Van Kesteren ER, Van Minnen J, Kurosky A, Geraerts WP.

J Neurobiol. 1999 Nov 15;41(3):399-413.

PMID:
10526318
38.

Behavioral and emotional problems among children of cocaine- and opiate-dependent parents.

Stanger C, Higgins ST, Bickel WK, Elk R, Grabowski J, Schmitz J, Amass L, Kirby KC, Seracini AM.

J Am Acad Child Adolesc Psychiatry. 1999 Apr;38(4):421-8.

PMID:
10199114
39.

Context modulates effects of nicotine abstinence on human cooperative responding.

Spiga R, Day JD 2nd, Schmitz JM, Broitman M, Elk R, Caperton-Brown H.

Exp Clin Psychopharmacol. 1998 Nov;6(4):390-8.

PMID:
9861553
40.

Medication take-home doses and contingency management.

Schmitz JM, Rhoades HM, Elk R, Creson D, Hussein I, Grabowski J.

Exp Clin Psychopharmacol. 1998 May;6(2):162-8.

PMID:
9608348
41.

Retention, HIV risk, and illicit drug use during treatment: methadone dose and visit frequency.

Rhoades HM, Creson D, Elk R, Schmitz J, Grabowski J.

Am J Public Health. 1998 Jan;88(1):34-9.

42.
43.

Social, ethical and practical aspects of perinatal substance use.

Anderson M, Elk R, Andres RL.

J Subst Abuse Treat. 1997 Sep-Oct;14(5):481-6.

PMID:
9437618
44.

Baseline assessment, study entry, and stabilization: double-blind clinical trials in drug dependence.

Grabowski J, Arnoni G, Elk R, Rhoades H, Schmitz J.

NIDA Res Monogr. 1997;175:158-81. Review.

PMID:
9467797
45.

Expression and characterization of molluscan insulin-related peptide VII from the mollusc Lymnaea stagnalis.

Smit AB, Spijker S, Van Minnen J, Burke JF, De Winter F, Van Elk R, Geraerts WP.

Neuroscience. 1996 Jan;70(2):589-96.

PMID:
8848162
46.

Behavioral treatment of cocaine-dependent pregnant women and TB-exposed patients.

Elk R, Schmitz J, Spiga R, Rhoades H, Andres R, Grabowski J.

Addict Behav. 1995 Jul-Aug;20(4):533-42.

PMID:
7484335
47.

Fluoxetine is ineffective for treatment of cocaine dependence or concurrent opiate and cocaine dependence: two placebo-controlled double-blind trials.

Grabowski J, Rhoades H, Elk R, Schmitz J, Davis C, Creson D, Kirby K.

J Clin Psychopharmacol. 1995 Jun;15(3):163-74.

PMID:
7635993
48.

Cessation of cocaine use during pregnancy: a preliminary comparison.

Elk R, Schmitz J, Manfredi L, Rhoades H, Andres R, Grabowski J.

Addict Behav. 1994 Nov-Dec;19(6):697-702.

PMID:
7701980
49.

A substance-abuse research-treatment clinic: effective procedures and systems.

Elk R, Grabowski J, Rhoades H, McLellan AT.

J Subst Abuse Treat. 1993 Sep-Oct;10(5):459-71.

PMID:
8246321
50.

Evolutionary conservation of the insulin gene structure in invertebrates: cloning of the gene encoding molluscan insulin-related peptide III from Lymnaea stagnalis.

Smit AB, van Marle A, van Elk R, Bogerd J, van Heerikhuizen H, Geraerts WP.

J Mol Endocrinol. 1993 Aug;11(1):103-13.

PMID:
8240668

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