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Activation of TRPA1 by volatile organic chemicals leading to sensory irritation.

Martinez JM, Eling TE.

ALTEX. 2019;36(4):572-582. doi: 10.14573/altex.1811012. Epub 2019 Apr 18.


Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung.

Wu Q, Jiang D, Schaefer NR, Harmacek L, O'Connor BP, Eling TE, Eickelberg O, Chu HW.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L514-L527. doi: 10.1152/ajplung.00324.2017. Epub 2017 Nov 30.


Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models.

Van't Erve TJ, Lih FB, Jelsema C, Deterding LJ, Eling TE, Mason RP, Kadiiska MB.

Free Radic Biol Med. 2016 Jun;95:65-73. doi: 10.1016/j.freeradbiomed.2016.03.001. Epub 2016 Mar 8.


Correction: Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.

Binder AK, Kosak JP, Janardhan KS, Moser G, Eling TE, Korach KS.

PLoS One. 2016 Mar 10;11(3):e0151504. doi: 10.1371/journal.pone.0151504. eCollection 2016. No abstract available.


Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.

Binder AK, Kosak JP, Janardhan KS, Moser G, Eling TE, Korach KS.

PLoS One. 2016 Jan 8;11(1):e0146518. doi: 10.1371/journal.pone.0146518. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0151504. Janhardhan, Kyathanahalli S [corrected to Janardhan, Kyathanahalli S].


NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway.

Min KW, Liggett JL, Silva G, Wu WW, Wang R, Shen RF, Eling TE, Baek SJ.

Oncogene. 2016 Jan 21;35(3):377-88. doi: 10.1038/onc.2015.95. Epub 2015 Apr 20.


Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation.

van 't Erve TJ, Lih FB, Kadiiska MB, Deterding LJ, Eling TE, Mason RP.

Free Radic Biol Med. 2015 Jun;83:245-51. doi: 10.1016/j.freeradbiomed.2015.03.004. Epub 2015 Mar 12.


hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling.

Wang X, Chrysovergis K, Kosak J, Kissling G, Streicker M, Moser G, Li R, Eling TE.

Aging (Albany NY). 2014 Aug;6(8):690-704.


Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression.

Li R, Grimm SA, Chrysovergis K, Kosak J, Wang X, Du Y, Burkholder A, Janardhan K, Mav D, Shah R, Eling TE, Wade PA.

Cell Metab. 2014 Apr 1;19(4):702-11. doi: 10.1016/j.cmet.2014.03.012.


NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism.

Chrysovergis K, Wang X, Kosak J, Lee SH, Kim JS, Foley JF, Travlos G, Singh S, Baek SJ, Eling TE.

Int J Obes (Lond). 2014 Dec;38(12):1555-64. doi: 10.1038/ijo.2014.27. Epub 2014 Feb 17.


Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.

Liggett JL, Zhang X, Eling TE, Baek SJ.

Cancer Lett. 2014 May 1;346(2):217-24. doi: 10.1016/j.canlet.2014.01.021. Epub 2014 Jan 29. Review.


Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity.

Wang X, Chrysovergis K, Kosak J, Eling TE.

Obesity (Silver Spring). 2014 May;22(5):1256-63. doi: 10.1002/oby.20638. Epub 2013 Dec 5.


NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response.

Kim JM, Kosak JP, Kim JK, Kissling G, Germolec DR, Zeldin DC, Bradbury JA, Baek SJ, Eling TE.

Mediators Inflamm. 2013;2013:641851. doi: 10.1155/2013/641851. Epub 2013 May 13.


Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells.

Shimizu S, Kadowaki M, Yoshioka H, Kambe A, Watanabe T, Kinyamu HK, Eling TE.

Biochem Biophys Res Commun. 2013 Jan 25;430(4):1277-82. doi: 10.1016/j.bbrc.2012.11.137. Epub 2012 Dec 19.


The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer.

Wang X, Baek SJ, Eling TE.

Biochem Pharmacol. 2013 Mar 1;85(5):597-606. doi: 10.1016/j.bcp.2012.11.025. Epub 2012 Dec 7. Review.


The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo.

Wang X, Chrysovergis K, Bienstock RJ, Shim M, Eling TE.

Prostate. 2012 May 1;72(6):677-89. doi: 10.1002/pros.21471. Epub 2011 Aug 1.


DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines.

Kadowaki M, Yoshioka H, Kamitani H, Watanabe T, Wade PA, Eling TE.

Int J Cancer. 2012 Jan 15;130(2):267-77. doi: 10.1002/ijc.26082. Epub 2011 May 25.


The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac.

Wang X, Kingsley PJ, Marnett LJ, Eling TE.

Cancer Prev Res (Phila). 2011 Jan;4(1):150-60. doi: 10.1158/1940-6207.CAPR-10-0196.


Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3.

Whitlock NC, Bahn JH, Lee SH, Eling TE, Baek SJ.

Cancer Prev Res (Phila). 2011 Jan;4(1):116-27. doi: 10.1158/1940-6207.CAPR-10-0218.


Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice.

Matsuoka T, Adair JE, Lih FB, Hsi LC, Rubino M, Eling TE, Tomer KB, Yashiro M, Hirakawa K, Olden K, Roberts JD.

Br J Cancer. 2010 Oct 12;103(8):1182-91. doi: 10.1038/sj.bjc.6605881. Epub 2010 Sep 14.


The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells.

Kambe A, Yoshioka H, Kamitani H, Watanabe T, Baek SJ, Eling TE.

Cancer Prev Res (Phila). 2009 Dec;2(12):1088-99. doi: 10.1158/1940-6207.CAPR-09-0140. Epub 2009 Nov 24.


Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.

Ashwell MS, Ceddia RP, House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J.

J Nutr Biochem. 2010 Sep;21(9):848-55. doi: 10.1016/j.jnutbio.2009.06.013. Epub 2009 Oct 3.


Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice.

Cekanova M, Lee SH, Donnell RL, Sukhthankar M, Eling TE, Fischer SM, Baek SJ.

Cancer Prev Res (Phila). 2009 May;2(5):450-8. doi: 10.1158/1940-6207.CAPR-09-0057. Epub 2009 Apr 28.


A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.

Iguchi G, Chrysovergis K, Lee SH, Baek SJ, Langenbach R, Eling TE.

Cancer Lett. 2009 Sep 18;282(2):152-8. doi: 10.1016/j.canlet.2009.03.006. Epub 2009 Apr 17.


Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG.

Taniura S, Kamitani H, Watanabe T, Eling TE.

Neurol Med Chir (Tokyo). 2008;48(11):500-5; discussion 505.


Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A.

Yoshioka H, Kamitani H, Watanabe T, Eling TE.

J Biol Chem. 2008 Nov 28;283(48):33129-37. doi: 10.1074/jbc.M805248200. Epub 2008 Sep 17.


A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.

Sukhthankar M, Yamaguchi K, Lee SH, McEntee MF, Eling TE, Hara Y, Baek SJ.

Gastroenterology. 2008 Jun;134(7):1972-80. doi: 10.1053/j.gastro.2008.02.095. Epub 2008 Mar 8.


Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism.

Shim M, Eling TE.

Mol Cancer Ther. 2008 Apr;7(4):961-71. doi: 10.1158/1535-7163.MCT-07-0470.


Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.

Kambe A, Iguchi G, Moon Y, Kamitani H, Watanabe T, Eling TE.

Biochim Biophys Acta. 2008 Jun;1783(6):1211-9. doi: 10.1016/j.bbamcr.2008.01.032. Epub 2008 Feb 20.


Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways.

Moon Y, Kim JI, Yang H, Eling TE.

Life Sci. 2008 Mar 12;82(11-12):591-9. doi: 10.1016/j.lfs.2007.11.030. Epub 2007 Dec 23.


BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity.

Kang HJ, Kim HJ, Kwon SH, Kang BD, Eling TE, Lee SH, Bae I.

Cancer Chemother Pharmacol. 2008 Sep;62(4):689-97. Epub 2007 Dec 12.


High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.

Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL.

Nat Med. 2007 Sep;13(9):1096-101. Epub 2007 Aug 26.


Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

Lee CR, Bottone FG Jr, Krahn JM, Li L, Mohrenweiser HW, Cook ME, Petrovich RM, Bell DA, Eling TE, Zeldin DC.

Pharmacogenet Genomics. 2007 Feb;17(2):145-60.


NSAID activated gene (NAG-1), a modulator of tumorigenesis.

Eling TE, Baek SJ, Shim M, Lee CH.

J Biochem Mol Biol. 2006 Nov 30;39(6):649-55.


Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.

Baek SJ, Okazaki R, Lee SH, Martinez J, Kim JS, Yamaguchi K, Mishina Y, Martin DW, Shoieb A, McEntee MF, Eling TE.

Gastroenterology. 2006 Nov;131(5):1553-60. Epub 2006 Sep 19.


Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth.

Lambert JR, Kelly JA, Shim M, Huffer WE, Nordeen SK, Baek SJ, Eling TE, Lucia MS.

J Cell Physiol. 2006 Sep;208(3):566-74.


Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth.

Martinez JM, Sali T, Okazaki R, Anna C, Hollingshead M, Hose C, Monks A, Walker NJ, Baek SJ, Eling TE.

J Pharmacol Exp Ther. 2006 Aug;318(2):899-906. Epub 2006 May 19.


Changes in gene expression contribute to cancer prevention by COX inhibitors.

Baek SJ, Eling TE.

Prog Lipid Res. 2006 Jan;45(1):1-16. Epub 2005 Nov 21. Review.


Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner.

Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, Baek SJ.

Carcinogenesis. 2006 May;27(5):972-81. Epub 2005 Nov 14.


A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.

Malathi K, Paranjape JM, Bulanova E, Shim M, Guenther-Johnson JM, Faber PW, Eling TE, Williams BR, Silverman RH.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14533-8. Epub 2005 Oct 3.


Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.

Kim JS, Baek SJ, Bottone FG Jr, Sali T, Eling TE.

Mol Cancer Res. 2005 Sep;3(9):511-7.


Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.

Bottone FG Jr, Moon Y, Alston-Mills B, Eling TE.

J Pharmacol Exp Ther. 2005 Nov;315(2):668-77. Epub 2005 Aug 3.


The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).

Bottone FG Jr, Moon Y, Kim JS, Alston-Mills B, Ishibashi M, Eling TE.

Mol Cancer Ther. 2005 May;4(5):693-703.


Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice.

House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J.

Physiol Genomics. 2005 May 11;21(3):351-61.


Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.

Lee SH, Kim JS, Yamaguchi K, Eling TE, Baek SJ.

Biochem Biophys Res Commun. 2005 Mar 4;328(1):63-9.


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