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Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets.

Hall E, Jönsson J, Ofori JK, Volkov P, Perfilyev A, Dekker-Nitert M, Eliasson L, Ling C, Bacos K.

Diabetes. 2019 Aug 16. pii: db180900. doi: 10.2337/db18-0900. [Epub ahead of print]


Tailoring bilberry powder functionality through preprocessing and drying.

Eliasson L, Oliveira G, Ehrnell M, Höglund E, Alminger M.

Food Sci Nutr. 2019 Feb 19;7(4):1379-1386. doi: 10.1002/fsn3.972. eCollection 2019 Apr.


The effect of adding berry fruit juice concentrates and by-product extract to sugar solution on osmotic dehydration and sensory properties of apples.

Samborska K, Eliasson L, Marzec A, Kowalska J, Piotrowski D, Lenart A, Kowalska H.

J Food Sci Technol. 2019 Apr;56(4):1927-1938. doi: 10.1007/s13197-019-03658-0. Epub 2019 Mar 4.


Tailoring bilberry powder functionality through processing: Effects of drying and fractionation on the stability of total polyphenols and anthocyanins.

Oliveira G, Eliasson L, Ehrnell M, Höglund E, Andlid T, Alminger M.

Food Sci Nutr. 2019 Feb 7;7(3):1017-1026. doi: 10.1002/fsn3.930. eCollection 2019 Mar.


The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification.

Luan C, Ye Y, Singh T, Barghouth M, Eliasson L, Artner I, Zhang E, Renström E.

Commun Biol. 2019 Mar 15;2:106. doi: 10.1038/s42003-019-0351-4. eCollection 2019.


Defective exocytosis and processing of insulin in a cystic fibrosis mouse model.

Edlund A, Barghouth M, Huhn M, Abels M, Esguerra J, Mollet I, Svedin E, Wendt A, Renstrom E, Zhang E, Wierup N, Scholte BJ, Flodström-Tullberg M, Eliasson L.

J Endocrinol. 2019 Feb 1. pii: JOE-18-0570.R1. doi: 10.1530/JOE-18-0570. [Epub ahead of print]


In Vivo Silencing of MicroRNA-132 Reduces Blood Glucose and Improves Insulin Secretion.

Bijkerk R, Esguerra JLS, Ellenbroek JH, Au YW, Hanegraaf MAJ, de Koning EJ, Eliasson L, van Zonneveld AJ.

Nucleic Acid Ther. 2019 Apr;29(2):67-72. doi: 10.1089/nat.2018.0763. Epub 2019 Jan 23.


miR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease.

Gallo W, Esguerra JLS, Eliasson L, Melander O.

PLoS One. 2018 Nov 8;13(11):e0206974. doi: 10.1371/journal.pone.0206974. eCollection 2018.


MicroRNAs in islet hormone secretion.

Esguerra JLS, Nagao M, Ofori JK, Wendt A, Eliasson L.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:11-19. doi: 10.1111/dom.13382. Review.


Islet microRNAs in health and type-2 diabetes.

Wendt A, Esguerra JL, Eliasson L.

Curr Opin Pharmacol. 2018 Dec;43:46-52. doi: 10.1016/j.coph.2018.08.003. Epub 2018 Aug 23. Review.


MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation.

Daneshpajooh M, Eliasson L, Bacos K, Ling C.

Acta Diabetol. 2018 Dec;55(12):1231-1235. doi: 10.1007/s00592-018-1201-4. Epub 2018 Aug 7.


N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.

Ström K, Morales-Alamo D, Ottosson F, Edlund A, Hjort L, Jörgensen SW, Almgren P, Zhou Y, Martin-Rincon M, Ekman C, Pérez-López A, Ekström O, Perez-Suarez I, Mattiasson M, de Pablos-Velasco P, Oskolkov N, Ahlqvist E, Wierup N, Eliasson L, Vaag A, Groop L, Stenkula KG, Fernandez C, Calbet JAL, Holmberg HC, Hansson O.

Sci Rep. 2018 Feb 14;8(1):3016. doi: 10.1038/s41598-018-21099-1.


She is in science to stay!

Birnir B, Eliasson L.

Acta Physiol (Oxf). 2018 May;223(1):e13048. doi: 10.1111/apha.13048. Epub 2018 Feb 23. No abstract available.


MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles.

Salunkhe VA, Ofori JK, Gandasi NR, Salö SA, Hansson S, Andersson ME, Wendt A, Barg S, Esguerra JLS, Eliasson L.

Physiol Rep. 2017 Nov;5(21). pii: e13493. doi: 10.14814/phy2.13493.


Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.

Motterle A, Gattesco S, Peyot ML, Esguerra JLS, Gomez-Ruiz A, Laybutt DR, Gilon P, Burdet F, Ibberson M, Eliasson L, Prentki M, Regazzi R.

Mol Metab. 2017 Nov;6(11):1407-1418. doi: 10.1016/j.molmet.2017.08.005. Epub 2017 Aug 18.


PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.

Henaoui IS, Jacovetti C, Guerra Mollet I, Guay C, Sobel J, Eliasson L, Regazzi R.

Diabetologia. 2017 Oct;60(10):1977-1986. doi: 10.1007/s00125-017-4368-2. Epub 2017 Jul 16.


Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.

Nicholas LM, Valtat B, Medina A, Andersson L, Abels M, Mollet IG, Jain D, Eliasson L, Wierup N, Fex M, Mulder H.

Mol Metab. 2017 May 19;6(7):651-663. doi: 10.1016/j.molmet.2017.05.005. eCollection 2017 Jul.


Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines.

Ofori JK, Malm HA, Mollet IG, Eliasson L, Esguerra JLS.

PeerJ. 2017 Jun 28;5:e3503. doi: 10.7717/peerj.3503. eCollection 2017.


Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH.

Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652.


Patients' Preferences for the Treatment of Metastatic Castrate-resistant Prostate Cancer: A Discrete Choice Experiment.

Eliasson L, de Freitas HM, Dearden L, Calimlim B, Lloyd AJ.

Clin Ther. 2017 Apr;39(4):723-737. doi: 10.1016/j.clinthera.2017.02.009. Epub 2017 Mar 31.


Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.

Ofori JK, Salunkhe VA, Bagge A, Vishnu N, Nagao M, Mulder H, Wollheim CB, Eliasson L, Esguerra JL.

Sci Rep. 2017 Mar 23;7:44986. doi: 10.1038/srep44986.


Evaluation of psoriasis patients' attitudes toward benefit-risk and therapeutic trade-offs in their choice of treatments.

Eliasson L, Bewley AP, Mughal F, Johnston KM, Kuznik A, Patel C, Lloyd AJ.

Patient Prefer Adherence. 2017 Feb 28;11:353-362. doi: 10.2147/PPA.S121838. eCollection 2017.


CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Edlund A, Pedersen MG, Lindqvist A, Wierup N, Flodström-Tullberg M, Eliasson L.

Sci Rep. 2017 Mar 7;7(1):90. doi: 10.1038/s41598-017-00098-8.


The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function.

Eliasson L.

Mol Cell Endocrinol. 2017 Nov 15;456:95-101. doi: 10.1016/j.mce.2017.02.043. Epub 2017 Feb 27. Review.


Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

Shcherbina L, Edlund A, Esguerra JL, Abels M, Zhou Y, Ottosson-Laakso E, Wollheim CB, Hansson O, Eliasson L, Wierup N.

Mol Cell Endocrinol. 2017 May 15;447:52-60. doi: 10.1016/j.mce.2017.02.027. Epub 2017 Feb 24.


Erratum to: Lessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications.

Eliasson L, Esguerra JLS, Wendt A.

Diabetol Int. 2017 Feb 14;8(2):153. doi: 10.1007/s13340-017-0308-0. eCollection 2017 Jun.


An 'alpha-beta' of pancreatic islet microribonucleotides.

Dalgaard LT, Eliasson L.

Int J Biochem Cell Biol. 2017 Jul;88:208-219. doi: 10.1016/j.biocel.2017.01.009. Epub 2017 Jan 22. Review.


Lessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications.

Eliasson L, Esguerra JLS, Wendt A.

Diabetol Int. 2017 Jan 23;8(2):139-152. doi: 10.1007/s13340-017-0304-4. eCollection 2017 Jun. Erratum in: Diabetol Int. 2017 Feb 14;8(2):153.


Osteopontin Affects Insulin Vesicle Localization and Ca2+ Homeostasis in Pancreatic Beta Cells from Female Mice.

Wendt A, Mollet IG, Knutsson A, Bolmgren VS, Hultgårdh-Nilsson A, Gomez MF, Eliasson L.

PLoS One. 2017 Jan 20;12(1):e0170498. doi: 10.1371/journal.pone.0170498. eCollection 2017.


Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival.

Juan-Mateu J, Rech TH, Villate O, Lizarraga-Mollinedo E, Wendt A, Turatsinze JV, Brondani LA, Nardelli TR, Nogueira TC, Esguerra JL, Alvelos MI, Marchetti P, Eliasson L, Eizirik DL.

J Biol Chem. 2017 Feb 24;292(8):3466-3480. doi: 10.1074/jbc.M116.748335. Epub 2017 Jan 11.


Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.

Volkov P, Bacos K, Ofori JK, Esguerra JL, Eliasson L, Rönn T, Ling C.

Diabetes. 2017 Apr;66(4):1074-1085. doi: 10.2337/db16-0996. Epub 2017 Jan 4.


Reduced blood glucose through thyroid hormone degradation product.

Eliasson L.

Acta Physiol (Oxf). 2017 Jun;220(2):184-185. doi: 10.1111/apha.12847. Epub 2017 Jan 23. No abstract available.


HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells.

Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C.

Diabetologia. 2017 Jan;60(1):116-125. Epub 2016 Oct 29.


Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.

Degerman E, In 't Zandt R, Pålbrink A, Eliasson L, Cayé-Thomasen P, Magnusson M.

Acta Otolaryngol. 2017 Jan;137(1):8-15. Epub 2016 Aug 15.


Erythropoietin and TRPV1 together in new formation.

Eliasson L.

Acta Physiol (Oxf). 2017 Feb;219(2):341-342. doi: 10.1111/apha.12765. Epub 2016 Aug 18. No abstract available.


Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion.

Salunkhe VA, Mollet IG, Ofori JK, Malm HA, Esguerra JL, Reinbothe TM, Stenkula KG, Wendt A, Eliasson L, Vikman J.

EBioMedicine. 2016 Aug;10:185-94. doi: 10.1016/j.ebiom.2016.07.007. Epub 2016 Jul 9.


Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion.

Mollet IG, Malm HA, Wendt A, Orho-Melander M, Eliasson L.

J Biol Chem. 2016 Aug 26;291(35):18440-52. doi: 10.1074/jbc.M116.716860. Epub 2016 Jul 8.


Partners for life.

Eliasson L, Wendt A.

Elife. 2016 May 18;5. pii: e16798. doi: 10.7554/eLife.16798.


Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes.

Bacos K, Gillberg L, Volkov P, Olsson AH, Hansen T, Pedersen O, Gjesing AP, Eiberg H, Tuomi T, Almgren P, Groop L, Eliasson L, Vaag A, Dayeh T, Ling C.

Nat Commun. 2016 Mar 31;7:11089. doi: 10.1038/ncomms11089.


Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells.

Salunkhe VA, Elvstam O, Eliasson L, Wendt A.

PLoS One. 2016 Mar 17;11(3):e0151592. doi: 10.1371/journal.pone.0151592. eCollection 2016.


Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting β-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.

Malm HA, Mollet IG, Berggreen C, Orho-Melander M, Esguerra JL, Göransson O, Eliasson L.

Mol Cell Endocrinol. 2016 Mar 15;424:23-33. doi: 10.1016/j.mce.2016.01.010. Epub 2016 Jan 13.


CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.

King BC, Esguerra JL, Golec E, Eliasson L, Kemper C, Blom AM.

J Immunol. 2016 Feb 15;196(4):1636-45. doi: 10.4049/jimmunol.1500516. Epub 2016 Jan 8.


Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M.

Diabetologia. 2016 Apr;59(4):744-54. doi: 10.1007/s00125-015-3847-6. Epub 2016 Jan 6.


A comparative study of infrared and microwave heating for microbial decontamination of paprika powder.

Eliasson L, Isaksson S, Lövenklev M, Ahrné L.

Front Microbiol. 2015 Sep 30;6:1071. doi: 10.3389/fmicb.2015.01071. eCollection 2015.


miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism.

Tattikota SG, Rathjen T, Hausser J, Khedkar A, Kabra UD, Pandey V, Sury M, Wessels HH, Mollet IG, Eliasson L, Selbach M, Zinzen RP, Zavolan M, Kadener S, Tschöp MH, Jastroch M, Friedländer MR, Poy MN.

J Biol Chem. 2015 Aug 14;290(33):20284-94. doi: 10.1074/jbc.M115.658625. Epub 2015 Jul 7.


Adherence to behavioural interventions in multiple sclerosis: Follow-up meeting report (AD@MS-2).

Heesen C, Bruce J, Gearing R, Moss-Morris R, Weinmann J, Hamalainen P, Motl R, Dalgas U, Kos D, Visioli F, Feys P, Solari A, Finlayson M, Eliasson L, Matthews V, Bogossian A, Liethmann K, Köpke S, Bissell P.

Mult Scler J Exp Transl Clin. 2015 May 12;1:2055217315585333. doi: 10.1177/2055217315585333. eCollection 2015 Jan-Dec.


Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents.

Christensen GL, Jacobsen ML, Wendt A, Mollet IG, Friberg J, Frederiksen KS, Meyer M, Bruun C, Eliasson L, Billestrup N.

Diabetologia. 2015 Jun;58(6):1282-90. doi: 10.1007/s00125-015-3568-x. Epub 2015 Apr 2.


Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice.

Bodin J, Kocbach Bølling A, Wendt A, Eliasson L, Becher R, Kuper F, Løvik M, Nygaard UC.

Toxicol Rep. 2015 Feb 28;2:99-110. doi: 10.1016/j.toxrep.2015.02.010. eCollection 2015.


Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.

Salunkhe VA, Esguerra JL, Ofori JK, Mollet IG, Braun M, Stoffel M, Wendt A, Eliasson L.

Acta Physiol (Oxf). 2015 Apr;213(4):882-92. doi: 10.1111/apha.12460. Epub 2015 Feb 15.


Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets.

Hall E, Volkov P, Dayeh T, Esguerra JL, Salö S, Eliasson L, Rönn T, Bacos K, Ling C.

Genome Biol. 2014 Dec 3;15(12):522. doi: 10.1186/s13059-014-0522-z.

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