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Items: 1 to 50 of 108


Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction.

Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ.

Cell Metab. 2019 May 7;29(5):1232. doi: 10.1016/j.cmet.2019.04.006. No abstract available.


P110β in the ventromedial hypothalamus regulates glucose and energy metabolism.

Fujikawa T, Choi YH, Yang DJ, Shin DM, Donato J Jr, Kohno D, Lee CE, Elias CF, Lee S, Kim KW.

Exp Mol Med. 2019 Apr 26;51(4):52. doi: 10.1038/s12276-019-0249-8.


Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency.

Franca MM, Han X, Funari MFA, Lerario AM, Nishi MY, Fontenele EGP, Domenice S, Jorge AAL, Garcia-Galiano D, Elias CF, Mendonca BB.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2827-2841. doi: 10.1210/jc.2018-02485.


PI3K signalling in leptin receptor cells: Role in growth and reproduction.

Garcia-Galiano D, Borges BC, Allen SJ, Elias CF.

J Neuroendocrinol. 2019 May;31(5):e12685. doi: 10.1111/jne.12685. Epub 2019 Jan 28. Review.


Insulin signaling in LepR cells modulates fat and glucose homeostasis independent of leptin.

Borges BC, Han X, Allen SJ, Garcia-Galiano D, Elias CF.

Am J Physiol Endocrinol Metab. 2019 Jan 1;316(1):E121-E134. doi: 10.1152/ajpendo.00287.2018. Epub 2018 Oct 30.


Neuroanatomical Framework of the Metabolic Control of Reproduction.

Hill JW, Elias CF.

Physiol Rev. 2018 Oct 1;98(4):2349-2380. doi: 10.1152/physrev.00033.2017. Review.


Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.

Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF.

Endocrinology. 2018 Apr 1;159(4):1718-1733. doi: 10.1210/en.2017-03053.


PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction.

Garcia-Galiano D, Borges BC, Donato J Jr, Allen SJ, Bellefontaine N, Wang M, Zhao JJ, Kozloff KM, Hill JW, Elias CF.

JCI Insight. 2017 Dec 7;2(23). pii: 96728. doi: 10.1172/jci.insight.96728.


Short-Term High-Fat Diet Increases Leptin Activation of CART Neurons and Advances Puberty in Female Mice.

Venancio JC, Margatho LO, Rorato R, Rosales RRC, Debarba LK, Coletti R, Antunes-Rodrigues J, Elias CF, Elias LLK.

Endocrinology. 2017 Nov 1;158(11):3929-3942. doi: 10.1210/en.2017-00452.


Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity.

Borges BC, Garcia-Galiano D, da Silveira Cruz-Machado S, Han X, Gavrilina GB, Saunders TL, Auchus RJ, Hammoud SS, Smith GD, Elias CF.

Endocrinology. 2017 Sep 1;158(9):2930-2943. doi: 10.1210/en.2017-00295.


Editorial: Neuropeptides and Behavior: From Motivation to Psychopathology.

Suchecki D, Elias CF.

Front Endocrinol (Lausanne). 2017 Aug 25;8:210. doi: 10.3389/fendo.2017.00210. eCollection 2017. No abstract available.


LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes.

Rorato R, Borges BC, Uchoa ET, Antunes-Rodrigues J, Elias CF, Elias LLK.

Int J Mol Sci. 2017 Jul 4;18(7). pii: E1431. doi: 10.3390/ijms18071431.


Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model.

Mohsen Z, Sim H, Garcia-Galiano D, Han X, Bellefontaine N, Saunders TL, Elias CF.

Brain Struct Funct. 2017 Dec;222(9):4111-4129. doi: 10.1007/s00429-017-1456-5. Epub 2017 Jun 14.


Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.

Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG Jr, Miller RA, Sandoval DA, Sadagurski M.

Mol Metab. 2017 Mar 16;6(5):393-405. doi: 10.1016/j.molmet.2017.03.001. eCollection 2017 May.


AMPKα2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice.

Torsoni MA, Borges BC, Cote JL, Allen SJ, Mahany E, Garcia-Galiano D, Elias CF.

Endocrinology. 2016 Dec;157(12):4803-4816. Epub 2016 Oct 12.


Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice.

Gal A, Lin PC, Cacioppo JA, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, Ko C.

PLoS One. 2016 Jul 21;11(7):e0159534. doi: 10.1371/journal.pone.0159534. eCollection 2016.


Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.

Stein LM, Tullock CW, Mathews SK, Garcia-Galiano D, Elias CF, Samson WK, Yosten GL.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R489-96. doi: 10.1152/ajpregu.00191.2016. Epub 2016 Jul 20.


PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges.

Borges BC, Elias CF, Elias LL.

Mol Cell Endocrinol. 2016 Dec 15;438:36-41. doi: 10.1016/j.mce.2016.07.005. Epub 2016 Jul 5. Review.


PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia.

Borges BC, Garcia-Galiano D, Rorato R, Elias LLK, Elias CF.

Mol Metab. 2016 Mar 19;5(6):379-391. doi: 10.1016/j.molmet.2016.03.003. eCollection 2016 Jun.


Neuroendocrine Regulation of Metabolism.

Cornejo MP, Hentges ST, Maliqueo M, Coirini H, Becu-Villalobos D, Elias CF.

J Neuroendocrinol. 2016 Jul;28(7). doi: 10.1111/jne.12395. Review.


Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state.

Allen SJ, Garcia-Galiano D, Borges BC, Burger LL, Boehm U, Elias CF.

Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1258-66. doi: 10.1152/ajpregu.00529.2015. Epub 2016 Apr 13.


ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice.

Greenwald-Yarnell ML, Marsh C, Allison MB, Patterson CM, Kasper C, MacKenzie A, Cravo R, Elias CF, Moenter SM, Myers MG Jr.

Endocrinology. 2016 Apr;157(4):1555-65. doi: 10.1210/en.2015-1928. Epub 2016 Feb 10.


The centrally projecting Edinger-Westphal nucleus--I: Efferents in the rat brain.

Dos Santos Júnior ED, Da Silva AV, Da Silva KR, Haemmerle CA, Batagello DS, Da Silva JM, Lima LB, Da Silva RJ, Diniz GB, Sita LV, Elias CF, Bittencourt JC.

J Chem Neuroanat. 2015 Oct;68:22-38. doi: 10.1016/j.jchemneu.2015.07.002. Epub 2015 Jul 21.


Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.

Qiu X, Dao H, Wang M, Heston A, Garcia KM, Sangal A, Dowling AR, Faulkner LD, Molitor SC, Elias CF, Hill JW.

PLoS One. 2015 May 6;10(5):e0121974. doi: 10.1371/journal.pone.0121974. eCollection 2015.


Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis.

Scott MM, Xu Y, Elias CF, Williams KW.

Front Neurosci. 2014 Dec 3;8:384. doi: 10.3389/fnins.2014.00384. eCollection 2014. No abstract available.


GABAergic transmission to kisspeptin neurons is differentially regulated by time of day and estradiol in female mice.

DeFazio RA, Elias CF, Moenter SM.

J Neurosci. 2014 Dec 3;34(49):16296-308. doi: 10.1523/JNEUROSCI.3057-14.2014.


Role of the adipocyte-derived hormone leptin in reproductive control.

Garcia-Galiano D, Allen SJ, Elias CF.

Horm Mol Biol Clin Investig. 2014 Sep;19(3):141-9. doi: 10.1515/hmbci-2014-0017. Review.


Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats.

Borges Bde C, Rorato RC, Uchoa ET, Marangon PB, Elias CF, Antunes-Rodrigues J, Elias LL.

Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E40-50. doi: 10.1152/ajpendo.00094.2014. Epub 2014 Oct 28.


Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity.

Pedroso JA, Buonfiglio DC, Cardinali LI, Furigo IC, Ramos-Lobo AM, Tirapegui J, Elias CF, Donato J Jr.

Mol Metab. 2014 Jun 12;3(6):608-18. doi: 10.1016/j.molmet.2014.06.001. eCollection 2014 Sep.


Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats.

Cavalcante JC, Bittencourt JC, Elias CF.

Brain Res. 2014 Sep 25;1582:77-90. doi: 10.1016/j.brainres.2014.07.034. Epub 2014 Jul 30.


Chemical identity of hypothalamic neurons engaged by leptin in reproductive control.

Ratra DV, Elias CF.

J Chem Neuroanat. 2014 Nov;61-62:233-8. doi: 10.1016/j.jchemneu.2014.05.005. Epub 2014 Jun 7. Review.


Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models.

Bellefontaine N, Elias CF.

Horm Behav. 2014 Jun;66(1):7-14. doi: 10.1016/j.yhbeh.2014.04.007. Epub 2014 Apr 16. Review.


Estradiol modulates Kiss1 neuronal response to ghrelin.

Frazao R, Dungan Lemko HM, da Silva RP, Ratra DV, Lee CE, Williams KW, Zigman JM, Elias CF.

Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E606-14. doi: 10.1152/ajpendo.00211.2013. Epub 2014 Jan 28.


A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction.

Elias CF.

Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R1-9. doi: 10.1152/ajpregu.00444.2013. Epub 2013 Nov 6. Review.


From precocious puberty to infertility: metabolic control of the reproductive function.

Hill JW, Alreja M, Elias CF.

Front Endocrinol (Lausanne). 2013 Apr 2;4:43. doi: 10.3389/fendo.2013.00043. eCollection 2013. No abstract available.


Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition.

Donato J Jr, Lee C, Ratra DV, Franci CR, Canteras NS, Elias CF.

Neuroscience. 2013 Jun 25;241:67-79. doi: 10.1016/j.neuroscience.2013.03.013. Epub 2013 Mar 19.


Leptin signaling in Kiss1 neurons arises after pubertal development.

Cravo RM, Frazao R, Perello M, Osborne-Lawrence S, Williams KW, Zigman JM, Vianna C, Elias CF.

PLoS One. 2013;8(3):e58698. doi: 10.1371/journal.pone.0058698. Epub 2013 Mar 7.


Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.

Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ.

Mol Endocrinol. 2013 Apr;27(4):598-605. doi: 10.1210/me.2012-1371. Epub 2013 Mar 15.


Discrete melanocortin-sensitive neuroanatomical pathway linking the ventral premmamillary nucleus to the paraventricular hypothalamus.

Gautron L, Cravo RM, Elmquist JK, Elias CF.

Neuroscience. 2013 Jun 14;240:70-82. doi: 10.1016/j.neuroscience.2013.02.024. Epub 2013 Feb 26.


Shift in Kiss1 cell activity requires estrogen receptor α.

Frazão R, Cravo RM, Donato J Jr, Ratra DV, Clegg DJ, Elmquist JK, Zigman JM, Williams KW, Elias CF.

J Neurosci. 2013 Feb 13;33(7):2807-20. doi: 10.1523/JNEUROSCI.1610-12.2013.


Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells.

Qiu X, Dowling AR, Marino JS, Faulkner LD, Bryant B, Brüning JC, Elias CF, Hill JW.

Endocrinology. 2013 Mar;154(3):1337-48. doi: 10.1210/en.2012-2056. Epub 2013 Feb 7.


Oxytocin in the central amygdaloid nucleus modulates the neuroendocrine responses induced by hypertonic volume expansion in the rat.

Margatho LO, Elias CF, Elias LL, Antunes-Rodrigues J.

J Neuroendocrinol. 2013 May;25(5):466-77. doi: 10.1111/jne.12021.


Kiss of the mutant mouse: how genetically altered mice advanced our understanding of kisspeptin's role in reproductive physiology.

Dungan Lemko HM, Elias CF.

Endocrinology. 2012 Nov;153(11):5119-29. doi: 10.1210/en.2012-1494. Epub 2012 Sep 25. Review.


Leptin signaling and circuits in puberty and fertility.

Elias CF, Purohit D.

Cell Mol Life Sci. 2013 Mar;70(5):841-62. doi: 10.1007/s00018-012-1095-1. Epub 2012 Aug 2. Review.


Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.

Vianna CR, Donato J Jr, Rossi J, Scott M, Economides K, Gautron L, Pierpont S, Elias CF, Elmquist JK.

J Neurosci. 2012 Jul 25;32(30):10331-7. doi: 10.1523/JNEUROSCI.4507-11.2012.


FOXO1 in the ventromedial hypothalamus regulates energy balance.

Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK.

J Clin Invest. 2012 Jul;122(7):2578-89. doi: 10.1172/JCI62848. Epub 2012 Jun 1.


Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.

Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, Elias CF, Lowell BB, Elmquist JK.

J Comp Neurol. 2012 Nov 1;520(16):3617-32. doi: 10.1002/cne.23116.


Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats.

Cesar-Tognoli LM, Salamoni SD, Tavares AA, Elias CF, Costa JC, Bittencourt JC, Palma MS.

Toxins (Basel). 2011 Feb;3(2):142-62. doi: 10.3390/toxins3020142. Epub 2011 Feb 22.


Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus).

Cavalcante JC, Cândido PL, Sita LV, do Nascimento ES Jr, Cavalcante Jde S, de Oliveira Costa MS, Bittencourt JC, Elias CF.

Brain Res. 2011 Nov 24;1425:47-61. doi: 10.1016/j.brainres.2011.09.020. Epub 2011 Sep 17.


Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction.

Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ.

Cell Metab. 2011 Oct 5;14(4):453-65. doi: 10.1016/j.cmet.2011.08.009. Erratum in: Cell Metab. 2019 May 7;29(5):1232.

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