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Items: 47

1.

Endothelin-1-mediated cerebral ischemia in mice: early cellular events and the role of caspase-3.

Dojo Soeandy C, Salmasi F, Latif M, Elia AJ, Suo NJ, Henderson JT.

Apoptosis. 2019 May 9. doi: 10.1007/s10495-019-01541-z. [Epub ahead of print]

PMID:
31073782
2.

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW.

Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072.

PMID:
30733420
3.

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.

Dominguez-Brauer C, Khatun R, Elia AJ, Thu KL, Ramachandran P, Baniasadi SP, Hao Z, Jones LD, Haight J, Sheng Y, Mak TW.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1148-E1157. doi: 10.1073/pnas.1621355114. Epub 2017 Jan 30.

4.

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

Cancer Cell. 2016 Aug 8;30(2):337-348. doi: 10.1016/j.ccell.2016.05.018. Epub 2016 Jul 14.

5.

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.

Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12.

6.

Metabolic reprogramming during neuronal differentiation.

Agostini M, Romeo F, Inoue S, Niklison-Chirou MV, Elia AJ, Dinsdale D, Morone N, Knight RA, Mak TW, Melino G.

Cell Death Differ. 2016 Sep 1;23(9):1502-14. doi: 10.1038/cdd.2016.36. Epub 2016 Apr 8.

7.

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.

Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.

8.

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.

Wang L, Opland D, Tsai S, Luk CT, Schroer SA, Allison MB, Elia AJ, Furlonger C, Suzuki A, Paige CJ, Mak TW, Winer DA, Myers MG Jr, Woo M.

Nat Med. 2014 May;20(5):484-92. doi: 10.1038/nm.3527. Epub 2014 Apr 20.

PMID:
24747746
9.

Largen: a molecular regulator of mammalian cell size control.

Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, Haight J, Wakeham A, Shahinian A, Ikura M, Topisirovic I, Sonenberg N, Mak TW.

Mol Cell. 2014 Mar 20;53(6):904-15. doi: 10.1016/j.molcel.2014.02.028.

10.

TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21.

11.

Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.

Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8. doi: 10.1073/pnas.1303386110. Epub 2013 Aug 14.

12.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.

13.

Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.

Cappello P, Blaser H, Gorrini C, Lin DC, Elia AJ, Wakeham A, Haider S, Boutros PC, Mason JM, Miller NA, Youngson B, Done SJ, Mak TW.

Oncogene. 2014 May 1;33(18):2375-84. doi: 10.1038/onc.2013.183. Epub 2013 May 27.

14.

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW.

Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113.

15.

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.

Oncogene. 2014 Feb 20;33(8):1047-54. doi: 10.1038/onc.2013.24. Epub 2013 Feb 25.

PMID:
23435421
16.

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Duncan GS, Brenner D, Tusche MW, Brüstle A, Knobbe CB, Elia AJ, Mock T, Bray MR, Krammer PH, Mak TW.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21034-9. doi: 10.1073/pnas.1215558110. Epub 2012 Dec 3.

17.

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27.

18.

Lipocalin 2 performs contrasting, location-dependent roles in APCmin tumor initiation and progression.

Reilly PT, Teo WL, Low MJ, Amoyo-Brion AA, Dominguez-Brauer C, Elia AJ, Berger T, Greicius G, Pettersson S, Mak TW.

Oncogene. 2013 Mar 7;32(10):1233-9. doi: 10.1038/onc.2012.159. Epub 2012 May 21.

19.

Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.

Reilly PT, Afzal S, Gorrini C, Lui K, Bukhman YV, Wakeham A, Haight J, Ling TW, Cheung CC, Elia AJ, Turner PV, Mak TW.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10243-8. doi: 10.1073/pnas.1106211108. Epub 2011 Jun 2.

20.

Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.

Hui KK, Kanungo AK, Elia AJ, Henderson JT.

Cell Death Differ. 2011 Nov;18(11):1780-90. doi: 10.1038/cdd.2011.50. Epub 2011 May 20.

21.

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):13984-90. doi: 10.1073/pnas.1008136107. Epub 2010 Aug 2.

22.

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay.

McIlwain DR, Pan Q, Reilly PT, Elia AJ, McCracken S, Wakeham AC, Itie-Youten A, Blencowe BJ, Mak TW.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12186-91. doi: 10.1073/pnas.1007336107. Epub 2010 Jun 21.

23.

Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.

Cheung CC, Yang C, Berger T, Zaugg K, Reilly P, Elia AJ, Wakeham A, You-Ten A, Chang N, Li L, Wan Q, Mak TW.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11883-8. doi: 10.1073/pnas.1006529107. Epub 2010 Jun 11.

24.

Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.

Berger T, Cheung CC, Elia AJ, Mak TW.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2995-3000. doi: 10.1073/pnas.1000101107. Epub 2010 Feb 1.

25.

Inhibition of apoptosome activation protects injured motor neurons from cell death.

Kanungo AK, Hao Z, Elia AJ, Mak TW, Henderson JT.

J Biol Chem. 2008 Aug 8;283(32):22105-12. doi: 10.1074/jbc.M800988200. Epub 2008 Jun 10.

26.

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A, Fong HE, Cheung CC, Mak TW.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1834-9. Epub 2006 Jan 30.

27.

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.

Mol Cell Biol. 2002 Sep;22(18):6521-32.

28.

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.

Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D.

Genes Dev. 2002 Apr 1;16(7):846-58.

29.

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.

Skinnider BF, Elia AJ, Gascoyne RD, Patterson B, Trumper L, Kapp U, Mak TW.

Blood. 2002 Jan 15;99(2):618-26.

30.

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.

Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zúñiga-Pflücker JC, Kroemer G, Penninger JM.

Nature. 2001 Mar 29;410(6828):549-54.

PMID:
11279485
31.

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.

Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T.

Neuron. 2000 Dec;28(3):819-33.

32.

Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.

Skinnider BF, Elia AJ, Gascoyne RD, Trümper LH, von Bonin F, Kapp U, Patterson B, Snow BE, Mak TW.

Blood. 2001 Jan 1;97(1):250-5.

33.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS.

Lomaga MA, Henderson JT, Elia AJ, Robertson J, Noyce RS, Yeh WC, Mak TW.

J Neurosci. 2000 Oct 1;20(19):7384-93.

34.

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.

Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC.

EMBO J. 2000 Sep 15;19(18):4976-85.

35.

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW.

Immunity. 2000 Jun;12(6):633-42.

36.

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph D, Yeh WC, Wakeham A, Rudolph B, Nallainathan D, Potter J, Elia AJ, Mak TW.

Genes Dev. 2000 Apr 1;14(7):854-62.

37.

Retinal stem cells in the adult mammalian eye.

Tropepe V, Coles BL, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, van der Kooy D.

Science. 2000 Mar 17;287(5460):2032-6.

38.

In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.

Woo M, Hakem A, Elia AJ, Hakem R, Duncan GS, Patterson BJ, Mak TW.

J Immunol. 1999 Nov 1;163(9):4909-16.

39.

Expression of human FALS SOD in motorneurons of Drosophila.

Elia AJ, Parkes TL, Kirby K, St George-Hyslop P, Boulianne GL, Phillips JP, Hilliker AJ.

Free Radic Biol Med. 1999 May;26(9-10):1332-8.

PMID:
10381207
40.

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.

Kapp U, Yeh WC, Patterson B, Elia AJ, Kägi D, Ho A, Hessel A, Tipsword M, Williams A, Mirtsos C, Itie A, Moyle M, Mak TW.

J Exp Med. 1999 Jun 21;189(12):1939-46.

41.

Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.

Barrantes IB, Elia AJ, Wünsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL.

Curr Biol. 1999 May 6;9(9):470-80.

42.

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.

Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW.

Curr Biol. 1998 Oct 22;8(21):1169-78.

43.

Apaf1 is required for mitochondrial pathways of apoptosis and brain development.

Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW.

Cell. 1998 Sep 18;94(6):739-50.

44.

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL.

Nat Genet. 1998 Jun;19(2):171-4.

PMID:
9620775
45.

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.

Yeh WC, de la Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry WS, Lowe SW, Goeddel DV, Mak TW.

Science. 1998 Mar 20;279(5358):1954-8.

46.

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.

de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, Samper E, Potter J, Wakeham A, Marengere L, Langille BL, Crabtree GR, Mak TW.

Nature. 1998 Mar 12;392(6672):182-6.

PMID:
9515963

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