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Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular α3β4* and α9α10 subtypes.

Arias HR, Jin XT, Gallino S, Peng C, Feuerbach D, García-Colunga J, Elgoyhen AB, Drenan RM, Ortells MO.

Neurochem Int. 2019 Dec;131:104552. doi: 10.1016/j.neuint.2019.104552. Epub 2019 Sep 20.


Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.

Di Guilmi MN, Boero LE, Castagna VC, Rodríguez-Contreras A, Wedemeyer C, Gómez-Casati ME, Elgoyhen AB.

J Neurosci. 2019 Sep 4;39(36):7037-7048. doi: 10.1523/JNEUROSCI.2536-18.2019. Epub 2019 Jun 19.


Inner Ear Genes Underwent Positive Selection and Adaptation in the Mammalian Lineage.

Pisciottano F, Cinalli AR, Stopiello JM, Castagna VC, Elgoyhen AB, Rubinstein M, Gómez-Casati ME, Franchini LF.

Mol Biol Evol. 2019 Aug 1;36(8):1653-1670. doi: 10.1093/molbev/msz077.


Developmental Synaptic Changes at the Transient Olivocochlear-Inner Hair Cell Synapse.

Kearney G, Zorrilla de San Martín J, Vattino LG, Elgoyhen AB, Wedemeyer C, Katz E.

J Neurosci. 2019 May 1;39(18):3360-3375. doi: 10.1523/JNEUROSCI.2746-18.2019. Epub 2019 Feb 12.


Therapeutic Approaches to the Treatment of Tinnitus.

Langguth B, Elgoyhen AB, Cederroth CR.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:291-313. doi: 10.1146/annurev-pharmtox-010818-021556. Epub 2018 Jul 25.


Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss.

Boero LE, Castagna VC, Di Guilmi MN, Goutman JD, Elgoyhen AB, Gómez-Casati ME.

J Neurosci. 2018 Aug 22;38(34):7440-7451. doi: 10.1523/JNEUROSCI.0363-18.2018. Epub 2018 Jul 20.


Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice.

Morley BJ, Whiteaker P, Elgoyhen AB.

Front Cell Neurosci. 2018 May 1;12:104. doi: 10.3389/fncel.2018.00104. eCollection 2018. No abstract available.


Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms.

Arias HR, Vázquez-Gómez E, Hernández-Abrego A, Gallino S, Feuerbach D, Ortells MO, Elgoyhen AB, García-Colunga J.

Int J Biochem Cell Biol. 2018 Jul;100:1-10. doi: 10.1016/j.biocel.2018.04.017. Epub 2018 Apr 25.


A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.

Wedemeyer C, Vattino LG, Moglie MJ, Ballestero J, Maison SF, Di Guilmi MN, Taranda J, Liberman MC, Fuchs PA, Katz E, Elgoyhen AB.

J Neurosci. 2018 Apr 18;38(16):3939-3954. doi: 10.1523/JNEUROSCI.2528-17.2018. Epub 2018 Mar 23.


Deletion of dopamine D2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes.

Tomasella E, Bechelli L, Ogando MB, Mininni C, Di Guilmi MN, De Fino F, Zanutto S, Elgoyhen AB, Marin-Burgin A, Gelman DM.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3476-3481. doi: 10.1073/pnas.1719897115. Epub 2018 Mar 12.


Compartmentalization of antagonistic Ca2+ signals in developing cochlear hair cells.

Moglie MJ, Fuchs PA, Elgoyhen AB, Goutman JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2095-E2104. doi: 10.1073/pnas.1719077115. Epub 2018 Feb 8.


Tinnitus Treatment with Oxytocin: A Pilot Study.

Azevedo AA, Figueiredo RR, Elgoyhen AB, Langguth B, Penido NO, Schlee W.

Front Neurol. 2017 Sep 21;8:494. doi: 10.3389/fneur.2017.00494. eCollection 2017.


α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.

Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J.

Learn Mem. 2017 May 15;24(6):231-244. doi: 10.1101/lm.045369.117. Print 2017 Jun.


Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians.

Cortese M, Papal S, Pisciottano F, Elgoyhen AB, Hardelin JP, Petit C, Franchini LF, El-Amraoui A.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2054-2059. doi: 10.1073/pnas.1618778114. Epub 2017 Feb 8.


Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.

Boffi JC, Marcovich I, Gill-Thind JK, Corradi J, Collins T, Lipovsek MM, Moglie M, Plazas PV, Craig PO, Millar NS, Bouzat C, Elgoyhen AB.

Mol Pharmacol. 2017 Mar;91(3):250-262. doi: 10.1124/mol.116.107482. Epub 2017 Jan 9. Erratum in: Mol Pharmacol. 2017 May;91(5):437.


A Latin American Perspective on Ion Channels.

Elgoyhen AB, Barajas-López C.

Mol Pharmacol. 2016 Sep;90(3):286-7. doi: 10.1124/mol.116.105510.


Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice.

Terreros G, Jorratt P, Aedo C, Elgoyhen AB, Delano PH.

J Neurosci. 2016 Jul 6;36(27):7198-209. doi: 10.1523/JNEUROSCI.4031-15.2016.


Editorial: Auditory Efferent System: New Insights from Cortex to Cochlea.

Delano PH, Elgoyhen AB.

Front Syst Neurosci. 2016 Jun 7;10:50. doi: 10.3389/fnsys.2016.00050. eCollection 2016. No abstract available.


Connexin 26 (GJB2) mutation in an Argentinean patient with keratitis-ichthyosis-deafness (KID) syndrome: a case report.

Dalamón VK, Buonfiglio P, Larralde M, Craig P, Lotersztein V, Choate K, Pallares N, Diamante V, Elgoyhen AB.

BMC Med Genet. 2016 May 4;17(1):37. doi: 10.1186/s12881-016-0298-y.


Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

Arias HR, Ravazzini F, Targowska-Duda KM, Kaczor AA, Feuerbach D, Boffi JC, Draczkowski P, Montag D, Brown BM, Elgoyhen AB, Jozwiak K, Puia G.

Int J Biochem Cell Biol. 2016 Jul;76:19-30. doi: 10.1016/j.biocel.2016.04.015. Epub 2016 Apr 26.


Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.

Dalamon V, Fiori MC, Figueroa VA, Oliva CA, Del Rio R, Gonzalez W, Canan J, Elgoyhen AB, Altenberg GA, Retamal MA.

Pflugers Arch. 2016 May;468(5):909-18. doi: 10.1007/s00424-016-1788-7. Epub 2016 Jan 14.


Potassium channels as promising new targets for pharmacologic treatment of tinnitus: Can Internet-based 'crowd sensing' initiated by patients speed up the transition from bench to bedside?

Langguth B, Elgoyhen AB, Schlee W.

Expert Opin Ther Targets. 2016;20(3):251-4. doi: 10.1517/14728222.2016.1125884. Epub 2016 Jan 22. No abstract available.


Tinnitus: perspectives from human neuroimaging.

Elgoyhen AB, Langguth B, De Ridder D, Vanneste S.

Nat Rev Neurosci. 2015 Oct;16(10):632-42. doi: 10.1038/nrn4003. Epub 2015 Sep 16. Review. Erratum in: Nat Rev Neurosci. 2015 Nov;16(11):700.


Cochlear hair cells: The sound-sensing machines.

Goutman JD, Elgoyhen AB, Gómez-Casati ME.

FEBS Lett. 2015 Nov 14;589(22):3354-61. doi: 10.1016/j.febslet.2015.08.030. Epub 2015 Aug 31. Review.


All Treatments in Tinnitus Are Experimental, Controversial, and Futuristic: A Comment on "Experimental, Controversial, and Futuristic Treatments for Chronic Tinnitus" by Folmer et al (2014).

De Ridder D, Vanneste S, Elgoyhen AB, Langguth B, de Nora M.

J Am Acad Audiol. 2015 Jun;26(6):595-7. doi: 10.3766/jaaa.14041. No abstract available.


Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses.

Katz E, Elgoyhen AB.

Front Syst Neurosci. 2014 Dec 2;8:224. doi: 10.3389/fnsys.2014.00224. eCollection 2014. Review.


Stephen F. Heinemann (1939–2014).

Elgoyhen AB, Swanson GT, Mulle C.

Neuron. 2014 Oct 1;84(1):15-7. No abstract available.


Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor.

Lipovsek M, Fierro A, Pérez EG, Boffi JC, Millar NS, Fuchs PA, Katz E, Elgoyhen AB.

Mol Biol Evol. 2014 Dec;31(12):3250-65. doi: 10.1093/molbev/msu258. Epub 2014 Sep 5.


Identifying tinnitus-related genes based on a side-effect network analysis.

Elgoyhen AB, Langguth B, Nowak W, Schecklmann M, De Ridder D, Vanneste S.

CPT Pharmacometrics Syst Pharmacol. 2014 Jan 29;3:e97. doi: 10.1038/psp.2013.75.


Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.

Johnson SL, Wedemeyer C, Vetter DE, Adachi R, Holley MC, Elgoyhen AB, Marcotti W.

Open Biol. 2013 Nov;3(11):130163.


Identification of four novel connexin 26 mutations in non-syndromic deaf patients: genotype-phenotype analysis in moderate cases.

Dalamón V, Florencia Wernert M, Lotersztein V, Craig PO, Diamante RR, Barteik ME, Curet C, Paoli B, Mansilla E, Elgoyhen AB.

Mol Biol Rep. 2013 Dec;40(12):6945-55. doi: 10.1007/s11033-013-2814-x. Epub 2013 Oct 25.


Activation of presynaptic GABA(B(1a,2)) receptors inhibits synaptic transmission at mammalian inhibitory cholinergic olivocochlear-hair cell synapses.

Wedemeyer C, Zorrilla de San Martín J, Ballestero J, Gómez-Casati ME, Torbidoni AV, Fuchs PA, Bettler B, Elgoyhen AB, Katz E.

J Neurosci. 2013 Sep 25;33(39):15477-87. doi: 10.1523/JNEUROSCI.2554-13.2013.


An integrative model of auditory phantom perception: tinnitus as a unified percept of interacting separable subnetworks.

De Ridder D, Vanneste S, Weisz N, Londero A, Schlee W, Elgoyhen AB, Langguth B.

Neurosci Biobehav Rev. 2014 Jul;44:16-32. doi: 10.1016/j.neubiorev.2013.03.021. Epub 2013 Apr 15.


Current pharmacological treatments for tinnitus.

Langguth B, Elgoyhen AB.

Expert Opin Pharmacother. 2012 Dec;13(17):2495-509. doi: 10.1517/14656566.2012.739608. Epub 2012 Nov 4. Review.


Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid.

Boffi JC, Wedemeyer C, Lipovsek M, Katz E, Calvo DJ, Elgoyhen AB.

Br J Pharmacol. 2013 Feb;168(4):954-65. doi: 10.1111/j.1476-5381.2012.02221.x.


Contralateral-noise effects on cochlear responses in anesthetized mice are dominated by feedback from an unknown pathway.

Maison SF, Usubuchi H, Vetter DE, Elgoyhen AB, Thomas SA, Liberman MC.

J Neurophysiol. 2012 Jul;108(2):491-500. doi: 10.1152/jn.01050.2011. Epub 2012 Apr 18.


Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor.

Lipovsek M, Im GJ, Franchini LF, Pisciottano F, Katz E, Fuchs PA, Elgoyhen AB.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4308-13. doi: 10.1073/pnas.1115488109. Epub 2012 Feb 27.


The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats.

Liu Y, Han N, Franchini LF, Xu H, Pisciottano F, Elgoyhen AB, Rajan KE, Zhang S.

Mol Biol Evol. 2012 May;29(5):1441-50. doi: 10.1093/molbev/msr310. Epub 2011 Dec 13.


Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

Coelho C, Figueiredo R, Frank E, Burger J, Schecklmann M, Landgrebe M, Langguth B, Elgoyhen AB.

Audiol Neurootol. 2012;17(3):179-88. doi: 10.1159/000335657. Epub 2012 Jan 31.


Tinnitus: network pathophysiology-network pharmacology.

Elgoyhen AB, Langguth B, Vanneste S, De Ridder D.

Front Syst Neurosci. 2012 Jan 25;6:1. doi: 10.3389/fnsys.2012.00001. eCollection 2012.


Emerging pharmacotherapy of tinnitus.

Langguth B, Elgoyhen AB.

Expert Opin Emerg Drugs. 2011 Dec;16(4):603-6. doi: 10.1517/14728214.2011.644273. Epub 2011 Dec 8.


Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells.

Ballestero J, Zorrilla de San Martín J, Goutman J, Elgoyhen AB, Fuchs PA, Katz E.

J Neurosci. 2011 Oct 12;31(41):14763-74. doi: 10.1523/JNEUROSCI.6788-10.2011.


The efferent medial olivocochlear-hair cell synapse.

Elgoyhen AB, Katz E.

J Physiol Paris. 2012 Jan;106(1-2):47-56. doi: 10.1016/j.jphysparis.2011.06.001. Epub 2011 Jul 6. Review.


Phantom percepts: tinnitus and pain as persisting aversive memory networks.

De Ridder D, Elgoyhen AB, Romo R, Langguth B.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8075-80. doi: 10.1073/pnas.1018466108. Epub 2011 Apr 18.


Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.

Elgoyhen AB, Franchini LF.

Hear Res. 2011 Mar;273(1-2):100-8. doi: 10.1016/j.heares.2009.12.028. Epub 2010 Jan 6. Review.


Pharmacological approaches to the treatment of tinnitus.

Elgoyhen AB, Langguth B.

Drug Discov Today. 2010 Apr;15(7-8):300-5. doi: 10.1016/j.drudis.2009.11.003. Epub 2009 Dec 2. Review.


GJB2 and GJB6 genes: molecular study and identification of novel GJB2 mutations in the hearing-impaired Argentinean population.

Dalamón V, Lotersztein V, Béhèran A, Lipovsek M, Diamante F, Pallares N, Francipane L, Frechtel G, Paoli B, Mansilla E, Diamante V, Elgoyhen AB.

Audiol Neurootol. 2010;15(3):194-202. doi: 10.1159/000254487. Epub 2009 Nov 4.


Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs.

Murthy V, Taranda J, Elgoyhen AB, Vetter DE.

Dev Neurobiol. 2009 Dec;69(14):931-49. doi: 10.1002/dneu.20753.


Emerging pharmacotherapy of tinnitus.

Langguth B, Salvi R, Elgoyhen AB.

Expert Opin Emerg Drugs. 2009 Dec;14(4):687-702. doi: 10.1517/14728210903206975. Review.


The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?

Elgoyhen AB, Katz E, Fuchs PA.

Biochem Pharmacol. 2009 Oct 1;78(7):712-9. doi: 10.1016/j.bcp.2009.05.023. Epub 2009 May 27. Review.

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